LOCUS       NM_198510               4964 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens inter-alpha-trypsin inhibitor heavy chain family
            member 6 (ITIH6), mRNA.
ACCESSION   NM_198510 XM_293311
VERSION     NM_198510.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4964)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4964)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z98046.1, AY358170.1 and
            CA413764.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_198510.2.
            
            Summary: The protein encoded by this gene belongs to the interalpha
            trypsin inhibitor heavy chain (ITIH) family. Interalpha trypsin
            inhibitor (ITI) is composed of two heavy chains (containing VWA
            domain) and one light chain. The light chain confers the
            protease-inhibitor function, while the heavy chains are involved in
            mediating protein-protein interactions with the components of the
            extracellular matrix. [provided by RefSeq, Sep 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358170.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968832,
                                           SAMEA2142853 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000218436.7/ ENSP00000218436.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                Z98046.1           42443-42457         c
            16-4699             AY358170.1         1-4684
            4700-4964           CA413764.1         37-301              c
FEATURES             Location/Qualifiers
     source          1..4964
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.22"
     gene            1..4964
                     /gene="ITIH6"
                     /gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
                     /note="inter-alpha-trypsin inhibitor heavy chain family
                     member 6"
                     /db_xref="GeneID:347365"
                     /db_xref="HGNC:HGNC:28907"
     exon            1..147
                     /gene="ITIH6"
                     /gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..3987
                     /gene="ITIH6"
                     /gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
                     /note="ITI-like protein; inter-alpha-trypsin inhibitor
                     heavy chain H5-like protein; inter-alpha inhibitor H5-like
                     protein; inter-alpha-trypsin inhibitor heavy chain H6"
                     /codon_start=1
                     /product="inter-alpha-trypsin inhibitor heavy chain H6
                     precursor"
                     /protein_id="NP_940912.1"
                     /db_xref="CCDS:CCDS14361.1"
                     /db_xref="GeneID:347365"
                     /db_xref="HGNC:HGNC:28907"
                     /translation="MSGWRYLICVSFLLTILLELTYQGPPVPASSSTKLLMTSYSMRS
                     TVVSRYAHTLVTSVLFNPHAEAHEAIFDLDLPHLAFISNFTMTINNKVYIAEVKEKHQ
                     AKKIYEEAHQQGKTAAHVGIRDRESEKFRISTSLAAGTEVTFSLAYEELLQRHQGQYQ
                     LVVSLRPGQLVKRLSIEVTVSERTGISYVHIPPLRTGRLRTNAHASEVDSPPSTRIER
                     GETCVRITYCPTLQDQSSISGSGIMADFLVQYDVVMEDIIGDVQIYDDYFIHYFAPRG
                     LPPMEKNVVFVIDVSSSMFGTKMEQTKTAMNVILSDLQANDYFNIISFSDTVNVWKAG
                     GSIQATIQNVHSAKDYLHCMEADGWTDVNSALLAAASVLNHSNQEPGRGPSVGRIPLI
                     IFLTDGEPTAGVTTPSVILSNVRQALGHRVSLFSLAFGDDADFTLLRRLSLENRGIAR
                     RIYEDTDAALQLKGLYEEISMPLLADVRLNYLGGLVGASPWAVFPNYFGGSELVVAGQ
                     VQPGKQELGIHLAARGPKDQLLVAHHSEGATNNSQKAFGCPGEPAPNVAHFIRRLWAY
                     VTIGELLDAHFQARDTTTRHLLAAKVLNLSLEYNFVTPLTSLVMVQPKQASEETRRQT
                     STSAGPDTIMPSSSSRHGLGVSTAQPALVPKVISPKSRPVKPKFYLSSTTTASTKKML
                     SSKELEPLGESPHTLSMPTYPKAKIPAQQDSGTLAQPTLRTKPTILVPSNSGTLLPLK
                     PGSLSHQNPDILPTNSRTQVPPVKPGIPASPKADTVKCVTPLHSKPGAPSHPQLGALT
                     SQAPKGLPQSRPGVSTLQVPKYPLHTRPRVPAPKTRNNMPHLGPGILLSKTPKILLSL
                     KPSAPPHQISTSISLSKPETPNPHMPQTPLPPRPDRPRPPLPESLSTFPNTISSSTGP
                     SSTTTTSVLGEPLPMPFTPTLPPGRFWHQYDLLPGPQRTRQVLGPSRPGVPTMSLLNS
                     SRPTPEGSPPNLPILLPSSILPEAISLLLLPEELELLSESMVESKFVESLNPPAFYTF
                     LTPDEDGSPNWDGNSEEILGGAGGSMESQGSSVGLAKGTLPSIFTFSSSVDGDPHFVI
                     QIPHSEEKICFTLNGHPGDLLQLIEDPKAGLHVSGKLLGAPPRPGHKDQTRTYFQIIT
                     VTTDKPRAYTITISRSSISLRGEGTLRLSWDQPALLKRPQLELYVAAAARLTLRLGPY
                     LEFLVLRHRYRHPSTLQLPHLGFYVANGSGLSPSARGLIGQFQHADIRLVTGPMGPCL
                     RRHHGPDVPVILGKRLLKDSPRLLPRWASCWLVKRSHVELLLGHPYLSYVL"
     exon            148..302
                     /gene="ITIH6"
                     /gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
                     /inference="alignment:Splign:2.1.0"
     exon            303..413
                     /gene="ITIH6"
                     /gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
                     /inference="alignment:Splign:2.1.0"
     exon            414..661
                     /gene="ITIH6"
                     /gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
                     /inference="alignment:Splign:2.1.0"
     exon            662..831
                     /gene="ITIH6"
                     /gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
                     /inference="alignment:Splign:2.1.0"
     exon            832..948
                     /gene="ITIH6"
                     /gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1120
                     /gene="ITIH6"
                     /gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..3154
                     /gene="ITIH6"
                     /gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
                     /inference="alignment:Splign:2.1.0"
     exon            3155..3247
                     /gene="ITIH6"
                     /gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
                     /inference="alignment:Splign:2.1.0"
     exon            3248..3283
                     /gene="ITIH6"
                     /gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
                     /inference="alignment:Splign:2.1.0"
     exon            3284..3397
                     /gene="ITIH6"
                     /gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
                     /inference="alignment:Splign:2.1.0"
     exon            3398..3775
                     /gene="ITIH6"
                     /gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
                     /inference="alignment:Splign:2.1.0"
     exon            3776..4964
                     /gene="ITIH6"
                     /gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4686..4691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITIH6"
                     /gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
                     /note="hexamer: AGTAAA"
     polyA_site      4706
                     /gene="ITIH6"
                     /gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
                     /note="major polyA site"
     regulatory      4943..4948
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITIH6"
                     /gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
                     /note="hexamer: CATAAA"
     polyA_site      4964
                     /gene="ITIH6"
                     /gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
                     /note="major polyA site"
ORIGIN      
        1 agatcttctg gatgtgaaca acagatccag gccagaggtg gcatcatgtc tgggtggagg
       61 tacctcatct gtgtcagctt tttgctgacc attcttcttg aactgacata ccagggaccc
      121 cctgtccccg cttcatcaag cacaaagttg ttaatgacaa gctattctat gcgctccacg
      181 gtggtgtctc gctatgccca caccttggtc acctctgtcc tgtttaatcc acatgctgaa
      241 gcccatgaag ccatctttga cctggatctg cctcatcttg cctttatctc caatttcact
      301 atgaccatca acaataaagt ctacattgca gaagtcaaag agaagcacca ggcaaagaaa
      361 atctatgaag aagcccatca gcagggaaag acagctgctc atgtaggcat cagggaccgg
      421 gaatcagaga agttccgcat ctccaccagc ctggcagcag gcacagaggt gactttttcc
      481 ctggcctatg aggaactgct tcagcggcac cagggccagt accagctggt ggtgagcctg
      541 aggcctggcc aattggtgaa gaggctgagc atagaggtta cagtgtcaga aaggacaggc
      601 atctcctatg tgcacatacc acccctgagg accggccgtc tgcgcaccaa tgcccatgca
      661 agtgaggtgg attcaccccc atccaccagg atcgagaggg gagagacctg tgtccgaatc
      721 acctactgcc cgacattgca agaccagtcg tccatctctg ggtcaggcat catggctgac
      781 ttcctggttc agtacgatgt ggtcatggag gacatcattg gagacgtgca gatttacgat
      841 gactatttca ttcactactt tgcccccaga ggccttccac ctatggagaa gaatgtggtt
      901 tttgttattg acgtaagcag ctccatgttt ggtaccaaga tggaacagac taaaacggcc
      961 atgaatgtga tcctcagtga ccttcaagcc aatgactact tcaacatcat ctccttttct
     1021 gacacagtta atgtttggaa agctggaggc tcaatccagg ccaccatcca gaatgtccac
     1081 agtgccaagg actacctgca ttgcatggaa gccgatggct ggacagacgt caactcagct
     1141 ctgctggcag ctgcttcagt gctgaaccat agcaaccagg agcctgggag gggccccagt
     1201 gtggggagga tccctcttat catcttcctg acggatgggg agcccacggc cggcgtgacg
     1261 acccccagtg tgatcctctc caatgtccgt caggcgctag gccacagggt atcccttttc
     1321 agcttggcct ttggggatga tgctgacttt acactgctgc gccgcctgtc cctggaaaac
     1381 cggggaatag cccggcgcat atatgaggac actgatgcgg ccctacagct gaagggcctc
     1441 tatgaggaga tctccatgcc tctgctggca gatgtgcgtc tgaactacct gggtggcttg
     1501 gttggggcct ccccttgggc cgttttcccc aactactttg gtggctctga gctggtggtg
     1561 gcaggacagg tgcagccagg caaacaggaa ctgggcatcc acctggcagc ccgtggcccc
     1621 aaggatcagc ttcttgtggc ccaccacagt gaaggggcca ccaacaacag ccagaaggcc
     1681 tttggttgcc caggggagcc agcccccaat gtggcccact tcatccgccg cctctgggcc
     1741 tatgtcacca ttggagaact gctggatgca cacttccaag ctcgtgacac caccactcgc
     1801 cacctgctgg ctgccaaagt cctcaacctg tcccttgaat acaactttgt cacacctctg
     1861 acttcactgg tcatggtgca acccaaacag gccagtgagg agaccaggag acagacttcc
     1921 acctctgctg ggccagacac catcatgccc tcatccagca gcaggcatgg cctaggggta
     1981 agcacagctc agccagcctt ggtgcccaag gtcatctccc ccaaatcaag gcctgtgaaa
     2041 ccaaagttct acttatcctc aactactact gcctctacca agaagatgct aagttccaaa
     2101 gagctggagc cattgggaga gagccctcat accctgtcaa tgcccacata cccaaaggcc
     2161 aaaattccag cacaacagga ttctggcacc ttggcccagc caactctcag gacaaaacct
     2221 accattcttg tgccctcaaa ttctggtact ctgttgcctc tgaagcccgg ctctctatca
     2281 caccagaatc ctgatatatt acccacgaac tccaggacac aagtcccacc tgtgaaacct
     2341 ggcatcccag cctcgcccaa agctgacact gtgaaatgtg ttactccact gcattccaaa
     2401 cctggtgctc catcgcaccc ccaacttggg gcactcacat cacaggcacc taaaggcctg
     2461 ccacagtcaa gacctggagt ctctacactt caggttccca agtacccact acacaccaga
     2521 cctagggttc ctgctcccaa gacccgaaac aacatgccac acctggggcc tggaatcctc
     2581 ttgtccaaga cccctaaaat cttattatct cttaaaccga gtgccccacc acaccaaatt
     2641 tccacaagca tatcactttc caagcctgag accccaaacc cccatatgcc tcaaacccca
     2701 ctacctccta gacctgacag accaaggccc ccacttcctg agagcctaag cacattccca
     2761 aatacaatct caagttccac aggtcccagc agtaccacaa ccacctctgt ccttggagaa
     2821 cccctcccca tgccctttac tcccactctg ccccctggaa ggttctggca tcagtatgac
     2881 ctcctcccgg gtccccagag gaccaggcaa gttctgggac catctaggcc aggagttcca
     2941 acaatgagcc tactcaacag ctccaggcct acaccagaag gcagccctcc aaacctgcca
     3001 atcttgctgc cttctagcat cctccctgag gccatcagtc tgctccttct ccctgaggag
     3061 ctagagctgc tgtctgaatc aatggtggaa tccaagttcg tggagtcctt gaacccacca
     3121 gctttctata ccttcctcac tcctgatgaa gatggaagtc caaactggga tggcaattct
     3181 gaggagatcc tgggaggagc tggaggcagc atggaatctc aaggaagttc tgtggggtta
     3241 gcaaaaggca cattgcctag catcttcacc ttctcctcct cagtggacgg ggacccccac
     3301 tttgtgatcc aaatcccaca ctcagaagag aagatctgct tcacactgaa tgggcaccct
     3361 ggggacttgc tgcagctcat agaggaccca aaggcagggc tgcatgtgag tgggaagctg
     3421 cttggcgcac caccaaggcc gggccacaag gaccagactc gcacctactt ccagatcatc
     3481 acagtcacta cagacaaacc ccgggcctat actatcacca tcagccgcag ttctatatct
     3541 ttgcgaggcg agggtacctt gcgcctgtcc tgggaccaac ctgccctgct gaagaggccc
     3601 cagctggagc tctatgtggc tgctgcagcc cgccttaccc tccgccttgg gccctacctt
     3661 gagttcctag tcctccgaca ccgctacagg catcccagta ccctgcaact accccacctg
     3721 gggttctacg tggccaatgg ctcaggcctc agcccctcag cccgtggcct gatagggcag
     3781 ttccagcacg cagacatccg actggtgaca ggacctatgg ggccatgctt acgaaggcac
     3841 catggcccag atgtgcctgt gattctaggc aagaggctgc tgaaggactc accaaggctg
     3901 ctgccccgct gggcttcctg ctggctggtg aagcgctctc atgtagagct gcttctgggc
     3961 cacccctacc tctcctatgt cctgtgatgg cttctgaatt ccagagccag gagacctgaa
     4021 tttgggagat ccagaaacca gggcatgggg tgagccaggg acagagaccc aaggacatgg
     4081 aagcacacac agggacacac agactcacgc atgttctaag gaacacatat acaagggtat
     4141 acaaacacat agacatgcag agacatagag tcagggactc ctgcatcttc atggtccttc
     4201 acatctccag tctcaccctc tccaaatcca tgctcctcac cagccctaca agccactttt
     4261 gtaaaacgaa aaaatgatca gtagttctgc tcacagcttt ccctaactcc tatggcatat
     4321 tcaaggctct cagagtttcc ctaacaaacc atgctcactc ctaccactgg accattgcat
     4381 gtgcttttcc ttctgcatga aacactcttc ctttgttcct gtaggtgagt ataattcatc
     4441 cttcaaatcc tagttgttac ctcttctagg aggcctttcc tgatgcctgc cctagattga
     4501 gtttggtcct gtcctctggg ttcctatagc ccacccccaa ccctccacgc tcacagtatt
     4561 tatactgtgt agtaatcatc tgtttacttg tctggatccc tgacttagac tgtgagatct
     4621 ttgagggcaa ggaccttttc tgaatcatct atgtatcccc agtgcctctc acataatagg
     4681 tgcttagtaa atatttgtta aaagaatgaa ttaattaatt aacaaaaaag gatcccataa
     4741 catagcaata gacacacata tatacatact cacaaccaaa gacacaggat cacacccgga
     4801 aaaacagtga caagggcaca gatatggatg gatagaggga cagacattta tggaaacaca
     4861 ggaatcacaa aacaaacatg gacatagggg tatagagaca taaaaagatg gggacaggga
     4921 gccagagtgg cagaatcagg gacataaact cagagaaaaa ggaa
//
