LOCUS       NM_002218               3282 bp    mRNA    linear   PRI 02-AUG-2024
DEFINITION  Homo sapiens inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4),
            transcript variant 1, mRNA.
ACCESSION   NM_002218
VERSION     NM_002218.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3282)
  AUTHORS   Ravindran,A., Holappa,L., Niskanen,H., Skovorodkin,I., Kaisto,S.,
            Beter,M., Kiema,M., Selvarajan,I., Nurminen,V., Aavik,E.,
            Aherrahrou,R., Pasonen-Seppanen,S., Fortino,V., Laakkonen,J.P.,
            Yla-Herttuala,S., Vainio,S., Ord,T. and Kaikkonen,M.U.
  TITLE     Translatome profiling reveals Itih4 as a novel smooth muscle
            cell-specific gene in atherosclerosis
  JOURNAL   Cardiovasc Res 120 (8), 869-882 (2024)
   PUBMED   38289873
  REMARK    GeneRIF: Translatome profiling reveals Itih4 as a novel smooth
            muscle cell-specific gene in atherosclerosis.
REFERENCE   2  (bases 1 to 3282)
  AUTHORS   Sun,Z., Zhang,Y., Zhou,H., Li,J., Zhou,Y. and Wang,L.
  TITLE     Serum interalpha-trypsin inhibitor heavy chain H4 may be an
            anti-inflammatory marker reflecting disease risk, activity and
            treatment outcome of ankylosing spondylitis
  JOURNAL   Scand J Clin Lab Invest 83 (8), 540-547 (2023)
   PUBMED   38156824
  REMARK    GeneRIF: Serum interalpha-trypsin inhibitor heavy chain H4 may be
            an anti-inflammatory marker reflecting disease risk, activity and
            treatment outcome of ankylosing spondylitis.
REFERENCE   3  (bases 1 to 3282)
  AUTHORS   Du,J., Lin,Y., Liang,H., Li,J., Wang,F., Jiang,C. and Shao,B.
  TITLE     Hyperglycosylated N-Linked Site 339 of gp120 Appears to Be Unique
            and May Contribute to CRF01_AE Transmission Among Men Who Have Sex
            with Men in China and Thailand
  JOURNAL   AIDS Res Hum Retroviruses 39 (9), 505-510 (2023)
   PUBMED   37335061
  REMARK    GeneRIF: Hyperglycosylated N-Linked Site 339 of gp120 Appears to Be
            Unique and May Contribute to CRF01_AE Transmission Among Men Who
            Have Sex with Men in China and Thailand.
REFERENCE   4  (bases 1 to 3282)
  AUTHORS   Park,H.B., Choi,B.C. and Baek,K.H.
  TITLE     PGK1 modulates balance between pro- and anti-inflammatory cytokines
            by interacting with ITI-H4
  JOURNAL   Biomed Pharmacother 161, 114437 (2023)
   PUBMED   36841032
  REMARK    GeneRIF: PGK1 modulates balance between pro- and anti-inflammatory
            cytokines by interacting with ITI-H4.
REFERENCE   5  (bases 1 to 3282)
  AUTHORS   Huo,Y., Lai,Y., Feng,Q., Wang,Q. and Li,J.
  TITLE     Serum ITIH4 in coronary heart disease: a potential
            anti-inflammatory biomarker related to stenosis degree and risk of
            major adverse cardiovascular events
  JOURNAL   Biomark Med 16 (18), 1279-1288 (2022)
   PUBMED   36891881
  REMARK    GeneRIF: Serum ITIH4 in coronary heart disease: a potential
            anti-inflammatory biomarker related to stenosis degree and risk of
            major adverse cardiovascular events.
REFERENCE   6  (bases 1 to 3282)
  AUTHORS   Saguchi,K., Tobe,T., Hashimoto,K., Nagasaki,Y., Oda,E., Nakano,Y.,
            Miura,N.H. and Tomita,M.
  TITLE     Isolation and characterization of the human inter-alpha-trypsin
            inhibitor family heavy chain-related protein (IHRP) gene (ITIHL1)
  JOURNAL   J Biochem 119 (5), 898-905 (1996)
   PUBMED   8797089
REFERENCE   7  (bases 1 to 3282)
  AUTHORS   Choi-Miura,N.H., Sano,Y., Oda,E., Nakano,Y., Tobe,T.,
            Yanagishita,T., Taniyama,M., Katagiri,T. and Tomita,M.
  TITLE     Purification and characterization of a novel glycoprotein which has
            significant homology to heavy chains of inter-alpha-trypsin
            inhibitor family from human plasma
  JOURNAL   J Biochem 117 (2), 400-407 (1995)
   PUBMED   7541790
REFERENCE   8  (bases 1 to 3282)
  AUTHORS   Nishimura,H., Kakizaki,I., Muta,T., Sasaki,N., Pu,P.X.,
            Yamashita,T. and Nagasawa,S.
  TITLE     cDNA and deduced amino acid sequence of human PK-120, a plasma
            kallikrein-sensitive glycoprotein
  JOURNAL   FEBS Lett 357 (2), 207-211 (1995)
   PUBMED   7805892
REFERENCE   9  (bases 1 to 3282)
  AUTHORS   Saguchi,K., Tobe,T., Hashimoto,K., Sano,Y., Nakano,Y., Miura,N.H.
            and Tomita,M.
  TITLE     Cloning and characterization of cDNA for inter-alpha-trypsin
            inhibitor family heavy chain-related protein (IHRP), a novel human
            plasma glycoprotein
  JOURNAL   J Biochem 117 (1), 14-18 (1995)
   PUBMED   7775381
REFERENCE   10 (bases 1 to 3282)
  AUTHORS   Tobe,T., Saguchi,K., Hashimoto,K., Miura,N.H., Tomita,M., Li,F.,
            Wang,Y., Minoshima,S. and Shimizu,N.
  TITLE     Mapping of human inter-alpha-trypsin inhibitor family heavy
            chain-related protein gene (ITIHL1) to human chromosome 3p21-->p14
  JOURNAL   Cytogenet Cell Genet 71 (3), 296-298 (1995)
   PUBMED   7587397
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC136392.1, BC136393.1,
            AW291001.1 and AC006254.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_002218.4.
            
            Summary: The protein encoded by this gene is secreted into the
            blood, where it is cleaved by plasma kallikrein into two smaller
            forms. Expression of this gene has been detected only in liver, and
            it seems to be upregulated during surgical trauma. This gene is
            part of a cluster of similar genes on chromosome 3. Two transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D38595.1, BC136393.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155590 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266041.9/ ENSP00000266041.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-824               BC136392.1         2-825
            825-2121            BC136393.1         826-2122
            2122-2974           BC136392.1         2138-2990
            2975-3254           AW291001.1         15-294              c
            3255-3282           AC006254.10        17767-17794
FEATURES             Location/Qualifiers
     source          1..3282
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.1"
     gene            1..3282
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /note="inter-alpha-trypsin inhibitor heavy chain 4"
                     /db_xref="GeneID:3700"
                     /db_xref="HGNC:HGNC:6169"
                     /db_xref="MIM:600564"
     exon            1..120
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..2823
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; plasma kallikrein-sensitive glycoprotein 120;
                     inter-alpha-trypsin inhibitor, heavy chain-like, 1;
                     inter-alpha (globulin) inhibitor H4 (plasma
                     Kallikrein-sensitive glycoprotein); ITI heavy chain H4;
                     inter-alpha-inhibitor heavy chain 4; inter-alpha-trypsin
                     inhibitor family heavy chain-related protein;
                     inter-alpha-trypsin inhibitor heavy chain family member 4"
                     /codon_start=1
                     /product="inter-alpha-trypsin inhibitor heavy chain H4
                     isoform 1 precursor"
                     /protein_id="NP_002209.2"
                     /db_xref="CCDS:CCDS2865.1"
                     /db_xref="GeneID:3700"
                     /db_xref="HGNC:HGNC:6169"
                     /db_xref="MIM:600564"
                     /translation="MKPPRPVRTCSKVLVLLSLLAIHQTTTAEKNGIDIYSLTVDSRV
                     SSRFAHTVVTSRVVNRANTVQEATFQMELPKKAFITNFSMIIDGMTYPGIIKEKAEAQ
                     AQYSAAVAKGKSAGLVKATGRNMEQFQVSVSVAPNAKITFELVYEELLKRRLGVYELL
                     LKVRPQQLVKHLQMDIHIFEPQGISFLETESTFMTNQLVDALTTWQNKTKAHIRFKPT
                     LSQQQKSPEQQETVLDGNLIIRYDVDRAISGGSIQIENGYFVHYFAPEGLTTMPKNVV
                     FVIDKSGSMSGRKIQQTREALIKILDDLSPRDQFNLIVFSTEATQWRPSLVPASAENV
                     NKARSFAAGIQALGGTNINDAMLMAVQLLDSSNQEERLPEGSVSLIILLTDGDPTVGE
                     TNPRSIQNNVREAVSGRYSLFCLGFGFDVSYAFLEKLALDNGGLARRIHEDSDSALQL
                     QDFYQEVANPLLTAVTFEYPSNAVEEVTQNNFRLLFKGSEMVVAGKLQDRGPDVLTAT
                     VSGKLPTQNITFQTESSVAEQEAEFQSPKYIFHNFMERLWAYLTIQQLLEQTVSASDA
                     DQQALRNQALNLSLAYSFVTPLTSMVVTKPDDQEQSQVAEKPMEGESRNRNVHSGSTF
                     FKYYLQGAKIPKPEASFSPRRGWNRQAGAAGSRMNFRPGVLSSRQLGLPGPPDVPDHA
                     AYHPFRRLAILPASAPPATSNPDPAVSRVMNMKIEETTMTTQTPAPIQAPSAILPLPG
                     QSVERLCVDPRHRQGPVNLLSDPEQGVEVTGQYEREKAGFSWIEVTFKNPLVWVHASP
                     EHVVVTRNRRSSAYKWKETLFSVMPGLKMTMDKTGLLLLSDPDKVTIGLLFWDGRGEG
                     LRLLLRDTDRFSSHVGGTLGQFYQEVLWGSPAASDDGRRTLRVQGNDHSATRERRLDY
                     QEGPPGVEISCWSVEL"
     exon            121..281
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            282..386
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            387..549
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            550..660
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            661..789
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            790..906
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1075
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1201
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1383
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1569
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1709
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1864
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1891
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..1942
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..1981
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2107
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2182
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2209
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2326
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2501
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2656
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..2753
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            2754..3282
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2938..2943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /note="hexamer: AAGAAA"
     polyA_site      2962
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /note="major polyA site"
ORIGIN      
        1 agaagcctcc tggcagacac tggagccacg atgaagcccc caaggcctgt ccgtacctgc
       61 agcaaagttc tcgtcctgct ttcactgctg gccatccacc agactactac tgccgaaaag
      121 aatggcatcg acatctacag cctcaccgtg gactccaggg tctcatcccg atttgcccac
      181 acggtcgtca ccagccgagt ggtcaatagg gccaatactg tgcaggaggc caccttccag
      241 atggagctgc ccaagaaagc cttcatcacc aacttctcca tgatcatcga tggcatgacc
      301 tacccaggga tcatcaagga gaaggctgaa gcccaggcac agtacagcgc agcagtggcc
      361 aagggaaaga gcgctggcct cgtcaaggcc accgggagaa acatggagca gttccaggtg
      421 tcggtcagtg tggctcccaa tgccaagatc acctttgagc tggtctatga ggagctgctc
      481 aagcggcgtt tgggggtgta cgagctgctg ctgaaagtgc ggccccagca gctggtcaag
      541 cacctgcaga tggacattca catcttcgag ccccagggca tcagctttct ggagacagag
      601 agcaccttca tgaccaacca gctggtagac gccctcacca cctggcagaa taagaccaag
      661 gctcacatcc ggttcaagcc aacactttcc cagcagcaaa agtccccaga gcagcaagaa
      721 acagtcctgg acggcaacct cattatccgc tatgatgtgg accgggccat ctccgggggc
      781 tccattcaga tcgagaacgg ctactttgta cactactttg cccccgaggg cctaaccaca
      841 atgcccaaga atgtggtctt tgtcattgac aagagcggct ccatgagtgg caggaaaatc
      901 cagcagaccc gggaagccct aatcaagatc ctggatgacc tcagccccag agaccagttc
      961 aacctcatcg tcttcagtac agaagcaact cagtggaggc catcactggt gccagcctca
     1021 gccgagaacg tgaacaaggc caggagcttt gctgcgggca tccaggccct gggagggacc
     1081 aacatcaatg atgcaatgct gatggctgtg cagttgctgg acagcagcaa ccaggaggag
     1141 cggctgcccg aagggagtgt ctcactcatc atcctgctca ccgatggcga ccccactgtg
     1201 ggggagacta accccaggag catccagaat aacgtgcggg aagctgtaag tggccggtac
     1261 agcctcttct gcctgggctt cggtttcgac gtcagctatg ccttcctgga gaagctggca
     1321 ctggacaatg gcggcctggc ccggcgcatc catgaggact cagactctgc cctgcagctc
     1381 caggacttct accaggaagt ggccaaccca ctgctgacag cagtgacctt cgagtaccca
     1441 agcaatgccg tggaggaggt cactcagaac aacttccggc tcctcttcaa gggctcagag
     1501 atggtggtgg ctgggaagct ccaggaccgg gggcctgatg tgctcacagc cacagtcagt
     1561 gggaagctgc ctacacagaa catcactttc caaacggagt ccagtgtggc agagcaggag
     1621 gcggagttcc agagccccaa gtatatcttc cacaacttca tggagaggct ctgggcatac
     1681 ctgactatcc agcagctgct ggagcaaact gtctccgcat ccgatgctga tcagcaggcc
     1741 ctccggaacc aagcgctgaa tttatcactt gcctacagct ttgtcacgcc tctcacatct
     1801 atggtagtca ccaaacccga tgaccaagag cagtctcaag ttgctgagaa gcccatggaa
     1861 ggcgaaagta gaaacaggaa tgtccactca ggttccactt tcttcaaata ttatctccag
     1921 ggagcaaaaa taccaaaacc agaggcttcc ttttctccaa gaagaggatg gaatagacaa
     1981 gctggagctg ctggctcccg gatgaatttc agacctgggg ttctcagctc caggcaactt
     2041 ggactcccag gacctcctga tgttcctgac catgctgctt accacccctt ccgccgtctg
     2101 gccatcttgc ctgcttcagc accaccagcc acctcaaatc ctgatccagc tgtgtctcgt
     2161 gtcatgaata tgaaaatcga agaaacaacc atgacaaccc aaaccccagc ccccatacag
     2221 gctccctctg ccatcctgcc actgcctggg cagagtgtgg agcggctctg tgtggacccc
     2281 agacaccgcc aggggccagt gaacctgctc tcagaccctg agcaaggggt tgaggtgact
     2341 ggccagtatg agagggagaa ggctgggttc tcatggatcg aagtgacctt caagaacccc
     2401 ctggtatggg ttcacgcatc ccctgaacac gtggtggtga ctcggaaccg aagaagctct
     2461 gcgtacaagt ggaaggagac gctattctca gtgatgcccg gcctgaagat gaccatggac
     2521 aagacgggtc tcctgctgct cagtgaccca gacaaagtga ccatcggcct gttgttctgg
     2581 gatggccgtg gggaggggct ccggctcctt ctgcgtgaca ctgaccgctt ctccagccac
     2641 gttggaggga cccttggcca gttttaccag gaggtgctct ggggatctcc agcagcatca
     2701 gatgacggca gacgcacgct gagggttcag ggcaatgacc actctgccac cagagagcgc
     2761 aggctggatt accaggaggg gcccccggga gtggagattt cctgctggtc tgtggagctg
     2821 tagttctgat ggaaggagct gtgcccaccc tgtacacttg gcttccccct gcaactgcag
     2881 ggccgcttct ggggcctgga ccaccatggg gaggaagagt cccactcatt acaaataaag
     2941 aaaggtggtg tgagcctggg aagtgggtgt ctccagttcc atgtggccaa atcctagggc
     3001 ctcaacctcg catcctgaac cttagcatcg tggaacacag aagcttccac tgtcagctct
     3061 caagagccca tggccaggaa ggcccatgct gagctttcag tccagcccct tcattttaca
     3121 aacaaggaaa ctgagctcga accacccatt tgagatgtca ctgtggcccc cagctagagg
     3181 cccagggctg ggagcattct ccaggagcag aggttcagtc tgcttcatgg tctcttggac
     3241 cagttttgac tacaaaaaaa aaaaaaaaaa aaatagagtg aa
//
