LOCUS       NM_001166449            3192 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4),
            transcript variant 2, mRNA.
ACCESSION   NM_001166449
VERSION     NM_001166449.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3192)
  AUTHORS   Ravindran,A., Holappa,L., Niskanen,H., Skovorodkin,I., Kaisto,S.,
            Beter,M., Kiema,M., Selvarajan,I., Nurminen,V., Aavik,E.,
            Aherrahrou,R., Pasonen-Seppanen,S., Fortino,V., Laakkonen,J.P.,
            Yla-Herttuala,S., Vainio,S., Ord,T. and Kaikkonen,M.U.
  TITLE     Translatome profiling reveals Itih4 as a novel smooth muscle
            cell-specific gene in atherosclerosis
  JOURNAL   Cardiovasc Res 120 (8), 869-882 (2024)
   PUBMED   38289873
  REMARK    GeneRIF: Translatome profiling reveals Itih4 as a novel smooth
            muscle cell-specific gene in atherosclerosis.
REFERENCE   2  (bases 1 to 3192)
  AUTHORS   Sun,Z., Zhang,Y., Zhou,H., Li,J., Zhou,Y. and Wang,L.
  TITLE     Serum interalpha-trypsin inhibitor heavy chain H4 may be an
            anti-inflammatory marker reflecting disease risk, activity and
            treatment outcome of ankylosing spondylitis
  JOURNAL   Scand J Clin Lab Invest 83 (8), 540-547 (2023)
   PUBMED   38156824
  REMARK    GeneRIF: Serum interalpha-trypsin inhibitor heavy chain H4 may be
            an anti-inflammatory marker reflecting disease risk, activity and
            treatment outcome of ankylosing spondylitis.
REFERENCE   3  (bases 1 to 3192)
  AUTHORS   Du,J., Lin,Y., Liang,H., Li,J., Wang,F., Jiang,C. and Shao,B.
  TITLE     Hyperglycosylated N-Linked Site 339 of gp120 Appears to Be Unique
            and May Contribute to CRF01_AE Transmission Among Men Who Have Sex
            with Men in China and Thailand
  JOURNAL   AIDS Res Hum Retroviruses 39 (9), 505-510 (2023)
   PUBMED   37335061
  REMARK    GeneRIF: Hyperglycosylated N-Linked Site 339 of gp120 Appears to Be
            Unique and May Contribute to CRF01_AE Transmission Among Men Who
            Have Sex with Men in China and Thailand.
REFERENCE   4  (bases 1 to 3192)
  AUTHORS   Park,H.B., Choi,B.C. and Baek,K.H.
  TITLE     PGK1 modulates balance between pro- and anti-inflammatory cytokines
            by interacting with ITI-H4
  JOURNAL   Biomed Pharmacother 161, 114437 (2023)
   PUBMED   36841032
  REMARK    GeneRIF: PGK1 modulates balance between pro- and anti-inflammatory
            cytokines by interacting with ITI-H4.
REFERENCE   5  (bases 1 to 3192)
  AUTHORS   Huo,Y., Lai,Y., Feng,Q., Wang,Q. and Li,J.
  TITLE     Serum ITIH4 in coronary heart disease: a potential
            anti-inflammatory biomarker related to stenosis degree and risk of
            major adverse cardiovascular events
  JOURNAL   Biomark Med 16 (18), 1279-1288 (2022)
   PUBMED   36891881
  REMARK    GeneRIF: Serum ITIH4 in coronary heart disease: a potential
            anti-inflammatory biomarker related to stenosis degree and risk of
            major adverse cardiovascular events.
REFERENCE   6  (bases 1 to 3192)
  AUTHORS   Saguchi,K., Tobe,T., Hashimoto,K., Nagasaki,Y., Oda,E., Nakano,Y.,
            Miura,N.H. and Tomita,M.
  TITLE     Isolation and characterization of the human inter-alpha-trypsin
            inhibitor family heavy chain-related protein (IHRP) gene (ITIHL1)
  JOURNAL   J Biochem 119 (5), 898-905 (1996)
   PUBMED   8797089
REFERENCE   7  (bases 1 to 3192)
  AUTHORS   Choi-Miura,N.H., Sano,Y., Oda,E., Nakano,Y., Tobe,T.,
            Yanagishita,T., Taniyama,M., Katagiri,T. and Tomita,M.
  TITLE     Purification and characterization of a novel glycoprotein which has
            significant homology to heavy chains of inter-alpha-trypsin
            inhibitor family from human plasma
  JOURNAL   J Biochem 117 (2), 400-407 (1995)
   PUBMED   7541790
REFERENCE   8  (bases 1 to 3192)
  AUTHORS   Nishimura,H., Kakizaki,I., Muta,T., Sasaki,N., Pu,P.X.,
            Yamashita,T. and Nagasawa,S.
  TITLE     cDNA and deduced amino acid sequence of human PK-120, a plasma
            kallikrein-sensitive glycoprotein
  JOURNAL   FEBS Lett 357 (2), 207-211 (1995)
   PUBMED   7805892
REFERENCE   9  (bases 1 to 3192)
  AUTHORS   Saguchi,K., Tobe,T., Hashimoto,K., Sano,Y., Nakano,Y., Miura,N.H.
            and Tomita,M.
  TITLE     Cloning and characterization of cDNA for inter-alpha-trypsin
            inhibitor family heavy chain-related protein (IHRP), a novel human
            plasma glycoprotein
  JOURNAL   J Biochem 117 (1), 14-18 (1995)
   PUBMED   7775381
REFERENCE   10 (bases 1 to 3192)
  AUTHORS   Tobe,T., Saguchi,K., Hashimoto,K., Miura,N.H., Tomita,M., Li,F.,
            Wang,Y., Minoshima,S. and Shimizu,N.
  TITLE     Mapping of human inter-alpha-trypsin inhibitor family heavy
            chain-related protein gene (ITIHL1) to human chromosome 3p21-->p14
  JOURNAL   Cytogenet Cell Genet 71 (3), 296-298 (1995)
   PUBMED   7587397
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK298412.1, AC006254.10,
            BC136392.1 and AW291001.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001166449.1.
            
            Summary: The protein encoded by this gene is secreted into the
            blood, where it is cleaved by plasma kallikrein into two smaller
            forms. Expression of this gene has been detected only in liver, and
            it seems to be upregulated during surgical trauma. This gene is
            part of a cluster of similar genes on chromosome 3. Two transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            segment compared to variant 1. The resulting isoform (2) has the
            same N- and C-termini but is shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK298412.1, SRR14038196.2615001.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155590, SAMEA2162895
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1138              AK298412.1         1-1138
            1139-1139           AC006254.10        6504-6504
            1140-2807           AK298412.1         1140-2807
            2808-2884           BC136392.1         2914-2990
            2885-3164           AW291001.1         15-294              c
            3165-3192           AC006254.10        17767-17794
FEATURES             Location/Qualifiers
     source          1..3192
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.1"
     gene            1..3192
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /note="inter-alpha-trypsin inhibitor heavy chain 4"
                     /db_xref="GeneID:3700"
                     /db_xref="HGNC:HGNC:6169"
                     /db_xref="MIM:600564"
     exon            1..120
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..2733
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; plasma kallikrein-sensitive glycoprotein 120;
                     inter-alpha-trypsin inhibitor, heavy chain-like, 1;
                     inter-alpha (globulin) inhibitor H4 (plasma
                     Kallikrein-sensitive glycoprotein); ITI heavy chain H4;
                     inter-alpha-inhibitor heavy chain 4; inter-alpha-trypsin
                     inhibitor family heavy chain-related protein;
                     inter-alpha-trypsin inhibitor heavy chain family member 4"
                     /codon_start=1
                     /product="inter-alpha-trypsin inhibitor heavy chain H4
                     isoform 2 precursor"
                     /protein_id="NP_001159921.1"
                     /db_xref="CCDS:CCDS54596.1"
                     /db_xref="GeneID:3700"
                     /db_xref="HGNC:HGNC:6169"
                     /db_xref="MIM:600564"
                     /translation="MKPPRPVRTCSKVLVLLSLLAIHQTTTAEKNGIDIYSLTVDSRV
                     SSRFAHTVVTSRVVNRANTVQEATFQMELPKKAFITNFSMIIDGMTYPGIIKEKAEAQ
                     AQYSAAVAKGKSAGLVKATGRNMEQFQVSVSVAPNAKITFELVYEELLKRRLGVYELL
                     LKVRPQQLVKHLQMDIHIFEPQGISFLETESTFMTNQLVDALTTWQNKTKAHIRFKPT
                     LSQQQKSPEQQETVLDGNLIIRYDVDRAISGGSIQIENGYFVHYFAPEGLTTMPKNVV
                     FVIDKSGSMSGRKIQQTREALIKILDDLSPRDQFNLIVFSTEATQWRPSLVPASAENV
                     NKARSFAAGIQALGGTNINDAMLMAVQLLDSSNQEERLPEGSVSLIILLTDGDPTVGE
                     TNPRSIQNNVREAVSGRYSLFCLGFGFDVSYAFLEKLALDNGGLARRIHEDSDSALQL
                     QDFYQEVANPLLTAVTFEYPSNAVEEVTQNNFRLLFKGSEMVVAGKLQDRGPDVLTAT
                     VSGKLPTQNITFQTESSVAEQEAEFQSPKYIFHNFMERLWAYLTIQQLLEQTVSASDA
                     DQQALRNQALNLSLAYSFVTPLTSMVVTKPDDQEQSQVAEKPMEGESRNRNVHSAGAA
                     GSRMNFRPGVLSSRQLGLPGPPDVPDHAAYHPFRRLAILPASAPPATSNPDPAVSRVM
                     NMKIEETTMTTQTPAPIQAPSAILPLPGQSVERLCVDPRHRQGPVNLLSDPEQGVEVT
                     GQYEREKAGFSWIEVTFKNPLVWVHASPEHVVVTRNRRSSAYKWKETLFSVMPGLKMT
                     MDKTGLLLLSDPDKVTIGLLFWDGRGEGLRLLLRDTDRFSSHVGGTLGQFYQEVLWGS
                     PAASDDGRRTLRVQGNDHSATRERRLDYQEGPPGVEISCWSVEL"
     exon            121..281
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            282..386
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            387..549
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            550..660
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            661..789
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            790..906
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1075
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1201
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1383
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1569
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1709
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1864
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1891
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2017
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2092
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2119
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2236
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2411
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2566
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2663
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     exon            2664..3192
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2848..2853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /note="hexamer: AAGAAA"
     polyA_site      2872
                     /gene="ITIH4"
                     /gene_synonym="GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120;
                     PK120"
                     /note="major polyA site"
ORIGIN      
        1 agaagcctcc tggcagacac tggagccacg atgaagcccc caaggcctgt ccgtacctgc
       61 agcaaagttc tcgtcctgct ttcactgctg gccatccacc agactactac tgccgaaaag
      121 aatggcatcg acatctacag cctcaccgtg gactccaggg tctcatcccg atttgcccac
      181 acggtcgtca ccagccgagt ggtcaatagg gccaatactg tgcaggaggc caccttccag
      241 atggagctgc ccaagaaagc cttcatcacc aacttctcca tgatcatcga tggcatgacc
      301 tacccaggga tcatcaagga gaaggctgaa gcccaggcac agtacagcgc agcagtggcc
      361 aagggaaaga gcgctggcct cgtcaaggcc accgggagaa acatggagca gttccaggtg
      421 tcggtcagtg tggctcccaa tgccaagatc acctttgagc tggtctatga ggagctgctc
      481 aagcggcgtt tgggggtgta cgagctgctg ctgaaagtgc ggccccagca gctggtcaag
      541 cacctgcaga tggacattca catcttcgag ccccagggca tcagctttct ggagacagag
      601 agcaccttca tgaccaacca gctggtagac gccctcacca cctggcagaa taagaccaag
      661 gctcacatcc ggttcaagcc aacactttcc cagcagcaaa agtccccaga gcagcaagaa
      721 acagtcctgg acggcaacct cattatccgc tatgatgtgg accgggccat ctccgggggc
      781 tccattcaga tcgagaacgg ctactttgta cactactttg cccccgaggg cctaaccaca
      841 atgcccaaga atgtggtctt tgtcattgac aagagcggct ccatgagtgg caggaaaatc
      901 cagcagaccc gggaagccct aatcaagatc ctggatgacc tcagccccag agaccagttc
      961 aacctcatcg tcttcagtac agaagcaact cagtggaggc catcactggt gccagcctca
     1021 gccgagaacg tgaacaaggc caggagcttt gctgcgggca tccaggccct gggagggacc
     1081 aacatcaatg atgcaatgct gatggctgtg cagttgctgg acagcagcaa ccaggaggag
     1141 cggctgcccg aagggagtgt ctcactcatc atcctgctca ccgatggcga ccccactgtg
     1201 ggggagacta accccaggag catccagaat aacgtgcggg aagctgtaag tggccggtac
     1261 agcctcttct gcctgggctt cggtttcgac gtcagctatg ccttcctgga gaagctggca
     1321 ctggacaatg gcggcctggc ccggcgcatc catgaggact cagactctgc cctgcagctc
     1381 caggacttct accaggaagt ggccaaccca ctgctgacag cagtgacctt cgagtaccca
     1441 agcaatgccg tggaggaggt cactcagaac aacttccggc tcctcttcaa gggctcagag
     1501 atggtggtgg ctgggaagct ccaggaccgg gggcctgatg tgctcacagc cacagtcagt
     1561 gggaagctgc ctacacagaa catcactttc caaacggagt ccagtgtggc agagcaggag
     1621 gcggagttcc agagccccaa gtatatcttc cacaacttca tggagaggct ctgggcatac
     1681 ctgactatcc agcagctgct ggagcaaact gtctccgcat ccgatgctga tcagcaggcc
     1741 ctccggaacc aagcgctgaa tttatcactt gcctacagct ttgtcacgcc tctcacatct
     1801 atggtagtca ccaaacccga tgaccaagag cagtctcaag ttgctgagaa gcccatggaa
     1861 ggcgaaagta gaaacaggaa tgtccactca gctggagctg ctggctcccg gatgaatttc
     1921 agacctgggg ttctcagctc caggcaactt ggactcccag gacctcctga tgttcctgac
     1981 catgctgctt accacccctt ccgccgtctg gccatcttgc ctgcttcagc accaccagcc
     2041 acctcaaatc ctgatccagc tgtgtctcgt gtcatgaata tgaaaatcga agaaacaacc
     2101 atgacaaccc aaaccccagc ccccatacag gctccctctg ccatcctgcc actgcctggg
     2161 cagagtgtgg agcggctctg tgtggacccc agacaccgcc aggggccagt gaacctgctc
     2221 tcagaccctg agcaaggggt tgaggtgact ggccagtatg agagggagaa ggctgggttc
     2281 tcatggatcg aagtgacctt caagaacccc ctggtatggg ttcacgcatc ccctgaacac
     2341 gtggtggtga ctcggaaccg aagaagctct gcgtacaagt ggaaggagac gctattctca
     2401 gtgatgcccg gcctgaagat gaccatggac aagacgggtc tcctgctgct cagtgaccca
     2461 gacaaagtga ccatcggcct gttgttctgg gatggccgtg gggaggggct ccggctcctt
     2521 ctgcgtgaca ctgaccgctt ctccagccac gttggaggga cccttggcca gttttaccag
     2581 gaggtgctct ggggatctcc agcagcatca gatgacggca gacgcacgct gagggttcag
     2641 ggcaatgacc actctgccac cagagagcgc aggctggatt accaggaggg gcccccggga
     2701 gtggagattt cctgctggtc tgtggagctg tagttctgat ggaaggagct gtgcccaccc
     2761 tgtacacttg gcttccccct gcaactgcag ggccgcttct ggggcctgga ccaccatggg
     2821 gaggaagagt cccactcatt acaaataaag aaaggtggtg tgagcctggg aagtgggtgt
     2881 ctccagttcc atgtggccaa atcctagggc ctcaacctcg catcctgaac cttagcatcg
     2941 tggaacacag aagcttccac tgtcagctct caagagccca tggccaggaa ggcccatgct
     3001 gagctttcag tccagcccct tcattttaca aacaaggaaa ctgagctcga accacccatt
     3061 tgagatgtca ctgtggcccc cagctagagg cccagggctg ggagcattct ccaggagcag
     3121 aggttcagtc tgcttcatgg tctcttggac cagttttgac tacaaaaaaa aaaaaaaaaa
     3181 aaatagagtg aa
//
