LOCUS       NM_004791               2436 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens integrin subunit beta like 1 (ITGBL1), transcript
            variant 1, mRNA.
ACCESSION   NM_004791
VERSION     NM_004791.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2436)
  AUTHORS   Shen,K., Xia,W., Wang,K., Li,J., Xu,W., Liu,H., Yang,K., Zhu,J.,
            Wang,J., Xi,Q., Shi,T. and Li,R.
  TITLE     ITGBL1 promotes anoikis resistance and metastasis in human gastric
            cancer via the AKT/FBLN2 axis
  JOURNAL   J Cell Mol Med 28 (4), e18113 (2024)
   PUBMED   38332530
  REMARK    GeneRIF: ITGBL1 promotes anoikis resistance and metastasis in human
            gastric cancer via the AKT/FBLN2 axis.
REFERENCE   2  (bases 1 to 2436)
  AUTHORS   Wang,Z., Fu,L., Zhang,J., Ge,Y., Guo,C., Wang,R., Deng,M., Wang,Q.
            and Wang,Z.
  TITLE     A comprehensive analysis of potential gastric cancer prognostic
            biomarker ITGBL1 associated with immune infiltration and
            epithelial-mesenchymal transition
  JOURNAL   Biomed Eng Online 21 (1), 30 (2022)
   PUBMED   35596183
  REMARK    GeneRIF: A comprehensive analysis of potential gastric cancer
            prognostic biomarker ITGBL1 associated with immune infiltration and
            epithelial-mesenchymal transition.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2436)
  AUTHORS   Du,T., Zhang,K., Zhang,Z., Guo,A., Yu,G. and Xu,Y.
  TITLE     ITGBL1 transcriptionally inhibited by JDP2 promotes the development
            of pancreatic cancer through the TGF-beta/Smad pathway
  JOURNAL   Braz J Med Biol Res 55, e11989 (2022)
   PUBMED   35584452
  REMARK    GeneRIF: ITGBL1 transcriptionally inhibited by JDP2 promotes the
            development of pancreatic cancer through the TGF-beta/Smad pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2436)
  AUTHORS   Jang,D.G., Kwon,K.Y., Song,E.K. and Park,T.J.
  TITLE     Integrin beta-like 1 protein (ITGBL1) promotes cell migration by
            preferentially inhibiting integrin-ECM binding at the trailing edge
  JOURNAL   Genes Genomics 44 (4), 405-413 (2022)
   PUBMED   35066808
  REMARK    GeneRIF: Integrin beta-like 1 protein (ITGBL1) promotes cell
            migration by preferentially inhibiting integrin-ECM binding at the
            trailing edge.
REFERENCE   5  (bases 1 to 2436)
  AUTHORS   Lu,Z. and Gao,Y.
  TITLE     Screening differentially expressed genes between endometriosis and
            ovarian cancer to find new biomarkers for endometriosis
  JOURNAL   Ann Med 53 (1), 1377-1389 (2021)
   PUBMED   34409913
  REMARK    GeneRIF: Screening differentially expressed genes between
            endometriosis and ovarian cancer to find new biomarkers for
            endometriosis.
REFERENCE   6  (bases 1 to 2436)
  AUTHORS   Velez Edwards,D.R., Naj,A.C., Monda,K., North,K.E., Neuhouser,M.,
            Magvanjav,O., Kusimo,I., Vitolins,M.Z., Manson,J.E.,
            O'Sullivan,M.J., Rampersaud,E. and Edwards,T.L.
  TITLE     Gene-environment interactions and obesity traits among
            postmenopausal African-American and Hispanic women in the Women's
            Health Initiative SHARe Study
  JOURNAL   Hum Genet 132 (3), 323-336 (2013)
   PUBMED   23192594
REFERENCE   7  (bases 1 to 2436)
  AUTHORS   Uuskula,L., Mannik,J., Rull,K., Minajeva,A., Koks,S., Vaas,P.,
            Teesalu,P., Reimand,J. and Laan,M.
  TITLE     Mid-gestational gene expression profile in placenta and link to
            pregnancy complications
  JOURNAL   PLoS One 7 (11), e49248 (2012)
   PUBMED   23145134
REFERENCE   8  (bases 1 to 2436)
  AUTHORS   Cody,J.D., Heard,P. and Hale,D.
  TITLE     Identification of two novel chromosome regions associated with
            isolated growth hormone deficiency
  JOURNAL   J Pediatr Endocrinol Metab 23 (11), 1159-1164 (2010)
   PUBMED   21284329
REFERENCE   9  (bases 1 to 2436)
  AUTHORS   Takagi,J., Beglova,N., Yalamanchili,P., Blacklow,S.C. and
            Springer,T.A.
  TITLE     Definition of EGF-like, closely interacting modules that bear
            activation epitopes in integrin beta subunits
  JOURNAL   Proc Natl Acad Sci U S A 98 (20), 11175-11180 (2001)
   PUBMED   11572973
REFERENCE   10 (bases 1 to 2436)
  AUTHORS   Berg,R.W., Leung,E., Gough,S., Morris,C., Yao,W.P., Wang,S.X.,
            Ni,J. and Krissansen,G.W.
  TITLE     Cloning and characterization of a novel beta integrin-related cDNA
            coding for the protein TIED ('ten beta integrin EGF-like repeat
            domains') that maps to chromosome band 13q33: A divergent
            stand-alone integrin stalk structure
  JOURNAL   Genomics 56 (2), 169-178 (1999)
   PUBMED   10051402
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355807.11, AL139800.10 and
            AL160153.11.
            
            On Nov 23, 2018 this sequence version replaced NM_004791.2.
            
            Summary: This gene encodes a beta integrin-related protein that is
            a member of the EGF-like protein family. The encoded protein
            contains integrin-like cysteine-rich repeats. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Nov
            2012].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036788.1, AF072752.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376180.8/ ENSP00000365351.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               AL355807.11        32947-33203
            258-475             AL355807.11        34155-34372
            476-622             AL355807.11        147971-148117
            623-745             AL139800.10        6653-6775
            746-886             AL139800.10        10516-10656
            887-1027            AL139800.10        14444-14584
            1028-1174           AL139800.10        29381-29527
            1175-1291           AL160153.11        24740-24856
            1292-1438           AL160153.11        38911-39057
            1439-1552           AL160153.11        46593-46706
            1553-2436           AL160153.11        47718-48601
FEATURES             Location/Qualifiers
     source          1..2436
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q33.1"
     gene            1..2436
                     /gene="ITGBL1"
                     /gene_synonym="OSCP; TIED"
                     /note="integrin subunit beta like 1"
                     /db_xref="GeneID:9358"
                     /db_xref="HGNC:HGNC:6164"
                     /db_xref="MIM:604234"
     exon            1..257
                     /gene="ITGBL1"
                     /gene_synonym="OSCP; TIED"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..1644
                     /gene="ITGBL1"
                     /gene_synonym="OSCP; TIED"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; osteoblast-specific cysteine-rich protein; ten
                     integrin EGF-like repeat domain-containing protein;
                     integrin, beta-like 1 (with EGF-like repeat domains);
                     integrin beta like 1"
                     /codon_start=1
                     /product="integrin beta-like protein 1 isoform 1
                     precursor"
                     /protein_id="NP_004782.1"
                     /db_xref="CCDS:CCDS9499.1"
                     /db_xref="GeneID:9358"
                     /db_xref="HGNC:HGNC:6164"
                     /db_xref="MIM:604234"
                     /translation="MRPPGFRNFLLLASSLLFAGLSAVPQSFSPSLRSWPGAACRLSR
                     AESERRCRAPGQPPGAALCHGRGRCDCGVCICHVTEPGMFFGPLCECHEWVCETYDGS
                     TCAGHGKCDCGKCKCDQGWYGDACQYPTNCDLTKKKSNQMCKNSQDIICSNAGTCHCG
                     RCKCDNSDGSGLVYGKFCECDDRECIDDETEEICGGHGKCYCGNCYCKAGWHGDKCEF
                     QCDITPWESKRRCTSPDGKICSNRGTCVCGECTCHDVDPTGDWGDIHGDTCECDERDC
                     RAVYDRYSDDFCSGHGQCNCGRCDCKAGWYGKKCEHPQSCTLSAEESIRKCQGSSDLP
                     CSGRGKCECGKCTCYPPGDRRVYGKTCECDDRRCEDLDGVVCGGHGTCSCGRCVCERG
                     WFGKLCQHPRKCNMTEEQSKNLCESADGILCSGKGSCHCGKCICSAEEWYISGEFCDC
                     DDRDCDKHDGLICTGNGICSCGNCECWDGWNGNACEIWLGSEYP"
     exon            258..475
                     /gene="ITGBL1"
                     /gene_synonym="OSCP; TIED"
                     /inference="alignment:Splign:2.1.0"
     exon            476..622
                     /gene="ITGBL1"
                     /gene_synonym="OSCP; TIED"
                     /inference="alignment:Splign:2.1.0"
     exon            623..745
                     /gene="ITGBL1"
                     /gene_synonym="OSCP; TIED"
                     /inference="alignment:Splign:2.1.0"
     exon            746..886
                     /gene="ITGBL1"
                     /gene_synonym="OSCP; TIED"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1027
                     /gene="ITGBL1"
                     /gene_synonym="OSCP; TIED"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1174
                     /gene="ITGBL1"
                     /gene_synonym="OSCP; TIED"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1291
                     /gene="ITGBL1"
                     /gene_synonym="OSCP; TIED"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1438
                     /gene="ITGBL1"
                     /gene_synonym="OSCP; TIED"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1552
                     /gene="ITGBL1"
                     /gene_synonym="OSCP; TIED"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..2436
                     /gene="ITGBL1"
                     /gene_synonym="OSCP; TIED"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2410..2415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGBL1"
                     /gene_synonym="OSCP; TIED"
                     /note="hexamer: AATAAA"
     polyA_site      2436
                     /gene="ITGBL1"
                     /gene_synonym="OSCP; TIED"
                     /note="major polyA site"
ORIGIN      
        1 aattgcaact ccggctggag ccccggacct gcaagcctgg gtgtccgtgg gtccgtctgc
       61 ccagccatct gctggtggca cctctccctc ctgccgcctc cctcggtgaa ccccaccttg
      121 cagaagtgca gctcgcccgg agcagcccag gagctcagca tgcgtccccc aggcttcagg
      181 aacttcttgc tgctggcgtc ctcccttctc tttgctgggt tgtcagctgt tcctcaaagc
      241 ttctcgccat ctctgaggag ctggccgggc gccgcctgca ggctgtcccg ggccgagtcg
      301 gagcgacgct gccgcgcacc tgggcagccc ccgggggccg cgctgtgcca cggccggggc
      361 cgctgcgact gcggcgtctg catctgccac gtgactgagc cgggcatgtt cttcgggccc
      421 ctgtgtgagt gccatgagtg ggtgtgcgag acctacgacg ggagcacctg tgcaggccat
      481 ggtaagtgtg actgtggcaa gtgcaagtgt gaccagggat ggtatgggga tgcttgccag
      541 tacccaacta actgtgactt gacaaagaag aaaagtaacc aaatgtgcaa gaattcacaa
      601 gacatcatct gctctaatgc aggtacatgt cactgtggca ggtgtaagtg tgataattca
      661 gatggaagtg gacttgtgta tggtaaattt tgtgagtgtg acgatagaga atgcatagac
      721 gatgaaacag aagaaatatg tggaggccat gggaagtgtt actgtggaaa ctgctactgc
      781 aaggctggtt ggcatggaga taaatgtgaa ttccagtgcg atatcacccc ctgggaaagc
      841 aagcgaagat gcacgtctcc agatggcaaa atctgcagta acagagggac ttgtgtatgt
      901 ggtgaatgta cctgtcacga tgttgatccg actggggact ggggagatat tcatggggac
      961 acctgtgaat gtgatgagag ggactgtaga gctgtctatg accgatattc tgatgacttc
     1021 tgttcaggtc atggacagtg taattgcgga agatgtgact gcaaagcagg ctggtatggg
     1081 aagaagtgtg agcacccaca gtcctgcacg ctgtcagctg aggagagcat caggaagtgc
     1141 cagggaagct cggatctgcc ttgctctggg aggggtaaat gtgaatgtgg caaatgcacc
     1201 tgctatcctc caggagatcg ccgggtgtat ggcaagactt gtgagtgtga tgatcgccgc
     1261 tgtgaagacc tcgatggtgt ggtctgtgga ggccacggca catgttcctg tggtcgctgt
     1321 gtttgtgaga gaggatggtt tggaaagctc tgccaacatc cgcggaagtg taacatgacg
     1381 gaagaacaaa gcaagaatct gtgtgaatca gcagatggca tattgtgctc ggggaagggt
     1441 tcttgtcatt gtgggaagtg catttgttct gctgaagagt ggtatatttc tggggagttc
     1501 tgtgactgtg atgacagaga ctgcgacaaa catgatggtc tcatttgtac agggaatgga
     1561 atatgtagct gtggaaactg tgaatgctgg gatggatgga atggaaatgc atgtgaaatc
     1621 tggcttggct cagaatatcc ttaacaatta catgagagag gtctggattc ttattttttc
     1681 tgggccatta gaacagataa atgcgaagga aaccatgtat attcaccact aggacaggtt
     1741 aaaaagacca ttgtatgttt ttctatttct gaattacgaa tgaaatccga gtacctatta
     1801 gaaatgagtt atgcaaattt agatgcaaat aacattagaa aaaaaagatt cttccataat
     1861 taacataagt ggttcctaac gagagcaatt tttccaccca aaagtcattt ggcaacatct
     1921 acagacaatt ttgattgtca cactgggtcg ggtaggaagg tatgctgcag acatttggtg
     1981 ggtagaggcc agggatgctg ctgagcatcc cgcagtgtac aggacagccc ccaaacaagg
     2041 aattatccag ccccaaatgc caatagggct caaactgaga aacattgagt tatatggcta
     2101 ttagaaatcc acattcttac acaagaaaga ccatattaga atctaaggaa aacatgcata
     2161 ttcacattaa ttaatcgatc agatttttcc agaattccgt atcagtcacc attttaatat
     2221 ggggacaatg aagacaagca cacaggaggt agaatatcag agtggggctg gatcaagggc
     2281 aaaaactggt cattaagtca tctgacatta aatcatttag ccactaagtt atttgtctac
     2341 tctcacttta aactcaccaa agaagattct cttaaagaaa ttatgaaaaa tgtacaattt
     2401 aacattttaa ataaatagtg acagaagttg tttata
//
