LOCUS       NM_002214               8974 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens integrin subunit beta 8 (ITGB8), mRNA.
ACCESSION   NM_002214
VERSION     NM_002214.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8974)
  AUTHORS   Ishida,Y., Shintani,T., Nobumoto,T., Sakurai,S., Hamana,T.,
            Yanamoto,S. and Hayashido,Y.
  TITLE     Interaction of Integrin alphavbeta8 With Type I Collagen Promotes
            Squamous Cell Carcinoma Cell Motility via RAC1 Activation
  JOURNAL   Anticancer Res 43 (11), 4833-4841 (2023)
   PUBMED   37909974
  REMARK    GeneRIF: Interaction of Integrin alphavbeta8 With Type I Collagen
            Promotes Squamous Cell Carcinoma Cell Motility via RAC1 Activation.
REFERENCE   2  (bases 1 to 8974)
  AUTHORS   Duan,Z., Lin,X., Wang,L., Zhen,Q., Jiang,Y., Chen,C., Yang,J.,
            Lee,C.H., Qin,Y., Li,Y., Zhao,B., Wang,J. and Zhang,Z.
  TITLE     Specificity of TGF-beta1 signal designated by LRRC33 and integrin
            alphaVbeta8
  JOURNAL   Nat Commun 13 (1), 4988 (2022)
   PUBMED   36008481
  REMARK    GeneRIF: Specificity of TGF-beta1 signal designated by LRRC33 and
            integrin alphaVbeta8.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8974)
  AUTHORS   Hou,W., Bridgeman,B., Malnassy,G., Ding,X., Cotler,S.J.,
            Dhanarajan,A. and Qiu,W.
  TITLE     Integrin subunit beta 8 contributes to lenvatinib resistance in HCC
  JOURNAL   Hepatol Commun 6 (7), 1786-1802 (2022)
   PUBMED   35238496
  REMARK    GeneRIF: Integrin subunit beta 8 contributes to lenvatinib
            resistance in HCC.
REFERENCE   4  (bases 1 to 8974)
  AUTHORS   Liu,Y., Xu,X., Zhang,Y., Mo,Y., Sun,X., Shu,L. and Ke,Y.
  TITLE     Paradoxical role of beta8 integrin on angiogenesis and vasculogenic
            mimicry in glioblastoma
  JOURNAL   Cell Death Dis 13 (6), 536 (2022)
   PUBMED   35676251
  REMARK    GeneRIF: Paradoxical role of beta8 integrin on angiogenesis and
            vasculogenic mimicry in glioblastoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8974)
  AUTHORS   Lin,X., Zhuang,S., Chen,X., Du,J., Zhong,L., Ding,J., Wang,L.,
            Yi,J., Hu,G., Tang,G., Luo,X., Liu,W. and Ye,F.
  TITLE     lncRNA ITGB8-AS1 functions as a ceRNA to promote colorectal cancer
            growth and migration through integrin-mediated focal adhesion
            signaling
  JOURNAL   Mol Ther 30 (2), 688-702 (2022)
   PUBMED   34371180
  REMARK    GeneRIF: lncRNA ITGB8-AS1 functions as a ceRNA to promote
            colorectal cancer growth and migration through integrin-mediated
            focal adhesion signaling.
REFERENCE   6  (bases 1 to 8974)
  AUTHORS   Mu,D., Cambier,S., Fjellbirkeland,L., Baron,J.L., Munger,J.S.,
            Kawakatsu,H., Sheppard,D., Broaddus,V.C. and Nishimura,S.L.
  TITLE     The integrin alpha(v)beta8 mediates epithelial homeostasis through
            MT1-MMP-dependent activation of TGF-beta1
  JOURNAL   J Cell Biol 157 (3), 493-507 (2002)
   PUBMED   11970960
REFERENCE   7  (bases 1 to 8974)
  AUTHORS   Cambier,S., Mu,D.Z., O'Connell,D., Boylen,K., Travis,W., Liu,W.H.,
            Broaddus,V.C. and Nishimura,S.L.
  TITLE     A role for the integrin alphavbeta8 in the negative regulation of
            epithelial cell growth
  JOURNAL   Cancer Res 60 (24), 7084-7093 (2000)
   PUBMED   11156415
REFERENCE   8  (bases 1 to 8974)
  AUTHORS   Pilewski,J.M., Latoche,J.D., Arcasoy,S.M. and Albelda,S.M.
  TITLE     Expression of integrin cell adhesion receptors during human airway
            epithelial repair in vivo
  JOURNAL   Am J Physiol 273 (1 Pt 1), L256-L263 (1997)
   PUBMED   9252563
REFERENCE   9  (bases 1 to 8974)
  AUTHORS   Nishimura,S.L., Sheppard,D. and Pytela,R.
  TITLE     Integrin alpha v beta 8. Interaction with vitronectin and
            functional divergence of the beta 8 cytoplasmic domain
  JOURNAL   J Biol Chem 269 (46), 28708-28715 (1994)
   PUBMED   7525578
REFERENCE   10 (bases 1 to 8974)
  AUTHORS   Moyle,M., Napier,M.A. and McLean,J.W.
  TITLE     Cloning and expression of a divergent integrin subunit beta 8
  JOURNAL   J Biol Chem 266 (29), 19650-19658 (1991)
   PUBMED   1918072
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004130.1, BC002630.2,
            BI861225.1, M73780.1 and AW516961.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002214.2.
            
            Summary: This gene is a member of the integrin beta chain family
            and encodes a single-pass type I membrane protein with a VWFA
            domain and four cysteine-rich repeats. This protein noncovalently
            binds to an alpha subunit to form a heterodimeric integrin complex.
            In general, integrin complexes mediate cell-cell and
            cell-extracellular matrix interactions and this complex plays a
            role in human airway epithelial proliferation. Alternatively
            spliced variants which encode different protein isoforms have been
            described; however, not all variants have been fully characterized.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.12804.1, M73780.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222573.5/ ENSP00000222573.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               AC004130.1         14615-14816
            203-709             BC002630.2         1-507
            710-872             BI861225.1         142-304
            873-874             AC004130.1         15487-15488
            875-1848            M73780.1           648-1621
            1849-2188           BC002630.2         1647-1986
            2189-4016           M73780.1           1962-3789
            4017-8874           AC004130.1         94512-99369
            8875-8974           AW516961.1         20-119              c
FEATURES             Location/Qualifiers
     source          1..8974
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p21.1"
     gene            1..8974
                     /gene="ITGB8"
                     /note="integrin subunit beta 8"
                     /db_xref="GeneID:3696"
                     /db_xref="HGNC:HGNC:6163"
                     /db_xref="MIM:604160"
     exon            1..1034
                     /gene="ITGB8"
                     /inference="alignment:Splign:2.1.0"
     CDS             908..3217
                     /gene="ITGB8"
                     /note="integrin beta-8"
                     /codon_start=1
                     /product="integrin beta-8 precursor"
                     /protein_id="NP_002205.1"
                     /db_xref="CCDS:CCDS5370.1"
                     /db_xref="GeneID:3696"
                     /db_xref="HGNC:HGNC:6163"
                     /db_xref="MIM:604160"
                     /translation="MCGSALAFFTAAFVCLQNDRRGPASFLWAAWVFSLVLGLGQGED
                     NRCASSNAASCARCLALGPECGWCVQEDFISGGSRSERCDIVSNLISKGCSVDSIEYP
                     SVHVIIPTENEINTQVTPGEVSIQLRPGAEANFMLKVHPLKKYPVDLYYLVDVSASMH
                     NNIEKLNSVGNDLSRKMAFFSRDFRLGFGSYVDKTVSPYISIHPERIHNQCSDYNLDC
                     MPPHGYIHVLSLTENITEFEKAVHRQKISGNIDTPEGGFDAMLQAAVCESHIGWRKEA
                     KRLLLVMTDQTSHLALDSKLAGIVVPNDGNCHLKNNVYVKSTTMEHPSLGQLSEKLID
                     NNINVIFAVQGKQFHWYKDLLPLLPGTIAGEIESKAANLNNLVVEAYQKLISEVKVQV
                     ENQVQGIYFNITAICPDGSRKPGMEGCRNVTSNDEVLFNVTVTMKKCDVTGGKNYAII
                     KPIGFNETAKIHIHRNCSCQCEDNRGPKGKCVDETFLDSKCFQCDENKCHFDEDQFSS
                     ESCKSHKDQPVCSGRGVCVCGKCSCHKIKLGKVYGKYCEKDDFSCPYHHGNLCAGHGE
                     CEAGRCQCFSGWEGDRCQCPSAAAQHCVNSKGQVCSGRGTCVCGRCECTDPRSIGRFC
                     EHCPTCYTACKENWNCMQCLHPHNLSQAILDQCKTSCALMEQQHYVDQTSECFSSPSY
                     LRIFFIIFIVTFLIGLLKVLIIRQVILQWNSNKIKSSSDYRVSASKKDKLILQSVCTR
                     AVTYRREKPEEIKMDISKLNAHETFRCNF"
     exon            1035..1120
                     /gene="ITGB8"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1295
                     /gene="ITGB8"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1542
                     /gene="ITGB8"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1708
                     /gene="ITGB8"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1867
                     /gene="ITGB8"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1963
                     /gene="ITGB8"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2053
                     /gene="ITGB8"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2188
                     /gene="ITGB8"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2594
                     /gene="ITGB8"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2820
                     /gene="ITGB8"
                     /inference="alignment:Splign:2.1.0"
     exon            2821..2930
                     /gene="ITGB8"
                     /inference="alignment:Splign:2.1.0"
     exon            2931..3094
                     /gene="ITGB8"
                     /inference="alignment:Splign:2.1.0"
     exon            3095..8974
                     /gene="ITGB8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8954..8959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGB8"
                     /note="hexamer: AATAAA"
     polyA_site      8974
                     /gene="ITGB8"
                     /note="major polyA site"
ORIGIN      
        1 agagcgcgcc agcaactcgg gctctggact gcgggacgcc tgagccgcgc actgaggcga
       61 aaaggacaag ggcacgcagc ccccgccccg cgaagccggg ctccggcacc tcgcggaacc
      121 tcccctcctg cgctcgcagc cgcaggcccc actccccgcc agggagggag cggcgatgcc
      181 tcgctctgtg cctgcgggtg tcggcgggtg cttctagggc gctcccagag ccgcctcccc
      241 ctgttgctgg catcccgagc ttcctccctt gccagccagg acgctgccga cttgtctttg
      301 cccgctgctc cgcagacggg gctgcaaagc tgcaactaat ggtgttggcc tccctgccca
      361 cctgtggaag caactgcgct gattgatgcg ccacagactt ttttcccctc gacctcgccg
      421 gcgtcccctc ccacagatcc agcatcaccc agtgaatgta cattagggtg gtttcccccc
      481 cagcttcggg ctttgtttgg gtttgattgt gtttggctct tcgctaagct gatttatgca
      541 gcagaagccc caccggctgg agagaaacaa aagctctttt ctttgtcccg gagcaggctg
      601 cggagccctt gcagagccct ctctccagtc gccgccgggg cccttggccg tcgaaggagg
      661 tgcttctcgc ggagaccgcg ggacccgccg tgccgagccg ggagggccgc aggggccctg
      721 agatgccgag cggtgcccgg gcccgcttac ctgcaccgct tgctccgagc cgcggggtcc
      781 gcctgctagg cctgcggaaa acgtcctagc gacactcggc ccgcgggccc cgaggtgcgc
      841 ccgggaggcg cgagcccgcg tccggaaggc agtcaggcgg cgggcgcggg gcgggctgtt
      901 ttgcattatg tgcggctcgg ccctggcttt ttttaccgct gcatttgtct gcctgcaaaa
      961 cgaccggcga ggtcccgcct cgttcctctg ggcagcctgg gtgttttcac ttgttcttgg
     1021 actgggccaa ggtgaagaca atagatgtgc atcttcaaat gcagcatcct gtgccaggtg
     1081 ccttgcgctg ggtccagaat gtggatggtg tgttcaagag gatttcattt caggtggatc
     1141 aagaagtgaa cgttgtgata ttgtttccaa tttaataagc aaaggctgct cagttgattc
     1201 aatagaatac ccatctgtgc atgttataat acccactgaa aatgaaatta atacccaggt
     1261 gacaccagga gaagtgtcta tccagctgcg tccaggagcc gaagctaatt ttatgctgaa
     1321 agttcatcct ctgaagaaat atcctgtgga tctttattat cttgttgatg tctcagcatc
     1381 aatgcacaat aatatagaaa aattaaattc cgttggaaac gatttatcta gaaaaatggc
     1441 atttttctcc cgtgactttc gtcttggatt tggctcatac gttgataaaa cagtttcacc
     1501 atacattagc atccaccccg aaaggattca taatcaatgc agtgactaca atttagactg
     1561 catgcctccc catggataca tccatgtgct gtctttgaca gagaacatca ctgagtttga
     1621 gaaagcagtt catagacaga agatctctgg aaacatagat acaccagaag gaggttttga
     1681 cgccatgctt caggcagctg tctgtgaaag tcatatcgga tggcgaaaag aggctaaaag
     1741 attgctgctg gtgatgacag atcagacgtc tcatctcgct cttgatagca aattggcagg
     1801 catagtggtg cccaatgacg gaaactgtca tctgaaaaac aacgtctatg tcaaatcgac
     1861 aaccatggaa cacccctcac taggccaact ttcagagaaa ttaatagaca acaacattaa
     1921 tgtcatcttt gcagttcaag gaaaacaatt tcattggtat aaggatcttc tacccctctt
     1981 gccaggcacc attgctggtg aaatagaatc aaaggctgca aacctcaata atttggtagt
     2041 ggaagcctat cagaagctca tttcagaagt gaaagttcag gtggaaaacc aggtacaagg
     2101 catctatttt aacattaccg ccatctgtcc agatgggtcc agaaagccag gcatggaagg
     2161 atgcagaaac gtgacgagca atgatgaagt tcttttcaat gtaacagtta caatgaaaaa
     2221 atgtgatgtc acaggaggaa aaaactatgc aataatcaaa cctattggtt ttaatgaaac
     2281 cgctaaaatt catatacaca gaaactgcag ctgtcagtgt gaggacaaca gaggacctaa
     2341 aggaaagtgt gtagatgaaa cttttctaga ttccaagtgt ttccagtgtg atgagaataa
     2401 atgtcatttt gatgaagatc agttttcttc tgagagttgc aagtcacaca aggatcagcc
     2461 tgtttgcagt ggtcgaggag tttgtgtttg tgggaaatgt tcatgtcaca aaattaagct
     2521 tggaaaagtg tatggaaaat actgtgaaaa ggatgacttt tcttgtccat atcaccatgg
     2581 aaatctgtgt gctgggcatg gagagtgtga agcaggcaga tgccaatgct tcagtggctg
     2641 ggaaggtgat cgatgccagt gcccttcagc agcagcccag cactgtgtca attcaaaggg
     2701 ccaagtgtgc agtggaagag gcacgtgtgt gtgtggaagg tgtgagtgca ccgatcccag
     2761 gagcatcggc cgcttctgtg aacactgccc cacctgttat acagcctgca aggaaaactg
     2821 gaattgtatg caatgccttc accctcacaa tttgtctcag gctatacttg atcagtgcaa
     2881 aacctcatgt gctctcatgg aacaacagca ttatgtcgac caaacttcag aatgtttctc
     2941 cagcccaagc tacttgagaa tatttttcat cattttcata gttacattct tgattgggtt
     3001 gcttaaagtc ctgatcatta gacaggtgat actacaatgg aatagtaata aaattaagtc
     3061 ctcatcagat tacagagtgt cagcctcaaa aaaggataag ttgattctgc aaagtgtttg
     3121 cacaagagca gtcacctacc gacgtgagaa gcctgaagaa ataaaaatgg atatcagcaa
     3181 attaaatgct catgaaactt tcaggtgcaa cttctaaaaa aagattttta aacacttaat
     3241 gggaaactgg aattgttaat aattgctcct aaagattata attttaaaag tcacaggagg
     3301 agacaaattg ctcacggtca tgccagttgc tggttgtaca ctcgaacgaa gactgacaag
     3361 tatcctcatc atgatgtgac tcacatagct gctgactttt tcagagaaaa atgtgtctta
     3421 ctactgtttg agactagtgt cgttgtagca ctttactgta atatataact tatttagatc
     3481 agcatagaat gtagatcctc tgaagagcac tgattacact ttacaggtac ctgttatccc
     3541 tacgcttccc agagagaaca atgctgtgag agagtttagc attgtgtcac tacaagggta
     3601 cagtaatccc tgcactggac atgtgaggaa aaaaataatc tggcaagtat attctaaggt
     3661 tgccaaacac ttcaacagtt ggtggttgaa tagacaagaa cagctagatg aataaatgat
     3721 tcgtgtttca ctctttcaag aggtgaacag atacaacctt aatcttaaaa gattattgct
     3781 ttttaaagtg tgtagtttta tgcatgtgtg tttatggttt gcttattttt gcaagatgga
     3841 tactaattcc agcattctct cctctttgcc tttatgtttt gttttctttt ttacaggata
     3901 agtttatgta tgtcacagat gactggatta attaagtgct aagttactac tgccataaaa
     3961 aactaataat acaatgtcac tttatcagaa tactagtttt aaaagctgaa tgttaatagg
     4021 ggacactgta aagtatcatc aaaacctgaa tagcttcatt gtgcacaagt gtggagtttt
     4081 gtatcctctt acctggtaaa ctgaagggat tgtttggcca tttcatttat cttatcatta
     4141 attcacaaga tagttagaaa ttctgcctca agcaaagtac cacattttga atgttttctt
     4201 agattttgat tgcaagtaga tatcagcatt ttttaaatga aaagctatat tatcttctcc
     4261 cttcaaggca gcctaaggat gttctttccc agaatcactc caacccttct tgccagaatt
     4321 cataaaagta caaaattgga gaatagatga tatcttagaa ataagctttt tttttttttt
     4381 tttttttttt tgagacggag tttcactctt gtcacccagg ctgaagtgca atggcgcaat
     4441 tagggttcac tgcaacctct gcctcccggg ttcaagcagt tctcctgcct cagcctcctg
     4501 agtagctggg attacaggca tccaccaccg tgcccagcta atttttgtat ttttagtaga
     4561 gacggggttt tgccatgttg gacaggttga tctcaaactc ctgacctcag gtgatctacc
     4621 ctcctcggcc tcccagagtg ttgggattac aggcatgagc caccatgcca ggctgctaat
     4681 tctccttttt agtgagttag ggaactgagc ctcagaaaac ttaaacgatt tctcagaaaa
     4741 cactcaagtg ataaagtggc cacattggaa aggagttttt atcttctcat tgtcaggcca
     4801 gtgttcattg cacaatatca tgctacctct tgaatcttta aaatattcaa ttggcaaatg
     4861 tttttcaatg tgatttactc atgtcttaag tgtatgagga aagttcaaag caaaatagaa
     4921 aggaataatt caaactgaat tgtccataat cagcttccag tctttcatgc taatcagctt
     4981 cttaagagac tgaagtatgg catacctaca ggggaattcc ttcgcaccat agcctgtatg
     5041 aacagtgttc cctggagttc tccagtgctc agcttgagac cttgatacac gggccatgag
     5101 ccctgtcttc cccaatggaa atttatttac acttacctta tccctatgga cttagtctga
     5161 ttttattggc taggagtcta acagtcctgt gtggatatac agttttgccc atgacaacaa
     5221 aggaatctat ccgaaatatc ttttttttta taataaactt ccaagatttg ctgtcttcca
     5281 gcacttgagt taaagtacta gatactgcat tttgatgaag actaacccca tctcatattc
     5341 taccctaaag agaactgaaa aacctataat aagttgttct ggagccaata aacacagcag
     5401 ctctgttaga tgtcctctac agccaagcac tttcaatgct aacttgaact gcatttcctt
     5461 cctcaaatga gagattgaca taattcagta ctgtgagtca cttgtataag aaacctttga
     5521 tcactaaaaa taatgtaaaa attgggttta gtagcctaat acacataacg ttcttcttaa
     5581 aaaggaaaat ggatggatgc ctgacaaccc tccaaaagaa aaaagtgtaa gatagccatt
     5641 aagatgatga caatttttga aatgaacatt atgatattta tgaacaataa acaaatttcc
     5701 gtatggaatg aattatccaa aaagagtata acaaaatgaa atccttaaaa atccagagtt
     5761 tatatttttt ttataccctc acttgtttgc actaacttta tagtggacca aggctgttac
     5821 cataggaagg gacaaacttc cttgtaggca actcagtgtt agacgatgat tgtggttatg
     5881 cttgcaaagt cttgtgctta tcttttttgt ttttacttaa aaagctaatt tttaaagatt
     5941 gtagggcttg tattttactt gaataattga tatcttcctg tgtaatgatt tgtgagatga
     6001 gaattaatat ttgactagtt agaattaatt aaatggtaag ggaacacagg gtactcttag
     6061 gttaaataat gtatgcaaat agagtctatt ttcaactaat atggccacag gagccttttg
     6121 agattcattg atattaaaca caattaatga aattttaaat tgttaacaga attgagaact
     6181 tgaacaacac ttttagtact gcagcatttt tgtgccctaa agtatgtaat gatttataaa
     6241 tgtgccatac atacactaca acataacatt tgctttgtta tgcattttat ttctctgggg
     6301 acaccattgc actgcagtgc acacgtattt ataaacattt gttatatttt tggaaacttg
     6361 ctaatattta ttaagtcata gacttttctg gaggacttaa aaattcacta aaaatctgat
     6421 tatgtcttaa atgttcagtt tatctttggt ttattaaaat aaaaaaaaaa tctaagatta
     6481 aacacagtag atatctctgg aggcaatttt ccaaaactca acattaaaat ttgtggatgc
     6541 atgagatgca atccttcaaa gaatgaatct gaaatatatt tttaatattt acttaatatc
     6601 cactgaagat atctttatgc aagacaagag tcagccatca gacactgaaa tatattatga
     6661 tagattatga agaattttct ctgtagaatt atattcttcc tggaacctgg tagagtagat
     6721 tagactcaaa ggctttttct tccttttctt actcctgttt tttccactca ctcttcccaa
     6781 gagatttcct aaagcttcaa gcttaataag cctaatagtg aaaaataact gaatttaatg
     6841 gtataatgaa gttcttcatt tccagacatc tttaattgat cttaaagctc atttgagtct
     6901 ttgcccctga acaaagacag acccattaaa atctaagaat tctaaatttt cacaactgtt
     6961 tgagcttctt ttcattttga aggatttgga atatatatgt tttcataaaa gtatcaagtg
     7021 aaatatagtt acatgggagc tcaatcatgt gcagattgca ttctgttatg ttgactcaat
     7081 atttaattta caactatcct tatttatatt gacctcaaga actccatttt atgcaatgca
     7141 gaccactgag atatagctaa cattctttca aataattttc cttttctttt ataattcctc
     7201 tatagcaaat ttttatgtat aactgattat acatatccat atttatattt cattgattcc
     7261 aagacatcac tttttcaatt taacatctct gaaattgtga catttcttgc aactgttggc
     7321 acttcagatg cagtgtttaa aattatgctt gaataaatat tacactaatc caactttacc
     7381 taaatgttta tgcatctagg caaattttgt tttcttataa agatttgaga gcccatttat
     7441 gacaaaatat gaaggcgaaa tttaaggaca actgagtcac gcacaactca acatggagcc
     7501 taactgatta tcagctcaga tcccgcatat cttgagttta caaaagctct ttcaggtccc
     7561 catttatact ttacgtgagt gcgaatgatt tcagcaaacc ctaacttaac taacaagaat
     7621 gggtaggtat gtctacgttt cattaacaaa tttttattat ttttattcta ttatatgaga
     7681 tccttttata ttatcatctc acttttaaac aaaattaact ggaaaaatat tacatggaac
     7741 tgtcatagtt aggttttgca gcatcttaca tgtcttgtat caatggcagg agaaaaatat
     7801 gataaaaaca atcagtgctg tgaaaaacaa ctttcttcta gagtcctctt actttttatt
     7861 cttctttatc atttgtgggt ttttccccct tggctctgat cactttaact tcaagcttat
     7921 gtaacgactg ttataaaact gcatatttaa attatttgaa ttatatgaaa taattgttca
     7981 gctatctggg cagctgttaa tgtaaacctg agagtaataa cactactctt ttatctacct
     8041 ggaatacttt tctgcataaa atttatcttt gtaagctaac tctattaatc aggtttcttc
     8101 tagcctctgc aacctacttc agttagaatt gtctaatact gctctattaa tcaggtttct
     8161 agcctctaca acctacttca gttaaaattg tctaatacag caatatttaa aaaaaaaaca
     8221 ctgcaattgt caaggatgga aaatgtgtga tttgtgtaaa caatttttac caactttaca
     8281 ttttcctaca gataaatgtg aaattttgat aagaagtcta cgcaatgaca agtatggtac
     8341 ataaatttta ttaagaatat tgagtataaa gtactttaat tctaaattat aagaaaatat
     8401 acatttgcac atattaatat agaaattcat tttgtgtata tttaacatag cttttaaact
     8461 attttacatt agctacttca ttatggtttc ttgaacttct gaaaaaaatt agaaatgtat
     8521 taaacttatc agtaacataa aaacttattt tgtttcacct aacgaatact gcgtttgtaa
     8581 aaataaattt aatatagaat atatttttaa attaaatatt tgaatataaa atagctctaa
     8641 gaaagaagca aattatcact gaacatattt cttattattt ctggctttga attatacgta
     8701 acttaaattg tcttaaatga tacagaatat tggagaatat gatactttca cataatatac
     8761 tatgaacctg ttcatataac tctgattgac tactaacttc tgttttatgt atttattaaa
     8821 gagctgacac tgtagtttgt ggtgagatgt ttatttttct aacagagctt ataacagtta
     8881 ggacaaggca tttaattaat gcatcattct gtttagtagt aggtgttaat caatatgaaa
     8941 ttctctgttt taaaataaaa atgtaaaaat ctaa
//
