LOCUS       NM_000889               2806 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens integrin subunit beta 7 (ITGB7), transcript variant 1,
            mRNA.
ACCESSION   NM_000889
VERSION     NM_000889.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2806)
  AUTHORS   Akasaka,H., Sato,D., Shihoya,W., Nureki,O. and Kise,Y.
  TITLE     Cryo-EM structure of I domain-containing integrin alphaEbeta7
  JOURNAL   Biochem Biophys Res Commun 721, 150121 (2024)
   PUBMED   38781659
  REMARK    GeneRIF: Cryo-EM structure of I domain-containing integrin
            alphaEbeta7.
REFERENCE   2  (bases 1 to 2806)
  AUTHORS   Roy Choudhury,S., Byrum,S.D., Alkam,D., Ashby,C., Zhan,F.,
            Tackett,A.J. and Van Rhee,F.
  TITLE     Expression of integrin beta-7 is epigenetically enhanced in
            multiple myeloma subgroups with high-risk cytogenetics
  JOURNAL   Clin Epigenetics 15 (1), 18 (2023)
   PUBMED   36737807
  REMARK    GeneRIF: Expression of integrin beta-7 is epigenetically enhanced
            in multiple myeloma subgroups with high-risk cytogenetics.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2806)
  AUTHORS   Xu,T., Liu,J., Xia,Y., Wang,Z., Li,X. and Gao,Q.
  TITLE     Integrated analysis reveals the participation of IL4I1, ITGB7, and
            FUT7 in reshaping the TNBC immune microenvironment by targeting
            glycolysis
  JOURNAL   Ann Med 53 (1), 916-928 (2021)
   PUBMED   34134578
  REMARK    GeneRIF: Integrated analysis reveals the participation of IL4I1,
            ITGB7, and FUT7 in reshaping the TNBC immune microenvironment by
            targeting glycolysis.
REFERENCE   4  (bases 1 to 2806)
  AUTHORS   Mora,J.R., Bono,M.R., Manjunath,N., Weninger,W., Cavanagh,L.L.,
            Rosemblatt,M. and Von Andrian,U.H.
  TITLE     Selective imprinting of gut-homing T cells by Peyer's patch
            dendritic cells
  JOURNAL   Nature 424 (6944), 88-93 (2003)
   PUBMED   12840763
REFERENCE   5  (bases 1 to 2806)
  AUTHORS   Erle,D.J., Brown,T., Christian,D. and Aris,R.
  TITLE     Lung epithelial lining fluid T cell subsets defined by distinct
            patterns of beta 7 and beta 1 integrin expression
  JOURNAL   Am J Respir Cell Mol Biol 10 (3), 237-244 (1994)
   PUBMED   7509610
REFERENCE   6  (bases 1 to 2806)
  AUTHORS   Jiang,W.M., Jenkins,D., Yuan,Q., Leung,E., Choo,K.H., Watson,J.D.
            and Krissansen,G.W.
  TITLE     The gene organization of the human beta 7 subunit, the common beta
            subunit of the leukocyte integrins HML-1 and LPAM-1
  JOURNAL   Int Immunol 4 (9), 1031-1040 (1992)
   PUBMED   1382574
REFERENCE   7  (bases 1 to 2806)
  AUTHORS   Ruegg,C., Postigo,A.A., Sikorski,E.E., Butcher,E.C., Pytela,R. and
            Erle,D.J.
  TITLE     Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte
            adherence to fibronectin and VCAM-1 and in homotypic cell
            clustering
  JOURNAL   J Cell Biol 117 (1), 179-189 (1992)
   PUBMED   1372909
REFERENCE   8  (bases 1 to 2806)
  AUTHORS   Parker,C.M., Cepek,K.L., Russell,G.J., Shaw,S.K., Posnett,D.N.,
            Schwarting,R. and Brenner,M.B.
  TITLE     A family of beta 7 integrins on human mucosal lymphocytes
  JOURNAL   Proc Natl Acad Sci U S A 89 (5), 1924-1928 (1992)
   PUBMED   1542691
REFERENCE   9  (bases 1 to 2806)
  AUTHORS   Baker,E., Sutherland,G.R., Jiang,W.M., Yuan,Q., Leung,E.,
            Watson,J.D. and Krissansen,G.W.
  TITLE     Mapping of the human integrin beta 7 gene (ITG beta 7) to 12q13.13
            by non-isotopic in situ hybridization
  JOURNAL   Mamm Genome 2 (4), 272-273 (1992)
   PUBMED   1543919
REFERENCE   10 (bases 1 to 2806)
  AUTHORS   Erle,D.J., Ruegg,C., Sheppard,D. and Pytela,R.
  TITLE     Complete amino acid sequence of an integrin beta subunit (beta 7)
            identified in leukocytes
  JOURNAL   J Biol Chem 266 (17), 11009-11016 (1991)
   PUBMED   2040616
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC296007.1 and S80335.1.
            
            On Nov 22, 2018 this sequence version replaced NM_000889.2.
            
            Summary: This gene encodes a protein that is a member of the
            integrin superfamily. Members of this family are adhesion receptors
            that function in signaling from the extracellular matrix to the
            cell. Integrins are heterodimeric integral membrane proteins
            composed of an alpha chain and a beta chain. The encoded protein
            forms dimers with an alpha4 chain or an alphaE chain and plays a
            role in leukocyte adhesion. Dimerization with alpha4 forms a homing
            receptor for migration of lymphocytes to the intestinal mucosa and
            Peyer's patches. Dimerization with alphaE permits binding to the
            ligand epithelial cadherin, a calcium-dependent adhesion molecule.
            Alternate splicing results in multiple transcript variants.
            Additional alternatively spliced transcript variants of this gene
            have been described, but their full-length nature is not known.
            [provided by RefSeq, Sep 2013].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Variants 1 and 3-8 all encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: S80335.1, SRR1163655.140810.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267082.10/ ENSP00000267082.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                DC296007.1         58-92
            36-2806             S80335.1           11-2781
FEATURES             Location/Qualifiers
     source          1..2806
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..2806
                     /gene="ITGB7"
                     /note="integrin subunit beta 7"
                     /db_xref="GeneID:3695"
                     /db_xref="HGNC:HGNC:6162"
                     /db_xref="MIM:147559"
     exon            1..50
                     /gene="ITGB7"
                     /inference="alignment:Splign:2.1.0"
     exon            51..173
                     /gene="ITGB7"
                     /inference="alignment:Splign:2.1.0"
     exon            174..377
                     /gene="ITGB7"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..2573
                     /gene="ITGB7"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; integrin beta-7; integrin beta 7 subunit; gut
                     homing receptor beta subunit"
                     /codon_start=1
                     /product="integrin beta-7 isoform a precursor"
                     /protein_id="NP_000880.1"
                     /db_xref="CCDS:CCDS8849.1"
                     /db_xref="GeneID:3695"
                     /db_xref="HGNC:HGNC:6162"
                     /db_xref="MIM:147559"
                     /translation="MVALPMVLVLLLVLSRGESELDAKIPSTGDATEWRNPHLSMLGS
                     CQPAPSCQKCILSHPSCAWCKQLNFTASGEAEARRCARREELLARGCPLEELEEPRGQ
                     QEVLQDQPLSQGARGEGATQLAPQRVRVTLRPGEPQQLQVRFLRAEGYPVDLYYLMDL
                     SYSMKDDLERVRQLGHALLVRLQEVTHSVRIGFGSFVDKTVLPFVSTVPSKLRHPCPT
                     RLERCQSPFSFHHVLSLTGDAQAFEREVGRQSVSGNLDSPEGGFDAILQAALCQEQIG
                     WRNVSRLLVFTSDDTFHTAGDGKLGGIFMPSDGHCHLDSNGLYSRSTEFDYPSVGQVA
                     QALSAANIQPIFAVTSAALPVYQELSKLIPKSAVGELSEDSSNVVQLIMDAYNSLSST
                     VTLEHSSLPPGVHISYESQCEGPEKREGKAEDRGQCNHVRINQTVTFWVSLQATHCLP
                     EPHLLRLRALGFSEELIVELHTLCDCNCSDTQPQAPHCSDGQGHLQCGVCSCAPGRLG
                     RLCECSVAELSSPDLESGCRAPNGTGPLCSGKGHCQCGRCSCSGQSSGHLCECDDASC
                     ERHEGILCGGFGRCQCGVCHCHANRTGRACECSGDMDSCISPEGGLCSGHGRCKCNRC
                     QCLDGYYGALCDQCPGCKTPCERHRDCAECGAFRTGPLATNCSTACAHTNVTLALAPI
                     LDDGWCKERTLDNQLFFFLVEDDARGTVVLRVRPQEKGADHTQAIVLGCVGGIVAVGL
                     GLVLAYRLSVEIYDRREYSRFEKEQQQLNWKQDSNPLYKSAITTTINPRFQEADSPTL
                     "
     exon            378..579
                     /gene="ITGB7"
                     /inference="alignment:Splign:2.1.0"
     exon            580..750
                     /gene="ITGB7"
                     /inference="alignment:Splign:2.1.0"
     exon            751..992
                     /gene="ITGB7"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1151
                     /gene="ITGB7"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1247
                     /gene="ITGB7"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1337
                     /gene="ITGB7"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1484
                     /gene="ITGB7"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1678
                     /gene="ITGB7"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1902
                     /gene="ITGB7"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2122
                     /gene="ITGB7"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2331
                     /gene="ITGB7"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2492
                     /gene="ITGB7"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2806
                     /gene="ITGB7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2788..2793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGB7"
                     /note="hexamer: AATAAA"
     polyA_site      2806
                     /gene="ITGB7"
                     /note="major polyA site"
ORIGIN      
        1 acacaaaggc tgctgctgcc gccagaggaa ggactgctct gcacgcacct atgtggaaac
       61 taaagcccag agagaaagtc tgacttgccc cacagccagt gagtgactgc agcagcacca
      121 gaatctggtc tgtttcctgt ttggctcttc taccactacg gcttgggatc tcgggcatgg
      181 tggctttgcc aatggtcctt gttttgctgc tggtcctgag cagaggtgag agtgaattgg
      241 acgccaagat cccatccaca ggggatgcca cagaatggcg gaatcctcac ctgtccatgc
      301 tggggtcctg ccagccagcc ccctcctgcc agaagtgcat cctctcacac cccagctgtg
      361 catggtgcaa gcaactgaac ttcaccgcgt cgggagaggc ggaggcgcgg cgctgcgccc
      421 gacgagagga gctgctggct cgaggctgcc cgctggagga gctggaggag ccccgcggcc
      481 agcaggaggt gctgcaggac cagccgctca gccagggcgc ccgcggagag ggtgccaccc
      541 agctggcgcc gcagcgggtc cgggtcacgc tgcggcctgg ggagccccag cagctccagg
      601 tccgcttcct tcgtgctgag ggatacccgg tggacctgta ctaccttatg gacctgagct
      661 actccatgaa ggacgacctg gaacgcgtgc gccagctcgg gcacgctctg ctggtccggc
      721 tgcaggaagt cacccattct gtgcgcattg gttttggttc ctttgtggac aaaacggtgc
      781 tgccctttgt gagcacagta ccctccaaac tgcgccaccc ctgccccacc cggctggagc
      841 gctgccagtc accattcagc tttcaccatg tgctgtccct gacgggggac gcacaagcct
      901 tcgagcggga ggtggggcgc cagagtgtgt ccggcaatct ggactcgcct gaaggtggct
      961 tcgatgccat tctgcaggct gcactctgcc aggagcagat tggctggaga aatgtgtccc
     1021 ggctgctggt gttcacttca gacgacacat tccatacagc tggggacggg aagttgggcg
     1081 gcattttcat gcccagtgat gggcactgcc acttggacag caatggcctc tacagtcgca
     1141 gcacagagtt tgactaccct tctgtgggtc aggtagccca ggccctctct gcagcaaata
     1201 tccagcccat ctttgctgtc accagtgccg cactgcctgt ctaccaggag ctgagtaaac
     1261 tgattcctaa gtctgcagtt ggggagctga gtgaggactc cagcaacgtg gtacagctca
     1321 tcatggatgc ttataatagc ctgtcttcca ccgtgaccct tgaacactct tcactccctc
     1381 ctggggtcca catttcttac gaatcccagt gtgagggtcc tgagaagagg gagggtaagg
     1441 ctgaggatcg aggacagtgc aaccacgtcc gaatcaacca gacggtgact ttctgggttt
     1501 ctctccaagc cacccactgc ctcccagagc cccatctcct gaggctccgg gcccttggct
     1561 tctcagagga gctgattgtg gagttgcaca cgctgtgtga ctgtaattgc agtgacaccc
     1621 agccccaggc tccccactgc agtgatggcc agggacacct acaatgtggt gtatgcagct
     1681 gtgcccctgg ccgcctaggt cggctctgtg agtgctctgt ggcagagctg tcctccccag
     1741 acctggaatc tgggtgccgg gctcccaatg gcacagggcc cctgtgcagt ggaaagggtc
     1801 actgtcaatg tggacgctgc agctgcagtg gacagagctc tgggcatctg tgcgagtgtg
     1861 acgatgccag ctgtgagcga catgagggca tcctctgcgg aggctttggt cgctgccaat
     1921 gtggagtatg tcactgtcat gccaaccgca cgggcagagc atgcgaatgc agtggggaca
     1981 tggacagttg catcagtccc gagggagggc tctgcagtgg gcatggacgc tgcaaatgca
     2041 accgctgcca gtgcttggac ggctactatg gtgctctatg cgaccaatgc ccaggctgca
     2101 agacaccatg cgagagacac cgggactgtg cagagtgtgg ggccttcagg actggcccac
     2161 tggccaccaa ctgcagtaca gcttgtgccc ataccaatgt gaccctggcc ttggccccta
     2221 tcttggatga tggctggtgc aaagagcgga ccctggacaa ccagctgttc ttcttcttgg
     2281 tggaggatga cgccagaggc acggtcgtgc tcagagtgag accccaagaa aagggagcag
     2341 accacacgca ggccattgtg ctgggctgcg tagggggcat cgtggcagtg gggctggggc
     2401 tggtcctggc ttaccggctc tcggtggaaa tctatgaccg ccgggaatac agtcgctttg
     2461 agaaggagca gcaacaactc aactggaagc aggacagtaa tcctctctac aaaagtgcca
     2521 tcacgaccac catcaatcct cgctttcaag aggcagacag tcccactctc tgaaggaggg
     2581 agggacactt acccaaggct cttctccttg gaggacagtg ggaactggag ggtgagagga
     2641 agggtgggtc tgtaagacct tggtagggga ctaattcact ggcgaggtgc ggccaccacc
     2701 ctacttcatt ttcagagtga cacccaagag ggctgcttcc catgcctgca accttgcatc
     2761 catctgggct accccaccca agtatacaat aaagtcttac ctcaga
//
