LOCUS       NM_000888               4641 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens integrin subunit beta 6 (ITGB6), transcript variant 1,
            mRNA.
ACCESSION   NM_000888
VERSION     NM_000888.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4641)
  AUTHORS   Zhang,Y., Chen,Z., Shen,Z., Qian,D., Wang,G., Wang,X., Xi,S. and
            Wang,X.
  TITLE     ITGB6 promotes pancreatic fibrosis and aggravates the malignant
            process of pancreatic cancer via JAK2/STAT3 signaling pathway
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 397 (8), 6093-6106 (2024)
   PUBMED   38418753
  REMARK    GeneRIF: ITGB6 promotes pancreatic fibrosis and aggravates the
            malignant process of pancreatic cancer via JAK2/STAT3 signaling
            pathway.
REFERENCE   2  (bases 1 to 4641)
  AUTHORS   Geyer,M., Geyer,F., Reuning,U., Klapproth,S., Wolff,K.D. and
            Nieberler,M.
  TITLE     CRISPR/Cas9-mediated knock out of ITGB6 in human OSCC cells reduced
            migration and proliferation ability
  JOURNAL   Head Face Med 20 (1), 37 (2024)
   PUBMED   38890650
  REMARK    GeneRIF: CRISPR/Cas9-mediated knock out of ITGB6 in human OSCC
            cells reduced migration and proliferation ability.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4641)
  AUTHORS   Liu,L., He,Z., Jiang,Z., Liu,Z. and Zhuang,X.
  TITLE     Acidity-induced ITGB6 promote migration and invasion of lung cancer
            cells by epithelial-mesenchymal transition and focal adhesion
  JOURNAL   Exp Cell Res 436 (1), 113962 (2024)
   PUBMED   38316250
  REMARK    GeneRIF: Acidity-induced ITGB6 promote migration and invasion of
            lung cancer cells by epithelial-mesenchymal transition and focal
            adhesion.
REFERENCE   4  (bases 1 to 4641)
  AUTHORS   Munger,J.S., Huang,X., Kawakatsu,H., Griffiths,M.J., Dalton,S.L.,
            Wu,J., Pittet,J.F., Kaminski,N., Garat,C., Matthay,M.A.,
            Rifkin,D.B. and Sheppard,D.
  TITLE     The integrin alpha v beta 6 binds and activates latent TGF beta 1:
            a mechanism for regulating pulmonary inflammation and fibrosis
  JOURNAL   Cell 96 (3), 319-328 (1999)
   PUBMED   10025398
REFERENCE   5  (bases 1 to 4641)
  AUTHORS   Huang,X.Z., Chen,A., Agrez,M. and Sheppard,D.
  TITLE     A point mutation in the integrin beta 6 subunit abolishes both
            alpha v beta 6 binding to fibronectin and receptor localization to
            focal contacts
  JOURNAL   Am J Respir Cell Mol Biol 13 (2), 245-251 (1995)
   PUBMED   7626292
REFERENCE   6  (bases 1 to 4641)
  AUTHORS   Weinacker,A., Ferrando,R., Elliott,M., Hogg,J., Balmes,J. and
            Sheppard,D.
  TITLE     Distribution of integrins alpha v beta 6 and alpha 9 beta 1 and
            their known ligands, fibronectin and tenascin, in human airways
  JOURNAL   Am J Respir Cell Mol Biol 12 (5), 547-556 (1995)
   PUBMED   7537970
REFERENCE   7  (bases 1 to 4641)
  AUTHORS   Fernandez-Ruiz,E. and Sanchez-Madrid,F.
  TITLE     Regional localization of the human integrin beta 6 gene (ITGB6) to
            chromosome 2q24-q31
  JOURNAL   Genomics 21 (3), 638-640 (1994)
   PUBMED   7959743
REFERENCE   8  (bases 1 to 4641)
  AUTHORS   Busk,M., Pytela,R. and Sheppard,D.
  TITLE     Characterization of the integrin alpha v beta 6 as a
            fibronectin-binding protein
  JOURNAL   J Biol Chem 267 (9), 5790-5796 (1992)
   PUBMED   1532572
REFERENCE   9  (bases 1 to 4641)
  AUTHORS   Krissansen,G.W., Yuan,Q., Jenkins,D., Jiang,W.M., Rooke,L.,
            Spurr,N.K., Eccles,M., Leung,E. and Watson,J.D.
  TITLE     Chromosomal locations of the genes coding for the integrin beta 6
            and beta 7 subunits
  JOURNAL   Immunogenetics 35 (1), 58-61 (1992)
   PUBMED   1729173
REFERENCE   10 (bases 1 to 4641)
  AUTHORS   Sheppard,D., Rozzo,C., Starr,L., Quaranta,V., Erle,D.J. and
            Pytela,R.
  TITLE     Complete amino acid sequence of a novel integrin beta subunit (beta
            6) identified in epithelial cells using the polymerase chain
            reaction
  JOURNAL   J Biol Chem 265 (20), 11502-11507 (1990)
   PUBMED   2365683
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB222211.1, AC092153.4,
            BC121178.2, AC080166.6, AL831998.1 and AI264144.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000888.4.
            
            Summary: This gene encodes a protein that is a member of the
            integrin superfamily. Members of this family are adhesion receptors
            that function in signaling from the extracellular matrix to the
            cell. Integrins are heterodimeric integral membrane proteins
            composed of an alpha chain and a beta chain. The encoded protein
            forms a dimer with an alpha v chain and this heterodimer can bind
            to ligands like fibronectin and transforming growth factor beta 1.
            Alternate splicing results in multiple transcript variants.
            [provided by RefSeq, Sep 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a). Variants 1 and 2
            encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL831998.1, AK290300.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000283249.7/ ENSP00000283249.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               DB222211.1         42-152
            112-112             AC092153.4         55676-55676         c
            113-190             DB222211.1         155-232
            191-2272            BC121178.2         2-2083
            2273-2273           AC080166.6         145593-145593       c
            2274-2590           BC121178.2         2085-2401
            2591-2885           AL831998.1         2571-2865
            2886-2886           AC080166.6         134902-134902       c
            2887-4566           AL831998.1         2867-4546
            4567-4567           AC080166.6         133221-133221       c
            4568-4638           AL831998.1         4548-4618
            4639-4641           AI264144.1         12-14               c
FEATURES             Location/Qualifiers
     source          1..4641
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q24.2"
     gene            1..4641
                     /gene="ITGB6"
                     /gene_synonym="AI1H"
                     /note="integrin subunit beta 6"
                     /db_xref="GeneID:3694"
                     /db_xref="HGNC:HGNC:6161"
                     /db_xref="MIM:147558"
     exon            1..270
                     /gene="ITGB6"
                     /gene_synonym="AI1H"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..2576
                     /gene="ITGB6"
                     /gene_synonym="AI1H"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; integrin, beta 6"
                     /codon_start=1
                     /product="integrin beta-6 isoform a precursor"
                     /protein_id="NP_000879.2"
                     /db_xref="CCDS:CCDS2212.1"
                     /db_xref="GeneID:3694"
                     /db_xref="HGNC:HGNC:6161"
                     /db_xref="MIM:147558"
                     /translation="MGIELLCLFFLFLGRNDHVQGGCALGGAETCEDCLLIGPQCAWC
                     AQENFTHPSGVGERCDTPANLLAKGCQLNFIENPVSQVEILKNKPLSVGRQKNSSDIV
                     QIAPQSLILKLRPGGAQTLQVHVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSRLS
                     KEMSKLTSNFRLGFGSFVEKPVSPFVKTTPEEIANPCSSIPYFCLPTFGFKHILPLTN
                     DAERFNEIVKNQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHF
                     GMDSKLAGIVIPNDGLCHLDSKNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQ
                     VHLYENYAKLIPGATVGLLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTA
                     ICNNGTLFQHQKKCSHMKVGDTASFSVTVNIPHCERRSRHIIIKPVGLGDALELLVSP
                     ECNCDCQKEVEVNSSKCHHGNGSFQCGVCACHPGHMGPRCECGEDMLSTDSCKEAPDH
                     PSCSGRGDCYCGQCICHLSPYGNIYGPYCQCDNFSCVRHKGLLCGGNGDCDCGECVCR
                     SGWTGEYCNCTTSTDSCVSEDGVLCSGRGDCVCGKCVCTNPGASGPTCERCPTCGDPC
                     NSKRSCIECHLSAAGQAREECVDKCKLAGATISEEEDFSKDGSVSCSLQGENECLITF
                     LITTDNEGKTIIHSINEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRK
                     EVAKFEAERSKAKWQTGTNPLYRGSTSTFKNVTYKHREKQKVDLSTDC"
     exon            271..350
                     /gene="ITGB6"
                     /gene_synonym="AI1H"
                     /inference="alignment:Splign:2.1.0"
     exon            351..555
                     /gene="ITGB6"
                     /gene_synonym="AI1H"
                     /inference="alignment:Splign:2.1.0"
     exon            556..802
                     /gene="ITGB6"
                     /gene_synonym="AI1H"
                     /inference="alignment:Splign:2.1.0"
     exon            803..968
                     /gene="ITGB6"
                     /gene_synonym="AI1H"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1130
                     /gene="ITGB6"
                     /gene_synonym="AI1H"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1226
                     /gene="ITGB6"
                     /gene_synonym="AI1H"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1316
                     /gene="ITGB6"
                     /gene_synonym="AI1H"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1451
                     /gene="ITGB6"
                     /gene_synonym="AI1H"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1869
                     /gene="ITGB6"
                     /gene_synonym="AI1H"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..2092
                     /gene="ITGB6"
                     /gene_synonym="AI1H"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2190
                     /gene="ITGB6"
                     /gene_synonym="AI1H"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2310
                     /gene="ITGB6"
                     /gene_synonym="AI1H"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..2477
                     /gene="ITGB6"
                     /gene_synonym="AI1H"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..4641
                     /gene="ITGB6"
                     /gene_synonym="AI1H"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4615..4620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGB6"
                     /gene_synonym="AI1H"
                     /note="hexamer: AATAAA"
     polyA_site      4641
                     /gene="ITGB6"
                     /gene_synonym="AI1H"
                     /note="major polyA site"
ORIGIN      
        1 gctttacctg tccaggtagc ctctgttttc atttcagtct taatgaaaac tttctaactt
       61 atatctcaag tttcttttca aagcagtgta agtagtattt aaaatgttat acttcaagaa
      121 agaaagactt taacgatatt cagcgttggt cttgtaacgc tgaaggtaat tcatttttta
      181 atcggtctgc acagcaagaa ctgaaacgaa tggggattga actgctttgc ctgttctttc
      241 tatttctagg aaggaatgat cacgtacaag gtggctgtgc cctgggaggt gcagaaacct
      301 gtgaagactg cctgcttatt ggacctcagt gtgcctggtg tgctcaggag aattttactc
      361 atccatctgg agttggcgaa aggtgtgata ccccagcaaa ccttttagct aaaggatgtc
      421 aattaaactt catcgaaaac cctgtctccc aagtagaaat acttaaaaat aagcctctca
      481 gtgtaggcag acagaaaaat agttctgaca ttgttcagat tgcgcctcaa agcttgatcc
      541 ttaagttgag accaggtggt gcgcagactc tgcaggtgca tgtccgccag actgaggact
      601 acccggtgga tttgtattac ctcatggacc tctccgcctc catggatgac gacctcaaca
      661 caataaagga gctgggctcc cggctttcca aagagatgtc taaattaacc agcaacttta
      721 gactgggctt cggatctttt gtggaaaaac ctgtatcccc ttttgtgaaa acaacaccag
      781 aagaaattgc caacccttgc agtagtattc catacttctg tttacctaca tttggattca
      841 agcacatttt gccattgaca aatgatgctg aaagattcaa tgaaattgtg aagaatcaga
      901 aaatttctgc taatattgac acacccgaag gtggatttga tgcaattatg caagctgctg
      961 tgtgtaagga aaaaattggc tggcggaatg actccctcca cctcctggtc tttgtgagtg
     1021 atgctgattc tcattttgga atggacagca aactagcagg catcgtcatt cctaatgacg
     1081 ggctctgtca cttggacagc aagaatgaat actccatgtc aactgtcttg gaatatccaa
     1141 caattggaca actcattgat aaactggtac aaaacaacgt gttattgatc ttcgctgtaa
     1201 cccaagaaca agttcattta tatgagaatt acgcaaaact tattcctgga gctacagtag
     1261 gtctacttca gaaggactcc ggaaacattc tccagctgat catctcagct tatgaagaac
     1321 tgcggtctga ggtggaactg gaagtattag gagacactga aggactcaac ttgtcattta
     1381 cagccatctg taacaacggt accctcttcc aacaccaaaa gaaatgctct cacatgaaag
     1441 tgggagacac agcttccttc agcgtgactg tgaatatccc acactgcgag agaagaagca
     1501 ggcacattat cataaagcct gtggggctgg gggatgccct ggaattactt gtcagcccag
     1561 aatgcaactg cgactgtcag aaagaagtgg aagtgaacag ctccaaatgt caccacggga
     1621 acggctcttt ccagtgtggg gtgtgtgcct gccaccctgg ccacatgggg cctcgctgtg
     1681 agtgtggcga ggacatgctg agcacagatt cctgcaagga ggccccagat catccctcct
     1741 gcagcggaag gggtgactgc tactgtgggc agtgtatctg ccacttgtct ccctatggaa
     1801 acatttatgg gccttattgc cagtgtgaca atttctcctg cgtgagacac aaagggctgc
     1861 tctgcggagg taacggcgac tgtgactgtg gtgaatgtgt gtgcaggagc ggctggactg
     1921 gcgagtactg caactgcacc accagcacgg actcctgcgt ctctgaagat ggagtgctct
     1981 gcagcgggcg cggggactgt gtttgtggca agtgtgtttg cacaaaccct ggagcctcag
     2041 gaccaacctg tgaacgatgt cctacctgtg gtgacccctg taactctaaa cggagctgca
     2101 ttgagtgcca cctgtcagca gctggccaag cccgagaaga atgtgtggac aagtgcaaac
     2161 tagctggtgc gaccatcagt gaagaagaag atttctcaaa ggatggttct gtttcctgct
     2221 ctctgcaagg agaaaatgaa tgtcttatta cattcctaat aactacagat aatgagggga
     2281 aaaccatcat tcacagcatc aatgaaaaag attgtccgaa gcctccaaac attcccatga
     2341 tcatgttagg ggtttccctg gctattcttc tcatcggggt tgtcctactg tgcatctgga
     2401 agctactggt gtcatttcat gatcgtaaag aagttgccaa atttgaagca gaacgatcaa
     2461 aagccaagtg gcaaacggga accaatccac tctacagagg atccacaagt acttttaaaa
     2521 atgtaactta taaacacagg gaaaaacaaa aggtagacct ttccacagat tgctagaact
     2581 actttatgca tgaaaaaagt ctgtttcact gatatgaaat gttaatgcac tatttaattt
     2641 ttttctcttt gttgcttcaa aatgaggttg gtttaagata ataataggac atctgcagat
     2701 aagtcatcct ctacatgaag gtgacagact gttggcagtt tcaaaataat caagaagaga
     2761 aatatcctta gcaaagagat gactttgggg atcatttgag gaatactaac tctgttgcat
     2821 taatgcttca aaaaatcatc aaatgattca tgggggcctg atttgcattt gaaaaatgtt
     2881 tgaaattaga gtctcatttg tttcaggaat gcagctacct gagttttttg tctcggcaaa
     2941 gtcacaaagc ccatatactc acattgtgtg tctatacttg ccaattaatt ctaaacttgt
     3001 aggaaatatg ccctctctta aaggagaatt ttttttaaat ctctgagaaa tgagattctg
     3061 agtttatttc agctaaaagg ttgcaattct tctgaagata tctcaaatat aaggttgaaa
     3121 gttaagtgtt aataattttt gtgaatttat acacacctaa acgttaagta cacaaatatt
     3181 ttatttgttt tacaaataag gaataagtaa tttataaatt aagaagttac ctataaaaat
     3241 aaaaagataa caaccctatc atatagctta tttttaaatt acctgaaaaa cgatattcta
     3301 cactgtttcc tttttgactc tgagttttca aactgttact tctcccatat ttctcaatcc
     3361 atttcactca gttgcacagt cttttaaacc ctgtaattgt cataccaaag tttcttttta
     3421 aaaaaaaatt actttaaatg cttagtttat tcaaagagcg atccaataat ataaaaggaa
     3481 catgtgttaa acacaataaa attttaaatg gctctaaatc aagcacatca agagtataca
     3541 agtcttaaag gctttttaat acatactctt ttcccatcta tgtaacccaa cttgcacatt
     3601 tcagctgcat gtggtgaata tgcatcatat atttacttta agaggtaaga ttttacttgc
     3661 aaaatacatg tgcaaattag ggatccatca gttgatggaa gagatggact ctagaatatt
     3721 atttcttgtg gttattactc ctttacaaag cactttcgtc tcacttgatc ctcataagga
     3781 aactaaggct cagaatgagt agagctgggt tcagaatcta gctcttctaa ctccaagcca
     3841 tctcctcttt ccactgcagg aaactgcctc ttttgtcagt gaaataatag aaagattgtg
     3901 ttagttaagt gataactgtc atttgtttga aaatgttcga gactgaacaa atagcattta
     3961 aactgctggc atatagatga gatattgtac ttttgtgcaa tgtttattac ctttgattaa
     4021 attgtaatgt gaagctttta ctaggtgaat agttcattat gtagtggagg cttcgtggtt
     4081 gtccattgaa ttgtcacagc aaaatctata agtttcttca attctacaag atagatccat
     4141 atacctttga tcacttggag actctttttt tgctggtttc tagataactc aggtaaatca
     4201 gacctttaca gagtacaggg ctaggtgaaa gaattactga aaaatcacct tgaaaatccg
     4261 aagggctgat atacccttta tgttcctgac tgatgcgcag aacctggggg aaatctacag
     4321 caatatacag gttgcaatgc tgataacaca acagcaatcc tctcctctac gtggacttac
     4381 tgttgttttt ttaattatta ttggaatggg attttagaaa atagaagtta cctttgtgtg
     4441 tgttttaggg aaggtagaga agaatctgct ctttctctga atactgtttt gaccccaggc
     4501 aggaccttgg aaaggccaaa acattaacag tagtacttct gttcactgaa gagttatgtt
     4561 acatgaagat aaaatggttt tgtcgtgttt attattgtat tttgtgttga tataaataaa
     4621 catggtaatt taaacaatga a
//
