LOCUS       NM_002213               4440 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens integrin subunit beta 5 (ITGB5), transcript variant 1,
            mRNA.
ACCESSION   NM_002213 XM_940600 XM_944676 XM_944679 XM_944682 XM_944685
            XM_944688 XM_944693
VERSION     NM_002213.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4440)
  AUTHORS   Chen,W., Yang,H., Huang,L., Fang,C., Yao,L., Liu,F. and Jin,T.
  TITLE     ROS-mediated ITGB5 promotes tongue squamous cell carcinoma
            metastasis through epithelial mesenchymal transition and cell
            adhesion signal pathway
  JOURNAL   J Cancer Res Clin Oncol 150 (8), 398 (2024)
   PUBMED   39180583
  REMARK    GeneRIF: ROS-mediated ITGB5 promotes tongue squamous cell carcinoma
            metastasis through epithelial mesenchymal transition and cell
            adhesion signal pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4440)
  AUTHORS   Lei,T., Lin,Y., Lai,X., Zhang,Y., Ma,Y., Wang,X., Liu,W., Tang,Q.,
            Yang,T., Feng,W. and Song,W.
  TITLE     ITGB5 facilitates gastric cancer metastasis by promoting TGFBR2
            endosomal recycling
  JOURNAL   Cancer Lett 592, 216953 (2024)
   PUBMED   38729557
  REMARK    GeneRIF: ITGB5 facilitates gastric cancer metastasis by promoting
            TGFBR2 endosomal recycling.
REFERENCE   3  (bases 1 to 4440)
  AUTHORS   Datta,R., Mukherjee,D., Podolsky,M.J., Yang,C.D., Alba,D.L.,
            Singh,S., Arnold,T.D., Koliwad,S., Lizama,C.O. and Atabai,K.
  TITLE     PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling
            through the beta5 integrin
  JOURNAL   J Biol Chem 300 (2), 105631 (2024)
   PUBMED   38199575
  REMARK    GeneRIF: PTP1B mediates the inhibitory effect of MFGE8 on insulin
            signaling through the beta5 integrin.
REFERENCE   4  (bases 1 to 4440)
  AUTHORS   Fathy,A.M., Rizk,A.Y., El Azeez Nosair,N.A., Abdelkarim,A.M. and
            Ellakany,M.F.
  TITLE     Assessment Of Endometrial Integrin Beta 5 In Women With Unexplained
            Recurrent Pregnancy Loss
  JOURNAL   J Pak Med Assoc 73(Suppl 4) (4), S114-S117 (2023)
   PUBMED   37482842
  REMARK    GeneRIF: Assessment Of Endometrial Integrin Beta 5 In Women With
            Unexplained Recurrent Pregnancy Loss.
REFERENCE   5  (bases 1 to 4440)
  AUTHORS   Nishimura,S.L., Sheppard,D. and Pytela,R.
  TITLE     Integrin alpha v beta 8. Interaction with vitronectin and
            functional divergence of the beta 8 cytoplasmic domain
  JOURNAL   J Biol Chem 269 (46), 28708-28715 (1994)
   PUBMED   7525578
REFERENCE   6  (bases 1 to 4440)
  AUTHORS   Adams,J.C. and Watt,F.M.
  TITLE     Expression of beta 1, beta 3, beta 4, and beta 5 integrins by human
            epidermal keratinocytes and non-differentiating keratinocytes
  JOURNAL   J Cell Biol 115 (3), 829-841 (1991)
   PUBMED   1918165
REFERENCE   7  (bases 1 to 4440)
  AUTHORS   McLean,J.W., Vestal,D.J., Cheresh,D.A. and Bodary,S.C.
  TITLE     cDNA sequence of the human integrin beta 5 subunit
  JOURNAL   J Biol Chem 265 (28), 17126-17131 (1990)
   PUBMED   2211615
REFERENCE   8  (bases 1 to 4440)
  AUTHORS   Smith,J.W., Vestal,D.J., Irwin,S.V., Burke,T.A. and Cheresh,D.A.
  TITLE     Purification and functional characterization of integrin alpha v
            beta 5. An adhesion receptor for vitronectin
  JOURNAL   J Biol Chem 265 (19), 11008-11013 (1990)
   PUBMED   1694173
REFERENCE   9  (bases 1 to 4440)
  AUTHORS   Suzuki,S., Huang,Z.S. and Tanihara,H.
  TITLE     Cloning of an integrin beta subunit exhibiting high homology with
            integrin beta 3 subunit
  JOURNAL   Proc Natl Acad Sci U S A 87 (14), 5354-5358 (1990)
   PUBMED   2371275
REFERENCE   10 (bases 1 to 4440)
  AUTHORS   Ramaswamy,H. and Hemler,M.E.
  TITLE     Cloning, primary structure and properties of a novel human integrin
            beta subunit
  JOURNAL   EMBO J 9 (5), 1561-1568 (1990)
   PUBMED   2328726
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC026342.34, X53002.1,
            BC006541.2, J05633.1, BX095583.1 and BQ007769.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002213.4.
            
            Summary: This gene encodes a beta subunit of integrin, which can
            combine with different alpha chains to form a variety of integrin
            heterodimers. Integrins are integral cell-surface receptors that
            participate in cell adhesion as well as cell-surface mediated
            signaling. The alphav beta5 integrin is involved in adhesion to
            vitronectin. [provided by RefSeq, Aug 2017].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X53002.1, BC006541.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296181.9/ ENSP00000296181.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AC026342.34        95132-95191
            61-69               X53002.1           1-9
            70-319              BC006541.2         2-251
            320-2298            J05633.1           1-1979
            2299-3012           BC006541.2         2231-2944
            3013-3435           J05633.1           2694-3116
            3436-3875           BX095583.1         258-697
            3876-4440           BQ007769.1         13-577              c
FEATURES             Location/Qualifiers
     source          1..4440
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.2"
     gene            1..4440
                     /gene="ITGB5"
                     /note="integrin subunit beta 5"
                     /db_xref="GeneID:3693"
                     /db_xref="HGNC:HGNC:6160"
                     /db_xref="MIM:147561"
     exon            1..435
                     /gene="ITGB5"
                     /inference="alignment:Splign:2.1.0"
     CDS             366..2765
                     /gene="ITGB5"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; testis secretory sperm-binding protein Li 217p;
                     integrin beta-5"
                     /codon_start=1
                     /product="integrin beta-5 isoform a precursor"
                     /protein_id="NP_002204.2"
                     /db_xref="CCDS:CCDS3030.1"
                     /db_xref="GeneID:3693"
                     /db_xref="HGNC:HGNC:6160"
                     /db_xref="MIM:147561"
                     /translation="MPRAPAPLYACLLGLCALLPRLAGLNICTSGSATSCEECLLIHP
                     KCAWCSKEDFGSPRSITSRCDLRANLVKNGCGGEIESPASSFHVLRSLPLSSKGSGSA
                     GWDVIQMTPQEIAVNLRPGDKTTFQLQVRQVEDYPVDLYYLMDLSLSMKDDLDNIRSL
                     GTKLAEEMRKLTSNFRLGFGSFVDKDISPFSYTAPRYQTNPCIGYKLFPNCVPSFGFR
                     HLLPLTDRVDSFNEEVRKQRVSRNRDAPEGGFDAVLQAAVCKEKIGWRKDALHLLVFT
                     TDDVPHIALDGKLGGLVQPHDGQCHLNEANEYTASNQMDYPSLALLGEKLAENNINLI
                     FAVTKNHYMLYKNFTALIPGTTVEILDGDSKNIIQLIINAYNSIRSKVELSVWDQPED
                     LNLFFTATCQDGVSYPGQRKCEGLKIGDTASFEVSLEARSCPSRHTEHVFALRPVGFR
                     DSLEVGVTYNCTCGCSVGLEPNSARCNGSGTYVCGLCECSPGYLGTRCECQDGENQSV
                     YQNLCREAEGKPLCSGRGDCSCNQCSCFESEFGKIYGPFCECDNFSCARNKGVLCSGH
                     GECHCGECKCHAGYIGDNCNCSTDISTCRGRDGQICSERGHCLCGQCQCTEPGAFGEM
                     CEKCPTCPDACSTKRDCVECLLLHSGKPDNQTCHSLCRDEVITWVDTIVKDDQEAVLC
                     FYKTAKDCVMMFTYVELPSGKSNLTVLREPECGNTPNAMTILLAVVGSILLVGLALLA
                     IWKLLVTIHDRREFAKFQSERSRARYEMASNPLYRKPISTHTVDFTFNKFNKSYNGTV
                     D"
     exon            436..521
                     /gene="ITGB5"
                     /inference="alignment:Splign:2.1.0"
     exon            522..726
                     /gene="ITGB5"
                     /inference="alignment:Splign:2.1.0"
     exon            727..976
                     /gene="ITGB5"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1145
                     /gene="ITGB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1307
                     /gene="ITGB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1403
                     /gene="ITGB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1493
                     /gene="ITGB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1628
                     /gene="ITGB5"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..2058
                     /gene="ITGB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2281
                     /gene="ITGB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2382
                     /gene="ITGB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2502
                     /gene="ITGB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2669
                     /gene="ITGB5"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..4440
                     /gene="ITGB5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3198..3203
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGB5"
                     /note="hexamer: AATAAA"
     polyA_site      3225
                     /gene="ITGB5"
                     /note="major polyA site"
     regulatory      3408..3413
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGB5"
                     /note="hexamer: ATTAAA"
     polyA_site      3420
                     /gene="ITGB5"
                     /note="major polyA site"
     regulatory      4418..4423
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGB5"
                     /note="hexamer: AATAAA"
     polyA_site      4440
                     /gene="ITGB5"
ORIGIN      
        1 agagtgtgcc ggcgcgcggg ggagtctcgg cgctgggcgc gtctcggagc ccaagtcgcg
       61 gccgccgagc ggagccagcc cctcccctac ccggagcagc ccgctggggc cgtcccgagc
      121 ggcgacacac taggagtccc ggccggccag ccagggcagc cgcggtcccg ggactcggcc
      181 gtgagtgctg cgggacggat ggtggcggcg gggcgcgggc cagcgcgggc gccgtgagcc
      241 ggagctgcgc gcggggcatg cggctgcggc ccccggccct cggcccccgc gctccggccc
      301 cagccccggc cgccggcccc cgcggagtgc agcgaccgcg ccgccgctga gggaggcgcc
      361 ccaccatgcc gcgggccccg gcgccgctgt acgcctgcct cctggggctc tgcgcgctcc
      421 tgccccggct cgcaggtctc aacatatgca ctagtggaag tgccacctca tgtgaagaat
      481 gtctgctaat ccacccaaaa tgtgcctggt gctccaaaga ggacttcgga agcccacggt
      541 ccatcacctc tcggtgtgat ctgagggcaa accttgtcaa aaatggctgt ggaggtgaga
      601 tagagagccc agccagcagc ttccatgtcc tgaggagcct gcccctcagc agcaagggtt
      661 cgggctctgc aggctgggac gtcattcaga tgacaccaca ggagattgcc gtgaacctcc
      721 ggcccggtga caagaccacc ttccagctac aggttcgcca ggtggaggac tatcctgtgg
      781 acctgtacta cctgatggac ctctccctgt ccatgaagga tgacttggac aatatccgga
      841 gcctgggcac caaactcgcg gaggagatga ggaagctcac cagcaacttc cggttgggat
      901 ttgggtcttt tgttgataag gacatctctc ctttctccta cacggcaccg aggtaccaga
      961 ccaatccgtg cattggttac aagttgtttc caaattgcgt cccctccttt gggttccgcc
     1021 atctgctgcc tctcacagac agagtggaca gcttcaatga ggaagttcgg aaacagaggg
     1081 tgtcccggaa ccgagatgcc cctgaggggg gctttgatgc agtactccag gcagccgtct
     1141 gcaaggagaa gattggctgg cgaaaggatg cactgcattt gctggtgttc acaacagatg
     1201 atgtgcccca catcgcattg gatggaaaat tgggaggcct ggtgcagcca cacgatggcc
     1261 agtgccacct gaacgaggcc aacgagtaca ctgcatccaa ccagatggac tatccatccc
     1321 ttgccttgct tggagagaaa ttggcagaga acaacatcaa cctcatcttt gcagtgacaa
     1381 aaaaccatta tatgctgtac aagaatttta cagccctgat acctggaaca acggtggaga
     1441 ttttagatgg agactccaaa aatattattc aactgattat taatgcatac aatagtatcc
     1501 ggtctaaagt ggagttgtca gtctgggatc agcctgagga tcttaatctc ttctttactg
     1561 ctacctgcca agatggggta tcctatcctg gtcagaggaa gtgtgagggt ctgaagattg
     1621 gggacacggc atcttttgaa gtatcattgg aggcccgaag ctgtcccagc agacacacgg
     1681 agcatgtgtt tgccctgcgg ccggtgggat tccgggacag cctggaggtg ggggtcacct
     1741 acaactgcac gtgcggctgc agcgtggggc tggaacccaa cagcgccagg tgcaacggga
     1801 gcgggaccta tgtctgcggc ctgtgtgagt gcagccccgg ctacctgggc accaggtgcg
     1861 agtgccagga tggggagaac cagagcgtgt accagaacct gtgccgggag gcagagggca
     1921 agccactgtg cagcgggcgt ggggactgca gctgcaacca gtgctcctgc ttcgagagcg
     1981 agtttggcaa gatctatggg cctttctgtg agtgcgacaa cttctcctgt gccaggaaca
     2041 agggagtcct ctgctcaggc catggcgagt gtcactgcgg ggaatgcaag tgccatgcag
     2101 gttacatcgg ggacaactgt aactgctcga cagacatcag cacatgccgg ggcagagatg
     2161 gccagatctg cagcgagcgt gggcactgtc tctgtgggca gtgccaatgc acggagccgg
     2221 gggcctttgg ggagatgtgt gagaagtgcc ccacctgccc ggatgcatgc agcaccaaga
     2281 gagattgcgt cgagtgcctg ctgctccact ctgggaaacc tgacaaccag acctgccaca
     2341 gcctatgcag ggatgaggtg atcacatggg tggacaccat cgtgaaagat gaccaggagg
     2401 ctgtgctatg tttctacaaa accgccaagg actgcgtcat gatgttcacc tatgtggagc
     2461 tccccagtgg gaagtccaac ctgaccgtcc tcagggagcc agagtgtgga aacaccccca
     2521 acgccatgac catcctcctg gctgtggtcg gtagcatcct ccttgttggg cttgcactcc
     2581 tggctatctg gaagctgctt gtcaccatcc acgaccggag ggagtttgca aagtttcaga
     2641 gcgagcgatc cagggcccgc tatgaaatgg cttcaaatcc attatacaga aagcctatct
     2701 ccacgcacac tgtggacttc accttcaaca agttcaacaa atcctacaat ggcactgtgg
     2761 actgatgttt ccttctccga ggggctggag cggggatctg atgaaaaggt cagactgaaa
     2821 cgccttgcac ggctgctcgg cttgatcaca gctccctagg taggcaccac agagaagacc
     2881 ttctagtgag cctgggccag gagcccacag tgcctgtaca ggaaggtgcc tggccatgtc
     2941 acctggctgc taggccagag ccatgccagg ctgcgtccct ccgagcttgg gataaagcaa
     3001 ggggaccttg gcgctctcag ctttccctgc cacatccagc ttgttgtccc aatgaaatac
     3061 tgagatgctg ggctgtctct cccttccagg aatgctgggc ccccagcctg gccagacaag
     3121 aagactgtca ggaagggtcg gagtctgtaa aaccagcata cagtttggct tttttcacat
     3181 tgatcatttt tatatgaaat aaaaagatcc tgcatttatg gtgtagttct gagtcctgag
     3241 acttttctgc gtgatggcta tgccttgcac acaggtgttg gtgatggggc tgttgagatg
     3301 cctgttgaag gtacatcgtt tgcaaatgtc agtttcctct cctgtccgtg tttgtttagt
     3361 acttttataa tgaaaagaaa caagattgtt tgggattgga agtaaagatt aaaaccaaaa
     3421 gaatttgtgt ttgtctgata ctctctgtgt gtttctttct ttctgagcgg acttaaaatg
     3481 gtgcccccag tggggattga agcggccgtg tacttcctca gggatgggac acaggctggt
     3541 ctgatactcc agactgcagc ttgtcaagta agcatgaggt gctcggggca gtgagggctg
     3601 tgcaaggggg aacactgagc agataccttt ggccccttcc agcttttact gacagagagt
     3661 tccaggctag acaccataaa aaccacccct tgttctgagg ggctgaggct ggaaatagat
     3721 tgtacagaca agcaagggtt gagtggtggt tcccacacga agtcatctct taatcatcat
     3781 tagcaatagc agttcccttc caaggcctcc cctcactccc gaaacactta cgtcccatgc
     3841 aggcccaatg caaaaaaaca catttgagct tttttcccgc agggccatga agtcccctta
     3901 agttcccata tctaagatgg ttgactgacc ctctcccctt atgtacagaa gaggaaactg
     3961 attctcagag aggggaagtg gcttgcccga gtgtttgtta ggaggttact gaatgacaaa
     4021 ctgttcctaa gaccccatct catgctggcc agagggccag cctcctcatt cctgcttgct
     4081 cttagaaaat ctttcactga tcattttttg tcactggaat aacttcaagg ttattatgct
     4141 ttcattccaa atggatctgt cctcagctct ggacccaatt ccccttactt cattttggca
     4201 aacactaagt caaatagtga aatgcctgtc actacataga acctattacc tggggcaaat
     4261 acgaacagat tgagtttcct tcatcttgtg taaatatgat gaaacagaga cctggtaact
     4321 tggtgacact gttaaaccct ttttgggata aagccaaatg taaatgaaaa cattaaacag
     4381 ataaattgtg gtgttgagac ttttctgaat tgagaaaaat aaatgtaatt ttggaagaaa
//
