LOCUS       NM_000213               5896 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens integrin subunit beta 4 (ITGB4), transcript variant 1,
            mRNA.
ACCESSION   NM_000213
VERSION     NM_000213.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5896)
  AUTHORS   Ma,D., Liu,S., Liu,K., Kong,L., Xiao,L., Xin,Q., Jiang,C. and Wu,J.
  TITLE     MDFI promotes the proliferation and tolerance to chemotherapy of
            colorectal cancer cells by binding ITGB4/LAMB3 to activate the AKT
            signaling pathway
  JOURNAL   Cancer Biol Ther 25 (1), 2314324 (2024)
   PUBMED   38375821
  REMARK    GeneRIF: MDFI promotes the proliferation and tolerance to
            chemotherapy of colorectal cancer cells by binding ITGB4/LAMB3 to
            activate the AKT signaling pathway.
REFERENCE   2  (bases 1 to 5896)
  AUTHORS   Yamanaka,K., Koma,Y.I., Urakami,S., Takahashi,R., Nagamata,S.,
            Omori,M., Torigoe,R., Yokoo,H., Nakanishi,T., Ishihara,N.,
            Tsukamoto,S., Kodama,T., Nishio,M., Shigeoka,M., Yokozaki,H. and
            Terai,Y.
  TITLE     YKL40/Integrin beta4 Axis Induced by the Interaction between Cancer
            Cells and Tumor-Associated Macrophages Is Involved in the
            Progression of High-Grade Serous Ovarian Carcinoma
  JOURNAL   Int J Mol Sci 25 (19), 10598 (2024)
   PUBMED   39408927
  REMARK    GeneRIF: YKL40/Integrin beta4 Axis Induced by the Interaction
            between Cancer Cells and Tumor-Associated Macrophages Is Involved
            in the Progression of High-Grade Serous Ovarian Carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5896)
  AUTHORS   Shi,Y., Fang,N., Wu,Y., Xu,H., Ning,A., Zhang,W., Liu,Y., Tao,X.,
            Chen,Q., Tian,T., Zhang,L., Chu,M. and Cui,J.
  TITLE     NEDD4L mediates ITGB4 ubiquitination and degradation to suppress
            esophageal carcinoma progression
  JOURNAL   Cell Commun Signal 22 (1), 302 (2024)
   PUBMED   38831335
  REMARK    GeneRIF: NEDD4L mediates ITGB4 ubiquitination and degradation to
            suppress esophageal carcinoma progression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5896)
  AUTHORS   Topuz,B.T., Guldiken,S., Tastekin,E., Topuz,C., Celik,M.,
            Bulbul,B.Y., Andac,B. and Yekdes,A.C.
  TITLE     The association between integrin beta4 overexpression and
            lymphovascular invasion in papillary thyroid cancer
  JOURNAL   Endokrynol Pol 75 (3), 310-316 (2024)
   PUBMED   38887115
  REMARK    GeneRIF: The association between integrin beta4 overexpression and
            lymphovascular invasion in papillary thyroid cancer.
REFERENCE   5  (bases 1 to 5896)
  AUTHORS   Lucky,A.W. and Gorell,E.
  TITLE     Epidermolysis Bullosa with Pyloric Atresia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301336
REFERENCE   6  (bases 1 to 5896)
  AUTHORS   Pfendner,E.G. and Lucky,A.W.
  TITLE     Junctional Epidermolysis Bullosa
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301304
REFERENCE   7  (bases 1 to 5896)
  AUTHORS   Hogervorst,F., Kuikman,I., van Kessel,A.G. and Sonnenberg,A.
  TITLE     Molecular cloning of the human alpha 6 integrin subunit.
            Alternative splicing of alpha 6 mRNA and chromosomal localization
            of the alpha 6 and beta 4 genes
  JOURNAL   Eur J Biochem 199 (2), 425-433 (1991)
   PUBMED   2070796
REFERENCE   8  (bases 1 to 5896)
  AUTHORS   Tamura,R.N., Rozzo,C., Starr,L., Chambers,J., Reichardt,L.F.,
            Cooper,H.M. and Quaranta,V.
  TITLE     Epithelial integrin alpha 6 beta 4: complete primary structure of
            alpha 6 and variant forms of beta 4
  JOURNAL   J Cell Biol 111 (4), 1593-1604 (1990)
   PUBMED   1976638
REFERENCE   9  (bases 1 to 5896)
  AUTHORS   Hogervorst,F., Kuikman,I., von dem Borne,A.E. and Sonnenberg,A.
  TITLE     Cloning and sequence analysis of beta-4 cDNA: an integrin subunit
            that contains a unique 118 kd cytoplasmic domain
  JOURNAL   EMBO J 9 (3), 765-770 (1990)
   PUBMED   2311578
REFERENCE   10 (bases 1 to 5896)
  AUTHORS   Suzuki,S. and Naitoh,Y.
  TITLE     Amino acid sequence of a novel integrin beta 4 subunit and primary
            expression of the mRNA in epithelial cells
  JOURNAL   EMBO J 9 (3), 757-763 (1990)
   PUBMED   2311577
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CA391583.1, X53587.1, X51841.1,
            AC087749.12, AI318403.1 and X52186.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000213.4.
            
            Summary: Integrins are heterodimers comprised of alpha and beta
            subunits, that are noncovalently associated transmembrane
            glycoprotein receptors. Different combinations of alpha and beta
            polypeptides form complexes that vary in their ligand-binding
            specificities. Integrins mediate cell-matrix or cell-cell adhesion,
            and transduced signals that regulate gene expression and cell
            growth. This gene encodes the integrin beta 4 subunit, a receptor
            for the laminins. This subunit tends to associate with alpha 6
            subunit and is likely to play a pivotal role in the biology of
            invasive carcinoma. Mutations in this gene are associated with
            epidermolysis bullosa with pyloric atresia. Multiple alternatively
            spliced transcript variants encoding distinct isoforms have been
            found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X53587.1, SRR14038197.633936.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000200181.8/ ENSP00000200181.3
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 CA391583.1         132-138
            8-1813              X53587.1           31-1836
            1814-4272           X51841.1           1776-4234
            4273-4399           X53587.1           4296-4422
            4400-4409           AC087749.12        198379-198388
            4410-4449           X53587.1           4432-4471
            4450-5657           X53587.1           4473-5680
            5658-5895           AI318403.1         1-238               c
            5896-5896           X52186.1           5690-5690
FEATURES             Location/Qualifiers
     source          1..5896
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..5896
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /note="integrin subunit beta 4"
                     /db_xref="GeneID:3691"
                     /db_xref="HGNC:HGNC:6158"
                     /db_xref="MIM:147557"
     exon            1..154
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            155..243
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..5633
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CD104 antigen"
                     /codon_start=1
                     /product="integrin beta-4 isoform 1 precursor"
                     /protein_id="NP_000204.3"
                     /db_xref="CCDS:CCDS11727.1"
                     /db_xref="GeneID:3691"
                     /db_xref="HGNC:HGNC:6158"
                     /db_xref="MIM:147557"
                     /translation="MAGPRPSPWARLLLAALISVSLSGTLANRCKKAPVKSCTECVRV
                     DKDCAYCTDEMFRDRRCNTQAELLAAGCQRESIVVMESSFQITEETQIDTTLRRSQMS
                     PQGLRVRLRPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVL
                     SQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTEDVDEFRN
                     KLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESAFHYEADGANV
                     LAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYE
                     KLHTYFPVSSLGVLQEDSSNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSKMFQK
                     TRTGSFHIRRGEVGIYQVQLRALEHVDGTHVCQLPEDQKGNIHLKPSFSDGLKMDAGI
                     ICDVCTCELQKEVRSARCSFNGDFVCGQCVCSEGWSGQTCNCSTGSLSDIQPCLREGE
                     DKPCSGRGECQCGHCVCYGEGRYEGQFCEYDNFQCPRTSGFLCNDRGRCSMGQCVCEP
                     GWTGPSCDCPLSNATCIDSNGGICNGRGHCECGRCHCHQQSLYTDTICEINYSAIHPG
                     LCEDLRSCVQCQAWGTGEKKGRTCEECNFKVKMVDELKRAEEVVVRCSFRDEDDDCTY
                     SYTMEGDGAPGPNSTVLVHKKKDCPPGSFWWLIPLLLLLLPLLALLLLLCWKYCACCK
                     ACLALLPCCNRGHMVGFKEDHYMLRENLMASDHLDTPMLRSGNLKGRDVVRWKVTNNM
                     QRPGFATHAASINPTELVPYGLSLRLARLCTENLLKPDTRECAQLRQEVEENLNEVYR
                     QISGVHKLQQTKFRQQPNAGKKQDHTIVDTVLMAPRSAKPALLKLTEKQVEQRAFHDL
                     KVAPGYYTLTADQDARGMVEFQEGVELVDVRVPLFIRPEDDDEKQLLVEAIDVPAGTA
                     TLGRRLVNITIIKEQARDVVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQD
                     GTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVDSLLRGRQVRRFHVQLSNPKF
                     GAHLGQPHSTTIIIRDPDELDRSFTSQMLSSQPPPHGDLGAPQNPNAKAAGSRKIHFN
                     WLPPSGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGE
                     GPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVND
                     DNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAIINLATQP
                     KRPMSIPIIPDIPIVDAQSGEDYDSFLMYSDDVLRSPSGSQRPSVSDDTGCGWKFEPL
                     LGEELDLRRVTWRLPPELIPRLSASSGRSSDAEAPHGPPDDGGAGGKGGSLPRSATPG
                     PPGEHLVNGRMDFAFPGSTNSLHRMTTTSAAAYGTHLSPHVPHRVLSTSSTLTRDYNS
                     LTRSEHSHSTTLPRDYSTLTSVSSHDSRLTAGVPDTPTRLVFSALGPTSLRVSWQEPR
                     CERPLQGYSVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGR
                     EREGVITIESQVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPN
                     GDIVGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEGFGP
                     EREGIITIESQDGGPFPQLGSRAGLFQHPLQSEYSSITTTHTSATEPFLVDGLTLGAQ
                     HLEAGGSLTRHVTQEFVSRTLTTSGTLSTHMDQQFFQT"
     exon            244..326
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            327..428
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            429..633
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            634..730
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            731..902
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1166
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1256
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1379
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1541
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1618
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1821
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..1925
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2024
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2154
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2277
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2384
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2418
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2610
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..2714
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2715..2773
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2797
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2798..2946
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2947..3126
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            3127..3275
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            3276..3480
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            3481..3638
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            3639..3819
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            3820..3957
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            3958..4140
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            4141..4272
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            4273..4482
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            4483..4722
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            4723..4872
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            4873..5061
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            5062..5217
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            5218..5382
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            5383..5493
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     exon            5494..5896
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5874..5879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /note="hexamer: AATAAA"
     polyA_site      5896
                     /gene="ITGB4"
                     /gene_synonym="CD104; GP150; JEB5A; JEB5B"
                     /note="major polyA site"
ORIGIN      
        1 cccccaaccc ccgcgcccgc cctcggacag tccctgctcg cccgcgcgct gcagccccat
       61 ctcctagcgg cagcccaggc gcggagggag cgagtccgcc ccgaggtagg tccaggacgg
      121 gcgcacagca gcagccgagg ctggccggga gagggaggaa gaggatggca gggccacgcc
      181 ccagcccatg ggccaggctg ctcctggcag ccttgatcag cgtcagcctc tctgggacct
      241 tggcaaaccg ctgcaagaag gccccagtga agagctgcac ggagtgtgtc cgtgtggata
      301 aggactgcgc ctactgcaca gacgagatgt tcagggaccg gcgctgcaac acccaggcgg
      361 agctgctggc cgcgggctgc cagcgggaga gcatcgtggt catggagagc agcttccaaa
      421 tcacagagga gacccagatt gacaccaccc tgcggcgcag ccagatgtcc ccccaaggcc
      481 tgcgggtccg tctgcggccc ggtgaggagc ggcattttga gctggaggtg tttgagccac
      541 tggagagccc cgtggacctg tacatcctca tggacttctc caactccatg tccgatgatc
      601 tggacaacct caagaagatg gggcagaacc tggctcgggt cctgagccag ctcaccagcg
      661 actacactat tggatttggc aagtttgtgg acaaagtcag cgtcccgcag acggacatga
      721 ggcctgagaa gctgaaggag ccctggccca acagtgaccc ccccttctcc ttcaagaacg
      781 tcatcagcct gacagaagat gtggatgagt tccggaataa actgcaggga gagcggatct
      841 caggcaacct ggatgctcct gagggcggct tcgatgccat cctgcagaca gctgtgtgca
      901 cgagggacat tggctggcgc ccggacagca cccacctgct ggtcttctcc accgagtcag
      961 ccttccacta tgaggctgat ggcgccaacg tgctggctgg catcatgagc cgcaacgatg
     1021 aacggtgcca cctggacacc acgggcacct acacccagta caggacacag gactacccgt
     1081 cggtgcccac cctggtgcgc ctgctcgcca agcacaacat catccccatc tttgctgtca
     1141 ccaactactc ctatagctac tacgagaagc ttcacaccta tttccctgtc tcctcactgg
     1201 gggtgctgca ggaggactcg tccaacatcg tggagctgct ggaggaggcc ttcaatcgga
     1261 tccgctccaa cctggacatc cgggccctag acagcccccg aggccttcgg acagaggtca
     1321 cctccaagat gttccagaag acgaggactg ggtcctttca catccggcgg ggggaagtgg
     1381 gtatatacca ggtgcagctg cgggcccttg agcacgtgga tgggacgcac gtgtgccagc
     1441 tgccggagga ccagaagggc aacatccatc tgaaaccttc cttctccgac ggcctcaaga
     1501 tggacgcggg catcatctgt gatgtgtgca cctgcgagct gcaaaaagag gtgcggtcag
     1561 ctcgctgcag cttcaacgga gacttcgtgt gcggacagtg tgtgtgcagc gagggctgga
     1621 gtggccagac ctgcaactgc tccaccggct ctctgagtga cattcagccc tgcctgcggg
     1681 agggcgagga caagccgtgc tccggccgtg gggagtgcca gtgcgggcac tgtgtgtgct
     1741 acggcgaagg ccgctacgag ggtcagttct gcgagtatga caacttccag tgtccccgca
     1801 cttccgggtt cctctgcaat gaccgaggac gctgctccat gggccagtgt gtgtgtgagc
     1861 ctggttggac aggcccaagc tgtgactgtc ccctcagcaa tgccacctgc atcgacagca
     1921 atgggggcat ctgtaatgga cgtggccact gtgagtgtgg ccgctgccac tgccaccagc
     1981 agtcgctcta cacggacacc atctgcgaga tcaactactc ggcgatccac ccgggcctct
     2041 gcgaggacct acgctcctgc gtgcagtgcc aggcgtgggg caccggcgag aagaaggggc
     2101 gcacgtgtga ggaatgcaac ttcaaggtca agatggtgga cgagcttaag agagccgagg
     2161 aggtggtggt gcgctgctcc ttccgggacg aggatgacga ctgcacctac agctacacca
     2221 tggaaggtga cggcgcccct gggcccaaca gcactgtcct ggtgcacaag aagaaggact
     2281 gccctccggg ctccttctgg tggctcatcc ccctgctcct cctcctcctg ccgctcctgg
     2341 ccctgctact gctgctatgc tggaagtact gtgcctgctg caaggcctgc ctggcacttc
     2401 tcccgtgctg caaccgaggt cacatggtgg gctttaagga agaccactac atgctgcggg
     2461 agaacctgat ggcctctgac cacttggaca cgcccatgct gcgcagcggg aacctcaagg
     2521 gccgtgacgt ggtccgctgg aaggtcacca acaacatgca gcggcctggc tttgccactc
     2581 atgccgccag catcaacccc acagagctgg tgccctacgg gctgtccttg cgcctggccc
     2641 gcctttgcac cgagaacctg ctgaagcctg acactcggga gtgcgcccag ctgcgccagg
     2701 aggtggagga gaacctgaac gaggtctaca ggcagatctc cggtgtacac aagctccagc
     2761 agaccaagtt ccggcagcag cccaatgccg ggaaaaagca agaccacacc attgtggaca
     2821 cagtgctgat ggcgccccgc tcggccaagc cggccctgct gaagcttaca gagaagcagg
     2881 tggaacagag ggccttccac gacctcaagg tggcccccgg ctactacacc ctcactgcag
     2941 accaggacgc ccggggcatg gtggagttcc aggagggcgt ggagctggtg gacgtacggg
     3001 tgcccctctt tatccggcct gaggatgacg acgagaagca gctgctggtg gaggccatcg
     3061 acgtgcccgc aggcactgcc accctcggcc gccgcctggt aaacatcacc atcatcaagg
     3121 agcaagccag agacgtggtg tcctttgagc agcctgagtt ctcggtcagc cgcggggacc
     3181 aggtggcccg catccctgtc atccggcgtg tcctggacgg cgggaagtcc caggtctcct
     3241 accgcacaca ggatggcacc gcgcagggca accgggacta catccccgtg gagggtgagc
     3301 tgctgttcca gcctggggag gcctggaaag agctgcaggt gaagctcctg gagctgcaag
     3361 aagttgactc cctcctgcgg ggccgccagg tccgccgttt ccacgtccag ctcagcaacc
     3421 ctaagtttgg ggcccacctg ggccagcccc actccaccac catcatcatc agggacccag
     3481 atgaactgga ccggagcttc acgagtcaga tgttgtcatc acagccaccc cctcacggcg
     3541 acctgggcgc cccgcagaac cccaatgcta aggccgctgg gtccaggaag atccatttca
     3601 actggctgcc cccttctggc aagccaatgg ggtacagggt aaagtactgg attcagggtg
     3661 actccgaatc cgaagcccac ctgctcgaca gcaaggtgcc ctcagtggag ctcaccaacc
     3721 tgtacccgta ttgcgactat gagatgaagg tgtgcgccta cggggctcag ggcgagggac
     3781 cctacagctc cctggtgtcc tgccgcaccc accaggaagt gcccagcgag ccagggcgtc
     3841 tggccttcaa tgtcgtctcc tccacggtga cccagctgag ctgggctgag ccggctgaga
     3901 ccaacggtga gatcacagcc tacgaggtct gctatggcct ggtcaacgat gacaaccgac
     3961 ctattgggcc catgaagaaa gtgctggttg acaaccctaa gaaccggatg ctgcttattg
     4021 agaaccttcg ggagtcccag ccctaccgct acacggtgaa ggcgcgcaac ggggccggct
     4081 gggggcctga gcgggaggcc atcatcaacc tggccaccca gcccaagagg cccatgtcca
     4141 tccccatcat ccctgacatc cctatcgtgg acgcccagag cggggaggac tacgacagct
     4201 tccttatgta cagcgatgac gttctacgct ctccatcggg cagccagagg cccagcgtct
     4261 ccgatgacac tggctgcggc tggaagttcg agcccctgct gggggaggag ctggacctgc
     4321 ggcgcgtcac gtggcggctg cccccggagc tcatcccgcg cctgtcggcc agcagcgggc
     4381 gctcctccga cgccgaggcg ccccacgggc ccccggacga cggcggcgcg ggcgggaagg
     4441 gcggcagcct gccccgcagt gcgacacccg ggccccccgg agagcacctg gtgaatggcc
     4501 ggatggactt tgccttcccg ggcagcacca actccctgca caggatgacc acgaccagtg
     4561 ctgctgccta tggcacccac ctgagcccac acgtgcccca ccgcgtgcta agcacatcct
     4621 ccaccctcac acgggactac aactcactga cccgctcaga acactcacac tcgaccacac
     4681 tgcccaggga ctactccacc ctcacctccg tctcctccca cgactctcgc ctgactgctg
     4741 gtgtgcccga cacgcccacc cgcctggtgt tctctgccct ggggcccaca tctctcagag
     4801 tgagctggca ggagccgcgg tgcgagcggc cgctgcaggg ctacagtgtg gagtaccagc
     4861 tgctgaacgg cggtgagctg catcggctca acatccccaa ccctgcccag acctcggtgg
     4921 tggtggaaga cctcctgccc aaccactcct acgtgttccg cgtgcgggcc cagagccagg
     4981 aaggctgggg ccgagagcgt gagggtgtca tcaccattga atcccaggtg cacccgcaga
     5041 gcccactgtg tcccctgcca ggctccgcct tcactttgag cactcccagt gccccaggcc
     5101 cgctggtgtt cactgccctg agcccagact cgctgcagct gagctgggag cggccacgga
     5161 ggcccaatgg ggatatcgtc ggctacctgg tgacctgtga gatggcccaa ggaggagggc
     5221 cagccaccgc attccgggtg gatggagaca gccccgagag ccggctgacc gtgccgggcc
     5281 tcagcgagaa cgtgccctac aagttcaagg tgcaggccag gaccactgag ggcttcgggc
     5341 cagagcgcga gggcatcatc accatagagt cccaggatgg aggacccttc ccgcagctgg
     5401 gcagccgtgc cgggctcttc cagcacccgc tgcaaagcga gtacagcagc atcaccacca
     5461 cccacaccag cgccaccgag cccttcctag tggatgggct gaccctgggg gcccagcacc
     5521 tggaggcagg cggctccctc acccggcatg tgacccagga gtttgtgagc cggacactga
     5581 ccaccagcgg aacccttagc acccacatgg accaacagtt cttccaaact tgaccgcacc
     5641 ctgccccacc cccgccacgt cccactaggc gtcctcccga ctcctctccc ggagcctcct
     5701 cagctactcc atccttgcac ccctgggggc ccagcccacc cgcatgcaca gagcaggggc
     5761 taggtgtctc ctgggaggca tgaagggggc aaggtccgtc ctctgtgggc ccaaacctat
     5821 ttgtaaccaa agagctggga gcagcacaag gacccagcct ttgttctgca cttaataaat
     5881 ggttttgcta ctgcta
//
