LOCUS       NM_014288                961 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens integrin subunit beta 3 binding protein (ITGB3BP),
            transcript variant 2, mRNA.
ACCESSION   NM_014288
VERSION     NM_014288.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 961)
  AUTHORS   Tian,T., Chen,L., Dou,Z., Yang,Z., Gao,X., Yuan,X., Wang,C.,
            Liu,R., Shen,Z., Gui,P., Teng,M., Meng,X., Hill,D.L., Li,L.,
            Zhang,X., Liu,X., Sun,L., Zang,J. and Yao,X.
  TITLE     Structural insights into human CCAN complex assembled onto DNA
  JOURNAL   Cell Discov 8 (1), 90 (2022)
   PUBMED   36085283
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 961)
  AUTHORS   Liang,Q., Tan,C., Xiao,F., Yin,F., Liu,M., Lei,L., Wu,L., Yang,Y.,
            Tan,H.J.J., Liu,S. and Zeng,X.
  TITLE     Integrated profiling identifies ITGB3BP as prognostic biomarker for
            hepatocellular carcinoma
  JOURNAL   Bosn J Basic Med Sci 21 (6), 712-723 (2021)
   PUBMED   33974527
  REMARK    GeneRIF: Integrated profiling identifies ITGB3BP as prognostic
            biomarker for hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 961)
  AUTHORS   Cao,Z., Ge,S., Xu,Z. and Ma,Y.Q.
  TITLE     beta3-Endonexin interacts with ninein in vascular endothelial cells
            to promote angiogenesis
  JOURNAL   Biochem Biophys Res Commun 566, 75-79 (2021)
   PUBMED   34118594
  REMARK    GeneRIF: beta3-Endonexin interacts with ninein in vascular
            endothelial cells to promote angiogenesis.
REFERENCE   4  (bases 1 to 961)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 961)
  AUTHORS   Li,D., Wang,F. and Samuels,H.H.
  TITLE     Domain structure of the NRIF3 family of coregulators suggests
            potential dual roles in transcriptional regulation
  JOURNAL   Mol Cell Biol 21 (24), 8371-8384 (2001)
   PUBMED   11713274
REFERENCE   6  (bases 1 to 961)
  AUTHORS   Ohtoshi,A., Maeda,T., Higashi,H., Ashizawa,S., Yamada,M. and
            Hatakeyama,M.
  TITLE     beta3-endonexin as a novel inhibitor of cyclin A-associated kinase
  JOURNAL   Biochem Biophys Res Commun 267 (3), 947-952 (2000)
   PUBMED   10673397
REFERENCE   7  (bases 1 to 961)
  AUTHORS   Tang,S., Gao,Y. and Ware,J.A.
  TITLE     Enhancement of endothelial cell migration and in vitro tube
            formation by TAP20, a novel beta 5 integrin-modulating, PKC
            theta-dependent protein
  JOURNAL   J Cell Biol 147 (5), 1073-1084 (1999)
   PUBMED   10579726
REFERENCE   8  (bases 1 to 961)
  AUTHORS   Li,D., Desai-Yajnik,V., Lo,E., Schapira,M., Abagyan,R. and
            Samuels,H.H.
  TITLE     NRIF3 is a novel coactivator mediating functional specificity of
            nuclear hormone receptors
  JOURNAL   Mol Cell Biol 19 (10), 7191-7202 (1999)
   PUBMED   10490654
REFERENCE   9  (bases 1 to 961)
  AUTHORS   Kashiwagi,H., Schwartz,M.A., Eigenthaler,M., Davis,K.A.,
            Ginsberg,M.H. and Shattil,S.J.
  TITLE     Affinity modulation of platelet integrin alphaIIbbeta3 by
            beta3-endonexin, a selective binding partner of the beta3 integrin
            cytoplasmic tail
  JOURNAL   J Cell Biol 137 (6), 1433-1443 (1997)
   PUBMED   9182673
REFERENCE   10 (bases 1 to 961)
  AUTHORS   Shattil,S.J., O'Toole,T., Eigenthaler,M., Thon,V., Williams,M.,
            Babior,B.M. and Ginsberg,M.H.
  TITLE     Beta 3-endonexin, a novel polypeptide that interacts specifically
            with the cytoplasmic tail of the integrin beta 3 subunit
  JOURNAL   J Cell Biol 131 (3), 807-816 (1995)
   PUBMED   7593198
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU853146.1, BC009929.2 and
            AA873717.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_014288.4.
            
            Summary: This gene encodes a transcriptional coregulator that binds
            to and enhances the activity of members of the nuclear receptor
            families, thyroid hormone receptors and retinoid X receptors. This
            protein also acts as a corepressor of NF-kappaB-dependent
            signaling. This protein induces apoptosis in breast cancer cells
            through a caspase 2-mediated signaling pathway. This protein is
            also a component of the centromere-specific histone H3 variant
            nucleosome associated complex (CENP-NAC) and may be involved in
            mitotic progression by recruiting the histone H3 variant CENP-A to
            the centromere. Alternate splicing results in multiple transcript
            variants. [provided by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1. Isoform 2 is
            shorter, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009929.2, AF175306.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000271002.15/ ENSP00000271002.10
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                BU853146.1         52-96
            46-958              BC009929.2         1-913
            959-961             AA873717.1         11-13               c
FEATURES             Location/Qualifiers
     source          1..961
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.3"
     gene            1..961
                     /gene="ITGB3BP"
                     /gene_synonym="CENP-R; CENPR; HSU37139; NRIF3; TAP20"
                     /note="integrin subunit beta 3 binding protein"
                     /db_xref="GeneID:23421"
                     /db_xref="HGNC:HGNC:6157"
                     /db_xref="MIM:605494"
     exon            1..97
                     /gene="ITGB3BP"
                     /gene_synonym="CENP-R; CENPR; HSU37139; NRIF3; TAP20"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..626
                     /gene="ITGB3BP"
                     /gene_synonym="CENP-R; CENPR; HSU37139; NRIF3; TAP20"
                     /note="isoform 2 is encoded by transcript variant 2; beta
                     3 endonexin; centromere protein R; integrin beta-3-binding
                     protein; nuclear receptor-interacting factor 3; integrin
                     beta 3 binding protein (beta3-endonexin)"
                     /codon_start=1
                     /product="centromere protein R isoform 2"
                     /protein_id="NP_055103.3"
                     /db_xref="CCDS:CCDS30736.1"
                     /db_xref="GeneID:23421"
                     /db_xref="HGNC:HGNC:6157"
                     /db_xref="MIM:605494"
                     /translation="MPVKRSLKLDGLLEENSFDPSKITRKKSVITYSPTTGTCQMSLF
                     ASPTSSEEQKHRNGLSNEKRKKLNHPSLTESKESTTKDNDEFMMLLSKVEKLSEEIME
                     IMQNLSSIQALEGSRELENLIGISCASHFLKREMQKTKELMTKVNKQKLFEKSTGLPH
                     KASRHLDSYEFLKAILN"
     exon            98..140
                     /gene="ITGB3BP"
                     /gene_synonym="CENP-R; CENPR; HSU37139; NRIF3; TAP20"
                     /inference="alignment:Splign:2.1.0"
     exon            141..276
                     /gene="ITGB3BP"
                     /gene_synonym="CENP-R; CENPR; HSU37139; NRIF3; TAP20"
                     /inference="alignment:Splign:2.1.0"
     exon            277..346
                     /gene="ITGB3BP"
                     /gene_synonym="CENP-R; CENPR; HSU37139; NRIF3; TAP20"
                     /inference="alignment:Splign:2.1.0"
     exon            347..425
                     /gene="ITGB3BP"
                     /gene_synonym="CENP-R; CENPR; HSU37139; NRIF3; TAP20"
                     /inference="alignment:Splign:2.1.0"
     exon            426..519
                     /gene="ITGB3BP"
                     /gene_synonym="CENP-R; CENPR; HSU37139; NRIF3; TAP20"
                     /inference="alignment:Splign:2.1.0"
     exon            520..576
                     /gene="ITGB3BP"
                     /gene_synonym="CENP-R; CENPR; HSU37139; NRIF3; TAP20"
                     /inference="alignment:Splign:2.1.0"
     exon            577..627
                     /gene="ITGB3BP"
                     /gene_synonym="CENP-R; CENPR; HSU37139; NRIF3; TAP20"
                     /inference="alignment:Splign:2.1.0"
     exon            628..961
                     /gene="ITGB3BP"
                     /gene_synonym="CENP-R; CENPR; HSU37139; NRIF3; TAP20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      938..943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGB3BP"
                     /gene_synonym="CENP-R; CENPR; HSU37139; NRIF3; TAP20"
                     /note="hexamer: AATAAA"
     polyA_site      961
                     /gene="ITGB3BP"
                     /gene_synonym="CENP-R; CENPR; HSU37139; NRIF3; TAP20"
                     /note="major polyA site"
ORIGIN      
        1 atgccttggc gtttcctttg gcggattttc tgttttcgga agttgctggg ttcgttttat
       61 tcagcggcag tggtgctttc ccgaatctca gaatgcctgt taaaagatca ctgaagttgg
      121 atggtctgtt agaagaaaat tcatttgatc cttcaaaaat cacaaggaag aaaagtgtta
      181 taacttattc tccaacaact ggaacttgtc aaatgagtct atttgcttct cccacaagtt
      241 ctgaagagca aaagcacaga aatggactat caaatgaaaa gagaaaaaaa ttgaatcacc
      301 ccagtttaac tgaaagcaaa gaatctacaa caaaagacaa tgatgaattc atgatgttgc
      361 tatcaaaagt tgagaaattg tcagaagaaa tcatggagat aatgcaaaat ttaagtagta
      421 tacaggcttt ggagggcagt agagagcttg aaaatctcat tggaatctcc tgtgcatcac
      481 atttcttaaa aagagaaatg cagaaaacca aagaactaat gacaaaagtg aataaacaaa
      541 aactgtttga aaagagtaca ggacttcctc acaaagcatc acgtcatctt gacagctatg
      601 aattccttaa agccatttta aactgaggca ttaagaagaa atgcactcac catgagcacc
      661 aacttctgca tctgcctgat catatttaaa ggaacagaga aatatttgta attaatctgc
      721 ccagtaaata ccagctcgta gcagttggca ggtgcatgtc tagataaaat ttcttgcagc
      781 taatttaaac tttctacacg caccagtaga taatctcaat gtaaataata catttcttct
      841 tggctcttta atgtaagcca acatggagag gaagatcttg acttatattc tgtaccacat
      901 acacttctgt ggacttttag catttgtggg tagacttaat aaagcatgta taaaagtggc
      961 a
//
