LOCUS       NM_000212               5941 bp    mRNA    linear   PRI 07-DEC-2024
DEFINITION  Homo sapiens integrin subunit beta 3 (ITGB3), mRNA.
ACCESSION   NM_000212
VERSION     NM_000212.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5941)
  AUTHORS   Ezzo,M., Spindler,K., Wang,J.B., Lee,D., Pecoraro,G., Cowen,J.,
            Pakshir,P. and Hinz,B.
  TITLE     Acute contact with profibrotic macrophages mechanically activates
            fibroblasts via alphavbeta3 integrin-mediated engagement of Piezo1
  JOURNAL   Sci Adv 10 (43), eadp4726 (2024)
   PUBMED   39441936
  REMARK    GeneRIF: Acute contact with profibrotic macrophages mechanically
            activates fibroblasts via alphavbeta3 integrin-mediated engagement
            of Piezo1.
REFERENCE   2  (bases 1 to 5941)
  AUTHORS   Irnaten,M., Gaynor,E. and O'Brien,C.
  TITLE     The Role of alphavbeta3 Integrin in Lamina Cribrosa Cell
            Mechanotransduction in Glaucoma
  JOURNAL   Cells 13 (17), 1487 (2024)
   PUBMED   39273058
  REMARK    GeneRIF: The Role of alphavbeta3 Integrin in Lamina Cribrosa Cell
            Mechanotransduction in Glaucoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5941)
  AUTHORS   Boz Er,A.B. and Er,I.
  TITLE     Targeting ITGbeta3 to Overcome Trastuzumab Resistance through
            Epithelial-Mesenchymal Transition Regulation in HER2-Positive
            Breast Cancer
  JOURNAL   Int J Mol Sci 25 (16), 8640 (2024)
   PUBMED   39201327
  REMARK    GeneRIF: Targeting ITGbeta3 to Overcome Trastuzumab Resistance
            through Epithelial-Mesenchymal Transition Regulation in
            HER2-Positive Breast Cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5941)
  AUTHORS   Fan,Y., Dong,S., Xia,Y., Yang,X., Lei,Q., Xu,F., Liang,D.,
            Liang,S., Zhang,M., Yang,F., Jing,Y., Li,L., Zhu,X., Bao,H.,
            Chen,Z. and Zeng,C.
  TITLE     Role of TSP-1 and its receptor ITGB3 in the renal
            tubulointerstitial injury of focal segmental glomerulosclerosis
  JOURNAL   J Biol Chem 300 (8), 107516 (2024)
   PUBMED   38960036
  REMARK    GeneRIF: Role of TSP-1 and its receptor ITGB3 in the renal
            tubulointerstitial injury of focal segmental glomerulosclerosis.
REFERENCE   5  (bases 1 to 5941)
  AUTHORS   Nam,A., Jain,S., Wu,C., Campos,A., Shepard,R.M., Yu,Z., Reddy,J.P.,
            Von Schalscha,T., Weis,S.M., Onaitis,M., Wettersten,H.I. and
            Cheresh,D.A.
  TITLE     Integrin alphavbeta3 Upregulation in Response to Nutrient Stress
            Promotes Lung Cancer Cell Metabolic Plasticity
  JOURNAL   Cancer Res 84 (10), 1630-1642 (2024)
   PUBMED   38588407
  REMARK    GeneRIF: Integrin alphavbeta3 Upregulation in Response to Nutrient
            Stress Promotes Lung Cancer Cell Metabolic Plasticity.
REFERENCE   6  (bases 1 to 5941)
  AUTHORS   Bajt,M.L., Loftus,J.C., Gawaz,M.P. and Ginsberg,M.H.
  TITLE     Characterization of a gain of function mutation of integrin alpha
            IIb beta 3 (platelet glycoprotein IIb-IIIa)
  JOURNAL   J Biol Chem 267 (31), 22211-22216 (1992)
   PUBMED   1429573
REFERENCE   7  (bases 1 to 5941)
  AUTHORS   Chen,Y.P., Djaffar,I., Pidard,D., Steiner,B., Cieutat,A.M.,
            Caen,J.P. and Rosa,J.P.
  TITLE     Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3
            subunit and defective activation of platelet integrin alpha IIb
            beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann
            thrombasthenia
  JOURNAL   Proc Natl Acad Sci U S A 89 (21), 10169-10173 (1992)
   PUBMED   1438206
REFERENCE   8  (bases 1 to 5941)
  AUTHORS   Wang,R., Furihata,K., McFarland,J.G., Friedman,K., Aster,R.H. and
            Newman,P.J.
  TITLE     An amino acid polymorphism within the RGD binding domain of
            platelet membrane glycoprotein IIIa is responsible for the
            formation of the Pena/Penb alloantigen system
  JOURNAL   J Clin Invest 90 (5), 2038-2043 (1992)
   PUBMED   1430225
REFERENCE   9  (bases 1 to 5941)
  AUTHORS   Jiang,W.M., Jenkins,D., Yuan,Q., Leung,E., Choo,K.H., Watson,J.D.
            and Krissansen,G.W.
  TITLE     The gene organization of the human beta 7 subunit, the common beta
            subunit of the leukocyte integrins HML-1 and LPAM-1
  JOURNAL   Int Immunol 4 (9), 1031-1040 (1992)
   PUBMED   1382574
REFERENCE   10 (bases 1 to 5941)
  AUTHORS   Bajt,M.L., Ginsberg,M.H., Frelinger,A.L. 3rd, Berndt,M.C. and
            Loftus,J.C.
  TITLE     A spontaneous mutation of integrin alpha IIb beta 3 (platelet
            glycoprotein IIb-IIIa) helps define a ligand binding site
  JOURNAL   J Biol Chem 267 (6), 3789-3794 (1992)
   PUBMED   1371279
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC068234.8 and M35999.1.
            
            On Nov 25, 2019 this sequence version replaced NM_000212.2.
            
            Summary: The ITGB3 protein product is the integrin beta chain beta
            3. Integrins are integral cell-surface proteins composed of an
            alpha chain and a beta chain. A given chain may combine with
            multiple partners resulting in different integrins. Integrin beta 3
            is found along with the alpha IIb chain in platelets. Integrins are
            known to participate in cell adhesion as well as cell-surface
            mediated signalling. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.3377103.1,
                                           SRR14038193.3244126.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000559488.7/ ENSP00000452786.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                AC068234.8         136546-136615       c
            71-1177             M35999.1           54-1160
            1178-1178           AC068234.8         99471-99471         c
            1179-1567           M35999.1           1162-1550
            1568-1568           AC068234.8         98031-98031         c
            1569-2442           M35999.1           1552-2425
            2443-5941           AC068234.8         76699-80197         c
FEATURES             Location/Qualifiers
     source          1..5941
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..5941
                     /gene="ITGB3"
                     /gene_synonym="BDPLT16; BDPLT2; BDPLT24; CD61; GP3A;
                     GPIIIa; GT; GT2"
                     /note="integrin subunit beta 3"
                     /db_xref="GeneID:3690"
                     /db_xref="HGNC:HGNC:6156"
                     /db_xref="MIM:173470"
     exon            1..114
                     /gene="ITGB3"
                     /gene_synonym="BDPLT16; BDPLT2; BDPLT24; CD61; GP3A;
                     GPIIIa; GT; GT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..2402
                     /gene="ITGB3"
                     /gene_synonym="BDPLT16; BDPLT2; BDPLT24; CD61; GP3A;
                     GPIIIa; GT; GT2"
                     /note="platelet membrane glycoprotein IIIa; integrin beta
                     3; integrin, beta 3 (platelet glycoprotein IIIa, antigen
                     CD61); integrin beta chain, beta 3"
                     /codon_start=1
                     /product="integrin beta-3 precursor"
                     /protein_id="NP_000203.2"
                     /db_xref="CCDS:CCDS11511.1"
                     /db_xref="GeneID:3690"
                     /db_xref="HGNC:HGNC:6156"
                     /db_xref="MIM:173470"
                     /translation="MRARPRPRPLWATVLALGALAGVGVGGPNICTTRGVSSCQQCLA
                     VSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGD
                     SSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNL
                     GTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKH
                     VLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTT
                     DAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIF
                     AVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEEL
                     SLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDS
                     LIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGWLGSQCECSEEDYRPSQ
                     QDECSPREGQPVCSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHG
                     QCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECGSCVCIQPGSYGDTC
                     EKCPTCPDACTFKKECVECKKFDRGALHDENTCNRYCRDEIESVKELKDTGKDAVNCT
                     YKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKGPDILVVLLSVMGAILLIGLAALLI
                     WKLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYRGT"
     exon            115..200
                     /gene="ITGB3"
                     /gene_synonym="BDPLT16; BDPLT2; BDPLT24; CD61; GP3A;
                     GPIIIa; GT; GT2"
                     /inference="alignment:Splign:2.1.0"
     exon            201..396
                     /gene="ITGB3"
                     /gene_synonym="BDPLT16; BDPLT2; BDPLT24; CD61; GP3A;
                     GPIIIa; GT; GT2"
                     /inference="alignment:Splign:2.1.0"
     exon            397..649
                     /gene="ITGB3"
                     /gene_synonym="BDPLT16; BDPLT2; BDPLT24; CD61; GP3A;
                     GPIIIa; GT; GT2"
                     /inference="alignment:Splign:2.1.0"
     exon            650..812
                     /gene="ITGB3"
                     /gene_synonym="BDPLT16; BDPLT2; BDPLT24; CD61; GP3A;
                     GPIIIa; GT; GT2"
                     /inference="alignment:Splign:2.1.0"
     exon            813..974
                     /gene="ITGB3"
                     /gene_synonym="BDPLT16; BDPLT2; BDPLT24; CD61; GP3A;
                     GPIIIa; GT; GT2"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1070
                     /gene="ITGB3"
                     /gene_synonym="BDPLT16; BDPLT2; BDPLT24; CD61; GP3A;
                     GPIIIa; GT; GT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1160
                     /gene="ITGB3"
                     /gene_synonym="BDPLT16; BDPLT2; BDPLT24; CD61; GP3A;
                     GPIIIa; GT; GT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1295
                     /gene="ITGB3"
                     /gene_synonym="BDPLT16; BDPLT2; BDPLT24; CD61; GP3A;
                     GPIIIa; GT; GT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1725
                     /gene="ITGB3"
                     /gene_synonym="BDPLT16; BDPLT2; BDPLT24; CD61; GP3A;
                     GPIIIa; GT; GT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1948
                     /gene="ITGB3"
                     /gene_synonym="BDPLT16; BDPLT2; BDPLT24; CD61; GP3A;
                     GPIIIa; GT; GT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2049
                     /gene="ITGB3"
                     /gene_synonym="BDPLT16; BDPLT2; BDPLT24; CD61; GP3A;
                     GPIIIa; GT; GT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2169
                     /gene="ITGB3"
                     /gene_synonym="BDPLT16; BDPLT2; BDPLT24; CD61; GP3A;
                     GPIIIa; GT; GT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2336
                     /gene="ITGB3"
                     /gene_synonym="BDPLT16; BDPLT2; BDPLT24; CD61; GP3A;
                     GPIIIa; GT; GT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..5941
                     /gene="ITGB3"
                     /gene_synonym="BDPLT16; BDPLT2; BDPLT24; CD61; GP3A;
                     GPIIIa; GT; GT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5918..5923
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGB3"
                     /gene_synonym="BDPLT16; BDPLT2; BDPLT24; CD61; GP3A;
                     GPIIIa; GT; GT2"
                     /note="hexamer: ATTAAA"
     polyA_site      5941
                     /gene="ITGB3"
                     /gene_synonym="BDPLT16; BDPLT2; BDPLT24; CD61; GP3A;
                     GPIIIa; GT; GT2"
                     /note="major polyA site"
ORIGIN      
        1 gtggggcggg cggagcgccg cgggaggcgg acgagatgcg agcgcggccg cggccccggc
       61 cgctctgggc gactgtgctg gcgctggggg cgctggcggg cgttggcgta ggagggccca
      121 acatctgtac cacgcgaggt gtgagctcct gccagcagtg cctggctgtg agccccatgt
      181 gtgcctggtg ctctgatgag gccctgcctc tgggctcacc tcgctgtgac ctgaaggaga
      241 atctgctgaa ggataactgt gccccagaat ccatcgagtt cccagtgagt gaggcccgag
      301 tactagagga caggcccctc agcgacaagg gctctggaga cagctcccag gtcactcaag
      361 tcagtcccca gaggattgca ctccggctcc ggccagatga ttcgaagaat ttctccatcc
      421 aagtgcggca ggtggaggat taccctgtgg acatctacta cttgatggac ctgtcttact
      481 ccatgaagga tgatctgtgg agcatccaga acctgggtac caagctggcc acccagatgc
      541 gaaagctcac cagtaacctg cggattggct tcggggcatt tgtggacaag cctgtgtcac
      601 catacatgta tatctcccca ccagaggccc tcgaaaaccc ctgctatgat atgaagacca
      661 cctgcttgcc catgtttggc tacaaacacg tgctgacgct aactgaccag gtgacccgct
      721 tcaatgagga agtgaagaag cagagtgtgt cacggaaccg agatgcccca gagggtggct
      781 ttgatgccat catgcaggct acagtctgtg atgaaaagat tggctggagg aatgatgcat
      841 cccacttgct ggtgtttacc actgatgcca agactcatat agcattggac ggaaggctgg
      901 caggcattgt ccagcctaat gacgggcagt gtcatgttgg tagtgacaat cattactctg
      961 cctccactac catggattat ccctctttgg ggctgatgac tgagaagcta tcccagaaaa
     1021 acatcaattt gatctttgca gtgactgaaa atgtagtcaa tctctatcag aactatagtg
     1081 agctcatccc agggaccaca gttggggttc tgtccatgga ttccagcaat gtcctccagc
     1141 tcattgttga tgcttatggg aaaatccgtt ctaaagtaga gctggaagtg cgtgacctcc
     1201 ctgaagagtt gtctctatcc ttcaatgcca cctgcctcaa caatgaggtc atccctggcc
     1261 tcaagtcttg tatgggactc aagattggag acacggtgag cttcagcatt gaggccaagg
     1321 tgcgaggctg tccccaggag aaggagaagt cctttaccat aaagcccgtg ggcttcaagg
     1381 acagcctgat cgtccaggtc acctttgatt gtgactgtgc ctgccaggcc caagctgaac
     1441 ctaatagcca tcgctgcaac aatggcaatg ggacctttga gtgtggggta tgccgttgtg
     1501 ggcctggctg gctgggatcc cagtgtgagt gctcagagga ggactatcgc ccttcccagc
     1561 aggacgaatg cagcccccgg gagggtcagc ccgtctgcag ccagcggggc gagtgcctct
     1621 gtggtcaatg tgtctgccac agcagtgact ttggcaagat cacgggcaag tactgcgagt
     1681 gtgacgactt ctcctgtgtc cgctacaagg gggagatgtg ctcaggccat ggccagtgca
     1741 gctgtgggga ctgcctgtgt gactccgact ggaccggcta ctactgcaac tgtaccacgc
     1801 gtactgacac ctgcatgtcc agcaatgggc tgctgtgcag cggccgcggc aagtgtgaat
     1861 gtggcagctg tgtctgtatc cagccgggct cctatgggga cacctgtgag aagtgcccca
     1921 cctgcccaga tgcctgcacc tttaagaaag aatgtgtgga gtgtaagaag tttgaccggg
     1981 gagccctaca tgacgaaaat acctgcaacc gttactgccg tgacgagatt gagtcagtga
     2041 aagagcttaa ggacactggc aaggatgcag tgaattgtac ctataagaat gaggatgact
     2101 gtgtcgtcag attccagtac tatgaagatt ctagtggaaa gtccatcctg tatgtggtag
     2161 aagagccaga gtgtcccaag ggccctgaca tcctggtggt cctgctctca gtgatggggg
     2221 ccattctgct cattggcctt gccgccctgc tcatctggaa actcctcatc accatccacg
     2281 accgaaaaga attcgctaaa tttgaggaag aacgcgccag agcaaaatgg gacacagcca
     2341 acaacccact gtataaagag gccacgtcta ccttcaccaa tatcacgtac cggggcactt
     2401 aatgataagc agtcatcctc agatcattat cagcctgtgc cacgattgca ggagtccctg
     2461 ccatcatgtt tacagaggac agtatttgtg gggagggatt tggggctcag agtggggtag
     2521 gttgggagaa tgtcagtatg tggaagtgtg ggtctgtgtg tgtgtatgtg ggggtctgtg
     2581 tgtttatgtg tgtgtgttgt gtgtgggagt gtgtaattta aaattgtgat gtgtcctgat
     2641 aagctgagct ccttagcctt tgtcccagaa tgcctcctgc agggattctt cctgcttagc
     2701 ttgagggtga ctatggagct gagcaggtgt tcttcattac ctcagtgaga agccagcttt
     2761 cctcatcagg ccattgtccc tgaagagaag ggcagggctg aggcctctca ttccagagga
     2821 agggacacca agccttggct ctaccctgag ttcataaatt tatggttctc aggcctgact
     2881 ctcagcagct atggtaggaa ctgctgggct tggcagcccg ggtcatctgt acctctgcct
     2941 cctttcccct ccctcaggcc gaaggaggag tcagggagag ctgaactatt agagctgcct
     3001 gtgccttttg ccatcccctc aacccagcta tggttctctc gcaagggaag tccttgcaag
     3061 ctaattcttt gacctgttgg gagtgaggat gtctgggcca ctcaggggtc attcatggcc
     3121 tgggggatgt accagcatct cccagttcat aatcacaacc cttcagattt gccttattgg
     3181 cagctctact ctggaggttt gtttagaaga agtgtgtcac ccttaggcca gcaccatctc
     3241 tttacctcct aattccacac cctcactgct gtagacattt gctatgagct ggggatgtct
     3301 ctcatgacca aatgcttttc ctcaaaggga gagagtgcta ttgtagagcc agaggtctgg
     3361 ccctatgctt ccggcctcct gtccctcatc catagcacct ccacatacct ggccctgtgc
     3421 cttggtgtgc tgtatccatc catggggctg attgtattta ccttctacct cttggctgcc
     3481 ttgtgaagga attattccca tgagttggct gggaataagt gccaggatgg aatgatgggt
     3541 cagttgtatc agcacgtgtg gcctgttctt ctatgggttg gacaacctca ttttaactca
     3601 gtctttaatc tgagaggcca cagtgcaatt ttattttatt tttctcatga tgaggttttc
     3661 ttaacttaaa agaacatgta tataaacatg cttgcattat atttgtaaat ttatgtgatg
     3721 gcaaagaagg agagcatagg aaaccacaca gacttgggca gggtacagac actcccactt
     3781 ggcatcattc acagcaagtc actggccagt ggctggatct gtgaggggct ctctcatgat
     3841 agaaggctat ggggatagat gtgtggacac attggacctt tcctgaggaa gagggactgt
     3901 tcttttgtcc cagaaaagca gtggctccat tggtgttgac atacatccaa cattaaaagc
     3961 cacccccaaa tgcccaagaa aaaaagaaag acttatcaac atttgttcca tgagcagaaa
     4021 actggagctc tggcctcagt gttacagcta aataatcttt aattaaggca agtcactttc
     4081 ttcttcttaa agctgttttc tagtttgaga aatgatggga ttttagcagc cagtcttgaa
     4141 ggtctctttc agtatcaaca ttctaagatg ctgggactta ctgtgtcatc aaatgtgcgg
     4201 ttaagattct ctgggatatt gatactgttt gtgtttttag ttgggagatc tgagagacct
     4261 ggctttggca agagcagatg tcattccata tcacctttct caatgaaagt ctcattctat
     4321 cctctctcca aacccgtttt ccaacatttg ttaatagtta cgtctctcct gatgtagcac
     4381 ttaagcttca tttagttatt atttctttct tcactttgca cacatttgca tccacatatt
     4441 agggaagagg aatccataag tagctgaaat atctattctg tattattgtg ttaacattga
     4501 gaataagcct tggaattaga tatggggcaa tgactgagcc ctgtctcacc catggattac
     4561 tccttactgt agggaatggc agtatggtag agggataaat agggggcggg gagggatagt
     4621 catggatcca agaagtcctt agaaatagtg gcagggaaca ggtgtggaag ctcatgcctg
     4681 taattataac cttcagctac taagacaggt gtggtggctc acgcctgtga ttataatctt
     4741 cagttactaa gacagagtcc atgagagtgt taatgggaca ttttctttag ataagatgtt
     4801 ttatatgaag aaactgtatc aaagggggaa gaaaatgtat ttaacaggtg aatcaaatca
     4861 ggaatcttgt ctgagctact ggaatgaagt tcacaggtct tgaagaccaa tattatttgt
     4921 caatatgtgg ggataacctg tagctgcatt catgaggtag caaatagcag ttttggcctg
     4981 tggggtgaac agctaaacag tgttctggca tcagataaca cggcacaaag ggattgtgtc
     5041 tagctctttt ggagaaaatt tatgtccagt ctcaggatct gtggacaata acggaaaact
     5101 ttgaatattc ctgacaagtt gccatattag gagtcagttc tttacttctc tgagattccc
     5161 aggtcatcca tgattttttt tttaatttga gacaaagcct cactcttgtt gcccaagctg
     5221 gaatgcaatg gcaagatctc agttcactgc aatctctgcc tctcaggttc aagccattct
     5281 cctgcctcag cctccccagt agccgggatt acaggcaccc gccaccacac ccggctaatt
     5341 tttgtatttt tagtagagac ggggtttcac catgttggcc aggctggtct cgaactcctg
     5401 accttaggcg atccaccttc ctcggcctcc cacagtgctg ggattacaag tgtgaagcac
     5461 tgtgcccggc cagtcatcca tgattttaat ggggtccaaa ggcctctttt tctttgttaa
     5521 gtattcctgg ttgaaatttc ttttcttttt tttttttttt ttgagacaga gtcttgctct
     5581 atcacccagg ctggagtgca gtggcacgat ctctgctcac tgcaagcttc gcctcccggg
     5641 ttcacgccat tctcctgcct cagcctcccg agtagctggg attacaggca cctgccacca
     5701 cgcccggcta atttcttttt gtatttttag tagagacggg gtttcacggt gttagccagg
     5761 aaggtctcga tctcctgacc tcgtgatcct cccgcctcgg cctcccaaag tgctgggatt
     5821 acaggcgtga gccactgccc ccggctgtgg ttgaaatttc ttaagtgcct tcctcacttc
     5881 ctaaccacct tctctgtttg ggtttgtgca acagtaaatt aaatgtactt tccaaaaaga
     5941 a
//
