LOCUS       NM_000211               2807 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens integrin subunit beta 2 (ITGB2), transcript variant 1,
            mRNA.
ACCESSION   NM_000211
VERSION     NM_000211.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2807)
  AUTHORS   Kling,L., Eulenberg-Gustavus,C., Jerke,U., Rousselle,A.,
            Eckardt,K.U., Schreiber,A. and Kettritz,R.
  TITLE     beta2-integrins control HIF1alpha activation in human neutrophils
  JOURNAL   Front Immunol 15, 1406967 (2024)
   PUBMED   39469705
  REMARK    GeneRIF: beta2-integrins control HIF1alpha activation in human
            neutrophils.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2807)
  AUTHORS   Xie,H., Jiang,Y., Xiang,Y., Wu,B., Zhao,J., Huang,R., Wang,M.,
            Wang,Y., Liu,J., Wu,D., Tian,D. and Bian,E.
  TITLE     Super-enhancer-driven LIF promotes the mesenchymal transition in
            glioblastoma by activating ITGB2 signaling feedback in microglia
  JOURNAL   Neuro Oncol 26 (8), 1438-1452 (2024)
   PUBMED   38554116
  REMARK    GeneRIF: Super-enhancer-driven LIF promotes the mesenchymal
            transition in glioblastoma by activating ITGB2 signaling feedback
            in microglia.
REFERENCE   3  (bases 1 to 2807)
  AUTHORS   Li,J., Cao,D., Jiang,L., Zheng,Y., Shao,S., Zhuang,A. and Xiang,D.
  TITLE     ITGB2-ICAM1 axis promotes liver metastasis in BAP1-mutated uveal
            melanoma with retained hypoxia and ECM signatures
  JOURNAL   Cell Oncol (Dordr) 47 (3), 951-965 (2024)
   PUBMED   38150154
  REMARK    GeneRIF: ITGB2-ICAM1 axis promotes liver metastasis in BAP1-mutated
            uveal melanoma with retained hypoxia and ECM signatures.
REFERENCE   4  (bases 1 to 2807)
  AUTHORS   Corbi,A.L., Vara,A., Ursa,A., Garcia Rodriguez,M.C., Fontan,G. and
            Sanchez-Madrid,F.
  TITLE     Molecular basis for a severe case of leukocyte adhesion deficiency
  JOURNAL   Eur J Immunol 22 (7), 1877-1881 (1992)
   PUBMED   1352501
REFERENCE   5  (bases 1 to 2807)
  AUTHORS   Matsuura,S., Kishi,F., Tsukahara,M., Nunoi,H., Matsuda,I.,
            Kobayashi,K. and Kajii,T.
  TITLE     Leukocyte adhesion deficiency: identification of novel mutations in
            two Japanese patients with a severe form
  JOURNAL   Biochem Biophys Res Commun 184 (3), 1460-1467 (1992)
   PUBMED   1590804
REFERENCE   6  (bases 1 to 2807)
  AUTHORS   Back,A.L., Kwok,W.W. and Hickstein,D.D.
  TITLE     Identification of two molecular defects in a child with leukocyte
            adherence deficiency
  JOURNAL   J Biol Chem 267 (8), 5482-5487 (1992)
   PUBMED   1347532
REFERENCE   7  (bases 1 to 2807)
  AUTHORS   Nelson,C., Rabb,H. and Arnaout,M.A.
  TITLE     Genetic cause of leukocyte adhesion molecule deficiency. Abnormal
            splicing and a missense mutation in a conserved region of CD18
            impair cell surface expression of beta 2 integrins
  JOURNAL   J Biol Chem 267 (5), 3351-3357 (1992)
   PUBMED   1346613
REFERENCE   8  (bases 1 to 2807)
  AUTHORS   Weitzman,J.B., Wells,C.E., Wright,A.H., Clark,P.A. and Law,S.K.
  TITLE     The gene organisation of the human beta 2 integrin subunit (CD18)
  JOURNAL   FEBS Lett 294 (1-2), 97-103 (1991)
   PUBMED   1683838
REFERENCE   9  (bases 1 to 2807)
  AUTHORS   Law,S.K., Gagnon,J., Hildreth,J.E., Wells,C.E., Willis,A.C. and
            Wong,A.J.
  TITLE     The primary structure of the beta-subunit of the cell surface
            adhesion glycoproteins LFA-1, CR3 and p150,95 and its relationship
            to the fibronectin receptor
  JOURNAL   EMBO J 6 (4), 915-919 (1987)
   PUBMED   2954816
REFERENCE   10 (bases 1 to 2807)
  AUTHORS   Kishimoto,T.K., O'Connor,K., Lee,A., Roberts,T.M. and Springer,T.A.
  TITLE     Cloning of the beta subunit of the leukocyte adhesion proteins:
            homology to an extracellular matrix receptor defines a novel
            supergene family
  JOURNAL   Cell 48 (4), 681-690 (1987)
   PUBMED   3028646
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK222505.1, AK095992.1,
            M15395.1 and CA447686.1.
            
            On Nov 23, 2018 this sequence version replaced NM_000211.4.
            
            Summary: This gene encodes an integrin beta chain, which combines
            with multiple different alpha chains to form different integrin
            heterodimers. Integrins are integral cell-surface proteins that
            participate in cell adhesion as well as cell-surface mediated
            signalling. The encoded protein plays an important role in immune
            response and defects in this gene cause leukocyte adhesion
            deficiency. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Dec 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Variants 1 and 2
            encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222505.1, M15395.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000652462.1/ ENSP00000498780.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-198               AK222505.1         9-206
            199-1182            AK095992.1         305-1288
            1183-2463           M15395.1           1173-2453
            2464-2807           CA447686.1         16-359              c
FEATURES             Location/Qualifiers
     source          1..2807
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..2807
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /note="integrin subunit beta 2"
                     /db_xref="GeneID:3689"
                     /db_xref="HGNC:HGNC:6155"
                     /db_xref="MIM:600065"
     exon            1..79
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:2.1.0"
     exon            80..140
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..2392
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; integrin beta-2; leukocyte-associated antigens
                     CD18/11A, CD18/11B, CD18/11C; complement receptor C3
                     beta-subunit; cell surface adhesion glycoprotein
                     (LFA-1/CR3/P150,959 beta subunit precursor); leukocyte
                     cell adhesion molecule CD18; integrin beta chain, beta 2;
                     integrin, beta 2 (complement component 3 receptor 3 and 4
                     subunit)"
                     /codon_start=1
                     /product="integrin beta-2 isoform 1 precursor"
                     /protein_id="NP_000202.3"
                     /db_xref="CCDS:CCDS13716.1"
                     /db_xref="GeneID:3689"
                     /db_xref="HGNC:HGNC:6155"
                     /db_xref="MIM:600065"
                     /translation="MLGLRPPLLALVGLLSLGCVLSQECTKFKVSSCRECIESGPGCT
                     WCQKLNFTGPGDPDSIRCDTRPQLLMRGCAADDIMDPTSLAETQEDHNGGQKQLSPQK
                     VTLYLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDLRNVKKLGGDLLRALNEI
                     TESGRIGFGSFVDKTVLPFVNTHPDKLRNPCPNKEKECQPPFAFRHVLKLTNNSNQFQ
                     TEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLG
                     AILTPNDGRCHLEDNLYKRSNEFDYPSVGQLAHKLAENNIQPIFAVTSRMVKTYEKLT
                     EIIPKSAVGELSEDSSNVVHLIKNAYNKLSSRVFLDHNALPDTLKVTYDSFCSNGVTH
                     RNQPRGDCDGVQINVPITFQVKVTATECIQEQSFVIRALGFTDIVTVQVLPQCECRCR
                     DQSRDRSLCHGKGFLECGICRCDTGYIGKNCECQTQGRSSQELEGSCRKDNNSIICSG
                     LGDCVCGQCLCHTSDVPGKLIYGQYCECDTINCERYNGQVCGGPGRGLCFCGKCRCHP
                     GFEGSACQCERTTEGCLNPRRVECSGRGRCRCNVCECHSGYQLPLCQECPGCPSPCGK
                     YISCAECLKFEKGPFGKNCSAACPGLQLSNNPVKGRTCKERDSEGCWVAYTLEQQDGM
                     DRYLIYVDESRECVAGPNIAAIVGGTVAGIVLIGILLLVIWKALIHLSDLREYRRFEK
                     EKLKSQWNNDNPLFKSATTTVMNPKFAES"
     exon            141..229
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:2.1.0"
     exon            230..410
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:2.1.0"
     exon            411..581
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:2.1.0"
     exon            582..823
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:2.1.0"
     exon            824..979
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1075
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1165
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1306
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1494
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1739
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1959
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2162
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2329
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2807
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2787..2792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /note="hexamer: AATACA"
     polyA_site      2807
                     /gene="ITGB2"
                     /gene_synonym="CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7"
                     /note="major polyA site"
ORIGIN      
        1 agacgtgacc cagggcagac tggtagcaaa gcccccacgc ccagccagga gcaccgccga
       61 ggactccagc acaccgaggg acatgctggg cctgcgcccc ccactgctcg ccctggtggg
      121 gctgctctcc ctcgggtgcg tcctctctca ggagtgcacg aagttcaagg tcagcagctg
      181 ccgggaatgc atcgagtcgg ggcccggctg cacctggtgc cagaagctga acttcacagg
      241 gccgggggat cctgactcca ttcgctgcga cacccggcca cagctgctca tgaggggctg
      301 tgcggctgac gacatcatgg accccacaag cctcgctgaa acccaggaag accacaatgg
      361 gggccagaag cagctgtccc cacaaaaagt gacgctttac ctgcgaccag gccaggcagc
      421 agcgttcaac gtgaccttcc ggcgggccaa gggctacccc atcgacctgt actatctgat
      481 ggacctctcc tactccatgc ttgatgacct caggaatgtc aagaagctag gtggcgacct
      541 gctccgggcc ctcaacgaga tcaccgagtc cggccgcatt ggcttcgggt ccttcgtgga
      601 caagaccgtg ctgccgttcg tgaacacgca ccctgataag ctgcgaaacc catgccccaa
      661 caaggagaaa gagtgccagc ccccgtttgc cttcaggcac gtgctgaagc tgaccaacaa
      721 ctccaaccag tttcagaccg aggtcgggaa gcagctgatt tccggaaacc tggatgcacc
      781 cgagggtggg ctggacgcca tgatgcaggt cgccgcctgc ccggaggaaa tcggctggcg
      841 caacgtcacg cggctgctgg tgtttgccac tgatgacggc ttccatttcg cgggcgacgg
      901 gaagctgggc gccatcctga cccccaacga cggccgctgt cacctggagg acaacttgta
      961 caagaggagc aacgaattcg actacccatc ggtgggccag ctggcgcaca agctggctga
     1021 aaacaacatc cagcccatct tcgcggtgac cagtaggatg gtgaagacct acgagaaact
     1081 caccgagatc atccccaagt cagccgtggg ggagctgtct gaggactcca gcaatgtggt
     1141 ccatctcatt aagaatgctt acaataaact ctcctccagg gtcttcctgg atcacaacgc
     1201 cctccccgac accctgaaag tcacctacga ctccttctgc agcaatggag tgacgcacag
     1261 gaaccagccc agaggtgact gtgatggcgt gcagatcaat gtcccgatca ccttccaggt
     1321 gaaggtcacg gccacagagt gcatccagga gcagtcgttt gtcatccggg cgctgggctt
     1381 cacggacata gtgaccgtgc aggttcttcc ccagtgtgag tgccggtgcc gggaccagag
     1441 cagagaccgc agcctctgcc atggcaaggg cttcttggag tgcggcatct gcaggtgtga
     1501 cactggctac attgggaaaa actgtgagtg ccagacacag ggccggagca gccaggagct
     1561 ggaaggaagc tgccggaagg acaacaactc catcatctgc tcagggctgg gggactgtgt
     1621 ctgcgggcag tgcctgtgcc acaccagcga cgtccccggc aagctgatat acgggcagta
     1681 ctgcgagtgt gacaccatca actgtgagcg ctacaacggc caggtctgcg gcggcccggg
     1741 gagggggctc tgcttctgcg ggaagtgccg ctgccacccg ggctttgagg gctcagcgtg
     1801 ccagtgcgag aggaccactg agggctgcct gaacccgcgg cgtgttgagt gtagtggtcg
     1861 tggccggtgc cgctgcaacg tatgcgagtg ccattcaggc taccagctgc ctctgtgcca
     1921 ggagtgcccc ggctgcccct caccctgtgg caagtacatc tcctgcgccg agtgcctgaa
     1981 gttcgaaaag ggcccctttg ggaagaactg cagcgcggcg tgtccgggcc tgcagctgtc
     2041 gaacaacccc gtgaagggca ggacctgcaa ggagagggac tcagagggct gctgggtggc
     2101 ctacacgctg gagcagcagg acgggatgga ccgctacctc atctatgtgg atgagagccg
     2161 agagtgtgtg gcaggcccca acatcgccgc catcgtcggg ggcaccgtgg caggcatcgt
     2221 gctgatcggc attctcctgc tggtcatctg gaaggctctg atccacctga gcgacctccg
     2281 ggagtacagg cgctttgaga aggagaagct caagtcccag tggaacaatg ataatcccct
     2341 tttcaagagc gccaccacga cggtcatgaa ccccaagttt gctgagagtt aggagcactt
     2401 ggtgaagaca aggccgtcag gacccaccat gtctgcccca tcacgcggcc gagacatggc
     2461 ttgccacagc tcttgaggat gtcaccaatt aaccagaaat ccagttattt tccgccctca
     2521 aaatgacagc catggccggc cgggtgcttc tgggggctcg tcggggggac agctccactc
     2581 tgactggcac agtctttgca tggagacttg aggagggagg gcttgaggtt ggtgaggtta
     2641 ggtgcgtgtt tcctgtgcaa gtcaggacat cagtctgatt aaaggtggtg ccaatttatt
     2701 tacatttaaa cttgtcaggg tataaaatga catcccatta attatattgt taatcaatca
     2761 cgtgtataga aaaaaaataa aacttcaata caggctgtcc atggaaa
//
