LOCUS       NM_004763               4153 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens integrin subunit beta 1 binding protein 1 (ITGB1BP1),
            transcript variant 1, mRNA.
ACCESSION   NM_004763
VERSION     NM_004763.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4153)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4153)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4153)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4153)
  AUTHORS   Su,V.L., Simon,B., Draheim,K.M. and Calderwood,D.A.
  TITLE     Serine phosphorylation of the small phosphoprotein ICAP1 inhibits
            its nuclear accumulation
  JOURNAL   J Biol Chem 295 (10), 3269-3284 (2020)
   PUBMED   32005669
  REMARK    GeneRIF: Serine phosphorylation of the small phosphoprotein ICAP1
            inhibits its nuclear accumulation.
REFERENCE   5  (bases 1 to 4153)
  AUTHORS   Bouin,A.P., Kyumurkov,A., Regent-Kloeckner,M., Ribba,A.S.,
            Faurobert,E., Fournier,H.N., Bourrin-Reynard,I., Manet-Dupe,S.,
            Oddou,C., Balland,M., Planus,E. and Albiges-Rizo,C.
  TITLE     ICAP-1 monoubiquitylation coordinates matrix density and rigidity
            sensing for cell migration through ROCK2-MRCKalpha balance
  JOURNAL   J Cell Sci 130 (3), 626-636 (2017)
   PUBMED   28049720
  REMARK    GeneRIF: ICAP-1 monoubiquitylation helps in switching from
            ROCK2-mediated to MRCKalpha-mediated cell contractility.
            Erratum:[J Cell Sci. 2017 Mar 15;130(6):1195. doi:
            10.1242/jcs.202218.. PMID: 28298614]
REFERENCE   6  (bases 1 to 4153)
  AUTHORS   Chang,D.D., Hoang,B.Q., Liu,J. and Springer,T.A.
  TITLE     Molecular basis for interaction between Icap1 alpha PTB domain and
            beta 1 integrin
  JOURNAL   J Biol Chem 277 (10), 8140-8145 (2002)
   PUBMED   11741908
  REMARK    GeneRIF: Site-directed mutagenesis showed that Leu(135), Ile(138),
            and Ile(139) of Icap1 alpha, and Leu(82) and Tyr(144), are required
            for the Icap1 alpha-beta(1) integrin interaction
REFERENCE   7  (bases 1 to 4153)
  AUTHORS   Zhang,J., Clatterbuck,R.E., Rigamonti,D., Chang,D.D. and Dietz,H.C.
  TITLE     Interaction between krit1 and icap1alpha infers perturbation of
            integrin beta1-mediated angiogenesis in the pathogenesis of
            cerebral cavernous malformation
  JOURNAL   Hum Mol Genet 10 (25), 2953-2960 (2001)
   PUBMED   11741838
REFERENCE   8  (bases 1 to 4153)
  AUTHORS   Gotthardt,M., Trommsdorff,M., Nevitt,M.F., Shelton,J.,
            Richardson,J.A., Stockinger,W., Nimpf,J. and Herz,J.
  TITLE     Interactions of the low density lipoprotein receptor gene family
            with cytosolic adaptor and scaffold proteins suggest diverse
            biological functions in cellular communication and signal
            transduction
  JOURNAL   J Biol Chem 275 (33), 25616-25624 (2000)
   PUBMED   10827173
REFERENCE   9  (bases 1 to 4153)
  AUTHORS   Bouvard,D. and Block,M.R.
  TITLE     Calcium/calmodulin-dependent protein kinase II controls integrin
            alpha5beta1-mediated cell adhesion through the integrin cytoplasmic
            domain associated protein-1alpha
  JOURNAL   Biochem Biophys Res Commun 252 (1), 46-50 (1998)
   PUBMED   9813144
REFERENCE   10 (bases 1 to 4153)
  AUTHORS   Chang,D.D., Wong,C., Smith,H. and Liu,J.
  TITLE     ICAP-1, a novel beta1 integrin cytoplasmic domain-associated
            protein, binds to a conserved and functionally important NPXY
            sequence motif of beta1 integrin
  JOURNAL   J Cell Biol 138 (5), 1149-1157 (1997)
   PUBMED   9281591
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC361372.1, BC012264.1,
            AC080162.7 and CA428076.1.
            
            On Jun 2, 2019 this sequence version replaced NM_004763.4.
            
            Summary: The cytoplasmic domains of integrins are essential for
            cell adhesion. The protein encoded by this gene binds to the beta1
            integrin cytoplasmic domain. The interaction between this protein
            and beta1 integrin is highly specific. Two isoforms of this protein
            are derived from alternatively spliced transcripts. The shorter
            form of this protein does not interact with the beta1 integrin
            cytoplasmic domain. The longer form is a phosphoprotein and the
            extent of its phosphorylation is regulated by the cell-matrix
            interaction, suggesting an important role of this protein during
            integrin-dependent cell adhesion. Several transcript variants, some
            protein-coding and some non-protein coding, have been found for
            this gene. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 3. Variants 1, 3, 4, and 5 all encode the same isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK289817.1, BC012264.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355346.9/ ENSP00000347504.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                DC361372.1         42-108
            68-639              BC012264.1         1-572
            640-640             AC080162.7         54592-54592         c
            641-960             BC012264.1         574-893
            961-1727            AC080162.7         52962-53728         c
            1728-1947           CA428076.1         18-237              c
            1948-4153           AC080162.7         50536-52741         c
FEATURES             Location/Qualifiers
     source          1..4153
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.1"
     gene            1..4153
                     /gene="ITGB1BP1"
                     /gene_synonym="ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1;
                     ICAP1A; ICAP1B"
                     /note="integrin subunit beta 1 binding protein 1"
                     /db_xref="GeneID:9270"
                     /db_xref="HGNC:HGNC:23927"
                     /db_xref="MIM:607153"
     exon            1..156
                     /gene="ITGB1BP1"
                     /gene_synonym="ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1;
                     ICAP1A; ICAP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            157..263
                     /gene="ITGB1BP1"
                     /gene_synonym="ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1;
                     ICAP1A; ICAP1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..794
                     /gene="ITGB1BP1"
                     /gene_synonym="ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1;
                     ICAP1A; ICAP1B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     integrin cytoplasmic domain-associated protein 1-beta;
                     integrin cytoplasmic domain-associated protein 1-alpha;
                     bodenin; integrin beta-1-binding protein 1"
                     /codon_start=1
                     /product="integrin beta-1-binding protein 1 isoform 1"
                     /protein_id="NP_004754.1"
                     /db_xref="CCDS:CCDS1662.1"
                     /db_xref="GeneID:9270"
                     /db_xref="HGNC:HGNC:23927"
                     /db_xref="MIM:607153"
                     /translation="MFRKGKKRHSSSSSQSSEISTKSKSVDSSLGGLSRSSTVASLDT
                     DSTKSSGQSNNNSDTCAEFRIKYVGAIEKLKLSEGKGLEGPLDLINYIDVAQQDGKLP
                     FVPPEEEFIMGVSKYGIKVSTSDQYDVLHRHALYLIIRMVCYDDGLGAGKSLLALKTT
                     DASNEEYSLWVYQCNSLEQAQAICKVLSTAFDSVLTSEKP"
     exon            264..342
                     /gene="ITGB1BP1"
                     /gene_synonym="ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1;
                     ICAP1A; ICAP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            343..479
                     /gene="ITGB1BP1"
                     /gene_synonym="ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1;
                     ICAP1A; ICAP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            480..572
                     /gene="ITGB1BP1"
                     /gene_synonym="ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1;
                     ICAP1A; ICAP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            573..722
                     /gene="ITGB1BP1"
                     /gene_synonym="ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1;
                     ICAP1A; ICAP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            723..4153
                     /gene="ITGB1BP1"
                     /gene_synonym="ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1;
                     ICAP1A; ICAP1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      942..947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGB1BP1"
                     /gene_synonym="ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1;
                     ICAP1A; ICAP1B"
                     /note="hexamer: ATTAAA"
     regulatory      957..962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGB1BP1"
                     /gene_synonym="ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1;
                     ICAP1A; ICAP1B"
                     /note="hexamer: ATTACA"
     polyA_site      968
                     /gene="ITGB1BP1"
                     /gene_synonym="ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1;
                     ICAP1A; ICAP1B"
                     /note="major polyA site"
     regulatory      979..984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGB1BP1"
                     /gene_synonym="ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1;
                     ICAP1A; ICAP1B"
                     /note="hexamer: AATGAA"
     polyA_site      980
                     /gene="ITGB1BP1"
                     /gene_synonym="ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1;
                     ICAP1A; ICAP1B"
     polyA_site      1009
                     /gene="ITGB1BP1"
                     /gene_synonym="ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1;
                     ICAP1A; ICAP1B"
     regulatory      1938..1943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGB1BP1"
                     /gene_synonym="ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1;
                     ICAP1A; ICAP1B"
                     /note="hexamer: AATAAA"
     polyA_site      1947
                     /gene="ITGB1BP1"
                     /gene_synonym="ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1;
                     ICAP1A; ICAP1B"
     polyA_site      1991
                     /gene="ITGB1BP1"
                     /gene_synonym="ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1;
                     ICAP1A; ICAP1B"
     regulatory      2012..2017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGB1BP1"
                     /gene_synonym="ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1;
                     ICAP1A; ICAP1B"
                     /note="hexamer: ATTAAA"
     regulatory      2029..2034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGB1BP1"
                     /gene_synonym="ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1;
                     ICAP1A; ICAP1B"
                     /note="hexamer: TATAAA"
     polyA_site      2034
                     /gene="ITGB1BP1"
                     /gene_synonym="ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1;
                     ICAP1A; ICAP1B"
     polyA_site      2065
                     /gene="ITGB1BP1"
                     /gene_synonym="ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1;
                     ICAP1A; ICAP1B"
     regulatory      2078..2083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGB1BP1"
                     /gene_synonym="ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1;
                     ICAP1A; ICAP1B"
                     /note="hexamer: AATATA"
     polyA_site      2104
                     /gene="ITGB1BP1"
                     /gene_synonym="ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1;
                     ICAP1A; ICAP1B"
ORIGIN      
        1 atagtcttgg aggcgcggcc cggcggacgt gggcaggagg gctggaaaag ccggcgctgg
       61 agcgggaacg ggagtagctg cctgggcgcc aaaggccgcg gcactcccac gcggaccccg
      121 aagtccgcaa cccggggatg ggcccgcggc tgcgagggga tcttctctgg atcaagcaat
      181 ggtggtgaaa aatgtttcgc aagggcaaaa aacgacacag tagtagcagt tcccaaagta
      241 gcgaaatcag tactaagagc aagtctgtgg attctagcct tgggggtctt tcacgatcca
      301 gcactgtggc cagcctcgac acagattcca ccaaaagctc aggacaaagc aacaataatt
      361 cagatacctg tgcagaattt cgaataaaat atgttggtgc cattgagaaa ctgaaactct
      421 ccgagggaaa aggccttgaa gggccattag acctgataaa ttatatagac gttgcccagc
      481 aagatggaaa gttgcctttt gttcctccgg aggaagaatt tattatggga gtttccaagt
      541 atggcataaa agtatcaaca tcagatcaat atgatgtttt gcacaggcat gctctctact
      601 taataatccg gatggtgtgt tacgatgacg gtctgggggc gggaaaaagc ttactggctc
      661 tgaagaccac agatgcaagc aatgaggaat acagcctgtg ggtttatcag tgcaacagcc
      721 tggaacaagc acaagccatt tgcaaggttt tatccaccgc ttttgactct gtattaacat
      781 ctgagaaacc ctgaatcctg caatcaagta gaagtcaact tcatctgaaa gttcagctgt
      841 tttcaaactg caatgctgaa atgttatgca aataatgaag ttatcccttg ctctagattt
      901 tctgaagaaa atggattgtg taaaatgctg atcatttgtt tattaaaatg tgtcctatta
      961 cacagtgagt taactctcaa tgaagtcatc tattttctgg gctaaaaaac ttcatttgtc
     1021 tttttcaact tctaataagc ttaacctaag tgtcacagaa gcctaggtgt cacagaggtc
     1081 cactcagtga caaacacaca ctgaaggcct gaggaagacg agatgtcaca gaggtccact
     1141 cagtgacaaa cacacactga aggcctgagg aagactagat gtcacagagg tccactcagt
     1201 gacaaacaca cactgaaggc ctgaggaaga cgagatgtca cagaggtcca ctcagtgaca
     1261 aacacacact gaaggcctga ggaagactag atgtcacaga ggtccactca gtgacaaaca
     1321 cacactgaag gcctgaggaa gacgagatgt cacagaggtc cactcagtga caaacacaca
     1381 ctgaaggcct gaggaagacg agatgtcaca gaggtccact cagtgacaaa cacacactga
     1441 aggcctgagg aagactagat gtcacagagg tccactcagt gacaaacaca cactgaaggc
     1501 ctgaggaaga cgagatgtca cagaggtcca ctcagtgaca aacacacact gaaggcctga
     1561 ggaagacgag atgtcacaga ggtccactca gtgacacaca ctgaaggcct gaggaagact
     1621 gaggacatgg gctcagtggt ggcttcccag tcatggtatc actggcatgg acctctgtcc
     1681 ggcagaggtg tggactggag accaggattc atgctggtct ggaacagtga cattgccaac
     1741 ttaagacaca caaagcagat tttcagaagt gtctggtcaa gataacatgc tggccaacca
     1801 caattcctag agttaagaga accttaaaag attaccgctc atgctaaaag tatgtaaaga
     1861 tcccatgtac agtatgatag tgtacttttt ttaaaggact gtcaatatac aaaactttaa
     1921 agattaaaaa cattaaaaat aaaaccatgt ccatttaaaa gtattttatt tttttccagt
     1981 caaatgacta gttaacaaga agagtaaact tattaaacat gctctaatta taaatcactg
     2041 cattaaggac aatgaaaata atcaatttcg gttatacaat atatacagtt gtgctgcaac
     2101 caaagtaatc aggtgaatga actgaatatc atacatctca aaatagcatc ctaagctgca
     2161 tattatgtta tccacccctt aacagatcac acagttactc ttagtctgtg tacatgttct
     2221 gagccatcat cccagatctg atggagaatg gcatgcaaaa tgccagaatc ctgcagctgc
     2281 agttcatgaa acataaactt taaatataaa tagatatcta caatgttttt ctttctctta
     2341 gttgcttttt taatttgcaa ggagcaaata actaagaaag gatattagca gggtcgttaa
     2401 tataatttct cctctggtaa gagtactatt agttactgca caatagcacc aaattgtaga
     2461 ctggaaaaat atttcctagg tatttatgta ccagtgaacc tgacagatta gtttgggact
     2521 ggagttctaa tgttgatatg aatcaacttt attccttata tagctggcac caggtggtca
     2581 aaaggctgac tataaaatac agatgcagga ggattgttaa aatagacata agtgcactgt
     2641 gcaaaataca tctgtttact taaatctatg agaaaattaa atgaagggtt caaacagaaa
     2701 ttaacaatta gtgaaaacag atgtagtgct ttaaaaaaaa acaaaaacaa aaaactacag
     2761 atataacaca tttttacccg gaactttgaa aggtaaaaag cgattgctat acaacatcat
     2821 aaaacattcc agtttgttct gtcttccttt ataacaaaaa caaaaagtac aatgccaaaa
     2881 aaaaaaaaaa ctctacacag tcttgcataa taaagacaag ctgcttcaat caaatgcacc
     2941 atcacaacaa atgcagttaa cagcattgct gcctcacttt ccaagcctat atgcaaattt
     3001 attcctttac ttttgttaaa agtccaagtg ggtatcatat gcctatttat tctcagagtg
     3061 ccaaaatttc caatattcct actatgaatc ttaccctcgc aattactaaa tagaggtatg
     3121 acagtcaagt tcattaaacg aatgagtttt ggttttataa tagacaacct aatcctctac
     3181 taccacccca agtagcttaa gaatgatatg atggcctgaa acagtaaaaa gtgggatgtt
     3241 tgggagtatt acctgggacc tatatatttc tgatatgttc ttgattataa acagatggac
     3301 agattcaatt tcaagacagt gtgactacca ttcctgttgg agtattatag aaatacaaga
     3361 cactaaactg agtaaacatt ctcctgggct agaagggaag gcagtggtac actcagtagg
     3421 aaacagcaag tgatgtgtta atacagcatg gtctgcgcca cagaattcta ctgtgtacag
     3481 ttgctttctg tgtgactcag gaagttcaag aaggcaaatt ccaaaacacc taaagcatat
     3541 aaactaattt aaaagaactg ttttgcaatc catcatcctt agtttttaac caaattcagg
     3601 aaatgcagtt ttatataacc tggaacagaa tgaactgtag ttaccctacg ttgtcataaa
     3661 ccatcagtag ttttgttaag tatgattgtt cacaacaggt tatacataca tgcagaatat
     3721 aatgatagct gcaacctcac aaattagggc tagaaagtac aatgctaatg tgtaaatttc
     3781 caagttgctt tttaaacact gggtggattt caaaggaatg tgtgtcttta aaggtgaact
     3841 gatggcattt tatcgagaaa gttcagagct gggctatgga cttctgaagc agcagttcac
     3901 tggccgccta aaataataat tgtgataaag gtcaccaact ccagaactgg gccaaggaat
     3961 gcaggaagaa tttattcatt aatgcaaaca tttttaggtt tagctaattc cgtagaggca
     4021 ggatcttgat tatgtataat agttaaaata acttttcagt tcacctgttg ggaaattcag
     4081 tttttcctaa taaatgcata gcaatgtttc atgaaaacca caaattataa aaacaattac
     4141 tgatatgtaa aaa
//
