LOCUS       NM_002211               3735 bp    mRNA    linear   PRI 06-MAR-2025
DEFINITION  Homo sapiens integrin subunit beta 1 (ITGB1), transcript variant
            1A, mRNA.
ACCESSION   NM_002211
VERSION     NM_002211.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3735)
  AUTHORS   Zhang,Y., Wang,C., Xu,Y. and Su,H.
  TITLE     Tetraspanin 3 promotes NSCLC cell proliferation via regulation of
            beta1 integrin intracellular recycling
  JOURNAL   Cell Mol Biol Lett 29 (1), 124 (2024)
   PUBMED   39333841
  REMARK    GeneRIF: Tetraspanin 3 promotes NSCLC cell proliferation via
            regulation of beta1 integrin intracellular recycling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3735)
  AUTHORS   Ellergezen,P., Coskun,B.N., Bozkurt,Z.Y., Cecen,G.S., Agca,H.,
            Pehlivan,Y., Dalkilic,H.E., Cavun,S. and Yanar,Y.B.
  TITLE     alpha9beta1 integrin & its ligands as new potential biomarkers in
            FMF
  JOURNAL   Indian J Med Res 160 (1), 102-108 (2024)
   PUBMED   39382510
  REMARK    GeneRIF: alpha9beta1 integrin & its ligands as new potential
            biomarkers in FMF.
REFERENCE   3  (bases 1 to 3735)
  AUTHORS   Armulik,A.
  TITLE     Splice variants of human beta 1 integrins: origin, biosynthesis and
            functions
  JOURNAL   Front Biosci 7, d219-d227 (2002)
   PUBMED   11779688
  REMARK    GeneRIF: Although cytoplasmic splice variants do not change the
            ligand-specificity of a beta 1 integrin, this review explains how
            clustering of different splice variants triggers signaling pathways
            that lead to a different cellular response.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3735)
  AUTHORS   Svineng,G., Fassler,R. and Johansson,S.
  TITLE     Identification of beta1C-2, a novel variant of the integrin beta1
            subunit generated by utilization of an alternative splice acceptor
            site in exon C
  JOURNAL   Biochem J 330 (Pt 3) (Pt 3), 1255-1263 (1998)
   PUBMED   9494094
REFERENCE   5  (bases 1 to 3735)
  AUTHORS   Belkin,A.M., Zhidkova,N.I., Balzac,F., Altruda,F., Tomatis,D.,
            Maier,A., Tarone,G., Koteliansky,V.E. and Burridge,K.
  TITLE     Beta 1D integrin displaces the beta 1A isoform in striated muscles:
            localization at junctional structures and signaling potential in
            nonmuscle cells
  JOURNAL   J Cell Biol 132 (1-2), 211-226 (1996)
   PUBMED   8567725
REFERENCE   6  (bases 1 to 3735)
  AUTHORS   Zhidkova,N.I., Belkin,A.M. and Mayne,R.
  TITLE     Novel isoform of beta 1 integrin expressed in skeletal and cardiac
            muscle
  JOURNAL   Biochem Biophys Res Commun 214 (1), 279-285 (1995)
   PUBMED   7545396
REFERENCE   7  (bases 1 to 3735)
  AUTHORS   van der Flier,A., Kuikman,I., Baudoin,C., van der Neut,R. and
            Sonnenberg,A.
  TITLE     A novel beta 1 integrin isoform produced by alternative splicing:
            unique expression in cardiac and skeletal muscle
  JOURNAL   FEBS Lett 369 (2-3), 340-344 (1995)
   PUBMED   7544298
REFERENCE   8  (bases 1 to 3735)
  AUTHORS   Cervella,P., Silengo,L., Pastore,C. and Altruda,F.
  TITLE     Human beta 1-integrin gene expression is regulated by two promoter
            regions
  JOURNAL   J Biol Chem 268 (7), 5148-5155 (1993)
   PUBMED   8444890
REFERENCE   9  (bases 1 to 3735)
  AUTHORS   Languino,L.R. and Ruoslahti,E.
  TITLE     An alternative form of the integrin beta 1 subunit with a variant
            cytoplasmic domain
  JOURNAL   J Biol Chem 267 (10), 7116-7120 (1992)
   PUBMED   1551917
REFERENCE   10 (bases 1 to 3735)
  AUTHORS   Parker,C.M., Cepek,K.L., Russell,G.J., Shaw,S.K., Posnett,D.N.,
            Schwarting,R. and Brenner,M.B.
  TITLE     A family of beta 7 integrins on human mucosal lymphocytes
  JOURNAL   Proc Natl Acad Sci U S A 89 (5), 1924-1928 (1992)
   PUBMED   1542691
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB063946.1, DB292597.1,
            CX868374.1, BX537407.1, BM973433.1 and AI261443.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002211.3.
            
            Summary: Integrins are heterodimeric proteins made up of alpha and
            beta subunits. At least 18 alpha and 8 beta subunits have been
            described in mammals. Integrin family members are membrane
            receptors involved in cell adhesion and recognition in a variety of
            processes including embryogenesis, hemostasis, tissue repair,
            immune response and metastatic diffusion of tumor cells. This gene
            encodes a beta subunit. Multiple alternatively spliced transcript
            variants which encode different protein isoforms have been found
            for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1A) represents the longest
            transcript and encodes the shorter isoform (1A). Both variants 1A
            and 1E encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX537407.1, BC020057.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302278.8/ ENSP00000303351.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                DB063946.1         136-145
            11-610              DB292597.1         1-600
            611-1214            CX868374.1         3-606
            1215-3218           BX537407.1         1204-3207
            3219-3661           BM973433.1         18-460              c
            3662-3735           AI261443.1         10-83               c
FEATURES             Location/Qualifiers
     source          1..3735
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p11.22"
     gene            1..3735
                     /gene="ITGB1"
                     /gene_synonym="CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA;
                     VLAB"
                     /note="integrin subunit beta 1"
                     /db_xref="GeneID:3688"
                     /db_xref="HGNC:HGNC:6153"
                     /db_xref="MIM:135630"
     exon            1..86
                     /gene="ITGB1"
                     /gene_synonym="CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA;
                     VLAB"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..2483
                     /gene="ITGB1"
                     /gene_synonym="CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA;
                     VLAB"
                     /note="isoform 1A precursor is encoded by transcript
                     variant 1A; integrin VLA-4 beta subunit; very late
                     activation protein, beta polypeptide; glycoprotein IIa;
                     integrin, beta 1 (fibronectin receptor, beta polypeptide,
                     antigen CD29 includes MDF2, MSK12); integrin beta 1"
                     /codon_start=1
                     /product="integrin beta-1 isoform 1A precursor"
                     /protein_id="NP_002202.2"
                     /db_xref="CCDS:CCDS7174.1"
                     /db_xref="GeneID:3688"
                     /db_xref="HGNC:HGNC:6153"
                     /db_xref="MIM:135630"
                     /translation="MNLQPIFWIGLISSVCCVFAQTDENRCLKANAKSCGECIQAGPN
                     CGWCTNSTFLQEGMPTSARCDDLEALKKKGCPPDDIENPRGSKDIKKNKNVTNRSKGT
                     AEKLKPEDITQIQPQQLVLRLRSGEPQTFTLKFKRAEDYPIDLYYLMDLSYSMKDDLE
                     NVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFS
                     YKNVLSLTNKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVF
                     STDAGFHFAGDGKLGGIVLPNDGQCHLENNMYTMSHYYDYPSIAHLVQKLSENNIQTI
                     FAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSLSSEVILENGKLSEG
                     VTISYKSYCKNGVNGTGENGRKCSNISIGDEVQFEISITSNKCPKKDSDSFKIRPLGF
                     TEEVEVILQYICECECQSEGIPESPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVN
                     SEDMDAYCRKENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGL
                     ICGGNGVCKCRVCECNPNYTGSACDCSLDTSTCEASNGQICNGRGICECGVCKCTDPK
                     FQGQTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDTCTQECSYFNITKVESRDKLPQP
                     VQPDPVSHCKEKDVDDCWFYFTYSVNGNNEVMVHVVENPECPTGPDIIPIVAGVVAGI
                     VLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK
                     "
     exon            87..153
                     /gene="ITGB1"
                     /gene_synonym="CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA;
                     VLAB"
                     /inference="alignment:Splign:2.1.0"
     exon            154..239
                     /gene="ITGB1"
                     /gene_synonym="CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA;
                     VLAB"
                     /inference="alignment:Splign:2.1.0"
     exon            240..462
                     /gene="ITGB1"
                     /gene_synonym="CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA;
                     VLAB"
                     /inference="alignment:Splign:2.1.0"
     exon            463..633
                     /gene="ITGB1"
                     /gene_synonym="CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA;
                     VLAB"
                     /inference="alignment:Splign:2.1.0"
     exon            634..872
                     /gene="ITGB1"
                     /gene_synonym="CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA;
                     VLAB"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1028
                     /gene="ITGB1"
                     /gene_synonym="CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA;
                     VLAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1124
                     /gene="ITGB1"
                     /gene_synonym="CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA;
                     VLAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1214
                     /gene="ITGB1"
                     /gene_synonym="CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA;
                     VLAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1355
                     /gene="ITGB1"
                     /gene_synonym="CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA;
                     VLAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1555
                     /gene="ITGB1"
                     /gene_synonym="CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA;
                     VLAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1794
                     /gene="ITGB1"
                     /gene_synonym="CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA;
                     VLAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..2017
                     /gene="ITGB1"
                     /gene_synonym="CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA;
                     VLAB"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2250
                     /gene="ITGB1"
                     /gene_synonym="CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA;
                     VLAB"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2417
                     /gene="ITGB1"
                     /gene_synonym="CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA;
                     VLAB"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..3735
                     /gene="ITGB1"
                     /gene_synonym="CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA;
                     VLAB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3632..3637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGB1"
                     /gene_synonym="CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA;
                     VLAB"
                     /note="hexamer: ATTAAA"
     polyA_site      3661
                     /gene="ITGB1"
                     /gene_synonym="CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA;
                     VLAB"
                     /note="major polyA site"
     regulatory      3713..3718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGB1"
                     /gene_synonym="CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA;
                     VLAB"
                     /note="hexamer: ATTAAA"
     polyA_site      3735
                     /gene="ITGB1"
                     /gene_synonym="CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA;
                     VLAB"
ORIGIN      
        1 gccagcccgc gggagaggcc cagcgggagt cgcggaacag caggcccgag cccaccgcgc
       61 cgggccccgg acgccgcgcg gaaaagatga atttacaacc aattttctgg attggactga
      121 tcagttcagt ttgctgtgtg tttgctcaaa cagatgaaaa tagatgttta aaagcaaatg
      181 ccaaatcatg tggagaatgt atacaagcag ggccaaattg tgggtggtgc acaaattcaa
      241 catttttaca ggaaggaatg cctacttctg cacgatgtga tgatttagaa gccttaaaaa
      301 agaagggttg ccctccagat gacatagaaa atcccagagg ctccaaagat ataaagaaaa
      361 ataaaaatgt aaccaaccgt agcaaaggaa cagcagagaa gctcaagcca gaggatatta
      421 ctcagatcca accacagcag ttggttttgc gattaagatc aggggagcca cagacattta
      481 cattaaaatt caagagagct gaagactatc ccattgacct ctactacctt atggacctgt
      541 cttactcaat gaaagacgat ttggagaatg taaaaagtct tggaacagat ctgatgaatg
      601 aaatgaggag gattacttcg gacttcagaa ttggatttgg ctcatttgtg gaaaagactg
      661 tgatgcctta cattagcaca acaccagcta agctcaggaa cccttgcaca agtgaacaga
      721 actgcaccag cccatttagc tacaaaaatg tgctcagtct tactaataaa ggagaagtat
      781 ttaatgaact tgttggaaaa cagcgcatat ctggaaattt ggattctcca gaaggtggtt
      841 tcgatgccat catgcaagtt gcagtttgtg gatcactgat tggctggagg aatgttacac
      901 ggctgctggt gttttccaca gatgccgggt ttcactttgc tggagatggg aaacttggtg
      961 gcattgtttt accaaatgat ggacaatgtc acctggaaaa taatatgtac acaatgagcc
     1021 attattatga ttatccttct attgctcacc ttgtccagaa actgagtgaa aataatattc
     1081 agacaatttt tgcagttact gaagaatttc agcctgttta caaggagctg aaaaacttga
     1141 tccctaagtc agcagtagga acattatctg caaattctag caatgtaatt cagttgatca
     1201 ttgatgcata caattccctt tcctcagaag tcattttgga aaacggcaaa ttgtcagaag
     1261 gcgtaacaat aagttacaaa tcttactgca agaacggggt gaatggaaca ggggaaaatg
     1321 gaagaaaatg ttccaatatt tccattggag atgaggttca atttgaaatt agcataactt
     1381 caaataagtg tccaaaaaag gattctgaca gctttaaaat taggcctctg ggctttacgg
     1441 aggaagtaga ggttattctt cagtacatct gtgaatgtga atgccaaagc gaaggcatcc
     1501 ctgaaagtcc caagtgtcat gaaggaaatg ggacatttga gtgtggcgcg tgcaggtgca
     1561 atgaagggcg tgttggtaga cattgtgaat gcagcacaga tgaagttaac agtgaagaca
     1621 tggatgctta ctgcaggaaa gaaaacagtt cagaaatctg cagtaacaat ggagagtgcg
     1681 tctgcggaca gtgtgtttgt aggaagaggg ataatacaaa tgaaatttat tctggcaaat
     1741 tctgcgagtg tgataatttc aactgtgata gatccaatgg cttaatttgt ggaggaaatg
     1801 gtgtttgcaa gtgtcgtgtg tgtgagtgca accccaacta cactggcagt gcatgtgact
     1861 gttctttgga tactagtact tgtgaagcca gcaacggaca gatctgcaat ggccggggca
     1921 tctgcgagtg tggtgtctgt aagtgtacag atccgaagtt tcaagggcaa acgtgtgaga
     1981 tgtgtcagac ctgccttggt gtctgtgctg agcataaaga atgtgttcag tgcagagcct
     2041 tcaataaagg agaaaagaaa gacacatgca cacaggaatg ttcctatttt aacattacca
     2101 aggtagaaag tcgggacaaa ttaccccagc cggtccaacc tgatcctgtg tcccattgta
     2161 aggagaagga tgttgacgac tgttggttct attttacgta ttcagtgaat gggaacaacg
     2221 aggtcatggt tcatgttgtg gagaatccag agtgtcccac tggtccagac atcattccaa
     2281 ttgtagctgg tgtggttgct ggaattgttc ttattggcct tgcattactg ctgatatgga
     2341 agcttttaat gataattcat gacagaaggg agtttgctaa atttgaaaag gagaaaatga
     2401 atgccaaatg ggacacgggt gaaaatccta tttataagag tgccgtaaca actgtggtca
     2461 atccgaagta tgagggaaaa tgagtactgc ccgtgcaaat cccacaacac tgaatgcaaa
     2521 gtagcaattt ccatagtcac agttaggtag ctttagggca atattgccat ggttttactc
     2581 atgtgcaggt tttgaaaatg tacaatatgt ataattttta aaatgtttta ttattttgaa
     2641 aataatgttg taattcatgc cagggactga caaaagactt gagacaggat ggttactctt
     2701 gtcagctaag gtcacattgt gcctttttga ccttttcttc ctggactatt gaaatcaagc
     2761 ttattggatt aagtgatatt tctatagcga ttgaaagggc aatagttaaa gtaatgagca
     2821 tgatgagagt ttctgttaat catgtattaa aactgatttt tagctttaca aatatgtcag
     2881 tttgcagtta tgcagaatcc aaagtaaatg tcctgctagc tagttaagga ttgttttaaa
     2941 tctgttattt tgctatttgc ctgttagaca tgactgatga catatctgaa agacaagtat
     3001 gttgagagtt gctggtgtaa aatacgtttg aaatagttga tctacaaagg ccatgggaaa
     3061 aattcagaga gttaggaagg aaaaaccaat agctttaaaa cctgtgtgcc attttaagag
     3121 ttacttaatg tttggtaact tttatgcctt cactttacaa attcaagcct tagataaaag
     3181 aaccgagcaa ttttctgcta aaaagtcctt gatttagcac tatttacata caggccatac
     3241 tttacaaagt atttgctgaa tggggacctt ttgagttgaa tttattttat tatttttatt
     3301 ttgtttaatg tctggtgctt tctgtcacct cttctaatct tttaatgtat ttgtttgcaa
     3361 ttttggggta agactttttt tatgagtact ttttctttga agttttagcg gtcaatttgc
     3421 ctttttaatg aacatgtgaa gttatactgt ggctatgcaa cagctctcac ctacgcgagt
     3481 cttactttga gttagtgcca taacagacca ctgtatgttt acttctcacc atttgagttg
     3541 cccatcttgt ttcacactag tcacattctt gttttaagtg cctttagttt taacagttca
     3601 ctttttacag tgctatttac tgaagttatt tattaaatat gcctaaaata cttaaatcgg
     3661 atgtcttgac tctgatgtat tttatcaggt tgtgtgcatg aaatttttat agattaaaga
     3721 agttgaggaa aagca
//
