LOCUS       NM_000887               4663 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens integrin subunit alpha X (ITGAX), transcript variant
            2, mRNA.
ACCESSION   NM_000887 XM_937997
VERSION     NM_000887.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4663)
  AUTHORS   Wang,X., Guan,Z., Tang,W., Wang,X., Xu,C., Shan,E., Wang,W. and
            Gao,Y.
  TITLE     PAX5/ITGAX Contributed to the Progression of Atherosclerosis by
            Regulation of B Differentiation via TNF-alpha Signaling Pathway
  JOURNAL   DNA Cell Biol 42 (2), 97-104 (2023)
   PUBMED   36730754
  REMARK    GeneRIF: PAX5/ITGAX Contributed to the Progression of
            Atherosclerosis by Regulation of B Differentiation via TNF-alpha
            Signaling Pathway.
REFERENCE   2  (bases 1 to 4663)
  AUTHORS   Ni,L., Li,P., Li,M., Huang,S. and Dang,N.
  TITLE     SERPINB8 and furin regulate ITGAX expression and affect the
            proliferation and invasion of melanoma cells
  JOURNAL   Exp Dermatol 32 (1), 24-29 (2023)
   PUBMED   36134483
  REMARK    GeneRIF: SERPINB8 and furin regulate ITGAX expression and affect
            the proliferation and invasion of melanoma cells.
REFERENCE   3  (bases 1 to 4663)
  AUTHORS   Yuan,C.T., Chuang,S.S., Cheng,P.Y., Chang,K., Wang,H., Tsai,J.H.,
            Liau,J.Y. and Chou,W.C.
  TITLE     Decreased CD11c-positive dendritic cells in the tumor
            microenvironment predict double-hit/triple-hit genotype and
            survival in diffuse large B-cell lymphoma
  JOURNAL   J Pathol Clin Res 8 (5), 436-447 (2022)
   PUBMED   35715938
  REMARK    GeneRIF: Decreased CD11c-positive dendritic cells in the tumor
            microenvironment predict double-hit/triple-hit genotype and
            survival in diffuse large B-cell lymphoma.
REFERENCE   4  (bases 1 to 4663)
  AUTHORS   Yan,S., Meng,L., Guo,X., Chen,Z., Zhang,Y. and Li,Y.
  TITLE     Identification of ITGAX and CCR1 as potential biomarkers of
            atherosclerosis via Gene Set Enrichment Analysis
  JOURNAL   J Int Med Res 50 (3), 3000605211039480 (2022)
   PUBMED   35287505
  REMARK    GeneRIF: Identification of ITGAX and CCR1 as potential biomarkers
            of atherosclerosis via Gene Set Enrichment Analysis.
REFERENCE   5  (bases 1 to 4663)
  AUTHORS   Nagy-Balo,Z., Kiss,R., Demeter,J., Bodor,C., Bajtay,Z. and Erdei,A.
  TITLE     BCR activated CLL B cells use both CR3 (CD11b/CD18) and CR4
            (CD11c/CD18) for adhesion while CR4 has a dominant role in
            migration towards SDF-1
  JOURNAL   PLoS One 16 (7), e0254853 (2021)
   PUBMED   34283878
  REMARK    GeneRIF: BCR activated CLL B cells use both CR3 (CD11b/CD18) and
            CR4 (CD11c/CD18) for adhesion while CR4 has a dominant role in
            migration towards SDF-1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4663)
  AUTHORS   Gaidano,G., Bergui,L., Schena,M., Gaboli,M., Cremona,O.,
            Marchisio,P.C. and Caligaris-Cappio,F.
  TITLE     Integrin distribution and cytoskeleton organization in normal and
            malignant monocytes
  JOURNAL   Leukemia 4 (10), 682-687 (1990)
   PUBMED   1976870
REFERENCE   7  (bases 1 to 4663)
  AUTHORS   Corbi,A.L., Garcia-Aguilar,J. and Springer,T.A.
  TITLE     Genomic structure of an integrin alpha subunit, the leukocyte
            p150,95 molecule
  JOURNAL   J Biol Chem 265 (5), 2782-2788 (1990)
   PUBMED   2303426
  REMARK    Erratum:[J Biol Chem 1990 Jul 25;265(21):12750-1]
REFERENCE   8  (bases 1 to 4663)
  AUTHORS   Corbi,A.L., Larson,R.S., Kishimoto,T.K., Springer,T.A. and
            Morton,C.C.
  TITLE     Chromosomal location of the genes encoding the leukocyte adhesion
            receptors LFA-1, Mac-1 and p150,95. Identification of a gene
            cluster involved in cell adhesion
  JOURNAL   J Exp Med 167 (5), 1597-1607 (1988)
   PUBMED   3284962
REFERENCE   9  (bases 1 to 4663)
  AUTHORS   Corbi,A.L., Miller,L.J., O'Connor,K., Larson,R.S. and Springer,T.A.
  TITLE     cDNA cloning and complete primary structure of the alpha subunit of
            a leukocyte adhesion glycoprotein, p150,95
  JOURNAL   EMBO J 6 (13), 4023-4028 (1987)
   PUBMED   3327687
REFERENCE   10 (bases 1 to 4663)
  AUTHORS   Miller,L.J., Wiebe,M. and Springer,T.A.
  TITLE     Purification and alpha subunit N-terminal sequences of human Mac-1
            and p150,95 leukocyte adhesion proteins
  JOURNAL   J Immunol 138 (8), 2381-2383 (1987)
   PUBMED   3549901
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA324567.1, BC038237.1,
            M81695.1, AC093520.4 and AW014280.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_000887.4.
            
            Summary: This gene encodes the integrin alpha X chain protein.
            Integrins are heterodimeric integral membrane proteins composed of
            an alpha chain and a beta chain. This protein combines with the
            beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred
            to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2
            complex seems to overlap the properties of the alpha M beta 2
            integrin in the adherence of neutrophils and monocytes to
            stimulated endothelium cells, and in the phagocytosis of complement
            coated particles. Two transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Nov
            2013].
            
            Transcript Variant: This variant (2) lacks an alternate intron in
            the 3' coding sequence compared to variant 1. The resulting isoform
            (2) has a shorter and distinct C-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M81695.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268296.9/ ENSP00000268296.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                DA324567.1         43-88
            47-1717             BC038237.1         1-1671
            1718-2343           M81695.1           1703-2328
            2344-2533           BC038237.1         2298-2487
            2534-3575           M81695.1           2519-3560
            3576-4631           AC093520.4         27417-28472         c
            4632-4661           AW014280.1         18-47               c
            4662-4663           AC093520.4         27385-27386         c
FEATURES             Location/Qualifiers
     source          1..4663
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..4663
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /note="integrin subunit alpha X"
                     /db_xref="GeneID:3687"
                     /db_xref="HGNC:HGNC:6152"
                     /db_xref="MIM:151510"
     exon            1..116
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..3571
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; integrin, alpha X (antigen CD11C (p150), alpha
                     polypeptide); leukocyte surface antigen p150,95, alpha
                     subunit; leu M5, alpha subunit; myeloid membrane antigen,
                     alpha subunit; p150 95 integrin alpha chain; CD11
                     antigen-like family member C; integrin alpha X; leukocyte
                     adhesion receptor p150,95; leukocyte adhesion glycoprotein
                     p150,95 alpha chain; integrin, alpha X (complement
                     component 3 receptor 4 subunit)"
                     /codon_start=1
                     /product="integrin alpha-X isoform 2 precursor"
                     /protein_id="NP_000878.2"
                     /db_xref="CCDS:CCDS10711.1"
                     /db_xref="GeneID:3687"
                     /db_xref="HGNC:HGNC:6152"
                     /db_xref="MIM:151510"
                     /translation="MTRTRAALLLFTALATSLGFNLDTEELTAFRVDSAGFGDSVVQY
                     ANSWVVVGAPQKITAANQTGGLYQCGYSTGACEPIGLQVPPEAVNMSLGLSLASTTSP
                     SQLLACGPTVHHECGRNMYLTGLCFLLGPTQLTQRLPVSRQECPRQEQDIVFLIDGSG
                     SISSRNFATMMNFVRAVISQFQRPSTQFSLMQFSNKFQTHFTFEEFRRSSNPLSLLAS
                     VHQLQGFTYTATAIQNVVHRLFHASYGARRDAAKILIVITDGKKEGDSLDYKDVIPMA
                     DAAGIIRYAIGVGLAFQNRNSWKELNDIASKPSQEHIFKVEDFDALKDIQNQLKEKIF
                     AIEGTETTSSSSFELEMAQEGFSAVFTPDGPVLGAVGSFTWSGGAFLYPPNMSPTFIN
                     MSQENVDMRDSYLGYSTELALWKGVQSLVLGAPRYQHTGKAVIFTQVSRQWRMKAEVT
                     GTQIGSYFGASLCSVDVDSDGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGWRRWWCDA
                     VLYGEQGHPWGRFGAALTVLGDVNGDKLTDVVIGAPGEEENRGAVYLFHGVLGPSISP
                     SHSQRIAGSQLSSRLQYFGQALSGGQDLTQDGLVDLAVGARGQVLLLRTRPVLWVGVS
                     MQFIPAEIPRSAFECREQVVSEQTLVQSNICLYIDKRSKNLLGSRDLQSSVTLDLALD
                     PGRLSPRATFQETKNRSLSRVRVLGLKAHCENFNLLLPSCVEDSVTPITLRLNFTLVG
                     KPLLAFRNLRPMLAADAQRYFTASLPFEKNCGADHICQDNLGISFSFPGLKSLLVGSN
                     LELNAEVMVWNDGEDSYGTTITFSHPAGLSYRYVAEGQKQGQLRSLHLTCDSAPVGSQ
                     GTWSTSCRINHLIFRGGAQITFLATFDVSPKAVLGDRLLLTANVSSENNTPRTSKTTF
                     QLELPVKYAVYTVVSSHEQFTKYLNFSESEEKESHVAMHRYQVNNLGQRDLPVSINFW
                     VPVELNQEAVWMDVEVSHPQNPSLRCSSEKIAPPASDFLAHIQKNPVLDCSIAGCLRF
                     RCDVPSFSVQEELDFTLKGNLSFGWVRQILQKKVSVVSVAEITFDTSVYSQLPGQEAF
                     MRAQTTTVLEKYKVHNPTPLIVGSSIGGLLLLALITAVLYKVGFFKRQYKEMMEEANG
                     QIAPENGTQTPSPPSEK"
     exon            117..222
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            223..326
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            327..397
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            398..509
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            510..640
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            641..786
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            787..940
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1091
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1165
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1295
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1438
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1579
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1789
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1920
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2084
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2239
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2371
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2445
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2587
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2704
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2784
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..2868
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            2869..2947
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            2948..3055
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3139
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            3140..3253
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3355
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            3356..3466
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            3467..4663
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4583..4588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /note="hexamer: ATTAAA"
     polyA_site      4601
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /note="major polyA site"
     regulatory      4643..4648
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
                     /note="hexamer: AATAAA"
     polyA_site      4663
                     /gene="ITGAX"
                     /gene_synonym="CD11C; SLEB6"
ORIGIN      
        1 acttgcttcc tcagtacctt ggtccagctc ttcctgcaac ggcccaggag ctcagagctc
       61 cacatctgac cttctagtca tgaccaggac cagggcagca ctcctcctgt tcacagcctt
      121 agcaacttct ctaggtttca acttggacac agaggagctg acagccttcc gtgtggacag
      181 cgctgggttt ggagacagcg tggtccagta tgccaactcc tgggtggtgg ttggagcccc
      241 ccaaaagata acagctgcca accaaacggg tggcctctac cagtgtggct acagcactgg
      301 tgcctgtgag cccatcggcc tgcaggtgcc cccggaggcc gtgaacatgt ccctgggcct
      361 gtccctggcg tctaccacca gcccttccca gctgctggcc tgcggcccca ccgtgcacca
      421 cgagtgcggg aggaacatgt acctcaccgg actctgcttc ctcctgggcc ccacccagct
      481 cacccagagg ctcccggtgt ccaggcagga gtgcccaaga caggagcagg acattgtgtt
      541 cctgatcgat ggctcaggca gcatctcctc ccgcaacttt gccacgatga tgaacttcgt
      601 gagagctgtg ataagccagt tccagagacc cagcacccag ttttccctga tgcagttctc
      661 caacaaattc caaacacact tcactttcga ggaattcagg cgcagctcaa accccctcag
      721 cctgttggct tctgttcacc agctgcaagg gtttacatac acggccaccg ccatccaaaa
      781 tgtcgtgcac cgattgttcc atgcctcata tggggcccgt agggatgccg ccaaaattct
      841 cattgtcatc actgatggga agaaagaagg cgacagcctg gattataagg atgtcatccc
      901 catggctgat gcagcaggca tcatccgcta tgcaattggg gttggattag cttttcaaaa
      961 cagaaattct tggaaagaat taaatgacat tgcatcgaag ccctcccagg aacacatatt
     1021 taaagtggag gactttgatg ctctgaaaga tattcaaaac caactgaagg agaagatctt
     1081 tgccattgag ggtacggaga ccacaagcag tagctccttc gaattggaga tggcacagga
     1141 gggcttcagc gctgtgttca cacctgatgg ccccgttctg ggggctgtgg ggagcttcac
     1201 ctggtctgga ggtgccttcc tgtacccccc aaatatgagc cctaccttca tcaacatgtc
     1261 tcaggagaat gtggacatga gggactctta cctgggttac tccaccgagc tggccctctg
     1321 gaaaggggtg cagagcctgg tcctgggggc cccccgctac cagcacaccg ggaaggctgt
     1381 catcttcacc caggtgtcca ggcaatggag gatgaaggcc gaagtcacgg ggactcagat
     1441 cggctcctac ttcggggcct ccctctgctc cgtggacgta gacagcgacg gcagcaccga
     1501 cctggtcctc atcggggccc cccattacta cgagcagacc cgagggggcc aggtgtctgt
     1561 gtgtcccttg cccagggggt ggagaaggtg gtggtgtgat gctgttctct acggggagca
     1621 gggccacccc tggggtcgct ttggggcggc tctgacagtg ctgggggatg tgaatgggga
     1681 caagctgaca gacgtggtca tcggggcccc aggagaggag gagaaccggg gtgctgtcta
     1741 cctgtttcac ggagtcttgg gacccagcat cagcccctcc cacagccagc ggatcgcggg
     1801 ctcccagctc tcctccaggc tgcagtattt tgggcaggca ctgagcgggg gtcaagacct
     1861 cacccaggat ggactggtgg acctggctgt gggggcccgg ggccaggtgc tcctgctcag
     1921 gaccagacct gtgctctggg tgggggtgag catgcagttc atacctgccg agatccccag
     1981 gtctgcgttt gagtgtcggg agcaggtggt ctctgagcag accctggtac agtccaacat
     2041 ctgcctttac attgacaaac gttctaagaa cctgcttggg agccgtgacc tccaaagctc
     2101 tgtgaccttg gacctggccc tcgaccctgg ccgcctgagt ccccgtgcca ccttccagga
     2161 aacaaagaac cggagtctga gccgagtccg agtcctcggg ctgaaggcac actgtgaaaa
     2221 cttcaacctg ctgctcccga gctgcgtgga ggactctgtg acccccatta ccttgcgtct
     2281 gaacttcacg ctggtgggca agcccctcct tgccttcaga aacctgcggc ctatgctggc
     2341 cgccgatgct cagagatact tcacggcctc cctacccttt gagaagaact gtggagccga
     2401 ccatatctgc caggacaatc tcggcatctc cttcagcttc ccaggcttga agtccctgct
     2461 ggtggggagt aacctggagc tgaacgcaga agtgatggtg tggaatgacg gggaagactc
     2521 ctacggaacc accatcacct tctcccaccc cgcaggactg tcctaccgct acgtggcaga
     2581 gggccagaaa caagggcagc tgcgttccct gcacctgaca tgtgacagcg ccccagttgg
     2641 gagccagggc acctggagca ccagctgcag aatcaaccac ctcatcttcc gtggcggcgc
     2701 ccagatcacc ttcttggcta cctttgacgt ctcccccaag gctgtcctgg gagaccggct
     2761 gcttctgaca gccaatgtga gcagtgagaa caacactccc aggaccagca agaccacctt
     2821 ccagctggag ctcccggtga agtatgctgt ctacactgtg gttagcagcc acgaacaatt
     2881 caccaaatac ctcaacttct cagagtctga ggagaaggaa agccatgtgg ccatgcacag
     2941 ataccaggtc aataacctgg gacagaggga cctgcctgtc agcatcaact tctgggtgcc
     3001 tgtggagctg aaccaggagg ctgtgtggat ggatgtggag gtctcccacc cccagaaccc
     3061 atcccttcgg tgctcctcag agaaaatcgc acccccagca tctgacttcc tggcgcacat
     3121 tcagaagaat cccgtgctgg actgctccat tgctggctgc ctgcggttcc gctgtgacgt
     3181 cccctccttc agcgtccagg aggagctgga tttcaccctg aagggcaacc tcagctttgg
     3241 ctgggtccgc cagatattgc agaagaaggt gtcggtcgtg agtgtggctg aaattacgtt
     3301 cgacacatcc gtgtactccc agcttccagg acaggaggca tttatgagag ctcagacgac
     3361 aacggtgctg gagaagtaca aggtccacaa ccccaccccc ctcatcgtag gcagctccat
     3421 tgggggtctg ttgctgctgg cactcatcac agcggtactg tacaaagttg gcttcttcaa
     3481 gcgtcagtac aaggaaatga tggaggaggc aaatggacaa attgccccag aaaacgggac
     3541 acagaccccc agcccgccca gtgagaaatg atcccctctt tgccttggac ttcttctccc
     3601 ccgcgagttt tccccactta cttaccctca cctgtcaggc ctgacgggga ggaaccactg
     3661 caccaccgag agaggctggg atgggcctgc ttcctgtctt tgggagaaaa cgtcttgctt
     3721 gggaaggggc ctttgtcttg tcaaggttcc aactggaaac ccttaggaca gggtccctgc
     3781 tgtgttcccc aaaggacttg acttgcaatt tctacctaga aatacatgga caataccccc
     3841 aggcctcagt ctcccttctc ccatgaggca cgaatgatct ttctttcctt tctttttttt
     3901 tttttttctt ttcttttttt tttttttgag acggagtctc gctctgtcac ccaggctgga
     3961 gtgcaatggc gtgatctcgg ctcactgcaa cctccgcctc ccgggttcaa gtaattctgc
     4021 tgtctcagcc tcctgagtag ctgggactac aggcacacgc cacctcgccc ggcccgatct
     4081 ttctaaaata cagttctgaa tatgctgctc atccccacct gtcttcaaca gctccccatt
     4141 accctcagga caatgtctga actctccagc ttcgcgtgag aagtcccctt ccatcccaga
     4201 gggtgggctt cagggcgcac agcatgagag gctctgtgcc cccatcaccc tcgtttccag
     4261 tgaattagtg tcatgtcagc atcagctcag ggcttcatcg tggggctctc agttccgatt
     4321 tcccaggctg aattgggagt gagatgcctg catgctgggt tctgcacagc tggcctcccg
     4381 cgttgggcaa cattgctggc tggaagggag gagcgccctc tagggaggga catggccccg
     4441 gtgcggctgc agctcaccca gccccagggg cagaagagac ccaaccactt ctattttttg
     4501 aggctatgaa tatagtacct gaaaaaatgc caagacatga ttattttttt aaaaagcgta
     4561 ctttaaatgt ttgtgttaat aaattaaaac atgcacaaaa agatgcatct accgctcttg
     4621 ggaaatatgt caaaggtcta aaaataaaaa agccttctgt gga
//
