LOCUS       NM_002210               7039 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens integrin subunit alpha V (ITGAV), transcript variant
            1, mRNA.
ACCESSION   NM_002210
VERSION     NM_002210.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7039)
  AUTHORS   Irnaten,M., Gaynor,E. and O'Brien,C.
  TITLE     The Role of alphavbeta3 Integrin in Lamina Cribrosa Cell
            Mechanotransduction in Glaucoma
  JOURNAL   Cells 13 (17), 1487 (2024)
   PUBMED   39273058
  REMARK    GeneRIF: The Role of alphavbeta3 Integrin in Lamina Cribrosa Cell
            Mechanotransduction in Glaucoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7039)
  AUTHORS   Lopez-Cerda,M., Lorenzo-Sanz,L., da Silva-Diz,V., Llop,S.,
            Penin,R.M., Bermejo,J.O., de Goeij-de Haas,R., Piersma,S.R.,
            Pham,T.V., Jimenez,C.R., Martin-Liberal,J. and Munoz,P.
  TITLE     IGF1R signaling induces epithelial-mesenchymal plasticity via ITGAV
            in cutaneous carcinoma
  JOURNAL   J Exp Clin Cancer Res 43 (1), 211 (2024)
   PUBMED   39075581
  REMARK    GeneRIF: IGF1R signaling induces epithelial-mesenchymal plasticity
            via ITGAV in cutaneous carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7039)
  AUTHORS   Nam,A., Jain,S., Wu,C., Campos,A., Shepard,R.M., Yu,Z., Reddy,J.P.,
            Von Schalscha,T., Weis,S.M., Onaitis,M., Wettersten,H.I. and
            Cheresh,D.A.
  TITLE     Integrin alphavbeta3 Upregulation in Response to Nutrient Stress
            Promotes Lung Cancer Cell Metabolic Plasticity
  JOURNAL   Cancer Res 84 (10), 1630-1642 (2024)
   PUBMED   38588407
  REMARK    GeneRIF: Integrin alphavbeta3 Upregulation in Response to Nutrient
            Stress Promotes Lung Cancer Cell Metabolic Plasticity.
REFERENCE   4  (bases 1 to 7039)
  AUTHORS   Xue,M., Xing,L., Yang,Y., Shao,M., Liao,F., Xu,F., Chen,Y.,
            Wang,S., Chen,B., Yao,C., Gu,G. and Tong,C.
  TITLE     A decrease in integrin alpha5beta1/FAK is associated with increased
            apoptosis of aortic smooth muscle cells in acute type a aortic
            dissection
  JOURNAL   BMC Cardiovasc Disord 24 (1), 180 (2024)
   PUBMED   38532364
  REMARK    GeneRIF: A decrease in integrin alpha5beta1/FAK is associated with
            increased apoptosis of aortic smooth muscle cells in acute type a
            aortic dissection.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7039)
  AUTHORS   Wang,H., Xu,Y.H. and Guo,Y.
  TITLE     Novel prognostic marker TGFBI affects the migration and invasion
            function of ovarian cancer cells and activates the integrin
            alphavbeta3-PI3K-Akt signaling pathway
  JOURNAL   J Ovarian Res 17 (1), 50 (2024)
   PUBMED   38395907
  REMARK    GeneRIF: Novel prognostic marker TGFBI affects the migration and
            invasion function of ovarian cancer cells and activates the
            integrin alphavbeta3-PI3K-Akt signaling pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7039)
  AUTHORS   Busk,M., Pytela,R. and Sheppard,D.
  TITLE     Characterization of the integrin alpha v beta 6 as a
            fibronectin-binding protein
  JOURNAL   J Biol Chem 267 (9), 5790-5796 (1992)
   PUBMED   1532572
REFERENCE   7  (bases 1 to 7039)
  AUTHORS   Moyle,M., Napier,M.A. and McLean,J.W.
  TITLE     Cloning and expression of a divergent integrin subunit beta 8
  JOURNAL   J Biol Chem 266 (29), 19650-19658 (1991)
   PUBMED   1918072
REFERENCE   8  (bases 1 to 7039)
  AUTHORS   Smith,J.W., Vestal,D.J., Irwin,S.V., Burke,T.A. and Cheresh,D.A.
  TITLE     Purification and functional characterization of integrin alpha v
            beta 5. An adhesion receptor for vitronectin
  JOURNAL   J Biol Chem 265 (19), 11008-11013 (1990)
   PUBMED   1694173
REFERENCE   9  (bases 1 to 7039)
  AUTHORS   Bodary,S.C. and McLean,J.W.
  TITLE     The integrin beta 1 subunit associates with the vitronectin
            receptor alpha v subunit to form a novel vitronectin receptor in a
            human embryonic kidney cell line
  JOURNAL   J Biol Chem 265 (11), 5938-5941 (1990)
   PUBMED   1690718
REFERENCE   10 (bases 1 to 7039)
  AUTHORS   Suzuki,S., Argraves,W.S., Pytela,R., Arai,H., Krusius,T.,
            Pierschbacher,M.D. and Ruoslahti,E.
  TITLE     cDNA and amino acid sequences of the cell adhesion protein receptor
            recognizing vitronectin reveal a transmembrane domain and
            homologies with other adhesion protein receptors
  JOURNAL   Proc Natl Acad Sci U S A 83 (22), 8614-8618 (1986)
   PUBMED   2430295
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC017101.10.
            
            On Nov 22, 2018 this sequence version replaced NM_002210.4.
            
            Summary: The product of this gene belongs to the integrin alpha
            chain family. Integrins are heterodimeric integral membrane
            proteins composed of an alpha subunit and a beta subunit that
            function in cell surface adhesion and signaling. The encoded
            preproprotein is proteolytically processed to generate light and
            heavy chains that comprise the alpha V subunit. This subunit
            associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits.
            The heterodimer consisting of alpha V and beta 3 subunits is also
            known as the vitronectin receptor. This integrin may regulate
            angiogenesis and cancer progression. Alternative splicing results
            in multiple transcript variants. Note that the integrin alpha 5 and
            integrin alpha V subunits are encoded by distinct genes. [provided
            by RefSeq, Oct 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.70334.1,
                                           SRR1660803.188516.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261023.8/ ENSP00000261023.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-468               AC017101.10        9034-9501
            469-599             AC017101.10        20999-21129
            600-691             AC017101.10        41317-41408
            692-806             AC017101.10        44451-44565
            807-868             AC017101.10        49775-49836
            869-914             AC017101.10        52307-52352
            915-1040            AC017101.10        55060-55185
            1041-1085           AC017101.10        56043-56087
            1086-1129           AC017101.10        57255-57298
            1130-1186           AC017101.10        57387-57443
            1187-1239           AC017101.10        59893-59945
            1240-1442           AC017101.10        60364-60566
            1443-1634           AC017101.10        65664-65855
            1635-1680           AC017101.10        68818-68863
            1681-1788           AC017101.10        70960-71067
            1789-1847           AC017101.10        73628-73686
            1848-2002           AC017101.10        75225-75379
            2003-2140           AC017101.10        78016-78153
            2141-2208           AC017101.10        82746-82813
            2209-2356           AC017101.10        83472-83619
            2357-2449           AC017101.10        84104-84196
            2450-2529           AC017101.10        85682-85761
            2530-2610           AC017101.10        86128-86208
            2611-2716           AC017101.10        86649-86754
            2717-2875           AC017101.10        87740-87898
            2876-2989           AC017101.10        88679-88792
            2990-3103           AC017101.10        94582-94695
            3104-3211           AC017101.10        94798-94905
            3212-3334           AC017101.10        95791-95913
            3335-7039           AC017101.10        96175-99879
FEATURES             Location/Qualifiers
     source          1..7039
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q32.1"
     gene            1..7039
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /note="integrin subunit alpha V"
                     /db_xref="GeneID:3685"
                     /db_xref="HGNC:HGNC:6150"
                     /db_xref="MIM:193210"
     exon            1..468
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..3430
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; antigen identified by monoclonal antibody L230;
                     integrin alpha-V; vitronectin receptor subunit alpha;
                     integrin, alpha V (vitronectin receptor, alpha
                     polypeptide, antigen CD51); integrin alphaVbeta3"
                     /codon_start=1
                     /product="integrin alpha-V isoform 1 preproprotein"
                     /protein_id="NP_002201.2"
                     /db_xref="CCDS:CCDS2292.1"
                     /db_xref="GeneID:3685"
                     /db_xref="HGNC:HGNC:6150"
                     /db_xref="MIM:193210"
                     /translation="MAFPPRRRLRLGPRGLPLLLSGLLLPLCRAFNLDVDSPAEYSGP
                     EGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEF
                     DATGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFL
                     QDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQV
                     AEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRA
                     ARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRG
                     SDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAA
                     PYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYP
                     DLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVSCFNVRFC
                     LKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCE
                     ELIAYLRDESEFRDKLTPITIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILL
                     DCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQAD
                     FIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTS
                     VKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPDHVFLPIPNWEHKENPET
                     EEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLYILHYDIDGPMNCTSDM
                     EINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIHTLGCGVAQCLKIVC
                     QVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDIT
                     NSTLVTTNVTWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRPPQEE
                     QEREQLQPHENGEGNSET"
     exon            469..599
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            600..691
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            692..806
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            807..868
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            869..914
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1040
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1085
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1129
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1186
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1239
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1442
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1634
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1680
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1788
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1847
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..2002
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2140
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2208
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2356
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2449
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2529
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2610
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..2716
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2875
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2876..2989
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2990..3103
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            3104..3211
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            3212..3334
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            3335..7039
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7016..7021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /note="hexamer: AATAAA"
     polyA_site      7039
                     /gene="ITGAV"
                     /gene_synonym="CD51; MSK8; VNRA; VTNR"
                     /note="major polyA site"
ORIGIN      
        1 agtccccagc ctcagacgct gcgtggagcg gcggagccgg agggaagcaa aggaccgtct
       61 gcgctgctgt ccccgccccg cgcgctctgc gcccctcgtc cctggcggtc gctccgaagc
      121 tcagccctct tgcctgcccc ggagctgtcc cgggctagcc gagaagagag cggccggcaa
      181 gtttgggcgc gcgcaggcgg cgggccgcgg gcactgggcg cctcgctggg gcggggggag
      241 gtggctaccg ctcccggctt ggcgtcccgc gcgcacttcg gcgatggctt ttccgccgcg
      301 gcgacggctg cgcctcggtc cccgcggcct cccgcttctt ctctcgggac tcctgctacc
      361 tctgtgccgc gccttcaacc tagacgtgga cagtcctgcc gagtactctg gccccgaggg
      421 aagttacttc ggcttcgccg tggatttctt cgtgcccagc gcgtcttccc ggatgtttct
      481 tctcgtggga gctcccaaag caaacaccac ccagcctggg attgtggaag gagggcaggt
      541 cctcaaatgt gactggtctt ctacccgccg gtgccagcca attgaatttg atgcaacagg
      601 caatagagat tatgccaagg atgatccatt ggaatttaag tcccatcagt ggtttggagc
      661 atctgtgagg tcgaaacagg ataaaatttt ggcctgtgcc ccattgtacc attggagaac
      721 tgagatgaaa caggagcgag agcctgttgg aacatgcttt cttcaagatg gaacaaagac
      781 tgttgagtat gctccatgta gatcacaaga tattgatgct gatggacagg gattttgtca
      841 aggaggattc agcattgatt ttactaaagc tgacagagta cttcttggtg gtcctggtag
      901 cttttattgg caaggtcagc ttatttcgga tcaagtggca gaaatcgtat ctaaatacga
      961 ccccaatgtt tacagcatca agtataataa ccaattagca actcggactg cacaagctat
     1021 ttttgatgac agctatttgg gttattctgt ggctgtcgga gatttcaatg gtgatggcat
     1081 agatgacttt gtttcaggag ttccaagagc agcaaggact ttgggaatgg tttatattta
     1141 tgatgggaag aacatgtcct ccttatacaa ttttactggc gagcagatgg ctgcatattt
     1201 cggattttct gtagctgcca ctgacattaa tggagatgat tatgcagatg tgtttattgg
     1261 agcacctctc ttcatggatc gtggctctga tggcaaactc caagaggtgg ggcaggtctc
     1321 agtgtctcta cagagagctt caggagactt ccagacgaca aagctgaatg gatttgaggt
     1381 ctttgcacgg tttggcagtg ccatagctcc tttgggagat ctggaccagg atggtttcaa
     1441 tgatattgca attgctgctc catatggggg tgaagataaa aaaggaattg tttatatctt
     1501 caatggaaga tcaacaggct tgaacgcagt cccatctcaa atccttgaag ggcagtgggc
     1561 tgctcgaagc atgccaccaa gctttggcta ttcaatgaaa ggagccacag atatagacaa
     1621 aaatggatat ccagacttaa ttgtaggagc ttttggtgta gatcgagcta tcttatacag
     1681 ggccagacca gttatcactg taaatgctgg tcttgaagtg taccctagca ttttaaatca
     1741 agacaataaa acctgctcac tgcctggaac agctctcaaa gtttcctgtt ttaatgttag
     1801 gttctgctta aaggcagatg gcaaaggagt acttcccagg aaacttaatt tccaggtgga
     1861 acttcttttg gataaactca agcaaaaggg agcaattcga cgagcactgt ttctctacag
     1921 caggtcccca agtcactcca agaacatgac tatttcaagg gggggactga tgcagtgtga
     1981 ggaattgata gcgtatctgc gggatgaatc tgaatttaga gacaaactca ctccaattac
     2041 tatttttatg gaatatcggt tggattatag aacagctgct gatacaacag gcttgcaacc
     2101 cattcttaac cagttcacgc ctgctaacat tagtcgacag gctcacattc tacttgactg
     2161 tggtgaagac aatgtctgta aacccaagct ggaagtttct gtagatagtg atcaaaagaa
     2221 gatctatatt ggggatgaca accctctgac attgattgtt aaggctcaga atcaaggaga
     2281 aggtgcctac gaagctgagc tcatcgtttc cattccactg caggctgatt tcatcggggt
     2341 tgtccgaaac aatgaagcct tagcaagact ttcctgtgca tttaagacag aaaaccaaac
     2401 tcgccaggtg gtatgtgacc ttggaaaccc aatgaaggct ggaactcaac tcttagctgg
     2461 tcttcgtttc agtgtgcacc agcagtcaga gatggatact tctgtgaaat ttgacttaca
     2521 aatccaaagc tcaaatctat ttgacaaagt aagcccagtt gtatctcaca aagttgatct
     2581 tgctgtttta gctgcagttg agataagagg agtctcgagt cctgatcatg tctttcttcc
     2641 gattccaaac tgggagcaca aggagaaccc tgagactgaa gaagatgttg ggccagttgt
     2701 tcagcacatc tatgagctga gaaacaatgg tccaagttca ttcagcaagg caatgctcca
     2761 tcttcagtgg ccttacaaat ataataataa cactctgttg tatatccttc attatgatat
     2821 tgatggacca atgaactgca cttcagatat ggagatcaac cctttgagaa ttaagatctc
     2881 atctttgcaa acaactgaaa agaatgacac ggttgccggg caaggtgagc gggaccatct
     2941 catcactaag cgggatcttg ccctcagtga aggagatatt cacactttgg gttgtggagt
     3001 tgctcagtgc ttgaagattg tctgccaagt tgggagatta gacagaggaa agagtgcaat
     3061 cttgtacgta aagtcattac tgtggactga gacttttatg aataaagaaa atcagaatca
     3121 ttcctattct ctgaagtcgt ctgcttcatt taatgtcata gagtttcctt ataagaatct
     3181 tccaattgag gatatcacca actccacatt ggttaccact aatgtcacct ggggcattca
     3241 gccagcgccc atgcctgtgc ctgtgtgggt gatcatttta gcagttctag caggattgtt
     3301 gctactggct gttttggtat ttgtaatgta caggatgggc ttttttaaac gggtccggcc
     3361 acctcaagaa gaacaagaaa gggagcagct tcaacctcat gaaaatggtg aaggaaactc
     3421 agaaacttaa ctgcagtttt taagttatgc tacatcttga cccactagaa ttagcaactt
     3481 tattatagat ttaaactttc ttcatgagga gtaaaaatcc aaggctttac tgctgatagt
     3541 gctaattggc attaaccaca aaatgagaat tatatttgtc aaccttctcc ttataaataa
     3601 gttcagacat acatttaata acatagggtg acttgtgttt ttaggtattt aaataataaa
     3661 atttcaaggg atagttttta ttcaatgtat ataagacagg tagtgcctga tttactactt
     3721 tatataaaat agtacctcct tcagttactg tttctgattt aatgtacgga actttatttg
     3781 ttgttgttgt tgttgttgtt gttgttgttt taaagcagtc caaatttgga ccttagcaat
     3841 catgtctttt gtataggtac ttaatgttaa tacatattac actacagttt acttttcaga
     3901 atactaaaga ctttataact gcatgaactt ggattttttt aatcactcat atggtagaat
     3961 tttataaaca catacatgat accatccaaa ttcttgcttt taataacaaa ggtacaatat
     4021 tttgttttag tatgaaaatc tggtagatcc tattacactt ctgtttatat taaatccaca
     4081 atattttatt acatttttaa cttgtataaa ttttaggtca aatccttcaa gccaacctat
     4141 actaaaaatt agttccataa tcacaaatgg ctcttttgtg taattgttta atttcacctg
     4201 aatatcataa tgcttaaagc catatggagt tggaaattat ttccaaagca tatttattcc
     4261 attgttttag tctggctatt tacagtataa aaaaagcatt tttattaaaa tactgtgtag
     4321 ttctttgaga tagttgctta tgcatatagt aagtattaca ttcttagagt agagcagagt
     4381 ttttagttag tattaattta ttttcctcca ttcatgtact tttccttata tttccaaaac
     4441 tgttactgag aatgggtcaa gatcagtgag aaatctttac agttgacagg aacctggacc
     4501 ccttacccca actttatgag taatgcttgg aataaaaact cttaaggcaa ctcactgatt
     4561 tacttctagc aatagcatga tgttacagga atattacctc tgtttaagca aggtaatgtg
     4621 taaaatcagt ctcggctgtc agaataactt ctaaaaggta tttttataag cagttcaagt
     4681 tactgaaaac cttttaaacc tttctgaagt tcgttagtat aaattacttt tctaggatta
     4741 ttaataaaag ccacataggt ggcaagttgt agttttatat ggctctgtag agtggtgaac
     4801 cttctagagg aatatatgat ttattcacag ttcctcaagg cctggggatg atgatcagtt
     4861 atacctattt ttgtgcaatt acatcatgtt gtacattaga aatggagagt ttaatagctc
     4921 tttaactgct gtcctcatta ggtaatgata aatatttccc ttaaataatt gactattttg
     4981 ctgtgtttta aaaatgattg aaatttatct tgccatatct cataatttca tgcacaagtt
     5041 gactgagcta atcttgagaa tatattcgta aaataggagc acatttagtt gaggtataca
     5101 aggtaggact ctagacaaaa ccttctattt tagctttagt gaatttcaaa agtaatgggt
     5161 cttggagtat agatttttat tagtagcttg aaagagctta atcatatgca gtaagtattt
     5221 ttattaccaa taaatttaaa attttttaag aaaaatattt ttatcctagg gccaagtgtt
     5281 gcctgccacc aatcagtaag ttagtctata acaaatttta ccctaacagt tttaccacct
     5341 agtaacagtc atttctgaaa atatgttgga tagaaagtca ctctttggca aaagtgttag
     5401 aatttgcttt tgtgccatct attcctttta tggcatctat cttgaaagta atcttgtatt
     5461 ggagattgaa agatgctgta atttagaaat taacatgata tcttaaatta cctttatgaa
     5521 atatagtttt gtataatagc atagattttc cttcaaaaaa tgaacattta tatatctaca
     5581 aaaatatgga gaagagtaat ttgaaagcct actttctgaa gaaaatggtg ggattttttt
     5641 ttatcatgat taaatatcaa aaaattgccc tatgaaaact ttaaatctct aaaacatttg
     5701 aaatactacc atatttgtga tttattgaga ataaaaatcc attttgaaat gtaaaatttt
     5761 tatgatctga ttcagtttta agaaaacatg aatgaactag aagatattaa aaacatttga
     5821 cattggtaag aaatattgat actgatattg atttttatat aggtatttat ttcagaattg
     5881 atattttgag aaaaatacat gtgagtcatt ttttctgttt ctcttttctc ttaacgatta
     5941 tcactgtaat tctgaatctg aaaggtaaaa caattagtca aaatattatt gccatcattc
     6001 tacctgtgtt atgaaactac ttattcatag ttaattctca ttaacactta catttccata
     6061 aagaaaactc aagtattaat aaaagagact ttactggctt aagagggctg tgaaagattt
     6121 ttgatagtga atcatgaccc taagggagag atttgtgtga taaaagtatt gtatataata
     6181 gatcagcgat ttttgtaagg caaacagaat ttgtaagttg gcagatcttc ctaagttgca
     6241 aaatgtaatg atgagcttgg tggagaagaa tgagtcgttc ttggaatacc tatgtgcagc
     6301 cactacccat ctcaatgtca ccttgtttgc attcttggat agcttgtata tgtagtagtt
     6361 tgatgaataa tttaaagaaa aacacctaaa atttgaaaaa tgattgtagg atcaaaaaag
     6421 gcagatgaaa ttacttaata ctcagtgttt tggagagtat tccttttagt ttgttggttg
     6481 gctggtttga acgatagaaa tatgcagcat gcaatatatg cttatatttc attttaattt
     6541 ctgatatata atgaacttct tgggagaggt actgaatctt tgatgttttt tgtcattgtt
     6601 ctcaagtgca atataacaat gtaaccaaat ctagataatt tcaaagttgt cattaattta
     6661 gtaagcctaa tataaacaaa tatttgtatt atttttgtta gcaggaaaga gtgattaagt
     6721 gaggttattt acccctaaat ggtccattct gcattgtatt tcaggctgga aatgaattat
     6781 tctttaccag ttttgaaaca ctttgaaata tcctaaggta acttggaagc tgtgtagtat
     6841 atcaaattaa tttgctacct aataacatag aaagtaaata tctttgtggt cacccacatt
     6901 gggtgagaca gaaaatgaat ctgttctaaa atttgtaatt tgctaacttg atttgagtta
     6961 gtgaaaactg gtacagtgtt ctgcttgatt tacaacatgt aacttgtgac tgtacaataa
     7021 acataagcat atggtacca
//
