LOCUS       NM_000632               4719 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens integrin subunit alpha M (ITGAM), transcript variant
            2, mRNA.
ACCESSION   NM_000632
VERSION     NM_000632.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4719)
  AUTHORS   Liu,Y.G., Peng,H.R., Ren,R.W., Zhao,P. and Zhao,L.J.
  TITLE     CD11b maintains West Nile virus replication through modulation of
            immune response in human neuroblastoma cells
  JOURNAL   Virol J 21 (1), 158 (2024)
   PUBMED   39004752
  REMARK    GeneRIF: CD11b maintains West Nile virus replication through
            modulation of immune response in human neuroblastoma cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4719)
  AUTHORS   Yang,C., Li,L., Ye,Z., Zhang,A., Bao,Y., Wu,X., Ren,G., Jiang,C.,
            Wang,O. and Wang,Z.
  TITLE     Mechanisms underlying neutrophils adhesion to triple-negative
            breast cancer cells via CD11b-ICAM1 in promoting breast cancer
            progression
  JOURNAL   Cell Commun Signal 22 (1), 340 (2024)
   PUBMED   38907234
  REMARK    GeneRIF: Mechanisms underlying neutrophils adhesion to
            triple-negative breast cancer cells via CD11b-ICAM1 in promoting
            breast cancer progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4719)
  AUTHORS   Duan,M., Zhang,X., Lou,Y., Feng,J., Guo,P., Ye,S., Lv,P. and
            Chen,Y.
  TITLE     Deletion of Tmem268 in mice suppresses anti-infectious immune
            responses by downregulating CD11b signaling
  JOURNAL   EMBO Rep 25 (6), 2550-2570 (2024)
   PUBMED   38730209
REFERENCE   4  (bases 1 to 4719)
  AUTHORS   Hou,L., Li,Z., Guo,X., Lv,J., Chong,Z., Xiao,Y., Zhang,L. and Li,Z.
  TITLE     ITGAM is a critical gene in ischemic stroke
  JOURNAL   Aging (Albany NY) 16 (8), 6852-6867 (2024)
   PUBMED   38637126
  REMARK    GeneRIF: ITGAM is a critical gene in ischemic stroke.
REFERENCE   5  (bases 1 to 4719)
  AUTHORS   Lou,Y., Li,P.H., Liu,X.Q., Wang,T.X., Liu,Y.L., Chen,C.C. and
            Ma,K.L.
  TITLE     ITGAM-mediated macrophages contribute to basement membrane damage
            in diabetic nephropathy and atherosclerosis
  JOURNAL   BMC Nephrol 25 (1), 72 (2024)
   PUBMED   38413872
  REMARK    GeneRIF: ITGAM-mediated macrophages contribute to basement membrane
            damage in diabetic nephropathy and atherosclerosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4719)
  AUTHORS   Pahl,H.L., Rosmarin,A.G. and Tenen,D.G.
  TITLE     Characterization of the myeloid-specific CD11b promoter
  JOURNAL   Blood 79 (4), 865-870 (1992)
   PUBMED   1346576
REFERENCE   7  (bases 1 to 4719)
  AUTHORS   Shelley,C.S. and Arnaout,M.A.
  TITLE     The promoter of the CD11b gene directs myeloid-specific and
            developmentally regulated expression
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10525-10529 (1991)
   PUBMED   1683702
REFERENCE   8  (bases 1 to 4719)
  AUTHORS   Hickstein,D.D., Hickey,M.J., Ozols,J., Baker,D.M., Back,A.L. and
            Roth,G.J.
  TITLE     cDNA sequence for the alpha M subunit of the human neutrophil
            adherence receptor indicates homology to integrin alpha subunits
  JOURNAL   Proc Natl Acad Sci U S A 86 (1), 257-261 (1989)
   PUBMED   2563162
REFERENCE   9  (bases 1 to 4719)
  AUTHORS   Corbi,A.L., Kishimoto,T.K., Miller,L.J. and Springer,T.A.
  TITLE     The human leukocyte adhesion glycoprotein Mac-1 (complement
            receptor type 3, CD11b) alpha subunit. Cloning, primary structure,
            and relation to the integrins, von Willebrand factor and factor B
  JOURNAL   J Biol Chem 263 (25), 12403-12411 (1988)
   PUBMED   2457584
REFERENCE   10 (bases 1 to 4719)
  AUTHORS   Arnaout,M.A., Gupta,S.K., Pierce,M.W. and Tenen,D.G.
  TITLE     Amino acid sequence of the alpha subunit of human leukocyte
            adhesion receptor Mo1 (complement receptor type 3)
  JOURNAL   J Cell Biol 106 (6), 2153-2158 (1988)
   PUBMED   2454931
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK057856.1, BC096348.3,
            AA436312.1 and AC093520.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 12, 2018 this sequence version replaced NM_000632.3.
            
            Summary: This gene encodes the integrin alpha M chain. Integrins
            are heterodimeric integral membrane proteins composed of an alpha
            chain and a beta chain. This I-domain containing alpha integrin
            combines with the beta 2 chain (ITGB2) to form a leukocyte-specific
            integrin referred to as macrophage receptor 1 ('Mac-1'), or
            inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2
            integrin is important in the adherence of neutrophils and monocytes
            to stimulated endothelium, and also in the phagocytosis of
            complement coated particles. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Mar 2009].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the central coding region, compared to variant 1.
            The resulting isoform (2) lacks one internal amino acid, compared
            to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.90372.1, BC096346.3
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000544665.9/ ENSP00000441691.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AK057856.1         12-37
            27-3671             BC096348.3         1-3645
            3672-3710           AA436312.1         390-428
            3711-4719           AC093520.4         77507-78515         c
FEATURES             Location/Qualifiers
     source          1..4719
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..4719
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /note="integrin subunit alpha M"
                     /db_xref="GeneID:3684"
                     /db_xref="HGNC:HGNC:6149"
                     /db_xref="MIM:120980"
     exon            1..118
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            119..224
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            225..328
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            329..399
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            400..517
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            518..648
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            649..794
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            795..948
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1099
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1173
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1303
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1446
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1587
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1797
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1928
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2092
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2247
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2379
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..2453
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2595
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2718
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            2719..2798
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..2882
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..2958
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            2959..3066
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            3067..3150
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            3151..3264
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            3265..3366
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            3367..3477
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     exon            3478..4719
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4692..4697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /note="hexamer: AATAAA"
     regulatory      4701..4706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /note="hexamer: AATATA"
     polyA_site      4711
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
                     /note="major polyA site"
     polyA_site      4719
                     /gene="ITGAM"
                     /gene_synonym="CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6"
ORIGIN      
        1 ccttctttgc tttggtggct tccttgtggt tcctcagtgg tgcctgcaac ccctggttca
       61 cctccttcca ggttctggct ccttccagcc atggctctca gagtccttct gttaacagcc
      121 ttgaccttat gtcatgggtt caacttggac actgaaaacg caatgacctt ccaagagaac
      181 gcaaggggct tcgggcagag cgtggtccag cttcagggat ccagggtggt ggttggagcc
      241 ccccaggaga tagtggctgc caaccaaagg ggcagcctct accagtgcga ctacagcaca
      301 ggctcatgcg agcccatccg cctgcaggtc cccgtggagg ccgtgaacat gtccctgggc
      361 ctgtccctgg cagccaccac cagcccccct cagctgctgg cctgtggtcc caccgtgcac
      421 cagacttgca gtgagaacac gtatgtgaaa gggctctgct tcctgtttgg atccaaccta
      481 cggcagcagc cccagaagtt cccagaggcc ctccgagggt gtcctcaaga ggatagtgac
      541 attgccttct tgattgatgg ctctggtagc atcatcccac atgactttcg gcggatgaag
      601 gagtttgtct caactgtgat ggagcaatta aaaaagtcca aaaccttgtt ctctttgatg
      661 cagtactctg aagaattccg gattcacttt accttcaaag agttccagaa caaccctaac
      721 ccaagatcac tggtgaagcc aataacgcag ctgcttgggc ggacacacac ggccacgggc
      781 atccgcaaag tggtacgaga gctgtttaac atcaccaacg gagcccgaaa gaatgccttt
      841 aagatcctag ttgtcatcac ggatggagaa aagtttggcg atcccttggg atatgaggat
      901 gtcatccctg aggcagacag agagggagtc attcgctacg tcattggggt gggagatgcc
      961 ttccgcagtg agaaatcccg ccaagagctt aataccatcg catccaagcc gcctcgtgat
     1021 cacgtgttcc aggtgaataa ctttgaggct ctgaagacca ttcagaacca gcttcgggag
     1081 aagatctttg cgatcgaggg tactcagaca ggaagtagca gctcctttga gcatgagatg
     1141 tctcaggaag gcttcagcgc tgccatcacc tctaatggcc ccttgctgag cactgtgggg
     1201 agctatgact gggctggtgg agtctttcta tatacatcaa aggagaaaag caccttcatc
     1261 aacatgacca gagtggattc agacatgaat gatgcttact tgggttatgc tgccgccatc
     1321 atcttacgga accgggtgca aagcctggtt ctgggggcac ctcgatatca gcacatcggc
     1381 ctggtagcga tgttcaggca gaacactggc atgtgggagt ccaacgctaa tgtcaagggc
     1441 acccagatcg gcgcctactt cggggcctcc ctctgctccg tggacgtgga cagcaacggc
     1501 agcaccgacc tggtcctcat cggggccccc cattactacg agcagacccg agggggccag
     1561 gtgtccgtgt gccccttgcc cagggggagg gctcggtggc agtgtgatgc tgttctctac
     1621 ggggagcagg gccaaccctg gggccgcttt ggggcagccc taacagtgct gggggacgta
     1681 aatggggaca agctgacgga cgtggccatt ggggccccag gagaggagga caaccggggt
     1741 gctgtttacc tgtttcacgg aacctcagga tctggcatca gcccctccca tagccagcgg
     1801 atagcaggct ccaagctctc tcccaggctc cagtattttg gtcagtcact gagtgggggc
     1861 caggacctca caatggatgg actggtagac ctgactgtag gagcccaggg gcacgtgctg
     1921 ctgctcaggt cccagccagt actgagagtc aaggcaatca tggagttcaa tcccagggaa
     1981 gtggcaagga atgtatttga gtgtaatgat caggtggtga aaggcaagga agccggagag
     2041 gtcagagtct gcctccatgt ccagaagagc acacgggatc ggctaagaga aggacagatc
     2101 cagagtgttg tgacttatga cctggctctg gactccggcc gcccacattc ccgcgccgtc
     2161 ttcaatgaga caaagaacag cacacgcaga cagacacagg tcttggggct gacccagact
     2221 tgtgagaccc tgaaactaca gttgccgaat tgcatcgagg acccagtgag ccccattgtg
     2281 ctgcgcctga acttctctct ggtgggaacg ccattgtctg ctttcgggaa cctccggcca
     2341 gtgctggcgg aggatgctca gagactcttc acagccttgt ttccctttga gaagaattgt
     2401 ggcaatgaca acatctgcca ggatgacctc agcatcacct tcagtttcat gagcctggac
     2461 tgcctcgtgg tgggtgggcc ccgggagttc aacgtgacag tgactgtgag aaatgatggt
     2521 gaggactcct acaggacaca ggtcaccttc ttcttcccgc ttgacctgtc ctaccggaag
     2581 gtgtccacgc tccagaacca gcgctcacag cgatcctggc gcctggcctg tgagtctgcc
     2641 tcctccaccg aagtgtctgg ggccttgaag agcaccagct gcagcataaa ccaccccatc
     2701 ttcccggaaa actcagaggt cacctttaat atcacgtttg atgtagactc taaggcttcc
     2761 cttggaaaca aactgctcct caaggccaat gtgaccagtg agaacaacat gcccagaacc
     2821 aacaaaaccg aattccaact ggagctgccg gtgaaatatg ctgtctacat ggtggtcacc
     2881 agccatgggg tctccactaa atatctcaac ttcacggcct cagagaatac cagtcgggtc
     2941 atgcagcatc aatatcaggt cagcaacctg gggcagagga gcctccccat cagcctggtg
     3001 ttcttggtgc ccgtccggct gaaccagact gtcatatggg accgccccca ggtcaccttc
     3061 tccgagaacc tctcgagtac gtgccacacc aaggagcgct tgccctctca ctccgacttt
     3121 ctggctgagc ttcggaaggc ccccgtggtg aactgctcca tcgctgtctg ccagagaatc
     3181 cagtgtgaca tcccgttctt tggcatccag gaagaattca atgctaccct caaaggcaac
     3241 ctctcgtttg actggtacat caagacctcg cataaccacc tcctgatcgt gagcacagct
     3301 gagatcttgt ttaacgattc cgtgttcacc ctgctgccgg gacagggggc gtttgtgagg
     3361 tcccagacgg agaccaaagt ggagccgttc gaggtcccca accccctgcc gctcatcgtg
     3421 ggcagctctg tcgggggact gctgctcctg gccctcatca ccgccgcgct gtacaagctc
     3481 ggcttcttca agcggcaata caaggacatg atgagtgaag ggggtccccc gggggccgaa
     3541 ccccagtagc ggctccttcc cgacagagct gcctctcggt ggccagcagg actctgccca
     3601 gaccacacgt agcccccagg ctgctggaca cgtcggacag cgaagtatcc ccgacaggac
     3661 gggcttgggc ttccatttgt gtgtgtgcaa gtgtgtatgt gcgtgtgtgc aagtgtctgt
     3721 gtgcaagtgt gtgcacatgt gtgcgtgtgc gtgcatgtgc acttgcacgc ccatgtgtga
     3781 gtgtgtgcaa gtatgtgagt gtgtccaagt gtgtgtgcgt gtgtccatgt gtgtgcaagt
     3841 gtgtgcatgt gtgcgagtgt gtgcatgtgt gtgctcaggg gcgtgtggct cacgtgtgtg
     3901 actcagatgt ctctggcgtg tgggtaggtg acggcagcgt agcctctccg gcagaaggga
     3961 actgcctggg ctcccttgtg cgtgggtgaa gccgctgctg ggttttcctc cgggagaggg
     4021 gacggtcaat cctgtgggtg aagacagagg gaaacacagc agcttctctc cactgaaaga
     4081 agtgggactt cccgtcgcct gcgagcctgc ggcctgctgg agcctgcgca gcttggatgg
     4141 agactccatg agaagccgtg ggtggaacca ggaacctcct ccacaccagc gctgatgccc
     4201 aataaagatg cccactgagg aatgatgaag cttcctttct ggattcattt attatttcaa
     4261 tgtgacttta attttttgga tggataagct tgtctatggt acaaaaatca caaggcattc
     4321 aagtgtacag tgaaaagtct ccctttccag atattcaagt cacctcctta aaggtagtca
     4381 agattgtgtt ttgaggtttc cttcagacag attccaggcg atgtgcaagt gtatgcacgt
     4441 gtgcacacac accacacata cacacacaca agctttttta cacaaatggt agcatacttt
     4501 atattggtct gtatcttgct ttttttcacc aatatttctc agacatcggt tcatattaag
     4561 acataaatta ctttttcatt cttttatacc gctgcatagt attccattgt gtgagtgtac
     4621 cataatgtat ttaaccagtc ttcttttgat atactatttt cattctcttg ttattgcatc
     4681 aatgctgagt taataaatca aatatatgtc atttttgca
//
