LOCUS       XM_005255313            5126 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens integrin subunit alpha L (ITGAL),
            transcript variant X1, mRNA.
ACCESSION   XM_005255313
VERSION     XM_005255313.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000016.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5126
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
     gene            1..5126
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /note="integrin subunit alpha L; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 126
                     ESTs, 313 long SRA reads, 10 Proteins, and 97% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 60 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:3683"
                     /db_xref="HGNC:HGNC:6148"
                     /db_xref="MIM:153370"
     CDS             97..3606
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /codon_start=1
                     /product="integrin alpha-L isoform X1"
                     /protein_id="XP_005255370.1"
                     /db_xref="GeneID:3683"
                     /db_xref="HGNC:HGNC:6148"
                     /db_xref="MIM:153370"
                     /translation="MKDSCITVMAMALLSGFFFFAPASSYNLDVRGARSFSPPRAGRH
                     FGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATD
                     PTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFL
                     FDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKRKDPD
                     ALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAA
                     KDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKIYVI
                     EGTSKQDLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGN
                     EPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQT
                     IHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVS
                     ELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPS
                     QRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRPVVDMVTLMSF
                     SPAEIPVHEVECSYSTSNKMKEGVNITICFQIKSLIPQFQGRLVANLTYTLQLDGHRT
                     RRRGLFPGGRHELRRNIAVTTSMSCTDFSFHFPVCVQDLISPINVSLNFSLWEEEGTP
                     RDQRAGKDIPPILRPSLHSETWEIPFEKNCGEDKKCEANLRVSFSPARSRALRLTAFA
                     SLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQIPVSCEELPEESRLLSR
                     ALSCNVSSPIFKAGHSVALQMMFNTLVNSSWGDSVELHANVTCNNEDSDLLEDNSATT
                     IIPILYPINILIQDQEDSTLYVSFTPKGPKIHQVKHMYQVRIQPSIHDHNIPTLEAVV
                     GVPQPPSEGPITHQWSVQMEPPVPCHYEDLERLPDAAEPCLPGALFRCPVVFRQEILV
                     QVIGTLELVGEIEASSMFSLCSSLSISFNSSKHFHLYGSNASLAQVVMKVDVVYEKQM
                     LYLYVLSGIGGLLLLLLIFIVLYKVGFFKRNLKEKMEAGRGVPNGIPAEDSEQLASGQ
                     EAGDPGCLKPLHEKDSESGGGKD"
ORIGIN      
        1 atcattttcc tctttcaccc tgtctaggtt gccagcaaat cccacgggcc tcctgacgct
       61 gcccctgggg ccacaggtcc ctcgagtgct ggaaggatga aggattcctg catcactgtg
      121 atggccatgg cgctgctgtc tgggttcttt ttcttcgcgc cggcctcgag ctacaacctg
      181 gacgtgcggg gcgcgcggag cttctcccca ccgcgcgccg ggaggcactt tggataccgc
      241 gtcctgcagg tcggaaacgg ggtcatcgtg ggagctccag gggaggggaa cagcacagga
      301 agcctctatc agtgccagtc gggcacagga cactgcctgc cagtcaccct gagaggttcc
      361 aactatacct ccaagtactt gggaatgacc ttggcaacag accccacaga tggaagcatt
      421 ttggcctgtg accctgggct gtctcgaacg tgtgaccaga acacctatct gagtggcctg
      481 tgttacctct tccgccagaa tctgcagggt cccatgctgc aggggcgccc tggttttcag
      541 gaatgtatca agggcaacgt agacctggta tttctgtttg atggttcgat gagcttgcag
      601 ccagatgaat ttcagaaaat tctggacttc atgaaggatg tgatgaagaa actcagcaac
      661 acttcgtacc agtttgctgc tgttcagttt tccacaagct acaaaacaga atttgatttc
      721 tcagattatg ttaaacggaa ggaccctgat gctctgctga agcatgtaaa gcacatgttg
      781 ctgttgacca atacctttgg tgccatcaat tatgtcgcga cagaggtgtt ccgggaggag
      841 ctgggggccc ggccagatgc caccaaagtg cttatcatca tcacggatgg ggaggccact
      901 gacagtggca acatcgatgc ggccaaagac atcatccgct acatcatcgg gattggaaag
      961 cattttcaga ccaaggagag tcaggagacc ctccacaaat ttgcatcaaa acccgcgagc
     1021 gagtttgtga aaattctgga cacatttgag aagctgaaag atctattcac tgagctgcag
     1081 aagaagatct atgtcattga gggcacaagc aaacaggacc tgacttcctt caacatggag
     1141 ctgtcctcca gcggcatcag tgctgacctc agcaggggcc atgcagtcgt gggggcagta
     1201 ggagccaagg actgggctgg gggctttctt gacctgaagg cagacctgca ggatgacaca
     1261 tttattggga atgaaccatt gacaccagaa gtgagagcag gctatttggg ttacaccgtg
     1321 acctggctgc cctcccggca aaagacttcg ttgctggcct cgggagcccc tcgataccag
     1381 cacatgggcc gagtgctgct gttccaagag ccacagggcg gaggacactg gagccaggtc
     1441 cagacaatcc atgggaccca gattggctct tatttcggtg gggagctgtg tggcgtcgac
     1501 gtggaccaag atggggagac agagctgctg ctgattggtg ccccactgtt ctatggggag
     1561 cagagaggag gccgggtgtt tatctaccag agaagacagt tggggtttga agaagtctca
     1621 gagctgcagg gggaccccgg ctacccactc gggcggtttg gagaagccat cactgctctg
     1681 acagacatca acggcgatgg gctggtagac gtggctgtgg gggcccctct ggaggagcag
     1741 ggggctgtgt acatcttcaa tgggaggcac ggggggctta gtccccagcc aagtcagcgg
     1801 atagaaggga cccaagtgct ctcaggaatt cagtggtttg gacgctccat ccatggggtg
     1861 aaggaccttg aaggggatgg cttggcagat gtggctgtgg gggctgagag ccagatgatc
     1921 gtgctgagct cccggcccgt ggtggatatg gtcaccctga tgtccttctc tccagctgag
     1981 atcccagtgc atgaagtgga gtgctcctat tcaaccagta acaagatgaa agaaggagtt
     2041 aatatcacaa tctgtttcca gatcaagtct ctcatccccc agttccaagg ccgcctggtt
     2101 gccaatctca cttacactct gcagctggat ggccaccgga ccagaagacg ggggttgttc
     2161 ccaggaggga gacatgaact cagaaggaat atagctgtca ccaccagcat gtcatgcact
     2221 gacttctcat ttcatttccc ggtatgtgtt caagacctca tctcccccat caatgtttcc
     2281 ctgaatttct ctctttggga ggaggaaggg acaccgaggg accaaagggc gggcaaggac
     2341 ataccgccca tcctgagacc ctccctgcac tcggaaacct gggagatccc ttttgagaag
     2401 aactgtgggg aggacaagaa gtgtgaggca aacttgagag tgtccttctc tcctgcaaga
     2461 tccagagccc tgcgtctaac tgcttttgcc agcctctctg tggagctgag cctgagtaac
     2521 ttggaagaag atgcttactg ggtccagctg gacctgcact tccccccggg actctccttc
     2581 cgcaaggtgg agatgctgaa gccccatagc cagatacctg tgagctgcga ggagcttcct
     2641 gaagagtcca ggcttctgtc cagggcatta tcttgcaatg tgagctctcc catcttcaaa
     2701 gcaggccact cggttgctct gcagatgatg tttaatacac tggtaaacag ctcctggggg
     2761 gactcggttg aattgcacgc caatgtgacc tgtaacaatg aggactcaga cctcctggag
     2821 gacaactcag ccactaccat catccccatc ctgtacccca tcaacatcct catccaggac
     2881 caagaagact ccacactcta tgtcagtttc acccccaaag gccccaagat ccaccaagtc
     2941 aagcacatgt accaggtgag gatccagcct tccatccacg accacaacat acccaccctg
     3001 gaggctgtgg ttggggtgcc acagcctccc agcgaggggc ccatcacaca ccagtggagc
     3061 gtgcagatgg agcctcccgt gccctgccac tatgaggatc tggagaggct cccggatgca
     3121 gctgagcctt gtctccccgg agccctgttc cgctgccctg ttgtcttcag gcaggagatc
     3181 ctcgtccaag tgatcgggac tctggagctg gtgggagaga tcgaggcctc ttccatgttc
     3241 agcctctgca gctccctctc catctccttc aacagcagca agcatttcca cctctatggc
     3301 agcaacgcct ccctggccca ggttgtcatg aaggttgacg tggtgtatga gaagcagatg
     3361 ctctacctct acgtgctgag cggcatcggg gggctgctgc tgctgctgct cattttcata
     3421 gtgctgtaca aggttggttt cttcaaacgg aacctgaagg agaagatgga ggctggcaga
     3481 ggtgtcccga atggaatccc tgcagaagac tctgagcagc tggcatctgg gcaagaggct
     3541 ggggatcccg gctgcctgaa gcccctccat gagaaggact ctgagagtgg tggtggcaag
     3601 gactgagtcc aggcctgtga ggtgcagagt gcccagaact ggactcagga tgcccagggc
     3661 cactctgcct ctgcctgcat tctgccgtgt gccctcgggc gagtcactgc ctctccctgg
     3721 ccctcagttt ccctatctcg aacatggaac tcattcctgc ctgtctcctt tgcaggctca
     3781 tagggaagac ctgctgaggg accagccaag agggctgcaa aagtgagggc ttgtcattac
     3841 cagacggttc accagcctct cttggtttcc ttccttggaa gagaatgtct gatctaaatg
     3901 tggagaaact gtagtctcag gacctaggga tgttctggcc ctcacccctg ccctgggatg
     3961 tccacagatg cctccacccc ccagaacctg tccttgcaca ctcccctgca ctggagtcca
     4021 gtctcttctg ctggcagaaa gcaaatgtga cctgtgtcac tacgtgactg tggcacacgc
     4081 cttgttcttg gccaaagacc aaattccttg gcatgccttc cagcaccctg caaaatgaga
     4141 ccctcgtggc cttccccagc ctcttctaga gccgtgatgc ctccctgttg aagctctggt
     4201 gacaccagcc tttctcccag gccaggctcc ttcctgtctt cctgcattca cccagacagc
     4261 tccctctgcc tgaaccttcc atctcgccac ccctccttcc ttgaccagca gatcccagct
     4321 cacgtcacac ttggttgggt cctcacatct ttcacacttc caccagcctg cactactccc
     4381 tcaaagcaca cgtcatgttt cttcatccgg cagcctggat gttttttccc tgtttaatga
     4441 ttgacgtact tagcagctat ctctcagtga actgtgaggg taaaggctat acttgtcttg
     4501 ttcaccttgg gatgatgcct catgatatgt cagggcgtgg gacatctagt aggtgcttga
     4561 cataatttca ctgaattaat gacagagcca gtgggaagat acagaaaaag aggggctggg
     4621 ctgggcgcgg tggttcacgc ctgtaatccc agcactttgg gaggccaagg agggtggatc
     4681 acctgaggtc aggagttaga ggccagcctg gcgaaacccc atctctacta aaaatacaaa
     4741 atccaggcgt ggtggcacac acctgtagtc ccagctactc aggaggttga ggtaggagaa
     4801 ttgcttgaac ctgggaggtg gaggttgcag tgagccaaga ttgcgccatt gcactccagc
     4861 ctgggcaaca cagcgagact ccgtctcaag gaaaaaataa aaataaaaag cgggcacggg
     4921 cccgtgacat ccccaccctt ggaggctgtc ttctcaggct ctgccctgcc ctagctccac
     4981 accctctccc aggacccatc acgcctgtgc agtggccccc acagaaagac tgagctcaag
     5041 gtgggaacca cgtctgctaa cttggagccc cagtgccaag cacagtgcct gcatgtattt
     5101 atccaataaa tgtgaaattc tgtcca
//
