LOCUS       NM_002209               5129 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens integrin subunit alpha L (ITGAL), transcript variant
            1, mRNA.
ACCESSION   NM_002209
VERSION     NM_002209.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5129)
  AUTHORS   Zhang,R., Zhu,G., Li,Z., Meng,Z., Huang,H., Ding,C., Wang,Y.,
            Chen,C., Li,Y., Liu,H. and Chen,J.
  TITLE     ITGAL expression in non-small-cell lung cancer tissue and its
            association with immune infiltrates
  JOURNAL   Front Immunol 15, 1382231 (2024)
   PUBMED   38646528
  REMARK    GeneRIF: ITGAL expression in non-small-cell lung cancer tissue and
            its association with immune infiltrates.
            Erratum:[Front Immunol. 2024 Apr 26;15:1415814. doi:
            10.3389/fimmu.2024.1415814.. PMID: 38736883]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5129)
  AUTHORS   Lacouture,C., Chaves,B., Guipouy,D., Houmadi,R., Duplan-Eche,V.,
            Allart,S., Destainville,N. and Dupre,L.
  TITLE     LFA-1 nanoclusters integrate TCR stimulation strength to tune
            T-cell cytotoxic activity
  JOURNAL   Nat Commun 15 (1), 407 (2024)
   PUBMED   38195629
  REMARK    GeneRIF: LFA-1 nanoclusters integrate TCR stimulation strength to
            tune T-cell cytotoxic activity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5129)
  AUTHORS   Wang,Q., Xiao,G., Li,N., Jiang,X. and Li,C.
  TITLE     lncRNA PCBP1-AS1 mediated downregulation of ITGAL as a prognostic
            biomarker in lung adenocarcinoma
  JOURNAL   Aging (Albany NY) 15 (10), 4510-4523 (2023)
   PUBMED   37256932
  REMARK    GeneRIF: lncRNA PCBP1-AS1 mediated downregulation of ITGAL as a
            prognostic biomarker in lung adenocarcinoma.
REFERENCE   4  (bases 1 to 5129)
  AUTHORS   Hickman,A., Koetsier,J., Kurtanich,T., Nielsen,M.C., Winn,G.,
            Wang,Y., Bentebibel,S.E., Shi,L., Punt,S., Williams,L.,
            Haymaker,C., Chesson,C.B., Fa'ak,F., Dominguez,A.L., Jones,R.,
            Kuiatse,I., Caivano,A.R., Khounlo,S., Warier,N.D., Marathi,U.,
            Market,R.V., Biediger,R.J., Craft,J.W. Jr., Hwu,P., Davies,M.A.,
            Woodside,D.G., Vanderslice,P., Diab,A., Overwijk,W.W. and
            Hailemichael,Y.
  TITLE     LFA-1 activation enriches tumor-specific T cells in a cold tumor
            model and synergizes with CTLA-4 blockade
  JOURNAL   J Clin Invest 132 (13) (2022)
   PUBMED   35552271
  REMARK    GeneRIF: LFA-1 activation enriches tumor-specific T cells in a cold
            tumor model and synergizes with CTLA-4 blockade.
REFERENCE   5  (bases 1 to 5129)
  AUTHORS   Garcia-Salido,A., Cuenca-Carcelen,S. and Castillo-Robleda,A.
  TITLE     CD64, CD11a and CD18 leukocytes expression in children with
            SARS-CoV-2 multisystem inflammatory syndrome versus children with
            Kawasaki disease: Similar but not the same
  JOURNAL   Med Clin (Barc) 156 (2), 89-91 (2021)
   PUBMED   33160625
  REMARK    GeneRIF: CD64, CD11a and CD18 leukocytes expression in children
            with SARS-CoV-2 multisystem inflammatory syndrome versus children
            with Kawasaki disease: Similar but not the same.
REFERENCE   6  (bases 1 to 5129)
  AUTHORS   Fawcett,J., Holness,C.L., Needham,L.A., Turley,H., Gatter,K.C.,
            Mason,D.Y. and Simmons,D.L.
  TITLE     Molecular cloning of ICAM-3, a third ligand for LFA-1,
            constitutively expressed on resting leukocytes
  JOURNAL   Nature 360 (6403), 481-484 (1992)
   PUBMED   1448173
REFERENCE   7  (bases 1 to 5129)
  AUTHORS   Alvarez,V., Pulido,R., Campanero,M.R., Paraiso,V., de
            Landazuri,M.O. and Sanchez-Madrid,F.
  TITLE     Differentially regulated cell surface expression of leukocyte
            adhesion receptors on neutrophils
  JOURNAL   Kidney Int 40 (5), 899-905 (1991)
   PUBMED   1762294
REFERENCE   8  (bases 1 to 5129)
  AUTHORS   Maurer,D., Holter,W., Majdic,O., Fischer,G.F. and Knapp,W.
  TITLE     CD27 expression by a distinct subpopulation of human B lymphocytes
  JOURNAL   Eur J Immunol 20 (12), 2679-2684 (1990)
   PUBMED   1702722
REFERENCE   9  (bases 1 to 5129)
  AUTHORS   Dustin,M.L. and Springer,T.A.
  TITLE     T-cell receptor cross-linking transiently stimulates adhesiveness
            through LFA-1
  JOURNAL   Nature 341 (6243), 619-624 (1989)
   PUBMED   2477710
REFERENCE   10 (bases 1 to 5129)
  AUTHORS   Larson,R.S., Corbi,A.L., Berman,L. and Springer,T.
  TITLE     Primary structure of the leukocyte function-associated molecule-1
            alpha subunit: an integrin with an embedded domain defining a
            protein superfamily
  JOURNAL   J Cell Biol 108 (2), 703-712 (1989)
   PUBMED   2537322
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK314246.1, BC008777.2 and
            CA430398.1.
            
            On May 17, 2019 this sequence version replaced NM_002209.2.
            
            Summary: ITGAL encodes the integrin alpha L chain. Integrins are
            heterodimeric integral membrane proteins composed of an alpha chain
            and a beta chain. This I-domain containing alpha integrin combines
            with the beta 2 chain (ITGB2) to form the integrin lymphocyte
            function-associated antigen-1 (LFA-1), which is expressed on all
            leukocytes. LFA-1 plays a central role in leukocyte intercellular
            adhesion through interactions with its ligands, ICAMs 1-3
            (intercellular adhesion molecules 1 through 3), and also functions
            in lymphocyte costimulatory signaling. Two transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y00796.1, AK314246.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356798.11/ ENSP00000349252.5
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1283              AK314246.1         35-1317
            1284-2331           BC008777.2         1048-2095
            2332-3609           AK314246.1         2366-3643
            3610-4900           BC008777.2         3371-4661
            4901-5129           CA430398.1         18-246              c
FEATURES             Location/Qualifiers
     source          1..5129
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..5129
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /note="integrin subunit alpha L"
                     /db_xref="GeneID:3683"
                     /db_xref="HGNC:HGNC:6148"
                     /db_xref="MIM:153370"
     exon            1..157
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..3609
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; antigen CD11A (p180), lymphocyte
                     function-associated antigen 1, alpha polypeptide; integrin
                     alpha-L; LFA-1 alpha; integrin gene promoter; LFA-1A; CD11
                     antigen-like family member A; leukocyte adhesion
                     glycoprotein LFA-1 alpha chain; leukocyte
                     function-associated molecule 1 alpha chain; integrin,
                     alpha L (antigen CD11A (p180), lymphocyte
                     function-associated antigen 1; alpha polypeptide)"
                     /codon_start=1
                     /product="integrin alpha-L isoform a precursor"
                     /protein_id="NP_002200.2"
                     /db_xref="CCDS:CCDS32433.1"
                     /db_xref="GeneID:3683"
                     /db_xref="HGNC:HGNC:6148"
                     /db_xref="MIM:153370"
                     /translation="MKDSCITVMAMALLSGFFFFAPASSYNLDVRGARSFSPPRAGRH
                     FGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATD
                     PTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFL
                     FDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKRKDPD
                     ALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAA
                     KDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKIYVI
                     EGTSKQDLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGN
                     EPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQT
                     IHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVS
                     ELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPS
                     QRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRPVVDMVTLMSF
                     SPAEIPVHEVECSYSTSNKMKEGVNITICFQIKSLIPQFQGRLVANLTYTLQLDGHRT
                     RRRGLFPGGRHELRRNIAVTTSMSCTDFSFHFPVCVQDLISPINVSLNFSLWEEEGTP
                     RDQRAQGKDIPPILRPSLHSETWEIPFEKNCGEDKKCEANLRVSFSPARSRALRLTAF
                     ASLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQIPVSCEELPEESRLLS
                     RALSCNVSSPIFKAGHSVALQMMFNTLVNSSWGDSVELHANVTCNNEDSDLLEDNSAT
                     TIIPILYPINILIQDQEDSTLYVSFTPKGPKIHQVKHMYQVRIQPSIHDHNIPTLEAV
                     VGVPQPPSEGPITHQWSVQMEPPVPCHYEDLERLPDAAEPCLPGALFRCPVVFRQEIL
                     VQVIGTLELVGEIEASSMFSLCSSLSISFNSSKHFHLYGSNASLAQVVMKVDVVYEKQ
                     MLYLYVLSGIGGLLLLLLIFIVLYKVGFFKRNLKEKMEAGRGVPNGIPAEDSEQLASG
                     QEAGDPGCLKPLHEKDSESGGGKD"
     exon            158..260
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            261..355
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            356..423
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            424..541
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            542..672
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            673..818
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            819..951
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1102
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1176
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1309
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1461
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1599
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1797
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1928
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2089
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2241
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2331
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2388
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2462
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..2604
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2715
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2716..2795
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..2882
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..2958
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2959..3072
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            3073..3129
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            3130..3228
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            3229..3324
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            3325..3435
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     exon            3436..5129
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5108..5113
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /note="hexamer: AATAAA"
     polyA_site      5129
                     /gene="ITGAL"
                     /gene_synonym="CD11A; LFA-1; LFA1A"
                     /note="major polyA site"
ORIGIN      
        1 atcattttcc tctttcaccc tgtctaggtt gccagcaaat cccacgggcc tcctgacgct
       61 gcccctgggg ccacaggtcc ctcgagtgct ggaaggatga aggattcctg catcactgtg
      121 atggccatgg cgctgctgtc tgggttcttt ttcttcgcgc cggcctcgag ctacaacctg
      181 gacgtgcggg gcgcgcggag cttctcccca ccgcgcgccg ggaggcactt tggataccgc
      241 gtcctgcagg tcggaaacgg ggtcatcgtg ggagctccag gggaggggaa cagcacagga
      301 agcctctatc agtgccagtc gggcacagga cactgcctgc cagtcaccct gagaggttcc
      361 aactatacct ccaagtactt gggaatgacc ttggcaacag accccacaga tggaagcatt
      421 ttggcctgtg accctgggct gtctcgaacg tgtgaccaga acacctatct gagtggcctg
      481 tgttacctct tccgccagaa tctgcagggt cccatgctgc aggggcgccc tggttttcag
      541 gaatgtatca agggcaacgt agacctggta tttctgtttg atggttcgat gagcttgcag
      601 ccagatgaat ttcagaaaat tctggacttc atgaaggatg tgatgaagaa actcagcaac
      661 acttcgtacc agtttgctgc tgttcagttt tccacaagct acaaaacaga atttgatttc
      721 tcagattatg ttaaacggaa ggaccctgat gctctgctga agcatgtaaa gcacatgttg
      781 ctgttgacca atacctttgg tgccatcaat tatgtcgcga cagaggtgtt ccgggaggag
      841 ctgggggccc ggccagatgc caccaaagtg cttatcatca tcacggatgg ggaggccact
      901 gacagtggca acatcgatgc ggccaaagac atcatccgct acatcatcgg gattggaaag
      961 cattttcaga ccaaggagag tcaggagacc ctccacaaat ttgcatcaaa acccgcgagc
     1021 gagtttgtga aaattctgga cacatttgag aagctgaaag atctattcac tgagctgcag
     1081 aagaagatct atgtcattga gggcacaagc aaacaggacc tgacttcctt caacatggag
     1141 ctgtcctcca gcggcatcag tgctgacctc agcaggggcc atgcagtcgt gggggcagta
     1201 ggagccaagg actgggctgg gggctttctt gacctgaagg cagacctgca ggatgacaca
     1261 tttattggga atgaaccatt gacaccagaa gtgagagcag gctatttggg ttacaccgtg
     1321 acctggctgc cctcccggca aaagacttcg ttgctggcct cgggagcccc tcgataccag
     1381 cacatgggcc gagtgctgct gttccaagag ccacagggcg gaggacactg gagccaggtc
     1441 cagacaatcc atgggaccca gattggctct tatttcggtg gggagctgtg tggcgtcgac
     1501 gtggaccaag atggggagac agagctgctg ctgattggtg ccccactgtt ctatggggag
     1561 cagagaggag gccgggtgtt tatctaccag agaagacagt tggggtttga agaagtctca
     1621 gagctgcagg gggaccccgg ctacccactc gggcggtttg gagaagccat cactgctctg
     1681 acagacatca acggcgatgg gctggtagac gtggctgtgg gggcccctct ggaggagcag
     1741 ggggctgtgt acatcttcaa tgggaggcac ggggggctta gtccccagcc aagtcagcgg
     1801 atagaaggga cccaagtgct ctcaggaatt cagtggtttg gacgctccat ccatggggtg
     1861 aaggaccttg aaggggatgg cttggcagat gtggctgtgg gggctgagag ccagatgatc
     1921 gtgctgagct cccggcccgt ggtggatatg gtcaccctga tgtccttctc tccagctgag
     1981 atcccagtgc atgaagtgga gtgctcctat tcaaccagta acaagatgaa agaaggagtt
     2041 aatatcacaa tctgtttcca gatcaagtct ctcatccccc agttccaagg ccgcctggtt
     2101 gccaatctca cttacactct gcagctggat ggccaccgga ccagaagacg ggggttgttc
     2161 ccaggaggga gacatgaact cagaaggaat atagctgtca ccaccagcat gtcatgcact
     2221 gacttctcat ttcatttccc ggtatgtgtt caagacctca tctcccccat caatgtttcc
     2281 ctgaatttct ctctttggga ggaggaaggg acaccgaggg accaaagggc gcagggcaag
     2341 gacataccgc ccatcctgag accctccctg cactcggaaa cctgggagat cccttttgag
     2401 aagaactgtg gggaggacaa gaagtgtgag gcaaacttga gagtgtcctt ctctcctgca
     2461 agatccagag ccctgcgtct aactgctttt gccagcctct ctgtggagct gagcctgagt
     2521 aacttggaag aagatgctta ctgggtccag ctggacctgc acttcccccc gggactctcc
     2581 ttccgcaagg tggagatgct gaagccccat agccagatac ctgtgagctg cgaggagctt
     2641 cctgaagagt ccaggcttct gtccagggca ttatcttgca atgtgagctc tcccatcttc
     2701 aaagcaggcc actcggttgc tctgcagatg atgtttaata cactggtaaa cagctcctgg
     2761 ggggactcgg ttgaattgca cgccaatgtg acctgtaaca atgaggactc agacctcctg
     2821 gaggacaact cagccactac catcatcccc atcctgtacc ccatcaacat cctcatccag
     2881 gaccaagaag actccacact ctatgtcagt ttcaccccca aaggccccaa gatccaccaa
     2941 gtcaagcaca tgtaccaggt gaggatccag ccttccatcc acgaccacaa catacccacc
     3001 ctggaggctg tggttggggt gccacagcct cccagcgagg ggcccatcac acaccagtgg
     3061 agcgtgcaga tggagcctcc cgtgccctgc cactatgagg atctggagag gctcccggat
     3121 gcagctgagc cttgtctccc cggagccctg ttccgctgcc ctgttgtctt caggcaggag
     3181 atcctcgtcc aagtgatcgg gactctggag ctggtgggag agatcgaggc ctcttccatg
     3241 ttcagcctct gcagctccct ctccatctcc ttcaacagca gcaagcattt ccacctctat
     3301 ggcagcaacg cctccctggc ccaggttgtc atgaaggttg acgtggtgta tgagaagcag
     3361 atgctctacc tctacgtgct gagcggcatc ggggggctgc tgctgctgct gctcattttc
     3421 atagtgctgt acaaggttgg tttcttcaaa cggaacctga aggagaagat ggaggctggc
     3481 agaggtgtcc cgaatggaat ccctgcagaa gactctgagc agctggcatc tgggcaagag
     3541 gctggggatc ccggctgcct gaagcccctc catgagaagg actctgagag tggtggtggc
     3601 aaggactgag tccaggcctg tgaggtgcag agtgcccaga actggactca ggatgcccag
     3661 ggccactctg cctctgcctg cattctgccg tgtgccctcg ggcgagtcac tgcctctccc
     3721 tggccctcag tttccctatc tcgaacatgg aactcattcc tgcctgtctc ctttgcaggc
     3781 tcatagggaa gacctgctga gggaccagcc aagagggctg caaaagtgag ggcttgtcat
     3841 taccagacgg ttcaccagcc tctcttggtt tccttccttg gaagagaatg tctgatctaa
     3901 atgtggagaa actgtagtct caggacctag ggatgttctg gccctcaccc ctgccctggg
     3961 atgtccacag atgcctccac cccccagaac ctgtccttgc acactcccct gcactggagt
     4021 ccagtctctt ctgctggcag aaagcaaatg tgacctgtgt cactacgtga ctgtggcaca
     4081 cgccttgttc ttggccaaag accaaattcc ttggcatgcc ttccagcacc ctgcaaaatg
     4141 agaccctcgt ggccttcccc agcctcttct agagccgtga tgcctccctg ttgaagctct
     4201 ggtgacacca gcctttctcc caggccaggc tccttcctgt cttcctgcat tcacccagac
     4261 agctccctct gcctgaacct tccatctcgc cacccctcct tccttgacca gcagatccca
     4321 gctcacgtca cacttggttg ggtcctcaca tctttcacac ttccaccagc ctgcactact
     4381 ccctcaaagc acacgtcatg tttcttcatc cggcagcctg gatgtttttt ccctgtttaa
     4441 tgattgacgt acttagcagc tatctctcag tgaactgtga gggtaaaggc tatacttgtc
     4501 ttgttcacct tgggatgatg cctcatgata tgtcagggcg tgggacatct agtaggtgct
     4561 tgacataatt tcactgaatt aatgacagag ccagtgggaa gatacagaaa aagaggggct
     4621 gggctgggcg cggtggttca cgcctgtaat cccagcactt tgggaggcca aggagggtgg
     4681 atcacctgag gtcaggagtt agaggccagc ctggcgaaac cccatctcta ctaaaaatac
     4741 aaaatccagg cgtggtggca cacacctgta gtcccagcta ctcaggaggt tgaggtagga
     4801 gaattgcttg aacctgggag gtggaggttg cagtgagcca agattgcgcc attgcactcc
     4861 agcctgggca acacagcgag actccgtctc aaggaaaaaa taaaaataaa aagcgggcac
     4921 gggcccgtga catccccacc cttggaggct gtcttctcag gctctgccct gccctagctc
     4981 cacaccctct cccaggaccc atcacgcctg tgcagtggcc cccacagaaa gactgagctc
     5041 aaggtgggaa ccacgtctgc taacttggag ccccagtgcc aagcacagtg cctgcatgta
     5101 tttatccaat aaatgtgaaa ttctgtcca
//
