LOCUS       NM_002208               3803 bp    mRNA    linear   PRI 27-AUG-2024
DEFINITION  Homo sapiens integrin subunit alpha E (ITGAE), transcript variant
            1, mRNA.
ACCESSION   NM_002208
VERSION     NM_002208.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3803)
  AUTHORS   Akasaka,H., Sato,D., Shihoya,W., Nureki,O. and Kise,Y.
  TITLE     Cryo-EM structure of I domain-containing integrin alphaEbeta7
  JOURNAL   Biochem Biophys Res Commun 721, 150121 (2024)
   PUBMED   38781659
  REMARK    GeneRIF: Cryo-EM structure of I domain-containing integrin
            alphaEbeta7.
REFERENCE   2  (bases 1 to 3803)
  AUTHORS   Hamid,M.H.B.A., Cespedes,P.F., Jin,C., Chen,J.L., Gileadi,U.,
            Antoun,E., Liang,Z., Gao,F., Teague,R., Manoharan,N.,
            Maldonado-Perez,D., Khalid-Alham,N., Cerundolo,L., Ciaoca,R.,
            Hester,S.S., Pinto-Fernandez,A., Draganov,S.D., Vendrell,I.,
            Liu,G., Yao,X., Kvalvaag,A., Dominey-Foy,D.C.C., Nanayakkara,C.,
            Kanellakis,N., Chen,Y.L., Waugh,C., Clark,S.A., Clark,K., Sopp,P.,
            Rahman,N.M., Verrill,C., Kessler,B.M., Ogg,G., Fernandes,R.A.,
            Fisher,R., Peng,Y., Dustin,M.L. and Dong,T.
  TITLE     Unconventional human CD61 pairing with CD103 promotes TCR signaling
            and antigen-specific T cell cytotoxicity
  JOURNAL   Nat Immunol 25 (5), 834-846 (2024)
   PUBMED   38561495
  REMARK    GeneRIF: Unconventional human CD61 pairing with CD103 promotes TCR
            signaling and antigen-specific T cell cytotoxicity.
REFERENCE   3  (bases 1 to 3803)
  AUTHORS   van den Bulk,J., van der Ploeg,M., Ijsselsteijn,M.E., Ruano,D., van
            der Breggen,R., Duhen,R., Peeters,K.C.M.J., Farina-Sarasqueta,A.,
            Verdegaal,E.M.E., van der Burg,S.H., Duhen,T. and de
            Miranda,N.F.C.C.
  TITLE     CD103 and CD39 coexpression identifies neoantigen-specific
            cytotoxic T cells in colorectal cancers with low mutation burden
  JOURNAL   J Immunother Cancer 11 (2) (2023)
   PUBMED   36792124
  REMARK    GeneRIF: CD103 and CD39 coexpression identifies neoantigen-specific
            cytotoxic T cells in colorectal cancers with low mutation burden.
REFERENCE   4  (bases 1 to 3803)
  AUTHORS   Nose,Y., Saito,T., Yamamoto,K., Yamashita,K., Tanaka,K.,
            Yamamoto,K., Makino,T., Takahashi,T., Kawashima,A., Haruna,M.,
            Hirata,M., Ueyama,A., Iwahori,K., Satoh,T., Kurokawa,Y., Eguchi,H.,
            Doki,Y. and Wada,H.
  TITLE     The tissue-resident marker CD103 on peripheral blood T cells
            predicts responses to anti-PD-1 therapy in gastric cancer
  JOURNAL   Cancer Immunol Immunother 72 (1), 169-181 (2023)
   PUBMED   35776160
  REMARK    GeneRIF: The tissue-resident marker CD103 on peripheral blood T
            cells predicts responses to anti-PD-1 therapy in gastric cancer.
REFERENCE   5  (bases 1 to 3803)
  AUTHORS   Xu,W., Bergsbaken,T. and Edelblum,K.L.
  TITLE     The multifunctional nature of CD103 (alphaEbeta7 integrin)
            signaling in tissue-resident lymphocytes
  JOURNAL   Am J Physiol Cell Physiol 323 (4), C1161-C1167 (2022)
   PUBMED   36036450
  REMARK    GeneRIF: The multifunctional nature of CD103 (alphaEbeta7 integrin)
            signaling in tissue-resident lymphocytes.
            Review article
REFERENCE   6  (bases 1 to 3803)
  AUTHORS   Austrup,F., Rebstock,S., Kilshaw,P.J. and Hamann,A.
  TITLE     Transforming growth factor-beta 1-induced expression of the
            mucosa-related integrin alpha E on lymphocytes is not associated
            with mucosa-specific homing
  JOURNAL   Eur J Immunol 25 (6), 1487-1491 (1995)
   PUBMED   7614974
REFERENCE   7  (bases 1 to 3803)
  AUTHORS   Begue,B., Sarnacki,S., le Deist,F., Buc,H., Gagnon,J., Meo,T. and
            Cerf-Bensussan,N.
  TITLE     HML-1, a novel integrin made of the beta 7 chain and of a
            distinctive alpha chain, exerts an accessory function in the
            activation of human IEL via the CD3-TCR pathway
  JOURNAL   Adv Exp Med Biol 371A, 67-75 (1995)
   PUBMED   8526015
REFERENCE   8  (bases 1 to 3803)
  AUTHORS   Shaw,S.K., Cepek,K.L., Murphy,E.A., Russell,G.J., Brenner,M.B. and
            Parker,C.M.
  TITLE     Molecular cloning of the human mucosal lymphocyte integrin alpha E
            subunit. Unusual structure and restricted RNA distribution
  JOURNAL   J Biol Chem 269 (8), 6016-6025 (1994)
   PUBMED   8119947
REFERENCE   9  (bases 1 to 3803)
  AUTHORS   Parker,C.M., Cepek,K.L., Russell,G.J., Shaw,S.K., Posnett,D.N.,
            Schwarting,R. and Brenner,M.B.
  TITLE     A family of beta 7 integrins on human mucosal lymphocytes
  JOURNAL   Proc Natl Acad Sci U S A 89 (5), 1924-1928 (1992)
   PUBMED   1542691
REFERENCE   10 (bases 1 to 3803)
  AUTHORS   Cerf-Bensussan,N., Jarry,A., Brousse,N., Lisowska-Grospierre,B.,
            Guy-Grand,D. and Griscelli,C.
  TITLE     A monoclonal antibody (HML-1) defining a novel membrane molecule
            present on human intestinal lymphocytes
  JOURNAL   Eur J Immunol 17 (9), 1279-1285 (1987)
   PUBMED   3498635
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from L25851.2 and AC116914.5.
            
            On Nov 24, 2018 this sequence version replaced NM_002208.4.
            
            Summary: Integrins are heterodimeric integral membrane proteins
            composed of an alpha chain and a beta chain. This gene encodes an
            I-domain-containing alpha integrin that undergoes
            post-translational cleavage in the extracellular domain, yielding
            disulfide-linked heavy and light chains. In combination with the
            beta 7 integrin, this protein forms the E-cadherin binding integrin
            known as the human mucosal lymphocyte-1 antigen. This protein is
            preferentially expressed in human intestinal intraepithelial
            lymphocytes (IEL), and in addition to a role in adhesion, it may
            serve as an accessory molecule for IEL activation. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L25851.2, BC113436.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263087.9/ ENSP00000263087.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1472              L25851.2           82-1553
            1473-1489           AC116914.5         48303-48319         c
            1490-2206           L25851.2           1571-2287
            2207-2207           AC116914.5         40358-40358         c
            2208-3099           L25851.2           2289-3180
            3100-3100           AC116914.5         22385-22385         c
            3101-3803           L25851.2           3182-3884
FEATURES             Location/Qualifiers
     source          1..3803
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..3803
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /note="integrin subunit alpha E"
                     /db_xref="GeneID:3682"
                     /db_xref="HGNC:HGNC:6147"
                     /db_xref="MIM:604682"
     exon            1..78
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..3584
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; HML-1 antigen; integrin alpha-IEL; antigen
                     CD103, human mucosal lymphocyte antigen 1; alpha
                     polypeptide; integrin alpha-E; mucosal lymphocyte 1
                     antigen; integrin, alpha E (antigen CD103, human mucosal
                     lymphocyte antigen 1; alpha polypeptide); human mucosal
                     lymphocyte antigen 1, alpha polypeptide"
                     /codon_start=1
                     /product="integrin alpha-E isoform 1 precursor"
                     /protein_id="NP_002199.3"
                     /db_xref="CCDS:CCDS32531.1"
                     /db_xref="GeneID:3682"
                     /db_xref="HGNC:HGNC:6147"
                     /db_xref="MIM:604682"
                     /translation="MWLFHTLLCIASLALLAAFNVDVARPWLTPKGGAPFVLSSLLHQ
                     DPSTNQTWLLVTSPRTKRTPGPLHRCSLVQDEILCHPVEHVPIPKGRHRGVTVVRSHH
                     GVLICIQVLVRRPHSLSSELTGTCSLLGPDLRPQAQANFFDLENLLDPDARVDTGDCY
                     SNKEGGGEDDVNTARQRRALEKEEEEDKEEEEDEEEEEAGTEIAIILDGSGSIDPPDF
                     QRAKDFISNMMRNFYEKCFECNFALVQYGGVIQTEFDLRDSQDVMASLARVQNITQVG
                     SVTKTASAMQHVLDSIFTSSHGSRRKASKVMVVLTDGGIFEDPLNLTTVINSPKMQGV
                     ERFAIGVGEEFKSARTARELNLIASDPDETHAFKVTNYMALDGLLSKLRYNIISMEGT
                     VGDALHYQLAQIGFSAQILDERQVLLGAVGAFDWSGGALLYDTRSRRGRFLNQTAAAA
                     ADAEAAQYSYLGYAVAVLHKTCSLSYIAGAPRYKHHGAVFELQKEGREASFLPVLEGE
                     QMGSYFGSELCPVDIDMDGSTDFLLVAAPFYHVHGEEGRVYVYRLSEQDGSFSLARIL
                     SGHPGFTNARFGFAMAAMGDLSQDKLTDVAIGAPLEGFGADDGASFGSVYIYNGHWDG
                     LSASPSQRIRASTVAPGLQYFGMSMAGGFDISGDGLADITVGTLGQAVVFRSRPVVRL
                     KVSMAFTPSALPIGFNGVVNVRLCFEISSVTTASESGLREALLNFTLDVDVGKQRRRL
                     QCSDVRSCLGCLREWSSGSQLCEDLLLMPTEGELCEEDCFSNASVKVSYQLQTPEGQT
                     DHPQPILDRYTEPFAIFQLPYEKACKNKLFCVAELQLATTVSQQELVVGLTKELTLNI
                     NLTNSGEDSYMTSMALNYPRNLQLKRMQKPPSPNIQCDDPQPVASVLIMNCRIGHPVL
                     KRSSAHVSVVWQLEENAFPNRTADITVTVTNSNERRSLANETHTLQFRHGFVAVLSKP
                     SIMYVNTGQGLSHHKEFLFHVHGENLFGAEYQLQICVPTKLRGLQVVAVKKLTRTQAS
                     TVCTWSQERACAYSSVQHVEEWHSVSCVIASDKENVTVAAEISWDHSEELLKDVTELQ
                     ILGEISFNKSLYEGLNAENHRTKITVVFLKDEKYHSLPIIIKGSVGGLLVLIVILVIL
                     FKCGFFKRKYQQLNLESIRKAQLKSENLLEEEN"
     exon            79..199
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            200..291
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            292..359
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            360..477
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            478..642
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            643..758
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            759..910
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1064
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1215
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1283
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1428
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1571
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1712
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1937
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2068
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2199
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2363
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2492
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2566
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2699
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2798
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..2878
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..2956
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            2957..3020
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..3128
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            3129..3185
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            3186..3281
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            3282..3377
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            3378..3488
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     exon            3489..3803
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3780..3785
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /note="hexamer: AATAAA"
     polyA_site      3803
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /note="major polyA site"
ORIGIN      
        1 gcactcgcct cggctcccac acagccgcct ctgctccagc aaggatgtgg ctcttccaca
       61 ctctgctctg catagccagc ctggccctgc tggccgcttt caatgtggat gtggcccggc
      121 cctggctcac gcccaaggga ggtgcccctt tcgtgctcag ctcccttctg caccaagacc
      181 ccagcaccaa ccagacctgg ctcctggtca ccagccccag aaccaagagg acaccagggc
      241 ccctccatcg atgttccctt gtccaggatg aaatcctttg ccatcctgta gagcatgtcc
      301 ccatccccaa ggggaggcac cggggagtga ccgttgtccg gagccaccac ggtgttttga
      361 tatgcattca agtgctggtc cggcggcctc acagcctcag ctcagaactc acaggcacct
      421 gtagcctcct gggccctgac ctccgtcccc aggctcaggc caacttcttc gaccttgaaa
      481 atctcctgga tccagatgca cgtgtggaca ctggagactg ctacagcaac aaagaaggcg
      541 gtggagaaga cgatgtgaac acagccaggc agcgccgggc tctggagaag gaggaggagg
      601 aagacaagga ggaggaggaa gacgaggagg aggaggaagc tggcaccgag attgccatca
      661 tcctggatgg ctcaggaagc attgatcccc cagactttca gagagccaaa gacttcatct
      721 ccaacatgat gaggaacttc tatgaaaagt gttttgagtg caactttgcc ttggtgcagt
      781 atggaggagt gatccagact gagtttgacc ttcgggacag ccaggatgtg atggcctccc
      841 tcgccagagt ccagaacatc actcaagtgg ggagtgtcac caagactgcc tcagccatgc
      901 aacacgtctt agacagcatc ttcacctcaa gccacggctc caggagaaag gcatccaagg
      961 tcatggtggt gctcaccgat ggtggcatat tcgaggaccc cctcaacctt acgacagtca
     1021 tcaactcccc caaaatgcag ggtgttgagc gctttgccat tggggtggga gaagaattta
     1081 agagtgctag gactgcgagg gaactgaacc tgatcgcctc agacccggat gagacccatg
     1141 ctttcaaggt gaccaactac atggcgctgg atgggctgct gagcaaactg cggtacaaca
     1201 tcatcagcat ggaaggcacg gttggagacg cccttcacta ccagctggca cagattggct
     1261 tcagtgctca gatcctggat gagcggcagg tgctgctcgg cgccgtcggg gcctttgact
     1321 ggtccggagg ggcgttgctc tacgacacac gcagccgccg gggccgcttc ctgaaccaga
     1381 cagcggcggc ggcggcagac gcggaggctg cgcagtacag ctacctgggt tacgctgtgg
     1441 ccgtgctgca caagacctgc agcctctcct acatcgcggg ggctccacgg tacaaacatc
     1501 atggggccgt gtttgagctc cagaaggagg gcagagaggc cagcttcctg ccagtgctgg
     1561 agggagagca gatggggtcc tattttggct ctgagctgtg ccctgtggac attgacatgg
     1621 atggaagcac ggacttcttg ctggtggctg ctccatttta ccacgttcat ggagaagaag
     1681 gcagagtcta cgtgtaccgt ctcagcgagc aggatggttc tttctccttg gcacgcatac
     1741 tgagtgggca ccccgggttc accaatgccc gctttggctt tgccatggcg gctatggggg
     1801 atctcagtca ggataagctc acagatgtgg ccatcggggc ccccctggaa ggttttgggg
     1861 cagatgatgg tgccagcttc ggcagtgtgt atatctacaa tggacactgg gacggcctct
     1921 ccgccagccc ctcgcagcgg atcagagcct ccacggtggc cccaggactc cagtacttcg
     1981 gcatgtccat ggctggtggc tttgatatta gtggcgacgg ccttgccgac atcaccgtgg
     2041 gcactctggg ccaggcggtt gtgttccgct cccggcctgt ggttcgcctg aaggtctcca
     2101 tggccttcac ccccagcgca ctgcccatcg gcttcaacgg cgtcgtgaat gtccgtttat
     2161 gttttgaaat cagctctgta accacagcct ctgagtcagg cctccgcgag gcacttctca
     2221 acttcacgct ggatgtggat gtggggaagc agaggagacg gctgcagtgt tcagacgtaa
     2281 gaagctgtct gggctgcctg agggagtgga gcagcggatc ccagctttgt gaggacctcc
     2341 tgctcatgcc cacagaggga gagctctgtg aggaggactg cttctccaat gccagtgtca
     2401 aagtcagcta ccagctccag acccctgagg gacagacgga ccatccccag cccatcctgg
     2461 accgctacac tgagcccttt gccatcttcc agctgcccta tgagaaggcc tgcaagaata
     2521 agctgttttg tgtcgcagaa ttacagttgg ccaccaccgt ctctcagcag gagttggtgg
     2581 tgggtctcac aaaggagctg accctgaaca ttaacctaac taactccggg gaagattcct
     2641 acatgacaag catggccttg aattacccca gaaacctgca gttgaagagg atgcaaaagc
     2701 ctccctctcc aaacattcag tgtgatgacc ctcagccggt tgcttctgtc ctgatcatga
     2761 actgcaggat tggtcacccc gtcctcaaga ggtcatctgc tcatgtttca gtcgtttggc
     2821 agctagagga gaatgccttt ccaaacagga cagcagacat cactgtgact gtcaccaatt
     2881 ccaatgaaag acggtctttg gccaacgaga cccacaccct tcaattcagg catggcttcg
     2941 ttgcagttct gtccaaacca tccataatgt acgtgaacac aggccagggg ctttctcacc
     3001 acaaagaatt cctcttccat gtacatgggg agaacctctt tggagcagaa taccagttgc
     3061 aaatttgcgt cccaaccaaa ttacgaggtc tccaggttgt agcagtgaag aagctgacga
     3121 ggactcaggc ctccacggtg tgcacctgga gtcaggagcg cgcttgtgcg tacagttcgg
     3181 ttcagcatgt ggaagaatgg cattcagtga gctgtgtcat cgcttcagat aaagaaaatg
     3241 tcaccgtggc tgcagagatc tcctgggatc actctgagga gttactaaaa gatgtaactg
     3301 aactgcagat ccttggtgaa atatctttca acaaatctct atatgaggga ctgaatgcag
     3361 agaaccacag aactaagatc actgtcgtct tcctgaaaga tgagaagtac cattctttgc
     3421 ctatcatcat taaaggcagc gttggtggac ttctggtgtt gatcgtgatt ctggtcatcc
     3481 tgttcaagtg tggctttttt aaaagaaaat atcaacaact gaacttggag agcatcagga
     3541 aggcccagct gaaatcagag aatctgctcg aagaagagaa ttaggacctg ctatccactg
     3601 ggagaggcta tcagccagtc ctgggacttg gagacccagc atcctttgca ttactttttc
     3661 cttcaggatg atctagagca gcatggagct gttggtagaa tattagtttt taaccataca
     3721 ttgtcccaaa agtgtctgtg cattgtgcaa aaagtaaact taggaaacat ttggtattaa
     3781 ataaatttac acttttcttt gca
//
