LOCUS       NP_002199               1179 aa            linear   PRI 27-APR-2025
DEFINITION  integrin alpha-E isoform 1 precursor [Homo sapiens].
ACCESSION   NP_002199
VERSION     NP_002199.3
DBSOURCE    REFSEQ: accession NM_002208.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1179)
  AUTHORS   Akasaka,H., Sato,D., Shihoya,W., Nureki,O. and Kise,Y.
  TITLE     Cryo-EM structure of I domain-containing integrin alphaEbeta7
  JOURNAL   Biochem Biophys Res Commun 721, 150121 (2024)
   PUBMED   38781659
  REMARK    GeneRIF: Cryo-EM structure of I domain-containing integrin
            alphaEbeta7.
REFERENCE   2  (residues 1 to 1179)
  AUTHORS   Hamid,M.H.B.A., Cespedes,P.F., Jin,C., Chen,J.L., Gileadi,U.,
            Antoun,E., Liang,Z., Gao,F., Teague,R., Manoharan,N.,
            Maldonado-Perez,D., Khalid-Alham,N., Cerundolo,L., Ciaoca,R.,
            Hester,S.S., Pinto-Fernandez,A., Draganov,S.D., Vendrell,I.,
            Liu,G., Yao,X., Kvalvaag,A., Dominey-Foy,D.C.C., Nanayakkara,C.,
            Kanellakis,N., Chen,Y.L., Waugh,C., Clark,S.A., Clark,K., Sopp,P.,
            Rahman,N.M., Verrill,C., Kessler,B.M., Ogg,G., Fernandes,R.A.,
            Fisher,R., Peng,Y., Dustin,M.L. and Dong,T.
  TITLE     Unconventional human CD61 pairing with CD103 promotes TCR signaling
            and antigen-specific T cell cytotoxicity
  JOURNAL   Nat Immunol 25 (5), 834-846 (2024)
   PUBMED   38561495
  REMARK    GeneRIF: Unconventional human CD61 pairing with CD103 promotes TCR
            signaling and antigen-specific T cell cytotoxicity.
REFERENCE   3  (residues 1 to 1179)
  AUTHORS   van den Bulk,J., van der Ploeg,M., Ijsselsteijn,M.E., Ruano,D., van
            der Breggen,R., Duhen,R., Peeters,K.C.M.J., Farina-Sarasqueta,A.,
            Verdegaal,E.M.E., van der Burg,S.H., Duhen,T. and de
            Miranda,N.F.C.C.
  TITLE     CD103 and CD39 coexpression identifies neoantigen-specific
            cytotoxic T cells in colorectal cancers with low mutation burden
  JOURNAL   J Immunother Cancer 11 (2) (2023)
   PUBMED   36792124
  REMARK    GeneRIF: CD103 and CD39 coexpression identifies neoantigen-specific
            cytotoxic T cells in colorectal cancers with low mutation burden.
REFERENCE   4  (residues 1 to 1179)
  AUTHORS   Nose,Y., Saito,T., Yamamoto,K., Yamashita,K., Tanaka,K.,
            Yamamoto,K., Makino,T., Takahashi,T., Kawashima,A., Haruna,M.,
            Hirata,M., Ueyama,A., Iwahori,K., Satoh,T., Kurokawa,Y., Eguchi,H.,
            Doki,Y. and Wada,H.
  TITLE     The tissue-resident marker CD103 on peripheral blood T cells
            predicts responses to anti-PD-1 therapy in gastric cancer
  JOURNAL   Cancer Immunol Immunother 72 (1), 169-181 (2023)
   PUBMED   35776160
  REMARK    GeneRIF: The tissue-resident marker CD103 on peripheral blood T
            cells predicts responses to anti-PD-1 therapy in gastric cancer.
REFERENCE   5  (residues 1 to 1179)
  AUTHORS   Xu,W., Bergsbaken,T. and Edelblum,K.L.
  TITLE     The multifunctional nature of CD103 (alphaEbeta7 integrin)
            signaling in tissue-resident lymphocytes
  JOURNAL   Am J Physiol Cell Physiol 323 (4), C1161-C1167 (2022)
   PUBMED   36036450
  REMARK    GeneRIF: The multifunctional nature of CD103 (alphaEbeta7 integrin)
            signaling in tissue-resident lymphocytes.
            Review article
REFERENCE   6  (residues 1 to 1179)
  AUTHORS   Austrup,F., Rebstock,S., Kilshaw,P.J. and Hamann,A.
  TITLE     Transforming growth factor-beta 1-induced expression of the
            mucosa-related integrin alpha E on lymphocytes is not associated
            with mucosa-specific homing
  JOURNAL   Eur J Immunol 25 (6), 1487-1491 (1995)
   PUBMED   7614974
REFERENCE   7  (residues 1 to 1179)
  AUTHORS   Begue,B., Sarnacki,S., le Deist,F., Buc,H., Gagnon,J., Meo,T. and
            Cerf-Bensussan,N.
  TITLE     HML-1, a novel integrin made of the beta 7 chain and of a
            distinctive alpha chain, exerts an accessory function in the
            activation of human IEL via the CD3-TCR pathway
  JOURNAL   Adv Exp Med Biol 371A, 67-75 (1995)
   PUBMED   8526015
REFERENCE   8  (residues 1 to 1179)
  AUTHORS   Shaw,S.K., Cepek,K.L., Murphy,E.A., Russell,G.J., Brenner,M.B. and
            Parker,C.M.
  TITLE     Molecular cloning of the human mucosal lymphocyte integrin alpha E
            subunit. Unusual structure and restricted RNA distribution
  JOURNAL   J Biol Chem 269 (8), 6016-6025 (1994)
   PUBMED   8119947
REFERENCE   9  (residues 1 to 1179)
  AUTHORS   Parker,C.M., Cepek,K.L., Russell,G.J., Shaw,S.K., Posnett,D.N.,
            Schwarting,R. and Brenner,M.B.
  TITLE     A family of beta 7 integrins on human mucosal lymphocytes
  JOURNAL   Proc Natl Acad Sci U S A 89 (5), 1924-1928 (1992)
   PUBMED   1542691
REFERENCE   10 (residues 1 to 1179)
  AUTHORS   Cerf-Bensussan,N., Jarry,A., Brousse,N., Lisowska-Grospierre,B.,
            Guy-Grand,D. and Griscelli,C.
  TITLE     A monoclonal antibody (HML-1) defining a novel membrane molecule
            present on human intestinal lymphocytes
  JOURNAL   Eur J Immunol 17 (9), 1279-1285 (1987)
   PUBMED   3498635
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from L25851.2 and AC116914.5.
            
            On Jun 8, 2007 this sequence version replaced NP_002199.2.
            
            Summary: Integrins are heterodimeric integral membrane proteins
            composed of an alpha chain and a beta chain. This gene encodes an
            I-domain-containing alpha integrin that undergoes
            post-translational cleavage in the extracellular domain, yielding
            disulfide-linked heavy and light chains. In combination with the
            beta 7 integrin, this protein forms the E-cadherin binding integrin
            known as the human mucosal lymphocyte-1 antigen. This protein is
            preferentially expressed in human intestinal intraepithelial
            lymphocytes (IEL), and in addition to a role in adhesion, it may
            serve as an accessory molecule for IEL activation. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L25851.2, BC113436.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263087.9/ ENSP00000263087.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1179
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     Protein         1..1179
                     /product="integrin alpha-E isoform 1 precursor"
                     /note="HML-1 antigen; integrin alpha-IEL; antigen CD103,
                     human mucosal lymphocyte antigen 1; alpha polypeptide;
                     integrin alpha-E; mucosal lymphocyte 1 antigen; integrin,
                     alpha E (antigen CD103, human mucosal lymphocyte antigen
                     1; alpha polypeptide); human mucosal lymphocyte antigen 1,
                     alpha polypeptide"
                     /calculated_mol_wt=128190
     sig_peptide     1..18
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1988
     mat_peptide     19..1179
                     /product="integrin alpha-E isoform 1"
                     /calculated_mol_wt=128190
     mat_peptide     19..177
                     /product="Integrin alpha-E light chain.
                     /id=PRO_0000016284"
                     /note="propagated from UniProtKB/Swiss-Prot (P38570.3)"
                     /calculated_mol_wt=17551
     Region          22..79
                     /region_name="FG-GAP 1"
                     /note="propagated from UniProtKB/Swiss-Prot (P38570.3)"
     Site            49
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P38570.3)"
     Region          80..138
                     /region_name="FG-GAP 2"
                     /note="propagated from UniProtKB/Swiss-Prot (P38570.3)"
     Region          145..199
                     /region_name="X-domain (extra domain)"
                     /note="propagated from UniProtKB/Swiss-Prot (P38570.3)"
     Region          158..200
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P38570.3)"
     mat_peptide     179..1177
                     /product="Integrin alpha-E heavy chain.
                     /id=PRO_0000016285"
                     /note="propagated from UniProtKB/Swiss-Prot (P38570.3)"
                     /calculated_mol_wt=110258
     Region          201..378
                     /region_name="vWA_integrins_alpha_subunit"
                     /note="Integrins are a class of adhesion receptors that
                     link the extracellular matrix to the cytoskeleton and
                     cooperate with growth factor receptors to promote celll
                     survival, cell cycle progression and cell migration.
                     Integrins consist of an alpha and a beta...; cd01469"
                     /db_xref="CDD:238746"
     Site            order(201,203,224,306,308,337,367)
                     /site_type="active"
                     /note="integrin inhibitor binding pocket [active]"
                     /db_xref="CDD:238746"
     Site            order(208,210,212,279,312)
                     /site_type="other"
                     /note="metal ion-dependent adhesion site (MIDAS)"
                     /db_xref="CDD:238746"
     Site            order(210..212,214,279)
                     /site_type="active"
                     /note="integrin-collagen binding site [active]"
                     /db_xref="CDD:238746"
     Site            271
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P38570.3)"
     Site            321
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P38570.3)"
     Region          390..442
                     /region_name="FG-GAP 3.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00803"
                     /note="propagated from UniProtKB/Swiss-Prot (P38570.3)"
     Site            444
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P38570.3)"
     Region          447..499
                     /region_name="FG-GAP 4.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00803"
                     /note="propagated from UniProtKB/Swiss-Prot (P38570.3)"
     Region          500..560
                     /region_name="FG-GAP 5.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00803"
                     /note="propagated from UniProtKB/Swiss-Prot (P38570.3)"
     Region          510..561
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          563..627
                     /region_name="FG-GAP 6.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00803"
                     /note="propagated from UniProtKB/Swiss-Prot (P38570.3)"
     Region          574..633
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          631..691
                     /region_name="FG-GAP 7.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00803"
                     /note="propagated from UniProtKB/Swiss-Prot (P38570.3)"
     Region          643..>678
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          677..>951
                     /region_name="Integrin_alpha2"
                     /note="Integrin alpha; pfam08441"
                     /db_xref="CDD:462478"
     Site            726
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P38570.3)"
     Site            782
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P38570.3)"
     Site            857
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P38570.3)"
     Site            934
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P38570.3)"
     Site            954
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P38570.3)"
     Site            1065
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P38570.3)"
     Site            1096
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P38570.3)"
     Site            1125..1147
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P38570.3)"
     Region          1150..1154
                     /region_name="GFFKR motif"
                     /note="propagated from UniProtKB/Swiss-Prot (P38570.3)"
     CDS             1..1179
                     /gene="ITGAE"
                     /gene_synonym="CD103; HUMINAE"
                     /coded_by="NM_002208.5:45..3584"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS32531.1"
                     /db_xref="GeneID:3682"
                     /db_xref="HGNC:HGNC:6147"
                     /db_xref="MIM:604682"
ORIGIN      
        1 mwlfhtllci aslallaafn vdvarpwltp kggapfvlss llhqdpstnq twllvtsprt
       61 krtpgplhrc slvqdeilch pvehvpipkg rhrgvtvvrs hhgvliciqv lvrrphslss
      121 eltgtcsllg pdlrpqaqan ffdlenlldp darvdtgdcy snkegggedd vntarqrral
      181 ekeeeedkee eedeeeeeag teiaiildgs gsidppdfqr akdfisnmmr nfyekcfecn
      241 falvqyggvi qtefdlrdsq dvmaslarvq nitqvgsvtk tasamqhvld siftsshgsr
      301 rkaskvmvvl tdggifedpl nlttvinspk mqgverfaig vgeefksart arelnliasd
      361 pdethafkvt nymaldglls klryniisme gtvgdalhyq laqigfsaqi lderqvllga
      421 vgafdwsgga llydtrsrrg rflnqtaaaa adaeaaqysy lgyavavlhk tcslsyiaga
      481 prykhhgavf elqkegreas flpvlegeqm gsyfgselcp vdidmdgstd fllvaapfyh
      541 vhgeegrvyv yrlseqdgsf slarilsghp gftnarfgfa maamgdlsqd kltdvaigap
      601 legfgaddga sfgsvyiyng hwdglsasps qrirastvap glqyfgmsma ggfdisgdgl
      661 aditvgtlgq avvfrsrpvv rlkvsmaftp salpigfngv vnvrlcfeis svttasesgl
      721 reallnftld vdvgkqrrrl qcsdvrsclg clrewssgsq lcedlllmpt egelceedcf
      781 snasvkvsyq lqtpegqtdh pqpildryte pfaifqlpye kacknklfcv aelqlattvs
      841 qqelvvgltk eltlninltn sgedsymtsm alnyprnlql krmqkppspn iqcddpqpva
      901 svlimncrig hpvlkrssah vsvvwqleen afpnrtadit vtvtnsnerr slanethtlq
      961 frhgfvavls kpsimyvntg qglshhkefl fhvhgenlfg aeyqlqicvp tklrglqvva
     1021 vkkltrtqas tvctwsqera cayssvqhve ewhsvscvia sdkenvtvaa eiswdhseel
     1081 lkdvtelqil geisfnksly eglnaenhrt kitvvflkde kyhslpiiik gsvggllvli
     1141 vilvilfkcg ffkrkyqqln lesirkaqlk senlleeen
//
