LOCUS       NM_005353               3889 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens integrin subunit alpha D (ITGAD), transcript variant
            2, mRNA.
ACCESSION   NM_005353 XM_496142
VERSION     NM_005353.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3889)
  AUTHORS   Zhao,F., Chen,T., Zhao,X., Wang,Q., Lan,Y., Liang,Y., Li,Y.,
            Wang,S., Yang,Y. and Yang,X.
  TITLE     LINC02190 inhibits the embryo-endometrial attachment by decreasing
            ITGAD expression
  JOURNAL   Reproduction 163 (2), 107-118 (2022)
   PUBMED   35038314
  REMARK    GeneRIF: LINC02190 inhibits the embryo-endometrial attachment by
            decreasing ITGAD expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3889)
  AUTHORS   Nakamura,K., Ikeuchi,T., Nara,K., Rhodes,C.S., Zhang,P., Chiba,Y.,
            Kazuno,S., Miura,Y., Ago,T., Arikawa-Hirasawa,E., Mukouyama,Y.S.
            and Yamada,Y.
  TITLE     Perlecan regulates pericyte dynamics in the maintenance and repair
            of the blood-brain barrier
  JOURNAL   J Cell Biol 218 (10), 3506-3525 (2019)
   PUBMED   31541017
REFERENCE   3  (bases 1 to 3889)
  AUTHORS   Aziz,M.H., Cui,K., Das,M., Brown,K.E., Ardell,C.L., Febbraio,M.,
            Pluskota,E., Han,J., Wu,H., Ballantyne,C.M., Smith,J.D.,
            Cathcart,M.K. and Yakubenko,V.P.
  TITLE     The Upregulation of Integrin alphaDbeta2 (CD11d/CD18) on
            Inflammatory Macrophages Promotes Macrophage Retention in Vascular
            Lesions and Development of Atherosclerosis
  JOURNAL   J Immunol 198 (12), 4855-4867 (2017)
   PUBMED   28500072
  REMARK    GeneRIF: findings suggest that CD11d/CD18 upregulation on
            proinflammatory macrophages may represent a common mechanism for
            macrophage retention at inflammatory sites, thereby promoting
            chronic inflammation and disease development.
REFERENCE   4  (bases 1 to 3889)
  AUTHORS   Siegers,G.M., Barreira,C.R., Postovit,L.M. and Dekaban,G.A.
  TITLE     CD11d beta2 integrin expression on human NK, B, and gammadelta T
            cells
  JOURNAL   J Leukoc Biol 101 (4), 1029-1035 (2017)
   PUBMED   27881604
  REMARK    GeneRIF: These results expand the potential for CD11d to regulate
            lymphocyte migration and tissue retention, and illuminate the
            possibility of a previously unconsidered role for CD11d in
            leukocyte biology and disease.
REFERENCE   5  (bases 1 to 3889)
  AUTHORS   Miyazaki,Y., Vieira-de-Abreu,A., Harris,E.S., Shah,A.M.,
            Weyrich,A.S., Castro-Faria-Neto,H.C. and Zimmerman,G.A.
  TITLE     Integrin alphaDbeta2 (CD11d/CD18) is expressed by human circulating
            and tissue myeloid leukocytes and mediates inflammatory signaling
  JOURNAL   PLoS One 9 (11), e112770 (2014)
   PUBMED   25415295
  REMARK    GeneRIF: alpha(D)beta(2) is a major member of the integrin
            repertoire of both circulating and tissue myeloid leukocytes in
            humans
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3889)
  AUTHORS   Van der Vieren,M., Crowe,D.T., Hoekstra,D., Vazeux,R.,
            Hoffman,P.A., Grayson,M.H., Bochner,B.S., Gallatin,W.M. and
            Staunton,D.E.
  TITLE     The leukocyte integrin alpha D beta 2 binds VCAM-1: evidence for a
            binding interface between I domain and VCAM-1
  JOURNAL   J Immunol 163 (4), 1984-1990 (1999)
   PUBMED   10438935
REFERENCE   7  (bases 1 to 3889)
  AUTHORS   Grayson,M.H., Van der Vieren,M., Sterbinsky,S.A., Michael
            Gallatin,W., Hoffman,P.A., Staunton,D.E. and Bochner,B.S.
  TITLE     alphadbeta2 integrin is expressed on human eosinophils and
            functions as an alternative ligand for vascular cell adhesion
            molecule 1 (VCAM-1)
  JOURNAL   J Exp Med 188 (11), 2187-2191 (1998)
   PUBMED   9841932
REFERENCE   8  (bases 1 to 3889)
  AUTHORS   Shelley,C.S., Da Silva,N., Georgakis,A., Chomienne,C. and
            Arnaout,M.A.
  TITLE     Mapping of the human CD11c (ITGAX) and CD11d (ITGAD) genes
            demonstrates that they are arranged in tandem separated by no more
            than 11.5 kb
  JOURNAL   Genomics 49 (2), 334-336 (1998)
   PUBMED   9598326
REFERENCE   9  (bases 1 to 3889)
  AUTHORS   Wong,D.A., Davis,E.M., LeBeau,M. and Springer,T.A.
  TITLE     Cloning and chromosomal localization of a novel gene-encoding a
            human beta 2-integrin alpha subunit
  JOURNAL   Gene 171 (2), 291-294 (1996)
   PUBMED   8666289
REFERENCE   10 (bases 1 to 3889)
  AUTHORS   Van der Vieren,M., Le Trong,H., Wood,C.L., Moore,P.F., St John,T.,
            Staunton,D.E. and Gallatin,W.M.
  TITLE     A novel leukointegrin, alpha d beta 2, binds preferentially to
            ICAM-3
  JOURNAL   Immunity 3 (6), 683-690 (1995)
   PUBMED   8777714
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093520.4 and AC026471.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_005353.2.
            
            Summary: This gene belongs to the beta-2 integrin family of
            membrane glycoproteins, which are are composed of non-covalently
            linked alpha and beta subunits to form a heterodimer. It encodes
            the alpha subunit of the cell surface heterodimers and is involved
            in the activation and adhesion functions of leukocytes. The gene is
            located about 11kb downstream of the integrin subunit alpha X gene,
            another member of the integrin family. It is expressed in the
            tissue and circulating myeloid leukocytes. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Dec
            2015].
            
            Transcript Variant: This variant (2) contains an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. It
            encodes isoform 2, which is shorter by an amino acid, compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB208945.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389202.3/ ENSP00000373854.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC093520.4         16993-17049         c
            58-163              AC093520.4         16043-16148         c
            164-267             AC093520.4         12922-13025         c
            268-338             AC093520.4         12718-12788         c
            339-453             AC093520.4         12475-12589         c
            454-584             AC093520.4         8139-8269           c
            585-730             AC093520.4         6739-6884           c
            731-884             AC093520.4         2716-2869           c
            885-1035            AC093520.4         2468-2618           c
            1036-1109           AC093520.4         1886-1959           c
            1110-1239           AC026471.6         80025-80154
            1240-1382           AC026471.6         80366-80508
            1383-1523           AC026471.6         80706-80846
            1524-1733           AC026471.6         80938-81147
            1734-1864           AC026471.6         82468-82598
            1865-2022           AC026471.6         82719-82876
            2023-2177           AC026471.6         84081-84235
            2178-2309           AC026471.6         84490-84621
            2310-2383           AC026471.6         85843-85916
            2384-2525           AC026471.6         86135-86276
            2526-2642           AC026471.6         87705-87821
            2643-2722           AC026471.6         87931-88010
            2723-2806           AC026471.6         88111-88194
            2807-2885           AC026471.6         92744-92822
            2886-2993           AC026471.6         92982-93089
            2994-3071           AC026471.6         93201-93278
            3072-3185           AC026471.6         93475-93588
            3186-3287           AC026471.6         93732-93833
            3288-3398           AC026471.6         94097-94207
            3399-3889           AC026471.6         95645-96135
FEATURES             Location/Qualifiers
     source          1..3889
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..3889
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /note="integrin subunit alpha D"
                     /db_xref="GeneID:3681"
                     /db_xref="HGNC:HGNC:6146"
                     /db_xref="MIM:602453"
     exon            1..57
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..3512
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; leukointegrin alpha D; CD11 antigen-like family
                     member D; beta-2 integrin alphaD subunit"
                     /codon_start=1
                     /product="integrin alpha-D isoform 2 precursor"
                     /protein_id="NP_005344.2"
                     /db_xref="CCDS:CCDS32438.1"
                     /db_xref="GeneID:3681"
                     /db_xref="HGNC:HGNC:6146"
                     /db_xref="MIM:602453"
                     /translation="MTFGTVLLLSVLASYHGFNLDVEEPTIFQEDAGGFGQSVVQFGG
                     SRLVVGAPLEVVAANQTGRLYDCAAATGMCQPIPLHIRPEAVNMSLGLTLAASTNGSR
                     LLACGPTLHRVCGENSYSKGSCLLLGSRWEIIQTVPDATPECPHQEMDIVFLIDGSGS
                     IDQNDFNQMKGFVQAVMGQFEGTDTLFALMQYSNLLKIHFTFTQFRTSPSQQSLVDPI
                     VQLKGLTFTATGILTVVTQLFHHKNGARKSAKKILIVITDGQKYKDPLEYSDVIPQAE
                     KAGIIRYAIGVGHAFQGPTARQELNTISSAPPQDHVFKVDNFAALGSIQKQLQEKIYA
                     VEGTQSRASSSFQHEMSQEGFSTALTMDGLFLGAVGSFSWSGGAFLYPPNMSPTFINM
                     SQENVDMRDSYLGYSTELALWKGVQNLVLGAPRYQHTGKAVIFTQVSRQWRKKAEVTG
                     TQIGSYFGASLCSVDVDSDGSTDLILIGAPHYYEQTRGGQVSVCPLPRGRVQWQCDAV
                     LRGEQGHPWGRFGAALTVLGDVNEDKLIDVAIGAPGEQENRGAVYLFHGASESGISPS
                     HSQRIASSQLSPRLQYFGQALSGGQDLTQDGLMDLAVGARGQVLLLRSLPVLKVGVAM
                     RFSPVEVAKAVYRCWEEKPSALEAGDATVCLTIQKSSLDQLGDIQSSVRFDLALDPGR
                     LTSRAIFNETKNPTLTRRKTLGLGIHCETLKLLLPDCVEDVVSPIILHLNFSLVREPI
                     PSPQNLRPVLAVGSQDLFTASLPFEKNCGQDGLCEGDLGVTLSFSGLQTLTVGSSLEL
                     NVIVTVWNAGEDSYGTVVSLYYPAGLSHRRVSGAQKQPHQSALRLACETVPTEDEGLR
                     SSRCSVNHPIFHEGSNGTFIVTFDVSYKATLGDRMLMRASASSENNKASSSKATFQLE
                     LPVKYAVYTMISRQEESTKYFNFATSDEKKMKEAEHRYRVNNLSQRDLAISINFWVPV
                     LLNGVAVWDVVMEAPSQSLPCVSERKPPQHSDFLTQISRSPMLDCSIADCLQFRCDVP
                     SFSVQEELDFTLKGNLSFGWVRETLQKKVLVVSVAEITFDTSVYSQLPGQEAFMRAQM
                     EMVLEEDEVYNAIPIIMGSSVGALLLLALITATLYKLGFFKRHYKEMLEDKPEDTATF
                     SGDDFSCVAPNVPLS"
     exon            58..163
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     exon            164..267
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     exon            268..338
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     exon            339..453
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     exon            454..584
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     exon            585..730
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     exon            731..884
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1035
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1109
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1239
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1382
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1523
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1733
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1864
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..2022
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2177
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2309
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2383
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2525
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2642
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2722
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..2806
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     exon            2807..2885
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..2993
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     exon            2994..3071
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     exon            3072..3185
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     exon            3186..3287
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     exon            3288..3398
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     exon            3399..3889
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3565..3570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /note="hexamer: CATAAA"
     polyA_site      3589
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /note="major polyA site"
     regulatory      3733..3738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /note="hexamer: CATAAA"
     polyA_site      3753
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /note="major polyA site"
ORIGIN      
        1 acttcccctc aacgcgctgc tcagggatga ccttcggcac tgtgcttctt ctgagtgtcc
       61 tggcttctta tcatggattc aacctggatg tggaggagcc tacgatcttc caggaggatg
      121 caggcggctt tgggcagagc gtggtgcagt tcggtggatc tcgactcgtg gtgggagcac
      181 ccctggaggt ggtggcggcc aaccagacgg gacggctgta tgactgcgca gctgccaccg
      241 gcatgtgcca gcccatcccg ctgcacatcc gccctgaggc cgtgaacatg tccttgggcc
      301 tgaccctggc agcctccacc aacggctccc ggctcctggc ctgtggcccg accctgcaca
      361 gagtctgtgg ggagaactca tactcaaagg gttcctgcct cctgctgggc tcgcgctggg
      421 agatcatcca gacagtcccc gacgccacgc cagagtgtcc acatcaagag atggacatcg
      481 tcttcctgat tgacggctct ggaagcattg accaaaatga ctttaaccag atgaagggct
      541 ttgtccaagc tgtcatgggc cagtttgagg gcactgacac cctgtttgca ctgatgcagt
      601 actcaaacct cctgaagatc cacttcacct tcacccaatt ccggaccagc ccgagccagc
      661 agagcctggt ggatcccatc gtccaactga aaggcctgac gttcacggcc acgggcatcc
      721 tgacagtggt gacacagcta tttcatcata agaatggggc ccgaaaaagt gccaagaaga
      781 tcctcattgt catcacagat gggcagaagt acaaagaccc cctggaatac agtgatgtca
      841 tcccccaggc agagaaggct ggcatcatcc gctacgctat cggggtggga cacgctttcc
      901 agggacccac tgccaggcag gagctgaata ccatcagctc agcgcctccg caggaccacg
      961 tgttcaaggt ggacaacttt gcagcccttg gcagcatcca gaagcagctg caggagaaga
     1021 tctatgcagt tgagggaacc cagtccaggg caagcagctc cttccagcac gagatgtccc
     1081 aagaaggctt cagcacagcc ctcacaatgg atggcctctt cctgggggct gtggggagct
     1141 ttagctggtc tggaggtgcc ttcctgtatc ccccaaatat gagccccacc ttcatcaaca
     1201 tgtctcagga gaatgtggac atgagggact cttacctggg ttactccacc gagctagccc
     1261 tgtggaaggg ggtacagaac ctggtcctgg gggccccccg ctaccagcat accgggaagg
     1321 ctgtcatctt cacccaggtg tccaggcaat ggaggaagaa ggccgaagtc acagggacgc
     1381 agatcggctc ctacttcggg gcctccctct gctctgtgga tgtggacagc gatggcagca
     1441 ccgacctgat cctcattggg gccccccatt actatgagca gacccgaggg ggccaggtgt
     1501 ccgtgtgtcc cttgcctagg gggagggtgc agtggcagtg tgacgctgtt ctccgtggtg
     1561 agcagggcca cccctggggc cgctttgggg cagccctgac agtgttgggg gatgtgaatg
     1621 aggacaagct gatagacgtg gccattgggg ccccgggaga gcaggagaac cggggtgctg
     1681 tctacctgtt tcacggagcc tcagaatccg gcatcagccc ctcccacagc cagcggattg
     1741 ccagctccca gctctccccc aggctgcagt attttgggca ggcgctgagt gggggtcagg
     1801 acctcaccca ggatggactg atggacctgg ccgtgggggc ccggggccag gtgctcctgc
     1861 tcaggagtct gccggtgctg aaagtggggg tggccatgag attcagccct gtggaggtgg
     1921 ccaaggctgt gtaccggtgc tgggaagaga agcccagtgc cctggaagct ggggacgcca
     1981 ccgtctgtct caccatccag aaaagctcac tggaccagct aggtgacatc caaagctctg
     2041 tcaggtttga tctggcactg gacccaggtc gtctgacttc tcgtgccatt ttcaatgaaa
     2101 ccaagaaccc cactttgact cgaagaaaaa ccctgggact ggggattcac tgtgaaaccc
     2161 tgaagctgct tttgccagat tgtgtggagg atgtggtgag ccccatcatt ctgcacctca
     2221 acttctcact ggtgagagag cccatcccct ccccccagaa cctgcgtcct gtgctggccg
     2281 tgggctcaca agacctcttc actgcttctc tccccttcga gaagaactgt gggcaagatg
     2341 gcctctgtga aggggacctg ggtgtcaccc tcagcttctc aggcctgcag accctgaccg
     2401 tggggagctc cctggagctc aacgtgattg tgactgtgtg gaacgcaggt gaggattcct
     2461 acggaaccgt ggtcagcctc tactatccag cagggctgtc gcaccgacgg gtgtcaggag
     2521 cccagaagca gccccatcag agtgccctgc gcctggcatg tgagacagtg cccactgagg
     2581 atgagggcct aagaagcagc cgctgcagtg tcaaccaccc catcttccat gagggctcta
     2641 acggcacctt catagtcaca ttcgatgtct cctacaaggc caccctggga gacaggatgc
     2701 ttatgagggc cagtgcaagc agtgagaaca ataaggcttc aagcagcaag gccaccttcc
     2761 agctggagct cccggtgaag tatgcagtct acaccatgat cagcaggcag gaagaatcca
     2821 ccaagtactt caactttgca acctccgatg agaagaaaat gaaagaggct gagcatcgat
     2881 accgtgtgaa taacctcagc cagcgagatc tggccatcag cattaacttc tgggttcctg
     2941 tcctgctgaa cggggtggct gtgtgggatg tggtcatgga ggccccatct cagagtctcc
     3001 cctgtgtttc agagagaaaa cctccccagc attctgactt cctgacccag atttcaagaa
     3061 gtcccatgct ggactgctcc attgctgact gcctgcagtt ccgctgtgac gtcccctcct
     3121 tcagcgtcca ggaggagctg gatttcaccc tgaagggcaa tctcagtttc ggctgggtcc
     3181 gcgagacatt gcagaagaag gtgttggtcg tgagtgtggc tgaaattacg ttcgacacat
     3241 ccgtgtactc ccagcttcca ggacaggagg catttatgag agctcagatg gagatggtgc
     3301 tagaagaaga cgaggtctac aatgccattc ccatcatcat gggcagctct gtgggggctc
     3361 tgctactgct ggcgctcatc acagccacac tgtacaagct tggcttcttc aaacgccact
     3421 acaaggaaat gctggaggac aagcctgaag acactgccac attcagtggg gacgatttca
     3481 gctgtgtggc cccaaatgtg cctttgtcct aataatccac tttcctgttt atctctacca
     3541 ctgtgggctg gacttgcttg caaccataaa tcaacttaca tggaaacaac ttctgcatag
     3601 atctgcactg gcctaagcaa cctaccaggt gctaagcacc ttctcggaga gatagagatt
     3661 gtaatgtttt tacatatctg tccatctttt tcagcaatga cccacttttt acagaagcag
     3721 gcatggtgcc agcataaatt ttcatatgct taagaattgt cacatgaaat gaggatgttt
     3781 atagcacact ttccttgcgt ggaagagcta taacccaggg acctgagtgc ctctctggga
     3841 atagtcgggg gaacctattt gtgggcattg aaaaagtttt ttcactttc
//
