LOCUS       NP_005344               1161 aa            linear   PRI 27-APR-2025
DEFINITION  integrin alpha-D isoform 2 precursor [Homo sapiens].
ACCESSION   NP_005344 XP_496142
VERSION     NP_005344.2
DBSOURCE    REFSEQ: accession NM_005353.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1161)
  AUTHORS   Zhao,F., Chen,T., Zhao,X., Wang,Q., Lan,Y., Liang,Y., Li,Y.,
            Wang,S., Yang,Y. and Yang,X.
  TITLE     LINC02190 inhibits the embryo-endometrial attachment by decreasing
            ITGAD expression
  JOURNAL   Reproduction 163 (2), 107-118 (2022)
   PUBMED   35038314
  REMARK    GeneRIF: LINC02190 inhibits the embryo-endometrial attachment by
            decreasing ITGAD expression.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1161)
  AUTHORS   Nakamura,K., Ikeuchi,T., Nara,K., Rhodes,C.S., Zhang,P., Chiba,Y.,
            Kazuno,S., Miura,Y., Ago,T., Arikawa-Hirasawa,E., Mukouyama,Y.S.
            and Yamada,Y.
  TITLE     Perlecan regulates pericyte dynamics in the maintenance and repair
            of the blood-brain barrier
  JOURNAL   J Cell Biol 218 (10), 3506-3525 (2019)
   PUBMED   31541017
REFERENCE   3  (residues 1 to 1161)
  AUTHORS   Aziz,M.H., Cui,K., Das,M., Brown,K.E., Ardell,C.L., Febbraio,M.,
            Pluskota,E., Han,J., Wu,H., Ballantyne,C.M., Smith,J.D.,
            Cathcart,M.K. and Yakubenko,V.P.
  TITLE     The Upregulation of Integrin alphaDbeta2 (CD11d/CD18) on
            Inflammatory Macrophages Promotes Macrophage Retention in Vascular
            Lesions and Development of Atherosclerosis
  JOURNAL   J Immunol 198 (12), 4855-4867 (2017)
   PUBMED   28500072
  REMARK    GeneRIF: findings suggest that CD11d/CD18 upregulation on
            proinflammatory macrophages may represent a common mechanism for
            macrophage retention at inflammatory sites, thereby promoting
            chronic inflammation and disease development.
REFERENCE   4  (residues 1 to 1161)
  AUTHORS   Siegers,G.M., Barreira,C.R., Postovit,L.M. and Dekaban,G.A.
  TITLE     CD11d beta2 integrin expression on human NK, B, and gammadelta T
            cells
  JOURNAL   J Leukoc Biol 101 (4), 1029-1035 (2017)
   PUBMED   27881604
  REMARK    GeneRIF: These results expand the potential for CD11d to regulate
            lymphocyte migration and tissue retention, and illuminate the
            possibility of a previously unconsidered role for CD11d in
            leukocyte biology and disease.
REFERENCE   5  (residues 1 to 1161)
  AUTHORS   Miyazaki,Y., Vieira-de-Abreu,A., Harris,E.S., Shah,A.M.,
            Weyrich,A.S., Castro-Faria-Neto,H.C. and Zimmerman,G.A.
  TITLE     Integrin alphaDbeta2 (CD11d/CD18) is expressed by human circulating
            and tissue myeloid leukocytes and mediates inflammatory signaling
  JOURNAL   PLoS One 9 (11), e112770 (2014)
   PUBMED   25415295
  REMARK    GeneRIF: alpha(D)beta(2) is a major member of the integrin
            repertoire of both circulating and tissue myeloid leukocytes in
            humans
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1161)
  AUTHORS   Van der Vieren,M., Crowe,D.T., Hoekstra,D., Vazeux,R.,
            Hoffman,P.A., Grayson,M.H., Bochner,B.S., Gallatin,W.M. and
            Staunton,D.E.
  TITLE     The leukocyte integrin alpha D beta 2 binds VCAM-1: evidence for a
            binding interface between I domain and VCAM-1
  JOURNAL   J Immunol 163 (4), 1984-1990 (1999)
   PUBMED   10438935
REFERENCE   7  (residues 1 to 1161)
  AUTHORS   Grayson,M.H., Van der Vieren,M., Sterbinsky,S.A., Michael
            Gallatin,W., Hoffman,P.A., Staunton,D.E. and Bochner,B.S.
  TITLE     alphadbeta2 integrin is expressed on human eosinophils and
            functions as an alternative ligand for vascular cell adhesion
            molecule 1 (VCAM-1)
  JOURNAL   J Exp Med 188 (11), 2187-2191 (1998)
   PUBMED   9841932
REFERENCE   8  (residues 1 to 1161)
  AUTHORS   Shelley,C.S., Da Silva,N., Georgakis,A., Chomienne,C. and
            Arnaout,M.A.
  TITLE     Mapping of the human CD11c (ITGAX) and CD11d (ITGAD) genes
            demonstrates that they are arranged in tandem separated by no more
            than 11.5 kb
  JOURNAL   Genomics 49 (2), 334-336 (1998)
   PUBMED   9598326
REFERENCE   9  (residues 1 to 1161)
  AUTHORS   Wong,D.A., Davis,E.M., LeBeau,M. and Springer,T.A.
  TITLE     Cloning and chromosomal localization of a novel gene-encoding a
            human beta 2-integrin alpha subunit
  JOURNAL   Gene 171 (2), 291-294 (1996)
   PUBMED   8666289
REFERENCE   10 (residues 1 to 1161)
  AUTHORS   Van der Vieren,M., Le Trong,H., Wood,C.L., Moore,P.F., St John,T.,
            Staunton,D.E. and Gallatin,W.M.
  TITLE     A novel leukointegrin, alpha d beta 2, binds preferentially to
            ICAM-3
  JOURNAL   Immunity 3 (6), 683-690 (1995)
   PUBMED   8777714
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093520.4 and AC026471.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Apr 15, 2005 this sequence version replaced
            XP_496142.1, NP_005344.1.
            
            Summary: This gene belongs to the beta-2 integrin family of
            membrane glycoproteins, which are are composed of non-covalently
            linked alpha and beta subunits to form a heterodimer. It encodes
            the alpha subunit of the cell surface heterodimers and is involved
            in the activation and adhesion functions of leukocytes. The gene is
            located about 11kb downstream of the integrin subunit alpha X gene,
            another member of the integrin family. It is expressed in the
            tissue and circulating myeloid leukocytes. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Dec
            2015].
            
            Transcript Variant: This variant (2) contains an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. It
            encodes isoform 2, which is shorter by an amino acid, compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB208945.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389202.3/ ENSP00000373854.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1161
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     Protein         1..1161
                     /product="integrin alpha-D isoform 2 precursor"
                     /note="leukointegrin alpha D; CD11 antigen-like family
                     member D; beta-2 integrin alphaD subunit"
                     /calculated_mol_wt=124968
     sig_peptide     1..17
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1809
     mat_peptide     18..1161
                     /product="integrin alpha-D isoform 2"
                     /calculated_mol_wt=124968
     Region          19..76
                     /region_name="FG-GAP 1.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00803"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13349.2)"
     Site            59
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q13349.2)"
     Region          77..136
                     /region_name="FG-GAP 2.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00803"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13349.2)"
     Site            87
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q13349.2)"
     Site            99
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q13349.2)"
     Region          149..324
                     /region_name="vWA_integrins_alpha_subunit"
                     /note="Integrins are a class of adhesion receptors that
                     link the extracellular matrix to the cytoskeleton and
                     cooperate with growth factor receptors to promote celll
                     survival, cell cycle progression and cell migration.
                     Integrins consist of an alpha and a beta...; cd01469"
                     /db_xref="CDD:238746"
     Site            order(149,151,172,252,254,283,313)
                     /site_type="active"
                     /note="integrin inhibitor binding pocket [active]"
                     /db_xref="CDD:238746"
     Site            order(156,158,160,225,258)
                     /site_type="other"
                     /note="metal ion-dependent adhesion site (MIDAS)"
                     /db_xref="CDD:238746"
     Site            order(158..160,162,225)
                     /site_type="active"
                     /note="integrin-collagen binding site [active]"
                     /db_xref="CDD:238746"
     Region          339..390
                     /region_name="FG-GAP 3.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00803"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13349.2)"
     Region          391..442
                     /region_name="FG-GAP 4.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00803"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13349.2)"
     Site            391
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q13349.2)"
     Region          443..503
                     /region_name="FG-GAP 5.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00803"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13349.2)"
     Region          453..509
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          506..564
                     /region_name="FG-GAP 6.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00803"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13349.2)"
     Region          516..571
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          569..629
                     /region_name="FG-GAP 7.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00803"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13349.2)"
     Region          581..>613
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          616..>957
                     /region_name="Integrin_alpha2"
                     /note="Integrin alpha; pfam08441"
                     /db_xref="CDD:462478"
     Site            690
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q13349.2)"
     Site            732
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q13349.2)"
     Site            872
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q13349.2)"
     Site            956
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q13349.2)"
     Site            1045
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q13349.2)"
     Site            1100..1120
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13349.2)"
     Region          1124..1138
                     /region_name="Integrin_alpha"
                     /note="Integrin alpha cytoplasmic region; pfam00357"
                     /db_xref="CDD:459778"
     Region          1126..1130
                     /region_name="GFFKR motif"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13349.2)"
     CDS             1..1161
                     /gene="ITGAD"
                     /gene_synonym="ADB2; CD11D"
                     /coded_by="NM_005353.3:27..3512"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS32438.1"
                     /db_xref="GeneID:3681"
                     /db_xref="HGNC:HGNC:6146"
                     /db_xref="MIM:602453"
ORIGIN      
        1 mtfgtvllls vlasyhgfnl dveeptifqe daggfgqsvv qfggsrlvvg aplevvaanq
       61 tgrlydcaaa tgmcqpiplh irpeavnmsl gltlaastng srllacgptl hrvcgensys
      121 kgsclllgsr weiiqtvpda tpecphqemd ivflidgsgs idqndfnqmk gfvqavmgqf
      181 egtdtlfalm qysnllkihf tftqfrtsps qqslvdpivq lkgltftatg iltvvtqlfh
      241 hkngarksak kilivitdgq kykdpleysd vipqaekagi iryaigvgha fqgptarqel
      301 ntissappqd hvfkvdnfaa lgsiqkqlqe kiyavegtqs rasssfqhem sqegfstalt
      361 mdglflgavg sfswsggafl yppnmsptfi nmsqenvdmr dsylgystel alwkgvqnlv
      421 lgapryqhtg kaviftqvsr qwrkkaevtg tqigsyfgas lcsvdvdsdg stdliligap
      481 hyyeqtrggq vsvcplprgr vqwqcdavlr geqghpwgrf gaaltvlgdv nedklidvai
      541 gapgeqenrg avylfhgase sgispshsqr iassqlsprl qyfgqalsgg qdltqdglmd
      601 lavgargqvl llrslpvlkv gvamrfspve vakavyrcwe ekpsaleagd atvcltiqks
      661 sldqlgdiqs svrfdlaldp grltsraifn etknptltrr ktlglgihce tlklllpdcv
      721 edvvspiilh lnfslvrepi pspqnlrpvl avgsqdlfta slpfekncgq dglcegdlgv
      781 tlsfsglqtl tvgsslelnv ivtvwnaged sygtvvslyy paglshrrvs gaqkqphqsa
      841 lrlacetvpt edeglrssrc svnhpifheg sngtfivtfd vsykatlgdr mlmrasasse
      901 nnkassskat fqlelpvkya vytmisrqee stkyfnfats dekkmkeaeh ryrvnnlsqr
      961 dlaisinfwv pvllngvavw dvvmeapsqs lpcvserkpp qhsdfltqis rspmldcsia
     1021 dclqfrcdvp sfsvqeeldf tlkgnlsfgw vretlqkkvl vvsvaeitfd tsvysqlpgq
     1081 eafmraqmem vleedevyna ipiimgssvg allllalita tlyklgffkr hykemledkp
     1141 edtatfsgdd fscvapnvpl s
//
