LOCUS       NM_002207               7860 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens integrin subunit alpha 9 (ITGA9), mRNA.
ACCESSION   NM_002207
VERSION     NM_002207.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7860)
  AUTHORS   Niibori-Nambu,A., Wang,C.Q., Chin,D.W.L., Chooi,J.Y., Hosoi,H.,
            Sonoki,T., Tham,C.Y., Nah,G.S.S., Cirovic,B., Tan,D.Q.,
            Takizawa,H., Sashida,G., Goh,Y., Tng,J., Fam,W.N., Fullwood,M.J.,
            Suda,T., Yang,H., Tergaonkar,V., Taniuchi,I., Li,S., Chng,W.J. and
            Osato,M.
  TITLE     Integrin-alpha9 overexpression underlies the niche-independent
            maintenance of leukemia stem cells in acute myeloid leukemia
  JOURNAL   Gene 928, 148761 (2024)
   PUBMED   39002785
  REMARK    GeneRIF: Integrin-alpha9 overexpression underlies the
            niche-independent maintenance of leukemia stem cells in acute
            myeloid leukemia.
REFERENCE   2  (bases 1 to 7860)
  AUTHORS   Ellergezen,P., Coskun,B.N., Bozkurt,Z.Y., Cecen,G.S., Agca,H.,
            Pehlivan,Y., Dalkilic,H.E., Cavun,S. and Yanar,Y.B.
  TITLE     alpha9beta1 integrin & its ligands as new potential biomarkers in
            FMF
  JOURNAL   Indian J Med Res 160 (1), 102-108 (2024)
   PUBMED   39382510
  REMARK    GeneRIF: alpha9beta1 integrin & its ligands as new potential
            biomarkers in FMF.
REFERENCE   3  (bases 1 to 7860)
  AUTHORS   Liu,W., Fang,S., Yang,Z., Ma,J., Tan,Y., Chen,Y., Zhang,K., Liu,K.
            and Gu,W.
  TITLE     ITGA9-AS1 up-regulates ITGA9 by targeting miR-4765 and recruiting
            HNRNPU to affect the proliferation and apoptosis of non-small cell
            lung cancer cells
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (14), 22-28 (2023)
   PUBMED   38279497
  REMARK    GeneRIF: ITGA9-AS1 up-regulates ITGA9 by targeting miR-4765 and
            recruiting HNRNPU to affect the proliferation and apoptosis of
            non-small cell lung cancer cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7860)
  AUTHORS   Morris,G.E., Denniff,M.J., Karamanavi,E., Andrews,S.A.,
            Kostogrys,R.B., Bountziouka,V., Ghaderi-Najafabadi,M., Shamkhi,N.,
            McConnell,G., Kaiser,M.A., Carleton,L., Schofield,C., Kessler,T.,
            Rainbow,R.D., Samani,N.J. and Webb,T.R.
  TITLE     The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction
            via integrins alpha9beta1 and alpha4beta1
  JOURNAL   Br J Pharmacol 179 (21), 4958-4973 (2022)
   PUBMED   35802072
REFERENCE   5  (bases 1 to 7860)
  AUTHORS   Navarro,N., Molist,C., Sansa-Girona,J., Zarzosa,P., Gallo-Oller,G.,
            Pons,G., Magdaleno,A., Guillen,G., Hladun,R., Garrido,M.,
            Segura,M.F., Hontecillas-Prieto,L., de Alava,E., Ponsati,B.,
            Fernandez-Carneado,J., Almazan-Moga,A., Valles-Miret,M.,
            Farrera-Sinfreu,J., de Toledo,J.S., Moreno,L., Gallego,S. and
            Roma,J.
  TITLE     Integrin alpha9 emerges as a key therapeutic target to reduce
            metastasis in rhabdomyosarcoma and neuroblastoma
  JOURNAL   Cell Mol Life Sci 79 (11), 546 (2022)
   PUBMED   36221013
  REMARK    GeneRIF: Integrin alpha9 emerges as a key therapeutic target to
            reduce metastasis in rhabdomyosarcoma and neuroblastoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7860)
  AUTHORS   Taooka,Y., Chen,J., Yednock,T. and Sheppard,D.
  TITLE     The integrin alpha9beta1 mediates adhesion to activated endothelial
            cells and transendothelial neutrophil migration through interaction
            with vascular cell adhesion molecule-1
  JOURNAL   J Cell Biol 145 (2), 413-420 (1999)
   PUBMED   10209034
REFERENCE   7  (bases 1 to 7860)
  AUTHORS   Yokosaki,Y., Matsuura,N., Higashiyama,S., Murakami,I., Obara,M.,
            Yamakido,M., Shigeto,N., Chen,J. and Sheppard,D.
  TITLE     Identification of the ligand binding site for the integrin alpha9
            beta1 in the third fibronectin type III repeat of tenascin-C
  JOURNAL   J Biol Chem 273 (19), 11423-11428 (1998)
   PUBMED   9565552
REFERENCE   8  (bases 1 to 7860)
  AUTHORS   Hibi,K., Yamakawa,K., Ueda,R., Horio,Y., Murata,Y., Tamari,M.,
            Uchida,K., Takahashi,T., Nakamura,Y. and Takahashi,T.
  TITLE     Aberrant upregulation of a novel integrin alpha subunit gene at
            3p21.3 in small cell lung cancer
  JOURNAL   Oncogene 9 (2), 611-619 (1994)
   PUBMED   8290272
REFERENCE   9  (bases 1 to 7860)
  AUTHORS   Palmer,E.L., Ruegg,C., Ferrando,R., Pytela,R. and Sheppard,D.
  TITLE     Sequence and tissue distribution of the integrin alpha 9 subunit, a
            novel partner of beta 1 that is widely distributed in epithelia and
            muscle
  JOURNAL   J Cell Biol 123 (5), 1289-1297 (1993)
   PUBMED   8245132
  REMARK    Erratum:[J Cell Biol 1994 Feb;124(3):395]
REFERENCE   10 (bases 1 to 7860)
  AUTHORS   Yamakawa,K., Takahashi,T., Horio,Y., Murata,Y., Takahashi,E.,
            Hibi,K., Yokoyama,S., Ueda,R., Takahashi,T. and Nakamura,Y.
  TITLE     Frequent homozygous deletions in lung cancer cell lines detected by
            a DNA marker located at 3p21.3-p22
  JOURNAL   Oncogene 8 (2), 327-330 (1993)
   PUBMED   8381220
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092055.2, BC030198.1,
            D25303.1, L24158.1, BX647350.1 and AC093415.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002207.2.
            
            Summary: This gene encodes an alpha integrin. Integrins are
            heterodimeric integral membrane glycoproteins composed of an alpha
            chain and a beta chain that mediate cell-cell and cell-matrix
            adhesion. The protein encoded by this gene, when bound to the beta
            1 chain, forms an integrin that is a receptor for VCAM1, cytotactin
            and osteopontin. Expression of this gene has been found to be
            upregulated in small cell lung cancers. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D25303.1, L24158.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147920, SAMEA2154405
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264741.10/ ENSP00000264741.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               AC092055.2         101543-101723       c
            182-1753            BC030198.1         208-1779
            1754-1755           AC092055.2         20403-20404         c
            1756-2073           BC030198.1         1782-2099
            2074-3413           D25303.1           1891-3230
            3414-3478           L24158.1           3075-3139
            3479-3529           D25303.1           3296-3346
            3530-4143           BX647350.1         345-958
            4144-7860           AC093415.2         79713-83429         c
FEATURES             Location/Qualifiers
     source          1..7860
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.2"
     gene            1..7860
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /note="integrin subunit alpha 9"
                     /db_xref="GeneID:3680"
                     /db_xref="HGNC:HGNC:6145"
                     /db_xref="MIM:603963"
     exon            1..419
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..3342
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /note="integrin alpha-RLC; integrin alpha-9"
                     /codon_start=1
                     /product="integrin alpha-9 precursor"
                     /protein_id="NP_002198.2"
                     /db_xref="CCDS:CCDS2669.1"
                     /db_xref="GeneID:3680"
                     /db_xref="HGNC:HGNC:6145"
                     /db_xref="MIM:603963"
                     /translation="MGGPAAPRGAGRLRALLLALVVAGIPAGAYNLDPQRPVHFQGPA
                     DSFFGYAVLEHFHDNTRWVLVGAPKADSKYSPSVKSPGAVFKCRVHTNPDRRCTELDM
                     ARGKNRGTSCGKTCREDRDDEWMGVSLARQPKADGRVLACAHRWKNIYYEADHILPHG
                     FCYIIPSNLQAKGRTLIPCYEEYKKKYGEEHGSCQAGIAGFFTEELVVMGAPGSFYWA
                     GTIKVLNLTDNTYLKLNDEVIMNRRYTYLGYAVTAGHFSHPSTIDVVGGAPQDKGIGK
                     VYIFRADRRSGTLIKIFQASGKKMGSYFGSSLCAVDLNGDGLSDLLVGAPMFSEIRDE
                     GQVTVYINRGNGALEEQLALTGDGAYNAHFGESIASLDDLDNDGFPDVAIGAPKEDDF
                     AGAVYIYHGDAGGIVPQYSMKLSGQKINPVLRMFGQSISGGIDMDGNGYPDVTVGAFM
                     SDSVVLLRARPVITVDVSIFLPGSINITAPQCHDGQQPVNCLNVTTCFSFHGKHVPGE
                     IGLNYVLMADVAKKEKGQMPRVYFVLLGETMGQVTEKLQLTYMEETCRHYVAHVKRRV
                     QDVISPIVFEAAYSLSEHVTGEEERELPPLTPVLRWKKGQKIAQKNQTVFERNCRSED
                     CAADLQLQGKLLLSSMDEKTLYLALGAVKNISLNISISNLGDDAYDANVSFNVSRELF
                     FINMWQKEEMGISCELLESDFLKCSVGFPFMRSKSKYEFSVIFDTSHLSGEEEVLSFI
                     VTAQSGNTERSESLHDNTLVLMVPLMHEVDTSITGIMSPTSFVYGESVDAANFIQLDD
                     LECHFQPINITLQVYNTGPSTLPGSSVSISFPNRLSSGGAEMFHVQEMVVGQEKGNCS
                     FQKNPTPCIIPQEQENIFHTIFAFFTKSGRKVLDCEKPGISCLTAHCNFSALAKEESR
                     TIDIYMLLNTEILKKDSSSVIQFMSRAKVKVDPALRVVEIAHGNPEEVTVVFEALHNL
                     EPRGYVVGWIIAISLLVGILIFLLLAVLLWKMGFFRRRYKEIIEAEKNRKENEDSWDW
                     VQKNQ"
     exon            420..547
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /inference="alignment:Splign:2.1.0"
     exon            548..654
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /inference="alignment:Splign:2.1.0"
     exon            655..778
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /inference="alignment:Splign:2.1.0"
     exon            779..846
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /inference="alignment:Splign:2.1.0"
     exon            847..976
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1062
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1131
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1269
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1375
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1470
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1561
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1607
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1762
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1923
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2073
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2150
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2301
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2388
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2468
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2558
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2667
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2775
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..2901
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..3021
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /inference="alignment:Splign:2.1.0"
     exon            3022..3123
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /inference="alignment:Splign:2.1.0"
     exon            3124..3243
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /inference="alignment:Splign:2.1.0"
     exon            3244..7860
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7839..7844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /note="hexamer: AATAAA"
     polyA_site      7860
                     /gene="ITGA9"
                     /gene_synonym="ALPHA-RLC; ITGA4L; RLC"
                     /note="major polyA site"
ORIGIN      
        1 agacttctcg ggcggactga ggacgccgcc gctcggggcc gcccctgtgc tcgccttcag
       61 cgcccgctca gcccgccgtc cgcgccccgg tggcgggccc gacgcccgca ttccgcccgt
      121 gtccaggcgc agagctcccg ccccggggag cttcctggcc gtcggcgggc cccgcggccc
      181 gcgcgctcgg cgccctgctc gccgggcaga ggggaaggcg gcggccggct ggggatgggc
      241 ggcccggctg cgccgagggg cgccgggagg ctccgcgcgc tgctgctggc gctggtggtc
      301 gcggggatcc ccgcgggcgc ctacaacctc gacccgcagc gccccgtgca cttccagggc
      361 cccgctgact cgttcttcgg ctacgcagtt ctggagcatt tccacgacaa cacgcgctgg
      421 gtccttgtgg gcgcaccaaa ggcagattcc aaatacagcc cttcagtgaa gtctcctggg
      481 gctgtgttta agtgccgtgt tcacaccaac cctgaccgga gatgcaccga actggacatg
      541 gctcgaggga agaatcgggg cacgtcctgc ggaaagacct gccgggaaga ccgcgatgat
      601 gagtggatgg gggtgagcct ggcccgacag cccaaggctg atggccgtgt gttggcctgt
      661 gctcatcgct ggaagaacat ctactatgaa gccgaccaca tcctacccca tggcttctgc
      721 tacatcatcc cctccaacct ccaggccaaa ggcaggacgc tgatcccttg ctatgaagag
      781 tataagaaga agtacggaga ggaacacggc tcctgccagg ctgggatagc gggcttcttc
      841 accgaggagc tggtggtgat gggtgctcca gggtcatttt attgggctgg aaccatcaaa
      901 gtgctgaacc ttacggacaa cacctattta aaactgaacg acgaagtgat catgaacagg
      961 cggtacacct acctgggcta cgcagtgacc gctggccact tctctcaccc gtccaccatt
     1021 gatgtggtag gaggtgcccc acaggacaaa ggcatcggca aggtttatat tttcagagct
     1081 gaccgaagat caggcacctt aattaagatc tttcaagcat caggtaaaaa gatgggctct
     1141 tacttcggct cctccttgtg cgcagttgac ctgaatgggg acggcctctc tgacctgctg
     1201 gtgggggccc ccatgttttc tgagatcagg gatgagggac aggtcactgt ctacatcaac
     1261 agaggaaatg gagccctcga ggagcagctg gctctgactg gggatggtgc ctacaatgcg
     1321 cactttggag agagcattgc cagcctggac gatctggaca atgatgggtt cccagatgtg
     1381 gccattggtg cacccaagga ggatgacttc gcaggggcgg tctatatcta tcatggtgat
     1441 gccggtggga tagtccctca gtactcaatg aaactgtctg ggcagaagat aaatccagtg
     1501 ctccggatgt ttggtcagtc catatcggga ggcattgata tggatggaaa tggctatcct
     1561 gatgtcactg ttggagcctt catgtccgac agcgtggttc ttctcagagc aaggcctgtc
     1621 attacggtgg atgtctccat cttcctcccg ggctccatca acatcacagc gcctcagtgt
     1681 cacgacggac agcagcctgt gaactgcctg aacgtcacca cctgcttcag cttccatggc
     1741 aaacacgttc caggagagat tggcctgaat tatgttctga tggctgacgt ggccaaaaag
     1801 gagaagggcc agatgcccag ggtctacttt gtgctgctgg gagagaccat gggtcaggtc
     1861 acagagaagc tgcagctgac ttacatggag gagacgtgtc gtcactatgt ggcccatgtg
     1921 aagcggaggg tgcaggacgt catcagcccg atcgtgtttg aagcagccta cagcctcagt
     1981 gagcatgtga ctggagagga ggagagggaa ctgccgcctc tgacaccagt tctccgctgg
     2041 aaaaagggac aaaagattgc ccaaaagaat cagactgttt ttgaaaggaa ttgccgttca
     2101 gaggactgtg ccgcagacct gcagcttcag ggtaaactgc tgctctccag tatggatgag
     2161 aaaaccctgt atctagcttt gggggctgtg aagaacatct ccctaaacat ctctatctcc
     2221 aacctcggag atgatgccta tgatgccaac gtgtccttca atgtttcccg ggagctcttc
     2281 ttcatcaaca tgtggcagaa ggaggagatg ggcatctcct gtgagctgct ggaatcggac
     2341 ttcctcaaat gcagcgtggg atttcctttc atgaggtcaa agtcaaagta tgaattcagc
     2401 gtgatctttg atacaagcca cctgtctggg gaagaggaag ttctcagctt cattgttact
     2461 gctcagagtg gcaacacgga gcgctctgaa tccctgcatg acaacaccct cgtgctgatg
     2521 gtgccactga tgcacgaggt ggacacgtcc atcaccggaa tcatgtctcc aacctccttt
     2581 gtatatggcg agtccgtgga cgcagccaac ttcattcagc tggatgacct ggagtgtcac
     2641 tttcagccca tcaatatcac ccttcaggtc tacaacactg gcccaagcac ccttccaggg
     2701 tcatctgtca gcatctcttt ccctaatcga ctctcatctg gtggtgcaga gatgtttcat
     2761 gtccaggaaa tggtggtggg ccaagagaag ggaaactgct ctttccagaa aaacccaact
     2821 ccctgcatca tccctcaaga acaagaaaat atcttccaca caatatttgc ttttttcaca
     2881 aagtctggaa gaaaagtctt ggactgtgaa aaaccaggaa tttcttgcct aacagcacac
     2941 tgtaacttta gtgctcttgc taaagaagaa agtcgtacta tagacattta catgctgctg
     3001 aacacagaaa tactgaaaaa ggacagttcg tctgtcatcc agttcatgtc ccgcgccaag
     3061 gtgaaggtgg atcctgccct aagggtggtg gaaatagctc atgggaaccc agaagaggtg
     3121 acggtggtct tcgaggccct gcacaatctg gagccccgtg gctacgtcgt ggggtggatc
     3181 atcgccatca gtttgttggt gggaatcctc atcttcctgc tgctggccgt gctgctctgg
     3241 aagatgggct tctttcgccg aaggtacaaa gaaattatcg aagctgagaa gaaccggaaa
     3301 gagaatgaag acagttggga ctgggtccag aaaaaccagt gagctgccac accagtcaca
     3361 tgacctgatc actagcctgt catccttggt ctttgtatct tccatatttg gaagaaaaaa
     3421 atcttctcca gatttttcgg aggccccact gatgctgttc tcttcttcat tctatcaagc
     3481 ccaggtgcca gcctgaggca gccacttcgg ccaggtcaca cgaccggggc cagcaccact
     3541 tcctttaaag atgaactctg aactttggag agtgagctac agagccgagc aatatttatg
     3601 gatgcaacac gcatggtcaa ccctcagggg aaaactgtta cctaaagtat ttttataaat
     3661 ataagccttt tatactgatt atgtctttta tatttgtatc gatgttttat tatttctatt
     3721 aaatagttat ataattcact caagcactga tatctggcct aaaatcttgg aagtacatgt
     3781 ccatgaatac aaattttaaa ggatgaaaat cttaccgtac tttggaactt gctgtttaaa
     3841 aagacagatg aaataagttg aagaaacctc atgtaatgaa tccaccaggc tggcagtggt
     3901 gcatataaac tgtgggtgtg gcaagacccc gaagacattt cacatcttta tcgcctcgat
     3961 caagtgtgga gtcacatgct aatgtgtgct aaagaactgt aagtgttttt tcatatgtac
     4021 ttttcattgg aagattccca acaagaattt ggatggaaaa cctgatccct agcaagaagt
     4081 ctgctctgta tcacctttat atagcagaca tgtcaccctg cttctacaca gatgatggat
     4141 gaaagcttgg agcaatgcca tgtggtcatc tggtaaacct cagaatggcg tctcatcctg
     4201 gacatcctgc atcagagttc acacaccaca aggactaaat ccttgtcccc taagcaaaga
     4261 attgggtctg aatgctgtga gggattgcct ttttgtggta attttcattg agagatcttc
     4321 atttccccta ccaccctggc tgtcccagct agtggtgatt gcagattcct tcccagagag
     4381 gacatttaac cgttttaaaa aaaatgtctt agattgggtt cccaagaagc agtccctgaa
     4441 acaaggattt gtgtgcaagt aacttattaa ggaagtattc ccaggggata ccagtaagag
     4501 agtgggggaa gcaggacaag gaaggagaca aagccaggca aatgtttgtc atttcaggga
     4561 gagctccatg aagtttagcc tcagcctgat caggggaact ccggaggaaa agttaggcct
     4621 cagaggtgtc ccaacctgaa tcaaggggct ggctgcaccc agaggagatg taaacgtttt
     4681 attctcaatt cctgctggcg taatggctcc agtagctcag gacagtcctc taaaggacaa
     4741 ccacagatgc atcctcagcc aggggagaca cagggaaatg atgcaaaaga aatgatgcaa
     4801 aggatctgag cagaacactg cccctcccca ccccctgaat gtgtgagtgc tgagttacgg
     4861 ccttcagtat ccaagctctc tgtttgacag tagatatatt gtcagatgca ctgtgctgct
     4921 tagttttgag tgcagtgtga ttttctgaaa gggcaatgag atgatggatg tagcatgctc
     4981 agcactgacc tggcccatag tgatcactca ataactgtta acagctatgg ctgctattcc
     5041 tactgatgga taaccatcta ataagacaga aaacatgggg ctaagagcag ggtctaacgg
     5101 agtcttaatg gcttattaca gcctgccaaa gtgccagcta catacacatg gcatccagtg
     5161 cggatgaaac aatctataaa accaagggtc tttcttatag cacctttttt actggaagct
     5221 aacacgttgg gagtccgtga acattgtcaa aaagacatca aactcaactt ctgggaagac
     5281 agatttttaa tacacatact tggctaatac tcacaaacat atctaaagtt ttggcaaaat
     5341 tatgagggtg atgggtgggt actaacctgg catggagcag gtgtgtcttt tggtttctta
     5401 tgcagttgac tctgctgcag ggagattaca gatgtaacct catgcttctc ttcctggtga
     5461 acatgggaat agaccaaaaa aatcaagggt caatggcatg aactaagctg atcctggaaa
     5521 tcagggatgt tgcatctaac tgtgggatgg aggcacagag gtagctacag ggagcaggac
     5581 gaggcaaaga aagcagctgt cactcagagt tcgcttatga gttttatcaa aagcagcaag
     5641 aaaagcagtc ttgggtgggt tttatcactt attaacagcc atttatgagg cccctgctgt
     5701 gtgtcaggca ctgtgcaagg tgctggaggt tccccagaga acacttcagg gacattttgc
     5761 ctcagggtgg caaaatgcag tggcatgtgg actttttgaa tgggatgcca tttgcagctt
     5821 tcctttgatg gactcttgtt cataatgcca tgttttcttt aatgaatcat ttaggattct
     5881 taggtgatat ttctggaaca gcaccatcaa cagctttggc cacatgcact tagagcaact
     5941 aacttgcctc ctgccggggt gtaggtgcgt tggtgacagt gtagaagggt gattcgcagg
     6001 cccatgttct gcccaccagc aaagccccac tggagaaggg tagactcctg tgggcagtct
     6061 cagagctggg acctatttgc ttctgcttga ttctgcgtgg gtggacccac atgagcagct
     6121 gtatacccag gaggtcacta agactttata aaggcaggtt ttaagaaaac cagccttggc
     6181 atcaccacca gcagatactg aaagcctccc caggaacctg tctggggaag gatgatgcct
     6241 ctgctggtct gatcgtgctg agtagcaggt gggctacggg gactggggag ttaagcattt
     6301 tgtgcagtga tagagaagtc aagcatatcg ttagcgctct ctcaacttgg gcagttcaca
     6361 agctccttcc cagctcagaa gccctctcta tgctctcagg ggaagcagat ggggtggatc
     6421 agtacatctg tgttaccctt ccagaatatt atttgaaaat tctacagtat gttctacttt
     6481 ctccccttcc tgcttccatg gtttcactgt ggaatcctat aagatattct cctgagcagt
     6541 attatttcag tttccttcag cttttagttg aatcttcaat gtggttttaa ccaactgttc
     6601 agagaactga aatggttttt aaatatgaaa aaggaccttt gtaaaaatgg agtaaaacag
     6661 tgcccctttt ttaaaaaaag ttttgcttat gcttaattta cataggactc aggagagttt
     6721 ggaacatcct ccaagtgggc catagagctg tcacaaagaa gaggccatga tgtttagaaa
     6781 caaggggaca ctagcaggag gggcagggtc cactggctta gtggcaactg acaggcatcc
     6841 attccgaata actcagcact gaggtttcct caggcagttc tttaggaaaa ctgtcagcat
     6901 catgggtact cagaggtatg gtagaccttg tagaagatcc actaggaagt cctccttcac
     6961 caaatcatgt agctactgcc cttgagccaa aggcaatgag gtttaaaaca aaaacccaac
     7021 agcactcctg ggaacatcct gttttccatg cggaagcata gcagatcccc agacgatccg
     7081 tgtgctgtat gctacctgtt gaaccctagc atggtggctt tttaaaaggt tatttatgac
     7141 ttttattttt gggtaaggca ttatggccag gtgcatgcag ttatgtctgg gttacgtgtg
     7201 aaacgtacat ctggtgaact gtatacttgg ctcaaacttc tcaaaattta gaggtgctgg
     7261 aaaggattgt cacttggagc ctttagtaga caaaaggcag aaagtgagca tcatttcaga
     7321 aatgctttag tatgcacact tttagctgat attttgatat atagaataat aatatacaca
     7381 gtggagaata ttcaaagagt ggctgaaggg agaatacaga gccagtaggg ccaaaatgaa
     7441 acttctagga tgtcttctga attttcagca catgggggga ataagtgaac aaatttccca
     7501 acatcgtgca atgctttata gcacaatgat ctagatttca gactgtgtta aggttttttc
     7561 tttgttgatg ttgttgtttt aattctaatg tgcacggtgt gactggcaga gtgagtttaa
     7621 aagctttacg agtgattaat tgcttggcag gcacccacgc tatctgcatt tccagaactt
     7681 tactgatgca tccatgtaca tttccactga ggaattttgg tgggtggggg gaggttgtgc
     7741 tgcctcacaa tgtcacgtgt attaaagtct aagcagtcac ttctgattca cttgcactgt
     7801 ttgggaaatg tcaggtttac aaaaacatac atgtttggaa taaaaaatgg ctgcaaacaa
//
