LOCUS       NM_002206               4126 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens integrin subunit alpha 7 (ITGA7), transcript variant
            2, mRNA.
ACCESSION   NM_002206
VERSION     NM_002206.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4126)
  AUTHORS   Yang,X.X. and Wang,C.
  TITLE     CircITGA7 regulates malignant phenotypes in bladder cancer cells
            via targeting miR-330-3p/KLF10 axis
  JOURNAL   Kaohsiung J Med Sci 40 (4), 324-334 (2024)
   PUBMED   38523597
  REMARK    GeneRIF: CircITGA7 regulates malignant phenotypes in bladder cancer
            cells via targeting miR-330-3p/KLF10 axis.
REFERENCE   2  (bases 1 to 4126)
  AUTHORS   Liu,X., Gao,R., Wu,Q., Li,G., Xu,X., Li,W., Liu,P., Wang,X.,
            Cai,J., Li,M. and Wang,Z.
  TITLE     ITGA7 loss drives the differentiation of adipose-derived
            mesenchymal stem cells to cancer-associated fibroblasts
  JOURNAL   Mol Carcinog 63 (3), 479-493 (2024)
   PUBMED   38174862
  REMARK    GeneRIF: ITGA7 loss drives the differentiation of adipose-derived
            mesenchymal stem cells to cancer-associated fibroblasts.
REFERENCE   3  (bases 1 to 4126)
  AUTHORS   Bugiardini,E., Nunes,A.M., Oliveira-Santos,A., Dagda,M.,
            Fontelonga,T.M., Barraza-Flores,P., Pittman,A.M., Morrow,J.M.,
            Parton,M., Houlden,H., Elliott,P.M., Syrris,P., Maas,R.P.,
            Akhtar,M.M., Kusters,B., Raaphorst,J., Schouten,M., Kamsteeg,E.J.,
            van Engelen,B., Hanna,M.G., Phadke,R., Lopes,L.R., Matthews,E. and
            Burkin,D.J.
  TITLE     Integrin alpha7 Mutations Are Associated With Adult-Onset Cardiac
            Dysfunction in Humans and Mice
  JOURNAL   J Am Heart Assoc 11 (23), e026494 (2022)
   PUBMED   36444867
  REMARK    GeneRIF: Integrin alpha7 Mutations Are Associated With Adult-Onset
            Cardiac Dysfunction in Humans and Mice.
REFERENCE   4  (bases 1 to 4126)
  AUTHORS   Li,C., Liu,J., Yang,W., Chen,C. and Wu,B.
  TITLE     The relationship among integrin alpha 7, CD133 and Nestin as well
            as their correlation with clinicopathological features and
            prognosis in astrocytoma patients
  JOURNAL   Clin Neurol Neurosurg 217, 107198 (2022)
   PUBMED   35430343
  REMARK    GeneRIF: The relationship among integrin alpha 7, CD133 and Nestin
            as well as their correlation with clinicopathological features and
            prognosis in astrocytoma patients.
REFERENCE   5  (bases 1 to 4126)
  AUTHORS   Yuan,N., Wang,L., Xi,Q., Zou,N., Zhang,X., Lu,X. and Zhang,Z.
  TITLE     ITGA7, CD133, ALDH1 are inter-correlated, and linked with poor
            differentiation, lymph node metastasis as well as worse survival in
            surgical cervical cancer
  JOURNAL   J Obstet Gynaecol Res 48 (4), 1011-1018 (2022)
   PUBMED   35194895
  REMARK    GeneRIF: ITGA7, CD133, ALDH1 are inter-correlated, and linked with
            poor differentiation, lymph node metastasis as well as worse
            survival in surgical cervical cancer.
REFERENCE   6  (bases 1 to 4126)
  AUTHORS   Wang,W., Wu,W., Desai,T., Ward,D.C. and Kaufman,S.J.
  TITLE     Localization of the alpha 7 integrin gene (ITGA7) on human
            chromosome 12q13: clustering of integrin and Hox genes implies
            parallel evolution of these gene families
  JOURNAL   Genomics 26 (3), 568-570 (1995)
   PUBMED   7607681
REFERENCE   7  (bases 1 to 4126)
  AUTHORS   Song,W.K., Wang,W., Sato,H., Bielser,D.A. and Kaufman,S.J.
  TITLE     Expression of alpha 7 integrin cytoplasmic domains during skeletal
            muscle development: alternate forms, conformational change, and
            homologies with serine/threonine kinases and tyrosine phosphatases
  JOURNAL   J Cell Sci 106 (Pt 4), 1139-1152 (1993)
   PUBMED   8126096
REFERENCE   8  (bases 1 to 4126)
  AUTHORS   Sparks,S.E., Quijano-Roy,S., Harper,A., Rutkowski,A., Gordon,E.,
            Hoffman,E.P. and Pegoraro,E.
  TITLE     Congenital Muscular Dystrophy Overview - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301468
REFERENCE   9  (bases 1 to 4126)
  AUTHORS   Song,W.K., Wang,W., Foster,R.F., Bielser,D.A. and Kaufman,S.J.
  TITLE     H36-alpha 7 is a novel integrin alpha chain that is developmentally
            regulated during skeletal myogenesis
  JOURNAL   J Cell Biol 117 (3), 643-657 (1992)
   PUBMED   1315319
  REMARK    Erratum:[J Cell Biol 1992 Jul;118(1):213]
REFERENCE   10 (bases 1 to 4126)
  AUTHORS   Kramer,R.H., Vu,M.P., Cheng,Y.F., Ramos,D.M., Timpl,R. and Waleh,N.
  TITLE     Laminin-binding integrin alpha 7 beta 1: functional
            characterization and expression in normal and malignant melanocytes
  JOURNAL   Cell Regul 2 (10), 805-817 (1991)
   PUBMED   1839357
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009779.18, DA398527.1,
            AB210036.1 and AF032108.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_002206.2.
            
            Summary: The protein encoded by this gene belongs to the integrin
            alpha chain family. Integrins are heterodimeric integral membrane
            proteins composed of an alpha chain and a beta chain. They mediate
            a wide spectrum of cell-cell and cell-matrix interactions, and thus
            play a role in cell migration, morphologic development,
            differentiation, and metastasis. This protein functions as a
            receptor for the basement membrane protein laminin-1. It is mainly
            expressed in skeletal and cardiac muscles and may be involved in
            differentiation and migration processes during myogenesis. Defects
            in this gene are associated with congenital myopathy. Alternatively
            spliced transcript variants encoding different isoforms have been
            noted for this gene. [provided by RefSeq, Feb 2009].
            
            Transcript Variant: This variant (2) contains an alternate in-frame
            coding exon compared to transcript variant 1. This results in a
            slightly shorter isoform (2) with a different internal protein
            segment compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF032108.1, BC050280.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257879.11/ ENSP00000257879.7
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC009779.18        29294-29295
            3-61                DA398527.1         4-62
            62-4122             AB210036.1         30-4090
            4123-4126           AF032108.1         4062-4065
FEATURES             Location/Qualifiers
     source          1..4126
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.2"
     gene            1..4126
                     /gene="ITGA7"
                     /note="integrin subunit alpha 7"
                     /db_xref="GeneID:3679"
                     /db_xref="HGNC:HGNC:6143"
                     /db_xref="MIM:600536"
     exon            1..428
                     /gene="ITGA7"
                     /inference="alignment:Splign:2.1.0"
     exon            429..556
                     /gene="ITGA7"
                     /inference="alignment:Splign:2.1.0"
     exon            557..636
                     /gene="ITGA7"
                     /inference="alignment:Splign:2.1.0"
     exon            637..892
                     /gene="ITGA7"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1012
                     /gene="ITGA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1220
                     /gene="ITGA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1414
                     /gene="ITGA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1503
                     /gene="ITGA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1631
                     /gene="ITGA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1727
                     /gene="ITGA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1789
                     /gene="ITGA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1959
                     /gene="ITGA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2109
                     /gene="ITGA7"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2225
                     /gene="ITGA7"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2418
                     /gene="ITGA7"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2499
                     /gene="ITGA7"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2579
                     /gene="ITGA7"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2654
                     /gene="ITGA7"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2757
                     /gene="ITGA7"
                     /inference="alignment:Splign:2.1.0"
     exon            2758..2934
                     /gene="ITGA7"
                     /inference="alignment:Splign:2.1.0"
     exon            2935..3066
                     /gene="ITGA7"
                     /inference="alignment:Splign:2.1.0"
     exon            3067..3180
                     /gene="ITGA7"
                     /inference="alignment:Splign:2.1.0"
     exon            3181..3279
                     /gene="ITGA7"
                     /inference="alignment:Splign:2.1.0"
     exon            3280..3405
                     /gene="ITGA7"
                     /inference="alignment:Splign:2.1.0"
     exon            3406..4126
                     /gene="ITGA7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4103..4108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGA7"
                     /note="hexamer: ATTAAA"
     polyA_site      4126
                     /gene="ITGA7"
                     /note="major polyA site"
ORIGIN      
        1 gtgggcgccg gagctgcggc tgctgtagtt gtcctagccg gtgctggggc ggcggggtgg
       61 cggagcggcg ggcgggcggg agggctggcg gggcgaacgt ctgggagacg tctgaaagac
      121 caacgagact ttggagacca gagacgcgcc tggggggacc tggggcttgg ggcgtgcgag
      181 atttcccttg cattcgctgg gagctcgcgc agggatcgtc ccatggccgg ggctcggagc
      241 cgcgaccctt ggggggcctc cgggatttgc tacctttttg gctccctgct cgtcgaactg
      301 ctcttctcac gggctgtcgc cttcaatctg gacgtgatgg gtgccttgcg caaggagggc
      361 gagccaggca gcctcttcgg cttctctgtg gccctgcacc ggcagttgca gccccgaccc
      421 cagagctggc tgctggtggg tgctccccag gccctggctc ttcctgggca gcaggcgaat
      481 cgcactggag gcctcttcgc ttgcccgttg agcctggagg agactgactg ctacagagtg
      541 gacatcgacc agggagctga tatgcaaaag gaaagcaagg agaaccagtg gttgggagtc
      601 agtgttcgga gccaggggcc tgggggcaag attgttacct gtgcacaccg atatgaggca
      661 aggcagcgag tggaccagat cctggagacg cgggatatga ttggtcgctg ctttgtgctc
      721 agccaggacc tggccatccg ggatgagttg gatggtgggg aatggaagtt ctgtgaggga
      781 cgcccccaag gccatgaaca atttgggttc tgccagcagg gcacagctgc cgccttctcc
      841 cctgatagcc actacctcct ctttggggcc ccaggaacct ataattggaa ggggttgctt
      901 tttgtgacca acattgatag ctcagacccc gaccagctgg tgtataaaac tttggaccct
      961 gctgaccggc tcccaggacc agccggagac ttggccctca atagctactt aggcttctct
     1021 attgactcgg ggaaaggtct ggtgcgtgca gaagagctga gctttgtggc tggagccccc
     1081 cgcgccaacc acaagggtgc tgtggtcatc ctgcgcaagg acagcgccag tcgcctggtg
     1141 cccgaggtta tgctgtctgg ggagcgcctg acctccggct ttggctactc actggctgtg
     1201 gctgacctca acagtgatgg ctggccagac ctgatagtgg gtgcccccta cttctttgag
     1261 cgccaagaag agctgggggg tgctgtgtat gtgtacttga accagggggg tcactgggct
     1321 gggatctccc ctctccggct ctgcggctcc cctgactcca tgttcgggat cagcctggct
     1381 gtcctggggg acctcaacca agatggcttt ccagatattg cagtgggtgc cccctttgat
     1441 ggtgatggga aagtcttcat ctaccatggg agcagcctgg gggttgtcgc caaaccttca
     1501 caggtgctgg agggcgaggc tgtgggcatc aagagcttcg gctactccct gtcaggcagc
     1561 ttggatatgg atgggaacca ataccctgac ctgctggtgg gctccctggc tgacaccgca
     1621 gtgctcttca gggccagacc catcctccat gtctcccatg aggtctctat tgctccacga
     1681 agcatcgacc tggagcagcc caactgtgct ggcggccact cggtctgtgt ggacctaagg
     1741 gtctgtttca gctacattgc agtccccagc agctatagcc ctactgtggc cctggactat
     1801 gtgttagatg cggacacaga ccggaggctc cggggccagg ttccccgtgt gacgttcctg
     1861 agccgtaacc tggaagaacc caagcaccag gcctcgggca ccgtgtggct gaagcaccag
     1921 catgaccgag tctgtggaga cgccatgttc cagctccagg aaaatgtcaa agacaagctt
     1981 cgggccattg tagtgacctt gtcctacagt ctccagaccc ctcggctccg gcgacaggct
     2041 cctggccagg ggctgcctcc agtggccccc atcctcaatg cccaccagcc cagcacccag
     2101 cgggcagaga tccacttcct gaagcaaggc tgtggtgaag acaagatctg ccagagcaat
     2161 ctgcagctgg tccgcgcccg cttctgtacc cgggtcagcg acacggaatt ccaacctctg
     2221 cccatggatg tggatggaac aacagccctg tttgcactga gtgggcagcc agtcattggc
     2281 ctggagctga tggtcaccaa cctgccatcg gacccagccc agccccaggc tgatggggat
     2341 gatgcccatg aagcccagct cctggtcatg cttcctgact cactgcacta ctcaggggtc
     2401 cgggccctgg accctgcgga gaagccactc tgcctgtcca atgagaatgc ctcccatgtt
     2461 gagtgtgagc tggggaaccc catgaagaga ggtgcccagg tcaccttcta cctcatcctt
     2521 agcacctccg ggatcagcat tgagaccacg gaactggagg tagagctgct gttggccacg
     2581 atcagtgagc aggagctgca tccagtctct gcacgagccc gtgtcttcat tgagctgcca
     2641 ctgtccattg caggaatggc cattccccag caactcttct tctctggtgt ggtgaggggc
     2701 gagagagcca tgcagtctga gcgggatgtg ggcagcaagg tcaagtatga ggtcacggtt
     2761 tccaaccaag gccagtcgct cagaaccctg ggctctgcct tcctcaacat catgtggcct
     2821 catgagattg ccaatgggaa gtggttgctg tacccaatgc aggttgagct ggagggcggg
     2881 caggggcctg ggcagaaagg gctttgctct cccaggccca acatcctcca cctggatgtg
     2941 gacagtaggg ataggaggcg gcgggagctg gagccacctg agcagcagga gcctggtgag
     3001 cggcaggagc ccagcatgtc ctggtggcca gtgtcctctg ctgagaagaa gaaaaacatc
     3061 accctggact gcgcccgggg cacggccaac tgtgtggtgt tcagctgccc actctacagc
     3121 tttgaccgcg cggctgtgct gcatgtctgg ggccgtctct ggaacagcac ctttctggag
     3181 gagtactcag ctgtgaagtc cctggaagtg attgtccggg ccaacatcac agtgaagtcc
     3241 tccataaaga acttgatgct ccgagatgcc tccacagtga tcccagtgat ggtatacttg
     3301 gaccccatgg ctgtggtggc agaaggagtg ccctggtggg tcatcctcct ggctgtactg
     3361 gctgggctgc tggtgctagc actgctggtg ctgctcctgt ggaagatggg attcttcaaa
     3421 cgggcgaagc accccgaggc caccgtgccc cagtaccatg cggtgaagat tcctcgggaa
     3481 gaccgacagc agttcaagga ggagaagacg ggcaccatcc tgaggaacaa ctggggcagc
     3541 ccccggcggg agggcccgga tgcacacccc atcctggctg ctgacgggca tcccgagctg
     3601 ggccccgatg ggcatccagg gccaggcacc gcctaggttc ccatgtccca gcctggcctg
     3661 tggctgccct ccatcccttc cccagagatg gctccttggg atgaagaggg tagagtgggc
     3721 tgctggtgtc gcatcaagat ttggcaggat cggcttcctc aggggcacag acctctccca
     3781 cccacaagaa ctcctcccac ccaacttccc cttagagtgc tgtgagatga gagtgggtaa
     3841 atcagggaca gggccatggg gtagggtgag aagggcaggg gtgtcctgat gcaaaggtgg
     3901 ggagaaggga tcctaatccc ttcctctccc attcaccctg tgtaacagga ccccaaggac
     3961 ctgcctcccc ggaagtgcct taacctagag ggtcggggag gaggttgtgt cactgactca
     4021 ggctgctcct tctctagttt cccctctcat ctgaccttag tttgctgcca tcagtctagt
     4081 ggtttcgtgg tttcgtctat ttattaaaaa atatttgaga acaaaa
//
