LOCUS       NM_000210               5816 bp    mRNA    linear   PRI 07-OCT-2024
DEFINITION  Homo sapiens integrin subunit alpha 6 (ITGA6), transcript variant
            2, mRNA.
ACCESSION   NM_000210
VERSION     NM_000210.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5816)
  AUTHORS   Guo,J., Zhang,J., Xiang,Y., Zhou,S., Yang,Y. and Zheng,J.
  TITLE     Long noncoding RNA SNHG3 interacts with microRNA-502-3p to mediate
            ITGA6 expression in liver hepatocellular carcinoma
  JOURNAL   Cancer Sci 115 (7), 2286-2300 (2024)
   PUBMED   38680094
  REMARK    GeneRIF: Long noncoding RNA SNHG3 interacts with microRNA-502-3p to
            mediate ITGA6 expression in liver hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 5816)
  AUTHORS   Zhang,J., Fu,L., Wang,H., Yonemura,A., Semba,T.,
            Yasuda-Yoshihara,N., Nishimura,A., Tajiri,T., Tong,Y., Yasuda,T.,
            Uchihara,T., Yamazaki,M., Okamoto,Y., Yamasaki,J., Nagano,O.,
            Baba,H. and Ishimoto,T.
  TITLE     RAC1-mediated integrin alpha-6 expression in E-cadherin-deficient
            gastric cancer cells promotes interactions with the stroma and
            peritoneal dissemination
  JOURNAL   Cancer Lett 591, 216901 (2024)
   PUBMED   38641311
  REMARK    GeneRIF: RAC1-mediated integrin alpha-6 expression in
            E-cadherin-deficient gastric cancer cells promotes interactions
            with the stroma and peritoneal dissemination.
REFERENCE   3  (bases 1 to 5816)
  AUTHORS   Zhao,K., Chen,L., Xie,Y., Ren,N., Li,J., Zhai,X., Zheng,S., Liu,K.,
            Wang,C., Qiu,Q., Peng,X., Wang,W., Liu,J., Che,Q., Fan,J., Hu,H.
            and Liu,M.
  TITLE     m6A/HOXA10-AS/ITGA6 axis aggravates oxidative resistance and
            malignant progression of laryngeal squamous cell carcinoma through
            regulating Notch and Keap1/Nrf2 pathways
  JOURNAL   Cancer Lett 587, 216735 (2024)
   PUBMED   38369001
  REMARK    GeneRIF: m6A/HOXA10-AS/ITGA6 axis aggravates oxidative resistance
            and malignant progression of laryngeal squamous cell carcinoma
            through regulating Notch and Keap1/Nrf2 pathways.
REFERENCE   4  (bases 1 to 5816)
  AUTHORS   Hou,S., Hao,X., Li,J., Weng,S., Wang,J., Zhao,T., Li,W., Hu,X.,
            Deng,B., Gu,J. and Hang,Q.
  TITLE     TM4SF1 promotes esophageal squamous cell carcinoma metastasis by
            interacting with integrin alpha6
  JOURNAL   Cell Death Dis 13 (7), 609 (2022)
   PUBMED   35835740
  REMARK    GeneRIF: TM4SF1 promotes esophageal squamous cell carcinoma
            metastasis by interacting with integrin alpha6.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5816)
  AUTHORS   Stewart,R.L. and O'Connor,K.L.
  TITLE     Clinical significance of the integrin alpha6beta4 in human
            malignancies
  JOURNAL   Lab Invest 95 (9), 976-986 (2015)
   PUBMED   26121317
  REMARK    Review article
REFERENCE   6  (bases 1 to 5816)
  AUTHORS   Lucky,A.W. and Gorell,E.
  TITLE     Epidermolysis Bullosa with Pyloric Atresia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301336
REFERENCE   7  (bases 1 to 5816)
  AUTHORS   Starr,L. and Quaranta,V.
  TITLE     An efficient and reliable method for cloning PCR-amplification
            products: a survey of point mutations in integrin cDNA
  JOURNAL   Biotechniques 13 (4), 612-618 (1992)
   PUBMED   1476731
REFERENCE   8  (bases 1 to 5816)
  AUTHORS   Tamura,R.N., Cooper,H.M., Collo,G. and Quaranta,V.
  TITLE     Cell type-specific integrin variants with alternative alpha chain
            cytoplasmic domains
  JOURNAL   Proc Natl Acad Sci U S A 88 (22), 10183-10187 (1991)
   PUBMED   1946438
REFERENCE   9  (bases 1 to 5816)
  AUTHORS   Hogervorst,F., Kuikman,I., van Kessel,A.G. and Sonnenberg,A.
  TITLE     Molecular cloning of the human alpha 6 integrin subunit.
            Alternative splicing of alpha 6 mRNA and chromosomal localization
            of the alpha 6 and beta 4 genes
  JOURNAL   Eur J Biochem 199 (2), 425-433 (1991)
   PUBMED   2070796
REFERENCE   10 (bases 1 to 5816)
  AUTHORS   Tamura,R.N., Rozzo,C., Starr,L., Chambers,J., Reichardt,L.F.,
            Cooper,H.M. and Quaranta,V.
  TITLE     Epithelial integrin alpha 6 beta 4: complete primary structure of
            alpha 6 and variant forms of beta 4
  JOURNAL   J Cell Biol 111 (4), 1593-1604 (1990)
   PUBMED   1976638
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB457895.1, X53586.1, X59512.1,
            AB208842.1, BG180469.1 and AC078883.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 31, 2019 this sequence version replaced NM_000210.3.
            
            Summary: The gene encodes a member of the integrin alpha chain
            family of proteins. Integrins are heterodimeric integral membrane
            proteins composed of an alpha chain and a beta chain that function
            in cell surface adhesion and signaling. The encoded preproprotein
            is proteolytically processed to generate light and heavy chains
            that comprise the alpha 6 subunit. This subunit may associate with
            a beta 1 or beta 4 subunit to form an integrin that interacts with
            extracellular matrix proteins including members of the laminin
            family. The alpha 6 beta 4 integrin may promote tumorigenesis,
            while the alpha 6 beta 1 integrin may negatively regulate
            erbB2/HER2 signaling. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Oct 2015].
            
            Transcript Variant: This variant (2) contains an alternate coding
            exon compared to variant 1, which results in a frameshift. The
            resulting isoform (b) is shorter and has a distinct C-terminus
            compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.11490.1,
                                           SRR1803611.34364.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000684293.1/ ENSP00000508249.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-461               DB457895.1         32-492
            462-2498            X53586.1           405-2441
            2499-3588           X59512.1           2278-3367
            3589-5631           AB208842.1         3157-5199
            5632-5798           BG180469.1         273-439
            5799-5806           AC078883.6         124568-124575
            5807-5812           BG180469.1         451-456
            5813-5816           AC078883.6         124582-124585
FEATURES             Location/Qualifiers
     source          1..5816
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..5816
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /note="integrin subunit alpha 6"
                     /db_xref="GeneID:3655"
                     /db_xref="HGNC:HGNC:6142"
                     /db_xref="MIM:147556"
     exon            1..385
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..3425
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /note="isoform b preproprotein is encoded by transcript
                     variant 2; integrin alpha6B; CD49 antigen-like family
                     member F; integrin, alpha 6; very late activation protein
                     6"
                     /codon_start=1
                     /product="integrin alpha-6 isoform b preproprotein"
                     /protein_id="NP_000201.2"
                     /db_xref="CCDS:CCDS2249.1"
                     /db_xref="GeneID:3655"
                     /db_xref="HGNC:HGNC:6142"
                     /db_xref="MIM:147556"
                     /translation="MAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLF
                     GFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRANRTGGLYSCDITARGPCTRIEFDND
                     ADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQN
                     LRIEDDMDGGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVR
                     VEQKNNTFFDMNIFEDGPYEVGGETEHDESLVPVPANSYLGFSLDSGKGIVSKDEITF
                     VSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDGEGLASSFGYDVAVVDLNKDGWQDIV
                     IGAPQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGTKDSMFGIAVKNIGDINQDGY
                     PDIAVGAPYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMDLDRNSYPDV
                     AVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVKSCFEYTAN
                     PAGYNPSISIVGTLEAEKERRKSGLSSRVQFRNQGSEPKYTQELTLKRQKQKVCMEET
                     LWLQDNIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLKE
                     GCGDDNVCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQKDIALEITVTNSP
                     SNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELG
                     NPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPITAKAKVVIELLLS
                     VSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWP
                     KEISNGKWLLYLVKVESKGLEKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDNRK
                     FSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYSKLNYLD
                     ILMRAFIDVTAAAENIRLPNAGTQVRVTVFPSKTVAQYSGVPWWIILVAILAGILMLA
                     LLVFILWKCGFFKRNKKDHYDATYHKAEIHAQPSDKERLTSDA"
     exon            386..510
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            511..590
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            591..846
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            847..978
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1189
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1383
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1472
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1591
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1690
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1752
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1913
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2057
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2173
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2363
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2447
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2527
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2605
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2606..2708
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2709..2882
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..2981
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2982..3092
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3093..3191
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3192..3317
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3318..3447
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3448..5816
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5530..5535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /note="hexamer: AATAAA"
     polyA_site      5550
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
     regulatory      5600..5605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /note="hexamer: TATAAA"
     polyA_site      5634
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /note="major polyA site"
     regulatory      5785..5790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /note="hexamer: AAGAAA"
     polyA_site      5816
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
ORIGIN      
        1 aacgggctca ttcagcggtc gcgagctgcc cgcgaggggg agcggccgga cggagagcgc
       61 gacccgtccc gggggtgggg ccgggcgcag cggcgagagg aggcgaaggt ggctgcggta
      121 gcagcagcgc ggcagcctcg gacccagccc ggagcgcagg gcggccgctg caggtccccg
      181 ctcccctccc cgtgcgtccg cccatggccg ccgccgggca gctgtgcttg ctctacctgt
      241 cggcggggct cctgtcccgg ctcggcgcag ccttcaactt ggacactcgg gaggacaacg
      301 tgatccggaa atatggagac cccgggagcc tcttcggctt ctcgctggcc atgcactggc
      361 aactgcagcc cgaggacaag cggctgttgc tcgtgggggc cccgcgggca gaagcgcttc
      421 cactgcagag agccaacaga acgggagggc tgtacagctg cgacatcacc gcccgggggc
      481 catgcacgcg gatcgagttt gataacgatg ctgaccccac gtcagaaagc aaggaagatc
      541 agtggatggg ggtcaccgtc cagagccaag gtccaggggg caaggtcgtg acatgtgctc
      601 accgatatga aaaaaggcag catgttaata cgaagcagga atcccgagac atctttgggc
      661 ggtgttatgt cctgagtcag aatctcagga ttgaagacga tatggatggg ggagattgga
      721 gcttttgtga tgggcgattg agaggccatg agaaatttgg ctcttgccag caaggtgtag
      781 cagctacttt tactaaagac tttcattaca ttgtatttgg agccccgggt acttataact
      841 ggaaagggat tgttcgtgta gagcaaaaga ataacacttt ttttgacatg aacatctttg
      901 aagatgggcc ttatgaagtt ggtggagaga ctgagcatga tgaaagtctc gttcctgttc
      961 ctgctaacag ttacttaggt ttttctttgg actcagggaa aggtattgtt tctaaagatg
     1021 agatcacttt tgtatctggt gctcccagag ccaatcacag tggagccgtg gttttgctga
     1081 agagagacat gaagtctgca catctcctcc ctgagcacat attcgatgga gaaggtctgg
     1141 cctcttcatt tggctatgat gtggcggtgg tggacctcaa caaggatggg tggcaagata
     1201 tagttattgg agccccacag tattttgata gagatggaga agttggaggt gcagtgtatg
     1261 tctacatgaa ccagcaaggc agatggaata atgtgaagcc aattcgtctt aatggaacca
     1321 aagattctat gtttggcatt gcagtaaaaa atattggaga tattaatcaa gatggctacc
     1381 cagatattgc agttggagct ccgtatgatg acttgggaaa ggtttttatc tatcatggat
     1441 ctgcaaatgg aataaatacc aaaccaacac aggttctcaa gggtatatca ccttattttg
     1501 gatattcaat tgctggaaac atggaccttg atcgaaattc ctaccctgat gttgctgttg
     1561 gttccctctc agattcagta actattttca gatcccggcc tgtgattaat attcagaaaa
     1621 ccatcacagt aactcctaac agaattgacc tccgccagaa aacagcgtgt ggggcgccta
     1681 gtgggatatg cctccaggtt aaatcctgtt ttgaatatac tgctaacccc gctggttata
     1741 atccttcaat atcaattgtg ggcacacttg aagctgaaaa agaaagaaga aaatctgggc
     1801 tatcctcaag agttcagttt cgaaaccaag gttctgagcc caaatatact caagaactaa
     1861 ctctgaagag gcagaaacag aaagtgtgca tggaggaaac cctgtggcta caggataata
     1921 tcagagataa actgcgtccc attcccataa ctgcctcagt ggagatccaa gagccaagct
     1981 ctcgtaggcg agtgaattca cttccagaag ttcttccaat tctgaattca gatgaaccca
     2041 agacagctca tattgatgtt cacttcttaa aagagggatg tggagacgac aatgtatgta
     2101 acagcaacct taaactagaa tataaatttt gcacccgaga aggaaatcaa gacaaatttt
     2161 cttatttacc aattcaaaaa ggtgtaccag aactagttct aaaagatcag aaggatattg
     2221 ctttagaaat aacagtgaca aacagccctt ccaacccaag gaatcccaca aaagatggcg
     2281 atgacgccca tgaggctaaa ctgattgcaa cgtttccaga cactttaacc tattctgcat
     2341 atagagaact gagggctttc cctgagaaac agttgagttg tgttgccaac cagaatggct
     2401 cgcaagctga ctgtgagctc ggaaatcctt ttaaaagaaa ttcaaatgtc actttttatt
     2461 tggttttaag tacaactgaa gtcacctttg acaccccaga tctggatatt aatctgaagt
     2521 tagaaacaac aagcaatcaa gataatttgg ctccaattac agctaaagca aaagtggtta
     2581 ttgaactgct tttatcggtc tcgggagttg ctaaaccttc ccaggtgtat tttggaggta
     2641 cagttgttgg cgagcaagct atgaaatctg aagatgaagt gggaagttta atagagtatg
     2701 aattcagggt aataaactta ggtaaacctc ttacaaacct cggcacagca accttgaaca
     2761 ttcagtggcc aaaagaaatt agcaatggga aatggttgct ttatttggtg aaagtagaat
     2821 ccaaaggatt ggaaaaggta acttgtgagc cacaaaagga gataaactcc ctgaacctaa
     2881 cggagtctca caactcaaga aagaaacggg aaattactga aaaacagata gatgataaca
     2941 gaaaattttc tttatttgct gaaagaaaat accagactct taactgtagc gtgaacgtga
     3001 actgtgtgaa catcagatgc ccgctgcggg ggctggacag caaggcgtct cttattttgc
     3061 gctcgaggtt atggaacagc acatttctag aggaatattc caaactgaac tacttggaca
     3121 ttctcatgcg agccttcatt gatgtgactg ctgctgccga aaatatcagg ctgccaaatg
     3181 caggcactca ggttcgagtg actgtgtttc cctcaaagac tgtagctcag tattcgggag
     3241 taccttggtg gatcatccta gtggctattc tcgctgggat cttgatgctt gctttattag
     3301 tgtttatact atggaagtgt ggtttcttca agagaaataa gaaagatcat tatgatgcca
     3361 catatcacaa ggctgagatc catgctcagc catctgataa agagaggctt acttctgatg
     3421 catagtattg atctacttct gtaattgtgt ggattcttta aacgctctag gtacgatgac
     3481 agtgttcccc gataccatgc tgtaaggatc cggaaagaag agcgagagat caaagatgaa
     3541 aagtatattg ataaccttga aaaaaaacag tggatcacaa agtggaacga aaatgaaagc
     3601 tactcatagc gggggcctaa aaaaaaaaag cttcacagta cccaaactgc tttttccaac
     3661 tcagaaattc aatttggatt taaaagcctg ctcaatccct gaggactgat ttcagagtga
     3721 ctacacacag tacgaaccta cagttttaac tgtggatatt gttacgtagc ctaaggctcc
     3781 tgttttgcac agccaaattt aaaactgttg gaatggattt ttctttaact gccgtaattt
     3841 aactttctgg gttgccttta tttttggcgt ggctgactta catcatgtgt tggggaaggg
     3901 cctgcccagt tgcactcagg tgacatcctc cagatagtgt agctgaggag gcacctacac
     3961 tcacctgcac taacagagtg gccgtcctaa cctcgggcct gctgcgcaga cgtccatcac
     4021 gttagctgtc ccacatcaca agactatgcc attggggtag ttgtgtttca acggaaagtg
     4081 ctgtcttaaa ctaaatgtgc aatagaaggt gatgttgcca tcctaccgtc ttttcctgtt
     4141 tcctagctgt gtgaatacct gctcacgtca aatgcataca agtttcattc tccctttcac
     4201 taaaacacac aggtgcaaca gacttgaatg ctagttatac ttatttgtat atggtattta
     4261 ttttttcttt tctttacaaa ccattttgtt attgactaac aggccaaaga gtctccagtt
     4321 tacccttcag gttggtttaa tcaatcagaa ttagagcatg ggaggtcatc actttgacct
     4381 aaattattta ctgcaaaaag aaaatcttta taaatgtacc agagagagtt gttttaataa
     4441 cttatctata aactataacc tctccttcat gacagcctcc accccacaac ccaaaaggtt
     4501 taagaaatag aattataact gtaaagatgt ttatttcagg cattggatat tttttacttt
     4561 agaagcctgc ataatgtttc tggatttcat actgtaacat tcaggaattc ttggagaaaa
     4621 tgggtttatt cactgaactc tagtgcggtt tactcactgc tgcaaatact gtatattcag
     4681 gacttgaaag aaatggtgaa tgcctatggt ggatccaaac tgatccagta taagactact
     4741 gaatctgcta ccaaaacagt taatcagtga gtcgatgttc tattttttgt tttgtttcct
     4801 cccctatctg tattcccaaa aattactttg gggctaattt aacaagaact ttaaattgtg
     4861 ttttaattgt aaaaatggca gggggtggaa ttattactct atacattcaa cagagactga
     4921 atagatatga aagctgattt tttttaatta ccatgcttca caatgttaag ttatatgggg
     4981 agcaacagca aacaggtgct aatttgtttt ggatatagta taagcagtgt ctgtgttttg
     5041 aaagaataga acacagtttg tagtgccact gttgttttgg gggggctttt ttcttttcgg
     5101 aaatcttaaa ccttaagata ctaaggacgt tgttttggtt gtactttgga attcttagtc
     5161 acaaaatata ttttgtttac aaaaatttct gtaaaacagg ttataacagt gtttaaagtc
     5221 tcagtttctt gcttggggaa cttgtgtccc taatgtgttt agattgctag attgctaagg
     5281 agctgatact ttgacagtgt ttttagacct gtgttactaa aaaaaagatg aatgtcctga
     5341 aaagggtgtt gggagggtgg ttcaacaaag aaacaaagat gttatggtgt ttagatttat
     5401 ggttgttaaa aatgtcatct caagtcaagt cactggtctg tttgcatttg atacattttt
     5461 gtactaacta gcattgtaaa attatttcat gattagaaat tacctgtgga tatttgtata
     5521 aaagtgtgaa ataaattttt tataaaagtg ttcattgttt cgtaacacag cattgtatat
     5581 gtgaagcaaa ctctaaaatt ataaatgaca acctgaatta tctatttcat caaaccaaag
     5641 ttcagtgttt ttatttttgg tgtctcatgt aatctcagat cagccaaaga tactagtgcc
     5701 aaagcaatgg gattcggggt ttttttctgt tttcgctcta tgtaggtgat cctcaagtct
     5761 ttcattttcc ttctttatga ttaaaagaaa cctacaggta tttaacaacc tacaaa
//
