LOCUS       NP_000201               1073 aa            linear   PRI 07-OCT-2024
DEFINITION  integrin alpha-6 isoform b preproprotein [Homo sapiens].
ACCESSION   NP_000201
VERSION     NP_000201.2
DBSOURCE    REFSEQ: accession NM_000210.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1073)
  AUTHORS   Guo,J., Zhang,J., Xiang,Y., Zhou,S., Yang,Y. and Zheng,J.
  TITLE     Long noncoding RNA SNHG3 interacts with microRNA-502-3p to mediate
            ITGA6 expression in liver hepatocellular carcinoma
  JOURNAL   Cancer Sci 115 (7), 2286-2300 (2024)
   PUBMED   38680094
  REMARK    GeneRIF: Long noncoding RNA SNHG3 interacts with microRNA-502-3p to
            mediate ITGA6 expression in liver hepatocellular carcinoma.
REFERENCE   2  (residues 1 to 1073)
  AUTHORS   Zhang,J., Fu,L., Wang,H., Yonemura,A., Semba,T.,
            Yasuda-Yoshihara,N., Nishimura,A., Tajiri,T., Tong,Y., Yasuda,T.,
            Uchihara,T., Yamazaki,M., Okamoto,Y., Yamasaki,J., Nagano,O.,
            Baba,H. and Ishimoto,T.
  TITLE     RAC1-mediated integrin alpha-6 expression in E-cadherin-deficient
            gastric cancer cells promotes interactions with the stroma and
            peritoneal dissemination
  JOURNAL   Cancer Lett 591, 216901 (2024)
   PUBMED   38641311
  REMARK    GeneRIF: RAC1-mediated integrin alpha-6 expression in
            E-cadherin-deficient gastric cancer cells promotes interactions
            with the stroma and peritoneal dissemination.
REFERENCE   3  (residues 1 to 1073)
  AUTHORS   Zhao,K., Chen,L., Xie,Y., Ren,N., Li,J., Zhai,X., Zheng,S., Liu,K.,
            Wang,C., Qiu,Q., Peng,X., Wang,W., Liu,J., Che,Q., Fan,J., Hu,H.
            and Liu,M.
  TITLE     m6A/HOXA10-AS/ITGA6 axis aggravates oxidative resistance and
            malignant progression of laryngeal squamous cell carcinoma through
            regulating Notch and Keap1/Nrf2 pathways
  JOURNAL   Cancer Lett 587, 216735 (2024)
   PUBMED   38369001
  REMARK    GeneRIF: m6A/HOXA10-AS/ITGA6 axis aggravates oxidative resistance
            and malignant progression of laryngeal squamous cell carcinoma
            through regulating Notch and Keap1/Nrf2 pathways.
REFERENCE   4  (residues 1 to 1073)
  AUTHORS   Hou,S., Hao,X., Li,J., Weng,S., Wang,J., Zhao,T., Li,W., Hu,X.,
            Deng,B., Gu,J. and Hang,Q.
  TITLE     TM4SF1 promotes esophageal squamous cell carcinoma metastasis by
            interacting with integrin alpha6
  JOURNAL   Cell Death Dis 13 (7), 609 (2022)
   PUBMED   35835740
  REMARK    GeneRIF: TM4SF1 promotes esophageal squamous cell carcinoma
            metastasis by interacting with integrin alpha6.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1073)
  AUTHORS   Stewart,R.L. and O'Connor,K.L.
  TITLE     Clinical significance of the integrin alpha6beta4 in human
            malignancies
  JOURNAL   Lab Invest 95 (9), 976-986 (2015)
   PUBMED   26121317
  REMARK    Review article
REFERENCE   6  (residues 1 to 1073)
  AUTHORS   Lucky,A.W. and Gorell,E.
  TITLE     Epidermolysis Bullosa with Pyloric Atresia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301336
REFERENCE   7  (residues 1 to 1073)
  AUTHORS   Starr,L. and Quaranta,V.
  TITLE     An efficient and reliable method for cloning PCR-amplification
            products: a survey of point mutations in integrin cDNA
  JOURNAL   Biotechniques 13 (4), 612-618 (1992)
   PUBMED   1476731
REFERENCE   8  (residues 1 to 1073)
  AUTHORS   Tamura,R.N., Cooper,H.M., Collo,G. and Quaranta,V.
  TITLE     Cell type-specific integrin variants with alternative alpha chain
            cytoplasmic domains
  JOURNAL   Proc Natl Acad Sci U S A 88 (22), 10183-10187 (1991)
   PUBMED   1946438
REFERENCE   9  (residues 1 to 1073)
  AUTHORS   Hogervorst,F., Kuikman,I., van Kessel,A.G. and Sonnenberg,A.
  TITLE     Molecular cloning of the human alpha 6 integrin subunit.
            Alternative splicing of alpha 6 mRNA and chromosomal localization
            of the alpha 6 and beta 4 genes
  JOURNAL   Eur J Biochem 199 (2), 425-433 (1991)
   PUBMED   2070796
REFERENCE   10 (residues 1 to 1073)
  AUTHORS   Tamura,R.N., Rozzo,C., Starr,L., Chambers,J., Reichardt,L.F.,
            Cooper,H.M. and Quaranta,V.
  TITLE     Epithelial integrin alpha 6 beta 4: complete primary structure of
            alpha 6 and variant forms of beta 4
  JOURNAL   J Cell Biol 111 (4), 1593-1604 (1990)
   PUBMED   1976638
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB457895.1, X53586.1, X59512.1,
            AB208842.1, BG180469.1 and AC078883.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 14, 2006 this sequence version replaced NP_000201.1.
            
            Summary: The gene encodes a member of the integrin alpha chain
            family of proteins. Integrins are heterodimeric integral membrane
            proteins composed of an alpha chain and a beta chain that function
            in cell surface adhesion and signaling. The encoded preproprotein
            is proteolytically processed to generate light and heavy chains
            that comprise the alpha 6 subunit. This subunit may associate with
            a beta 1 or beta 4 subunit to form an integrin that interacts with
            extracellular matrix proteins including members of the laminin
            family. The alpha 6 beta 4 integrin may promote tumorigenesis,
            while the alpha 6 beta 1 integrin may negatively regulate
            erbB2/HER2 signaling. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Oct 2015].
            
            Transcript Variant: This variant (2) contains an alternate coding
            exon compared to variant 1, which results in a frameshift. The
            resulting isoform (b) is shorter and has a distinct C-terminus
            compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.11490.1,
                                           SRR1803611.34364.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000684293.1/ ENSP00000508249.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1073
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     Protein         1..1073
                     /product="integrin alpha-6 isoform b preproprotein"
                     /note="integrin alpha6B; CD49 antigen-like family member
                     F; integrin, alpha 6; very late activation protein 6"
                     /calculated_mol_wt=117231
     sig_peptide     1..23
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2264
     Region          40..100
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          254..306
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          314..367
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          374..425
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          431..>454
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          465..939
                     /region_name="Integrin_alpha2"
                     /note="Integrin alpha; pfam08441"
                     /db_xref="CDD:462478"
     Region          1038..1052
                     /region_name="Integrin_alpha"
                     /note="Integrin alpha cytoplasmic region; pfam00357"
                     /db_xref="CDD:459778"
     CDS             1..1073
                     /gene="ITGA6"
                     /gene_synonym="CD49f; ITGA6A; ITGA6B; JEB6; VLA-6"
                     /coded_by="NM_000210.4:204..3425"
                     /note="isoform b preproprotein is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS2249.1"
                     /db_xref="GeneID:3655"
                     /db_xref="HGNC:HGNC:6142"
                     /db_xref="MIM:147556"
ORIGIN      
        1 maaagqlcll ylsagllsrl gaafnldtre dnvirkygdp gslfgfslam hwqlqpedkr
       61 lllvgaprae alplqranrt gglyscdita rgpctriefd ndadptsesk edqwmgvtvq
      121 sqgpggkvvt cahryekrqh vntkqesrdi fgrcyvlsqn lrieddmdgg dwsfcdgrlr
      181 ghekfgscqq gvaatftkdf hyivfgapgt ynwkgivrve qknntffdmn ifedgpyevg
      241 getehdeslv pvpansylgf sldsgkgivs kdeitfvsga pranhsgavv llkrdmksah
      301 llpehifdge glassfgydv avvdlnkdgw qdivigapqy fdrdgevgga vyvymnqqgr
      361 wnnvkpirln gtkdsmfgia vknigdinqd gypdiavgap yddlgkvfiy hgsangintk
      421 ptqvlkgisp yfgysiagnm dldrnsypdv avgslsdsvt ifrsrpvini qktitvtpnr
      481 idlrqktacg apsgiclqvk scfeytanpa gynpsisivg tleaekerrk sglssrvqfr
      541 nqgsepkytq eltlkrqkqk vcmeetlwlq dnirdklrpi pitasveiqe pssrrrvnsl
      601 pevlpilnsd epktahidvh flkegcgddn vcnsnlkley kfctregnqd kfsylpiqkg
      661 vpelvlkdqk dialeitvtn spsnprnptk dgddaheakl iatfpdtlty sayrelrafp
      721 ekqlscvanq ngsqadcelg npfkrnsnvt fylvlsttev tfdtpdldin lklettsnqd
      781 nlapitakak vvielllsvs gvakpsqvyf ggtvvgeqam ksedevgsli eyefrvinlg
      841 kpltnlgtat lniqwpkeis ngkwllylvk veskglekvt cepqkeinsl nlteshnsrk
      901 kreitekqid dnrkfslfae rkyqtlncsv nvncvnircp lrgldskasl ilrsrlwnst
      961 fleeysklny ldilmrafid vtaaaenirl pnagtqvrvt vfpsktvaqy sgvpwwiilv
     1021 ailagilmla llvfilwkcg ffkrnkkdhy datyhkaeih aqpsdkerlt sda
//
