LOCUS       NM_002205               4250 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens integrin subunit alpha 5 (ITGA5), mRNA.
ACCESSION   NM_002205
VERSION     NM_002205.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4250)
  AUTHORS   Messe,M., Bernhard,C., Foppolo,S., Thomas,L., Marchand,P.,
            Herold-Mende,C., Idbaih,A., Kessler,H., Etienne-Selloum,N.,
            Ochoa,C., Tambar,U.K., Elati,M., Laquerriere,P., Entz-Werle,N.,
            Martin,S., Reita,D. and Dontenwill,M.
  TITLE     Hypoxia-driven heterogeneous expression of alpha5 integrin in
            glioblastoma stem cells is linked to HIF-2alpha
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (8), 167471 (2024)
   PUBMED   39154793
  REMARK    GeneRIF: Hypoxia-driven heterogeneous expression of alpha5 integrin
            in glioblastoma stem cells is linked to HIF-2alpha.
REFERENCE   2  (bases 1 to 4250)
  AUTHORS   Ezzo,M., Spindler,K., Wang,J.B., Lee,D., Pecoraro,G., Cowen,J.,
            Pakshir,P. and Hinz,B.
  TITLE     Acute contact with profibrotic macrophages mechanically activates
            fibroblasts via alphavbeta3 integrin-mediated engagement of Piezo1
  JOURNAL   Sci Adv 10 (43), eadp4726 (2024)
   PUBMED   39441936
  REMARK    GeneRIF: Acute contact with profibrotic macrophages mechanically
            activates fibroblasts via alphavbeta3 integrin-mediated engagement
            of Piezo1.
REFERENCE   3  (bases 1 to 4250)
  AUTHORS   Fu,Y., Sun,X., He,Q., Gu,Z., Jia,X. and Zhuang,Z.
  TITLE     Connexin 43 controls metastatic behavior in triple negative breast
            cancer through TGFbeta1-Smad3-intergin alphaV signaling axis Based
            on optical image diagnosis
  JOURNAL   SLAS Technol 29 (5), 100190 (2024)
   PUBMED   39299505
  REMARK    GeneRIF: Connexin 43 controls metastatic behavior in triple
            negative breast cancer through TGFbeta1-Smad3-intergin alphaV
            signaling axis Based on optical image diagnosis.
REFERENCE   4  (bases 1 to 4250)
  AUTHORS   Lu,H., Ai,J., Zheng,Y., Zhou,W., Zhang,L., Zhu,J., Zhang,H. and
            Wang,S.
  TITLE     IGFBP2/ITGA5 promotes gefitinib resistance via activating
            STAT3/CXCL1 axis in non-small cell lung cancer
  JOURNAL   Cell Death Dis 15 (6), 447 (2024)
   PUBMED   38918360
  REMARK    GeneRIF: IGFBP2/ITGA5 promotes gefitinib resistance via activating
            STAT3/CXCL1 axis in non-small cell lung cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4250)
  AUTHORS   Wu,Z., Jiao,M., Shu,C., Zhang,S., Wang,J., Pu,J., Zhu,J., Zeng,Y.,
            Zhu,Y. and Liu,Z.
  TITLE     Integrin alphaVbeta1-activated PYK2 promotes the progression of
            non-small-cell lung cancer via the STAT3-VGF axis
  JOURNAL   Cell Commun Signal 22 (1), 313 (2024)
   PUBMED   38844957
  REMARK    GeneRIF: Integrin alphaVbeta1-activated PYK2 promotes the
            progression of non-small-cell lung cancer via the STAT3-VGF axis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4250)
  AUTHORS   Birkenmeier,T.M., McQuillan,J.J., Boedeker,E.D., Argraves,W.S.,
            Ruoslahti,E. and Dean,D.C.
  TITLE     The alpha 5 beta 1 fibronectin receptor. Characterization of the
            alpha 5 gene promoter
  JOURNAL   J Biol Chem 266 (30), 20544-20549 (1991)
   PUBMED   1834647
REFERENCE   7  (bases 1 to 4250)
  AUTHORS   Brake,D.A., Debouck,C. and Biesecker,G.
  TITLE     Identification of an Arg-Gly-Asp (RGD) cell adhesion site in human
            immunodeficiency virus type 1 transactivation protein, tat
  JOURNAL   J Cell Biol 111 (3), 1275-1281 (1990)
   PUBMED   2202737
REFERENCE   8  (bases 1 to 4250)
  AUTHORS   Smith,J.W., Vestal,D.J., Irwin,S.V., Burke,T.A. and Cheresh,D.A.
  TITLE     Purification and functional characterization of integrin alpha v
            beta 5. An adhesion receptor for vitronectin
  JOURNAL   J Biol Chem 265 (19), 11008-11013 (1990)
   PUBMED   1694173
REFERENCE   9  (bases 1 to 4250)
  AUTHORS   Dedhar,S. and Gray,V.
  TITLE     Isolation of a novel integrin receptor mediating
            Arg-Gly-Asp-directed cell adhesion to fibronectin and type I
            collagen from human neuroblastoma cells. Association of a novel
            beta 1-related subunit with alpha v
  JOURNAL   J Cell Biol 110 (6), 2185-2193 (1990)
   PUBMED   1693626
REFERENCE   10 (bases 1 to 4250)
  AUTHORS   Argraves,W.S., Pytela,R., Suzuki,S., Millan,J.L.,
            Pierschbacher,M.D. and Ruoslahti,E.
  TITLE     cDNA sequences from the alpha subunit of the fibronectin receptor
            predict a transmembrane domain and a short cytoplasmic peptide
  JOURNAL   J Biol Chem 261 (28), 12922-12924 (1986)
   PUBMED   2944883
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK312414.1, BC008786.2 and
            BX647780.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002205.4.
            
            Summary: The product of this gene belongs to the integrin alpha
            chain family. Integrins are heterodimeric integral membrane
            proteins composed of an alpha subunit and a beta subunit that
            function in cell surface adhesion and signaling. The encoded
            preproprotein is proteolytically processed to generate light and
            heavy chains that comprise the alpha 5 subunit. This subunit
            associates with the beta 1 subunit to form a fibronectin receptor.
            This integrin may promote tumor invasion, and higher expression of
            this gene may be correlated with shorter survival time in lung
            cancer patients. Note that the integrin alpha 5 and integrin alpha
            V subunits are encoded by distinct genes. [provided by RefSeq, Oct
            2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X06256.1, AK312414.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000293379.9/ ENSP00000293379.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1149              AK312414.1         1-1149
            1150-1384           BC008786.2         1135-1369
            1385-3218           AK312414.1         1385-3218
            3219-4250           BX647780.1         3965-4996
FEATURES             Location/Qualifiers
     source          1..4250
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..4250
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /note="integrin subunit alpha 5"
                     /db_xref="GeneID:3678"
                     /db_xref="HGNC:HGNC:6141"
                     /db_xref="MIM:135620"
     exon            1..286
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..3218
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /note="very late activation protein 5, alpha subunit;
                     fibronectin receptor, alpha subunit; integrin, alpha 5
                     (fibronectin receptor, alpha polypeptide); integrin
                     alpha-5; integrin alpha-F; CD49 antigen-like family member
                     E; fibronectin receptor subunit alpha; ITGA5/SLC9B1
                     fusion"
                     /codon_start=1
                     /product="integrin alpha-5 precursor"
                     /protein_id="NP_002196.4"
                     /db_xref="CCDS:CCDS8880.1"
                     /db_xref="GeneID:3678"
                     /db_xref="HGNC:HGNC:6141"
                     /db_xref="MIM:135620"
                     /translation="MGSRTPESPLHAVQLRWGPRRRPPLLPLLLLLLPPPPRVGGFNL
                     DAEAPAVLSGPPGSFFGFSVEFYRPGTDGVSVLVGAPKANTSQPGVLQGGAVYLCPWG
                     ASPTQCTPIEFDSKGSRLLESSLSSSEGEEPVEYKSLQWFGATVRAHGSSILACAPLY
                     SWRTEKEPLSDPVGTCYLSTDNFTRILEYAPCRSDFSWAAGQGYCQGGFSAEFTKTGR
                     VVLGGPGSYFWQGQILSATQEQIAESYYPEYLINLVQGQLQTRQASSIYDDSYLGYSV
                     AVGEFSGDDTEDFVAGVPKGNLTYGYVTILNGSDIRSLYNFSGEQMASYFGYAVAATD
                     VNGDGLDDLLVGAPLLMDRTPDGRPQEVGRVYVYLQHPAGIEPTPTLTLTGHDEFGRF
                     GSSLTPLGDLDQDGYNDVAIGAPFGGETQQGVVFVFPGGPGGLGSKPSQVLQPLWAAS
                     HTPDFFGSALRGGRDLDGNGYPDLIVGSFGVDKAVVYRGRPIVSASASLTIFPAMFNP
                     EERSCSLEGNPVACINLSFCLNASGKHVADSIGFTVELQLDWQKQKGGVRRALFLASR
                     QATLTQTLLIQNGAREDCREMKIYLRNESEFRDKLSPIHIALNFSLDPQAPVDSHGLR
                     PALHYQSKSRIEDKAQILLDCGEDNICVPDLQLEVFGEQNHVYLGDKNALNLTFHAQN
                     VGEGGAYEAELRVTAPPEAEYSGLVRHPGNFSSLSCDYFAVNQSRLLVCDLGNPMKAG
                     ASLWGGLRFTVPHLRDTKKTIQFDFQILSKNLNNSQSDVVSFRLSVEAQAQVTLNGVS
                     KPEAVLFPVSDWHPRDQPQKEEDLGPAVHHVYELINQGPSSISQGVLELSCPQALEGQ
                     QLLYVTRVTGLNCTTNHPINPKGLELDPEGSLHHQQKREAPSRSSASSGPQILKCPEA
                     ECFRLRCELGPLHQQESQSLQLHFRVWAKTFLQREHQPFSLQCEAVYKALKMPYRILP
                     RQLPQKERQVATAVQWTKAEGSYGVPLWIIILAILFGLLLLGLLIYILYKLGFFKRSL
                     PYGTAMEKAQLKPPATSDA"
     exon            287..417
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     exon            418..530
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     exon            531..651
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     exon            652..713
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     exon            714..759
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     exon            760..885
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     exon            886..930
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     exon            931..974
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1031
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1084
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1293
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1485
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1531
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1633
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1689
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1844
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..1982
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2050
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2201
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2294
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2374
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2455
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2561
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2711
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..2795
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..2909
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..3011
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     exon            3012..3134
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     exon            3135..4250
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4211..4216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /note="hexamer: AATAAA"
     polyA_site      4250
                     /gene="ITGA5"
                     /gene_synonym="CD49e; FNRA; VLA-5; VLA5A"
                     /note="major polyA site"
ORIGIN      
        1 attcgcctct gggaggttta ggaagcggct ccgggtcggt ggccccagga cagggaagag
       61 cgggcgctat ggggagccgg acgccagagt cccctctcca cgccgtgcag ctgcgctggg
      121 gcccccggcg ccgacccccg ctgctgccgc tgctgttgct gctgctgccg ccgccaccca
      181 gggtcggggg cttcaactta gacgcggagg ccccagcagt actctcgggg cccccgggct
      241 ccttcttcgg attctcagtg gagttttacc ggccgggaac agacggggtc agtgtgctgg
      301 tgggagcacc caaggctaat accagccagc caggagtgct gcagggtggt gctgtctacc
      361 tctgtccttg gggtgccagc cccacacagt gcacccccat tgaatttgac agcaaaggct
      421 ctcggctcct ggagtcctca ctgtccagct cagagggaga ggagcctgtg gagtacaagt
      481 ccttgcagtg gttcggggca acagttcgag cccatggctc ctccatcttg gcatgcgctc
      541 cactgtacag ctggcgcaca gagaaggagc cactgagcga ccccgtgggc acctgctacc
      601 tctccacaga taacttcacc cgaattctgg agtatgcacc ctgccgctca gatttcagct
      661 gggcagcagg acagggttac tgccaaggag gcttcagtgc cgagttcacc aagactggcc
      721 gtgtggtttt aggtggacca ggaagctatt tctggcaagg ccagatcctg tctgccactc
      781 aggagcagat tgcagaatct tattaccccg agtacctgat caacctggtt caggggcagc
      841 tgcagactcg ccaggccagt tccatctatg atgacagcta cctaggatac tctgtggctg
      901 ttggtgaatt cagtggtgat gacacagaag actttgttgc tggtgtgccc aaagggaacc
      961 tcacttacgg ctatgtcacc atccttaatg gctcagacat tcgatccctc tacaacttct
     1021 caggggaaca gatggcctcc tactttggct atgcagtggc cgccacagac gtcaatgggg
     1081 acgggctgga tgacttgctg gtgggggcac ccctgctcat ggatcggacc cctgacgggc
     1141 ggcctcagga ggtgggcagg gtctacgtct acctgcagca cccagccggc atagagccca
     1201 cgcccaccct taccctcact ggccatgatg agtttggccg atttggcagc tccttgaccc
     1261 ccctggggga cctggaccag gatggctaca atgatgtggc catcggggct ccctttggtg
     1321 gggagaccca gcagggagta gtgtttgtat ttcctggggg cccaggaggg ctgggctcta
     1381 agccttccca ggttctgcag cccctgtggg cagccagcca caccccagac ttctttggct
     1441 ctgcccttcg aggaggccga gacctggatg gcaatggata tcctgatctg attgtggggt
     1501 cctttggtgt ggacaaggct gtggtataca ggggccgccc catcgtgtcc gctagtgcct
     1561 ccctcaccat cttccccgcc atgttcaacc cagaggagcg gagctgcagc ttagagggga
     1621 accctgtggc ctgcatcaac cttagcttct gcctcaatgc ttctggaaaa cacgttgctg
     1681 actccattgg tttcacagtg gaacttcagc tggactggca gaagcagaag ggaggggtac
     1741 ggcgggcact gttcctggcc tccaggcagg caaccctgac ccagaccctg ctcatccaga
     1801 atggggctcg agaggattgc agagagatga agatctacct caggaacgag tcagaatttc
     1861 gagacaaact ctcgccgatt cacatcgctc tcaacttctc cttggacccc caagccccag
     1921 tggacagcca cggcctcagg ccagccctac attatcagag caagagccgg atagaggaca
     1981 aggctcagat cttgctggac tgtggagaag acaacatctg tgtgcctgac ctgcagctgg
     2041 aagtgtttgg ggagcagaac catgtgtacc tgggtgacaa gaatgccctg aacctcactt
     2101 tccatgccca gaatgtgggt gagggtggcg cctatgaggc tgagcttcgg gtcaccgccc
     2161 ctccagaggc tgagtactca ggactcgtca gacacccagg gaacttctcc agcctgagct
     2221 gtgactactt tgccgtgaac cagagccgcc tgctggtgtg tgacctgggc aaccccatga
     2281 aggcaggagc cagtctgtgg ggtggccttc ggtttacagt ccctcatctc cgggacacta
     2341 agaaaaccat ccagtttgac ttccagatcc tcagcaagaa tctcaacaac tcgcaaagcg
     2401 acgtggtttc ctttcggctc tccgtggagg ctcaggccca ggtcaccctg aacggtgtct
     2461 ccaagcctga ggcagtgcta ttcccagtaa gcgactggca tccccgagac cagcctcaga
     2521 aggaggagga cctgggacct gctgtccacc atgtctatga gctcatcaac caaggcccca
     2581 gctccattag ccagggtgtg ctggaactca gctgtcccca ggctctggaa ggtcagcagc
     2641 tcctatatgt gaccagagtt acgggactca actgcaccac caatcacccc attaacccaa
     2701 agggcctgga gttggatccc gagggttccc tgcaccacca gcaaaaacgg gaagctccaa
     2761 gccgcagctc tgcttcctcg ggacctcaga tcctgaaatg cccggaggct gagtgtttca
     2821 ggctgcgctg tgagctcggg cccctgcacc aacaagagag ccaaagtctg cagttgcatt
     2881 tccgagtctg ggccaagact ttcttgcagc gggagcacca gccatttagc ctgcagtgtg
     2941 aggctgtgta caaagccctg aagatgccct accgaatcct gcctcggcag ctgccccaaa
     3001 aagagcgtca ggtggccaca gctgtgcaat ggaccaaggc agaaggcagc tatggcgtcc
     3061 cactgtggat catcatccta gccatcctgt ttggcctcct gctcctaggt ctactcatct
     3121 acatcctcta caagcttgga ttcttcaaac gctccctccc atatggcacc gccatggaaa
     3181 aagctcagct caagcctcca gccacctctg atgcctgagt cctcccaatt tcagactccc
     3241 attcctgaag aaccagtccc cccaccctca ttctactgaa aaggaggggt ctgggtactt
     3301 cttgaaggtg ctgacggcca gggagaagct cctctcccca gcccagagac atacttgaag
     3361 ggccagagcc aggggggtga ggagctgggg atccctcccc cccatgcact gtgaaggacc
     3421 cttgtttaca cataccctct tcatggatgg gggaactcag atccagggac agaggcccca
     3481 gcctccctga agcctttgca ttttggagag tttcctgaaa caacttggaa agataactag
     3541 gaaatccatt cacagttctt tgggccagac atgccacaag gacttcctgt ccagctccaa
     3601 cctgcaaaga tctgtcctca gccttgccag agatccaaaa gaagccccca gctaagaacc
     3661 tggaacttgg ggagttaaga cctggcagct ctggacagcc ccaccctggt gggccaacaa
     3721 agaacactaa ctatgcatgg tgccccagga ccagctcagg acagatgcca cacaaggata
     3781 gatgctggcc cagggcccag agcccagctc caaggggaat cagaactcaa atggggccag
     3841 atccagcctg gggtctggag ttgatctgga acccagactc agacattggc acctaatcca
     3901 ggcagatcca ggactatatt tgggcctgct ccagacctga tcctggaggc ccagttcacc
     3961 ctgatttagg agaagccagg aatttcccag gaccctgaag gggccatgat ggcaacagat
     4021 ctggaacctc agcctggcca gacacaggcc ctccctgttc cccagagaaa ggggagccca
     4081 ctgtcctggg cctgcagaat ttgggttctg cctgccagct gcactgatgc tgcccctcat
     4141 ctctctgccc aacccttccc tcaccttggc accagacacc caggacttat ttaaactctg
     4201 ttgcaagtgc aataaatctg acccagtgcc cccactgacc agaactagaa
//
