LOCUS       NM_002204               4889 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens integrin subunit alpha 3 (ITGA3), mRNA.
ACCESSION   NM_002204
VERSION     NM_002204.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4889)
  AUTHORS   Moye,A.L., Dost,A.F., Ietswaart,R., Sengupta,S., Ya,V., Aluya,C.,
            Fahey,C.G., Louie,S.M., Paschini,M. and Kim,C.F.
  TITLE     Early-stage lung cancer is driven by a transitional cell state
            dependent on a KRAS-ITGA3-SRC axis
  JOURNAL   EMBO J 43 (14), 2843-2861 (2024)
   PUBMED   38755258
  REMARK    GeneRIF: Early-stage lung cancer is driven by a transitional cell
            state dependent on a KRAS-ITGA3-SRC axis.
REFERENCE   2  (bases 1 to 4889)
  AUTHORS   Park,E., Barclay,W.E., Barrera,A., Liao,T.C., Salzler,H.R.,
            Reddy,T.E., Shinohara,M.L. and Ciofani,M.
  TITLE     Integrin alpha3 promotes TH17 cell polarization and extravasation
            during autoimmune neuroinflammation
  JOURNAL   Sci Immunol 8 (88), eadg7597 (2023)
   PUBMED   37831759
  REMARK    GeneRIF: Integrin alpha3 promotes TH17 cell polarization and
            extravasation during autoimmune neuroinflammation.
REFERENCE   3  (bases 1 to 4889)
  AUTHORS   Yao,J. and Wang,L.
  TITLE     Integrin alpha3 Mediates Stemness and Invasion of Glioblastoma by
            Regulating POU3F2
  JOURNAL   Curr Protein Pept Sci 24 (3), 247-256 (2023)
   PUBMED   36843258
  REMARK    GeneRIF: Integrin alpha3 Mediates Stemness and Invasion of
            Glioblastoma by Regulating POU3F2.
REFERENCE   4  (bases 1 to 4889)
  AUTHORS   Wang,Y., Yang,D., Zhu,R., Dai,F., Yuan,M., Zhang,L., Zheng,Y.,
            Liu,S., Yang,X. and Cheng,Y.
  TITLE     YY1/ITGA3 pathway may affect trophoblastic cells migration and
            invasion ability
  JOURNAL   J Reprod Immunol 153, 103666 (2022)
   PUBMED   35970081
  REMARK    GeneRIF: YY1/ITGA3 pathway may affect trophoblastic cells migration
            and invasion ability.
REFERENCE   5  (bases 1 to 4889)
  AUTHORS   Margadant,C., Charafeddine,R.A. and Sonnenberg,A.
  TITLE     Unique and redundant functions of integrins in the epidermis
  JOURNAL   FASEB J 24 (11), 4133-4152 (2010)
   PUBMED   20624931
  REMARK    Review article
REFERENCE   6  (bases 1 to 4889)
  AUTHORS   Rojiani,M.V., Finlay,B.B., Gray,V. and Dedhar,S.
  TITLE     In vitro interaction of a polypeptide homologous to human Ro/SS-A
            antigen (calreticulin) with a highly conserved amino acid sequence
            in the cytoplasmic domain of integrin alpha subunits
  JOURNAL   Biochemistry 30 (41), 9859-9866 (1991)
   PUBMED   1911778
REFERENCE   7  (bases 1 to 4889)
  AUTHORS   Takada,Y., Murphy,E., Pil,P., Chen,C., Ginsberg,M.H. and
            Hemler,M.E.
  TITLE     Molecular cloning and expression of the cDNA for alpha 3 subunit of
            human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin,
            laminin, and collagen
  JOURNAL   J Cell Biol 115 (1), 257-266 (1991)
   PUBMED   1655803
REFERENCE   8  (bases 1 to 4889)
  AUTHORS   Tsuji,T., Hakomori,S. and Osawa,T.
  TITLE     Identification of human galactoprotein b3, an oncogenic
            transformation-induced membrane glycoprotein, as VLA-3 alpha
            subunit: the primary structure of human integrin alpha 3
  JOURNAL   J Biochem 109 (4), 659-665 (1991)
   PUBMED   1714443
REFERENCE   9  (bases 1 to 4889)
  AUTHORS   Takada,Y., Strominger,J.L. and Hemler,M.E.
  TITLE     The very late antigen family of heterodimers is part of a
            superfamily of molecules involved in adhesion and embryogenesis
  JOURNAL   Proc Natl Acad Sci U S A 84 (10), 3239-3243 (1987)
   PUBMED   3033641
REFERENCE   10 (bases 1 to 4889)
  AUTHORS   Rettig,W.J., Dracopoli,N.C., Goetzger,T.A., Spengler,B.A.,
            Biedler,J.L., Oettgen,H.F. and Old,L.J.
  TITLE     Somatic cell genetic analysis of human cell surface antigens:
            chromosomal assignments and regulation of expression in
            rodent-human hybrid cells
  JOURNAL   Proc Natl Acad Sci U S A 81 (20), 6437-6441 (1984)
   PUBMED   6593709
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA655978.1, BC150190.1,
            AK289961.1 and BU631476.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002204.3.
            
            Summary: The gene encodes a member of the integrin alpha chain
            family of proteins. Integrins are heterodimeric integral membrane
            proteins composed of an alpha chain and a beta chain that function
            as cell surface adhesion molecules. The encoded preproprotein is
            proteolytically processed to generate light and heavy chains that
            comprise the alpha 3 subunit. This subunit joins with a beta 1
            subunit to form an integrin that interacts with extracellular
            matrix proteins including members of the laminin family. Expression
            of this gene may be correlated with breast cancer metastasis.
            [provided by RefSeq, Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150190.1, M59911.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320031.13/ ENSP00000315190.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                DA655978.1         143-157
            16-656              BC150190.1         1-641
            657-657             AK289961.1         425-425
            658-4887            BC150190.1         643-4872
            4888-4889           BU631476.1         22-23               c
FEATURES             Location/Qualifiers
     source          1..4889
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..4889
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /note="integrin subunit alpha 3"
                     /db_xref="GeneID:3675"
                     /db_xref="HGNC:HGNC:6139"
                     /db_xref="MIM:605025"
     exon            1..536
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             331..3486
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /note="antigen identified by monoclonal antibody J143;
                     very late activation protein 3 receptor, alpha-3 subunit;
                     galactoprotein B3; very late activation receptor subunit
                     alpha-3; CD49 antigen-like family member C; integrin,
                     alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3
                     receptor); integrin alpha 3; testicular tissue protein Li
                     98; testicular tissue protein Li 96"
                     /codon_start=1
                     /product="integrin alpha-3 preproprotein"
                     /protein_id="NP_002195.1"
                     /db_xref="CCDS:CCDS11558.1"
                     /db_xref="GeneID:3675"
                     /db_xref="HGNC:HGNC:6139"
                     /db_xref="MIM:605025"
                     /translation="MGPGPSRAPRAPRLMLCALALMVAAGGCVVSAFNLDTRFLVVKE
                     AGNPGSLFGYSVALHRQTERQQRYLLLAGAPRELAVPDGYTNRTGAVYLCPLTAHKDD
                     CERMNITVKNDPGHHIIEDMWLGVTVASQGPAGRVLVCAHRYTQVLWSGSEDQRRMVG
                     KCYVRGNDLELDSSDDWQTYHNEMCNSNTDYLETGMCQLGTSGGFTQNTVYFGAPGAY
                     NWKGNSYMIQRKEWDLSEYSYKDPEDQGNLYIGYTMQVGSFILHPKNITIVTGAPRHR
                     HMGAVFLLSQEAGGDLRRRQVLEGSQVGAYFGSAIALADLNNDGWQDLLVGAPYYFER
                     KEEVGGAIYVFMNQAGTSFPAHPSLLLHGPSGSAFGLSVASIGDINQDGFQDIAVGAP
                     FEGLGKVYIYHSSSKGLLRQPQQVIHGEKLGLPGLATFGYSLSGQMDVDENFYPDLLV
                     GSLSDHIVLLRARPVINIVHKTLVPRPAVLDPALCTATSCVQVELCFAYNQSAGNPNY
                     RRNITLAYTLEADRDRRPPRLRFAGSESAVFHGFFSMPEMRCQKLELLLMDNLRDKLR
                     PIIISMNYSLPLRMPDRPRLGLRSLDAYPILNQAQALENHTEVQFQKECGPDNKCESN
                     LQMRAAFVSEQQQKLSRLQYSRDVRKLLLSINVTNTRTSERSGEDAHEALLTLVVPPA
                     LLLSSVRPPGACQANETIFCELGNPFKRNQRMELLIAFEVIGVTLHTRDLQVQLQLST
                     SSHQDNLWPMILTLLVDYTLQTSLSMVNHRLQSFFGGTVMGESGMKTVEDVGSPLKYE
                     FQVGPMGEGLVGLGTLVLGLEWPYEVSNGKWLLYPTEITVHGNGSWPCRPPGDLINPL
                     NLTLSDPGDRPSSPQRRRRQLDPGGGQGPPPVTLAAAKKAKSETVLTCATGRAHCVWL
                     ECPIPDAPVVTNVTVKARVWNSTFIEDYRDFDRVRVNGWATLFLRTSIPTINMENKTT
                     WFSVDIDSELVEELPAEIELWLVLVAVGAGLLLLGLIILLLWKCGFFKRARTRALYEA
                     KRQKAEMKSQPSETERLTDDY"
     exon            537..664
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /inference="alignment:Splign:2.1.0"
     exon            665..744
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /inference="alignment:Splign:2.1.0"
     exon            745..994
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1081
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1289
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1486
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1575
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1712
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1799
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1867
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2004
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2154
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2252
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2400
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2469
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2549
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2627
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2730
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..2913
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..3036
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /inference="alignment:Splign:2.1.0"
     exon            3037..3150
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /inference="alignment:Splign:2.1.0"
     exon            3151..3249
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /inference="alignment:Splign:2.1.0"
     exon            3250..3375
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /inference="alignment:Splign:2.1.0"
     exon            3376..3517
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /inference="alignment:Splign:2.1.0"
     exon            3518..4889
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4868..4873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /note="hexamer: AATAAA"
     polyA_site      4889
                     /gene="ITGA3"
                     /gene_synonym="CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; JEB7;
                     MSK18; VCA-2; VL3A; VLA3a"
                     /note="major polyA site"
ORIGIN      
        1 agatccgccg cgaagccggg atcgaaggcg acagcgcggc caagggggcg cggccgggac
       61 aagctggggg ccggttgccc ggggcaggga cggcggcgac ccggccgctg gggaggcagg
      121 aagatagacc cacggatctt aggaagggat ccgagagcgc agctgtgaaa ctggctgggg
      181 ctgggggcac gaaaccgatc agcgctacgg agcgcagcgg ccggcgggtt ccagtgtcct
      241 ccggcggcgc ggggagcagg tgaacaggtc ctcacgccca gctccgcgcc ctcacgcgct
      301 ctcgccggga ccccgcttcc gctggcagcc atgggccccg gccccagccg cgcgccccgc
      361 gccccacgcc tgatgctctg tgcgctcgcc ttgatggtgg cggccggcgg ctgcgtcgtc
      421 tccgccttca acctggatac ccgattcctg gtagtgaagg aggccgggaa cccgggcagc
      481 ctcttcggct actcggtcgc cctccatcgg cagacagagc ggcagcagcg ctacctgctc
      541 ctggctggtg ccccccggga gctcgctgtg cccgatggct acaccaaccg gactggtgct
      601 gtgtacctgt gcccactcac tgcccacaag gatgactgtg agcggatgaa catcacagtg
      661 aaaaatgacc ctggccatca cattattgag gacatgtggc ttggagtgac tgtggccagc
      721 cagggccctg caggcagagt tctggtctgt gcccaccgct acacccaggt gctgtggtca
      781 gggtcagaag accagcggcg catggtgggc aagtgctacg tgcgaggcaa tgacctagag
      841 ctggactcca gtgatgactg gcagacctac cacaacgaga tgtgcaatag caacacagac
      901 tacctggaga cgggcatgtg ccagctgggc accagcggtg gcttcaccca gaacactgtg
      961 tacttcggcg cccccggtgc ctacaactgg aaaggaaaca gctacatgat tcagcgcaag
     1021 gagtgggact tatctgagta tagttacaag gacccagagg accaaggaaa cctctatatt
     1081 gggtacacga tgcaggtagg cagcttcatc ctgcacccca aaaacatcac cattgtgaca
     1141 ggtgccccac ggcaccgaca tatgggcgcg gtgttcttgc tgagccagga ggcaggcgga
     1201 gacctgcgga ggaggcaggt gctggagggc tcgcaggtgg gcgcctattt tggcagcgcc
     1261 attgccctgg cagacctgaa caatgatggg tggcaggacc tcctggtggg cgccccctac
     1321 tacttcgaga ggaaagagga agtagggggt gccatctatg tcttcatgaa ccaggcggga
     1381 acctccttcc ctgctcaccc ctcactcctt cttcatggcc ccagtggctc tgcctttggt
     1441 ttatctgtgg ccagcattgg tgacatcaac caggatggat ttcaggatat tgctgtggga
     1501 gctccgtttg aaggcttggg caaagtgtac atctatcaca gtagctctaa ggggctcctt
     1561 agacagcccc agcaggtaat ccatggagag aagctgggac tgcctgggtt ggccaccttc
     1621 ggctattccc tcagtgggca gatggatgtg gatgagaact tctacccaga ccttctagtg
     1681 ggaagcctgt cagaccacat tgtgctgctg cgggcccggc ccgtcatcaa catcgtccac
     1741 aagaccttgg tgcccaggcc agctgtgctg gaccctgcac tttgcacggc cacctcttgt
     1801 gtgcaagtgg agctgtgctt tgcttacaac cagagtgccg ggaaccccaa ctacaggcga
     1861 aacatcaccc tggcctacac tctggaggct gacagggacc gccggccgcc ccggctccgc
     1921 tttgccggca gtgagtccgc tgtcttccac ggcttcttct ccatgcccga gatgcgctgc
     1981 cagaagctgg agctgctcct gatggacaac ctccgtgaca aactccgccc catcatcatc
     2041 tccatgaact actctttacc tttgcggatg cccgatcgcc cccggctggg gctgcggtcc
     2101 ctggacgcct acccgatcct caaccaggca caggctctgg agaaccacac tgaggtccag
     2161 ttccagaagg agtgcgggcc tgacaacaag tgtgagagca acttgcagat gcgggcagcc
     2221 ttcgtgtcag agcagcagca gaagctgagc aggctccagt acagcagaga cgtccggaaa
     2281 ttgctcctga gcatcaacgt gacgaacacc cggacctcgg agcgctccgg ggaggacgcc
     2341 cacgaggcgc tgctcaccct ggtggtgcct cccgccctgc tgctgtcctc agtgcgcccc
     2401 cccggggcct gccaagctaa tgagaccatc ttttgcgagc tggggaaccc cttcaaacgg
     2461 aaccagagga tggagctgct catcgccttt gaggtcatcg gggtgaccct gcacacaagg
     2521 gaccttcagg tgcagctgca gctctccacg tcgagtcacc aggacaacct gtggcccatg
     2581 atcctcactc tgctggtgga ctatacactc cagacctcgc ttagcatggt aaatcaccgg
     2641 ctacaaagct tctttggggg gacagtgatg ggtgagtctg gcatgaaaac tgtggaggat
     2701 gtaggaagcc ccctcaagta tgaattccag gtgggcccaa tgggggaggg gctggtgggc
     2761 ctggggaccc tggtcctagg tctggagtgg ccctacgaag tcagcaatgg caagtggctg
     2821 ctgtatccca cggagatcac cgtccatggc aatgggtcct ggccctgccg accacctgga
     2881 gaccttatca accctctcaa cctcactctt tctgaccctg gggacaggcc atcatcccca
     2941 cagcgcaggc ggcgacagct ggatccaggg ggaggccagg gccccccacc tgtcactctg
     3001 gctgctgcca aaaaagccaa gtctgagact gtgctgacct gtgccacagg gcgtgcccac
     3061 tgtgtgtggc tagagtgccc catccctgat gcccccgttg tcaccaacgt gactgtgaag
     3121 gcacgagtgt ggaacagcac cttcatcgag gattacagag actttgaccg agtccgggta
     3181 aatggctggg ctaccctatt cctccgaacc agcatcccca ccatcaacat ggagaacaag
     3241 accacgtggt tctctgtgga cattgactcg gagctggtgg aggagctgcc ggccgaaatc
     3301 gagctgtggc tggtgctggt ggccgtgggt gcagggctgc tgctgctggg gctgatcatc
     3361 ctcctgctgt ggaagtgcgg cttcttcaag cgagcccgca ctcgcgccct gtatgaagct
     3421 aagaggcaga aggcggagat gaagagccag ccgtcagaga cagagaggct gaccgacgac
     3481 tactgagggg gcagcccccc gcccccggcc cacctggtgt gacttcttta agcggacccg
     3541 ctattatcag atcatgccca agtaccacgc agtgcggatc cgggaggagg agcgctaccc
     3601 acctccaggg agcaccctgc ccaccaagaa gcactgggtg accagctggc agactcggga
     3661 ccaatactac tgacgtcctc cctgatccca ccccctcctc ccccagtgtc ccctttcttc
     3721 ctatttatca taagttatgc ctctgacagt ccacaggggc caccaccttt ggctggtagc
     3781 agcaggctca ggcacataca cctcgtcaag agcatgcaca tgctgtctgg ccctggggat
     3841 cttcccacag gagggccagc gctgtggacc ttacaacgcc gagtgcactg cattcctgtg
     3901 ccctagatgc acgtggggcc cactgctcgt ggactgtgct ggtgcatcac ggatggtgca
     3961 tgggctcgcc gtgtctcagc ctctgccagc gccaaaacaa gccaaagagc ctcccaccag
     4021 agccgggagg aaaaggcccc tgcaatgtgg tgacacctcc ccctttcaca ctggatccat
     4081 cttgagccac agtcactgga ttgactttgc tgtcaaaact actgacaggg agcagccccc
     4141 gggccgctgg ctggtgggcc cccaatgaca cccatgccag agaggtgggg atcctgccta
     4201 aggttgtcta cgggggcact tggaggacct ggcgtgctca gacccaacag caaaggaact
     4261 agaaagaagg acccagaacg gcttgctttc ctgcatctct gtgaagcctc tctccttggc
     4321 cacagactga actcgcaggg aatgcagcag gaaggaacaa agacaggcaa acggcaacgt
     4381 agcctgggct cactgtgctg gggcacggcg ggatcctcca cagagaggag gggaccaatt
     4441 ctggacagac agatgttggg aggatacaga ggagatgcca cttctcactc accactacca
     4501 gccagcctca gaaggcccca gagagaccct gcaagaccac ggagggagcg acacttgaat
     4561 gtagaatagg cagggggccc tgccccaccc catccagcca gaccccacgc tgaccatgcg
     4621 tcaggggcct agaggtggag ttcttagcta tccttggctt tcagagccag cctggctctg
     4681 ccccctcccc catgggctgt gtcctaaggc ccatttgaga agctgaggct agttccagaa
     4741 aacctctcct gacccctgcc tgttggcagg cccactcccc agccccagcc ccttccatgg
     4801 tactgtagca ggggaattcc ctccccctcc ttgtgccttc tttgtatata ggcttctcac
     4861 ggcgaccaat aaacagctcc cagtttgta
//
