LOCUS       NM_000419               3479 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens integrin subunit alpha 2b (ITGA2B), mRNA.
ACCESSION   NM_000419
VERSION     NM_000419.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3479)
  AUTHORS   Huo,T., Wu,H., Moussa,Z., Sen,M., Dalton,V. and Wang,Z.
  TITLE     Full-length alphaIIbbeta3 cryo-EM structure reveals intact integrin
            initiate-activation intrinsic architecture
  JOURNAL   Structure 32 (7), 899-906 (2024)
   PUBMED   38579706
  REMARK    GeneRIF: Full-length alphaIIbbeta3 cryo-EM structure reveals intact
            integrin initiate-activation intrinsic architecture.
REFERENCE   2  (bases 1 to 3479)
  AUTHORS   Lu,X.M., Fu,D.Y., Zhang,Y.F., Zhao,L.D., Wang,L., Yang,J., Liu,J.,
            Zheng,J.W., Yang,L.H. and Wang,G.
  TITLE     [Pedigree Analysis and Molecular Mechanism Study of Hereditary
            Glanzmann Thrombasthenia Caused by Compound Heterozygous Mutation
            of the ITGA2B Gene]
  JOURNAL   Zhonghua Xue Ye Xue Za Zhi 45 (4), 370-377 (2024)
   PUBMED   38951065
  REMARK    GeneRIF: [Pedigree Analysis and Molecular Mechanism Study of
            Hereditary Glanzmann Thrombasthenia Caused by Compound Heterozygous
            Mutation of the ITGA2B Gene].
REFERENCE   3  (bases 1 to 3479)
  AUTHORS   Chandrasekaran,F.P., Vishal,A., Arora,U., Kumar,S. U, George,C. PD
            and Nelson,E.J.R.
  TITLE     Molecular dynamics simulations corroborate recombinant expression
            studies carried out on three alphaIIb beta-propeller mutations
            reported in Indian Glanzmann thrombasthenia patients
  JOURNAL   J Cell Biochem 124 (7), 989-1001 (2023)
   PUBMED   37210732
  REMARK    GeneRIF: Molecular dynamics simulations corroborate recombinant
            expression studies carried out on three alphaIIb beta-propeller
            mutations reported in Indian Glanzmann thrombasthenia patients.
REFERENCE   4  (bases 1 to 3479)
  AUTHORS   Takada,Y.K., Simon,S.I. and Takada,Y.
  TITLE     The C-type lectin domain of CD62P (P-selectin) functions as an
            integrin ligand
  JOURNAL   Life Sci Alliance 6 (7), e202201747 (2023)
   PUBMED   37184585
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3479)
  AUTHORS   Nurden,A.T., Pillois,X. and Wilcox,D.A.
  TITLE     Glanzmann thrombasthenia: state of the art and future directions
  JOURNAL   Semin Thromb Hemost 39 (6), 642-655 (2013)
   PUBMED   23929305
  REMARK    GeneRIF: Studies indicate that Glanzmann thrombasthenia (GT) is
            caused by quantitative or qualitative deficiencies of
            alphaIIbbeta3, an integrin coded by the ITGA2B and ITGB3 genes.
            Review article
REFERENCE   6  (bases 1 to 3479)
  AUTHORS   Bajt,M.L., Loftus,J.C., Gawaz,M.P. and Ginsberg,M.H.
  TITLE     Characterization of a gain of function mutation of integrin alpha
            IIb beta 3 (platelet glycoprotein IIb-IIIa)
  JOURNAL   J Biol Chem 267 (31), 22211-22216 (1992)
   PUBMED   1429573
REFERENCE   7  (bases 1 to 3479)
  AUTHORS   Smyth,S.S., Hillery,C.A. and Parise,L.V.
  TITLE     Fibrinogen binding to purified platelet glycoprotein IIb-IIIa
            (integrin alpha IIb beta 3) is modulated by lipids
  JOURNAL   J Biol Chem 267 (22), 15568-15577 (1992)
   PUBMED   1639797
REFERENCE   8  (bases 1 to 3479)
  AUTHORS   Lauweryns,B., van den Oord,J.J. and Missotten,L.
  TITLE     Localization of the cytoadhesin integrins in the human cornea. An
            immunohistochemical study using monoclonal antibodies
  JOURNAL   Graefes Arch Clin Exp Ophthalmol 230 (3), 264-268 (1992)
   PUBMED   1375923
REFERENCE   9  (bases 1 to 3479)
  AUTHORS   Burk,C.D., Newman,P.J., Lyman,S., Gill,J., Coller,B.S. and Poncz,M.
  TITLE     A deletion in the gene for glycoprotein IIb associated with
            Glanzmann's thrombasthenia
  JOURNAL   J Clin Invest 87 (1), 270-276 (1991)
   PUBMED   1702098
REFERENCE   10 (bases 1 to 3479)
  AUTHORS   Poncz,M., Eisman,R., Heidenreich,R., Silver,S.M., Vilaire,G.,
            Surrey,S., Schwartz,E. and Bennett,J.S.
  TITLE     Structure of the platelet membrane glycoprotein IIb. Homology to
            the alpha subunits of the vitronectin and fibronectin membrane
            receptors
  JOURNAL   J Biol Chem 262 (18), 8476-8482 (1987)
   PUBMED   2439501
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007722.9, BM148153.1,
            J02764.1, BE409167.1, X06831.1 and CD175774.1.
            
            On May 24, 2019 this sequence version replaced NM_000419.4.
            
            Summary: This gene encodes a member of the integrin alpha chain
            family of proteins. The encoded preproprotein is proteolytically
            processed to generate light and heavy chains that associate through
            disulfide linkages to form a subunit of the alpha-IIb/beta-3
            integrin cell adhesion receptor. This receptor plays a crucial role
            in the blood coagulation system, by mediating platelet aggregation.
            Mutations in this gene are associated with platelet-type bleeding
            disorders, which are characterized by a failure of platelet
            aggregation, including Glanzmann thrombasthenia. [provided by
            RefSeq, Jan 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC126442.1, J02764.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000262407.6/
                                                ENSP00000262407.5
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AC007722.9         61318-61365
            49-457              BM148153.1         2-410
            458-1113            J02764.1           283-938
            1114-1133           BE409167.1         353-372
            1134-2073           J02764.1           959-1898
            2074-2360           X06831.1           725-1011
            2361-3478           J02764.1           2186-3303
            3479-3479           CD175774.1         522-522
FEATURES             Location/Qualifiers
     source          1..3479
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..3479
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /note="integrin subunit alpha 2b"
                     /db_xref="GeneID:3674"
                     /db_xref="HGNC:HGNC:6138"
                     /db_xref="MIM:607759"
     exon            1..364
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..3296
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /note="platelet fibrinogen receptor, alpha subunit;
                     platelet-specific antigen BAK; GPalpha IIb; platelet
                     membrane glycoprotein IIb; protein phosphatase 1,
                     regulatory subunit 93; alphaIIb protein; integrin, alpha
                     2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen
                     CD41)"
                     /codon_start=1
                     /product="integrin alpha-IIb preproprotein"
                     /protein_id="NP_000410.2"
                     /db_xref="CCDS:CCDS32665.1"
                     /db_xref="GeneID:3674"
                     /db_xref="HGNC:HGNC:6138"
                     /db_xref="MIM:607759"
                     /translation="MARALCPLQALWLLEWVLLLLGPCAAPPAWALNLDPVQLTFYAG
                     PNGSQFGFSLDFHKDSHGRVAIVVGAPRTLGPSQEETGGVFLCPWRAEGGQCPSLLFD
                     LRDETRNVGSQTLQTFKARQGLGASVVSWSDVIVACAPWQHWNVLEKTEEAEKTPVGS
                     CFLAQPESGRRAEYSPCRGNTLSRIYVENDFSWDKRYCEAGFSSVVTQAGELVLGAPG
                     GYYFLGLLAQAPVADIFSSYRPGILLWHVSSQSLSFDSSNPEYFDGYWGYSVAVGEFD
                     GDLNTTEYVVGAPTWSWTLGAVEILDSYYQRLHRLRGEQMASYFGHSVAVTDVNGDGR
                     HDLLVGAPLYMESRADRKLAEVGRVYLFLQPRGPHALGAPSLLLTGTQLYGRFGSAIA
                     PLGDLDRDGYNDIAVAAPYGGPSGRGQVLVFLGQSEGLRSRPSQVLDSPFPTGSAFGF
                     SLRGAVDIDDNGYPDLIVGAYGANQVAVYRAQPVVKASVQLLVQDSLNPAVKSCVLPQ
                     TKTPVSCFNIQMCVGATGHNIPQKLSLNAELQLDRQKPRQGRRVLLLGSQQAGTTLNL
                     DLGGKHSPICHTTMAFLRDEADFRDKLSPIVLSLNVSLPPTEAGMAPAVVLHGDTHVQ
                     EQTRIVLDCGEDDVCVPQLQLTASVTGSPLLVGADNVLELQMDAANEGEGAYEAELAV
                     HLPQGAHYMRALSNVEGFERLICNQKKENETRVVLCELGNPMKKNAQIGIAMLVSVGN
                     LEEAGESVSFQLQIRSKNSQNPNSKIVLLDVPVRAEAQVELRGNSFPASLVVAAEEGE
                     REQNSLDSWGPKVEHTYELHNNGPGTVNGLHLSIHLPGQSQPSDLLYILDIQPQGGLQ
                     CFPQPPVNPLKVDWGLPIPSPSPIHPAHHKRDRRQIFLPEPEQPSRLQDPVLVSCDSA
                     PCTVVQCDLQEMARGQRAMVTVLAFLWLPSLYQRPLDQFVLQSHAWFNVSSLPYAVPP
                     LSLPRGEAQVWTQLLRALEERAIPIWWVLVGVLGGLLLLTILVLAMWKVGFFKRNRPP
                     LEEDDEEGE"
     exon            365..486
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     exon            487..584
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     exon            585..750
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     exon            751..800
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     exon            801..846
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     exon            847..975
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1023
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1067
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1121
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1174
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1386
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1569
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1615
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1720
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1776
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1928
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2054
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2122
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2270
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2363
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2443
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2524
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2624
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2777
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     exon            2778..2903
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     exon            2904..3017
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..3119
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     exon            3120..3236
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     exon            3237..3479
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3459..3464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /note="hexamer: AATAAA"
     polyA_site      3479
                     /gene="ITGA2B"
                     /gene_synonym="BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb;
                     GT; GT1; GTA; HPA3; PPP1R93"
                     /note="major polyA site"
ORIGIN      
        1 acttcctggc aattctagcc accatgagtc caggggctat agccctttgc tctgcccgtt
       61 gctcagcaag ttacttgggg ttccagtttg ataagaaaag acttcctgtg gaggaatctg
      121 aagggaagga ggaggagctg gcccattcct gcctgggagg ttgtggaaga aggaagatgg
      181 ccagagcttt gtgtccactg caagccctct ggcttctgga gtgggtgctg ctgctcttgg
      241 gaccttgtgc tgcccctcca gcctgggcct tgaacctgga cccagtgcag ctcaccttct
      301 atgcaggccc caatggcagc cagtttggat tttcactgga cttccacaag gacagccatg
      361 ggagagtggc catcgtggtg ggcgccccgc ggaccctggg ccccagccag gaggagacgg
      421 gcggcgtgtt cctgtgcccc tggagggccg agggcggcca gtgcccctcg ctgctctttg
      481 acctccgtga tgagacccga aatgtaggct cccaaacttt acaaaccttc aaggcccgcc
      541 aaggactggg ggcgtcggtc gtcagctgga gcgacgtcat tgtggcctgc gccccctggc
      601 agcactggaa cgtcctagaa aagactgagg aggctgagaa gacgcccgta ggtagctgct
      661 ttttggctca gccagagagc ggccgccgcg ccgagtactc cccctgtcgc gggaacaccc
      721 tgagccgcat ttacgtggaa aatgatttta gctgggacaa gcgttactgt gaagcgggct
      781 tcagctccgt ggtcactcag gccggagagc tggtgcttgg ggctcctggc ggctattatt
      841 tcttaggtct cctggcccag gctccagttg cggatatttt ctcgagttac cgcccaggca
      901 tccttttgtg gcacgtgtcc tcccagagcc tctcctttga ctccagcaac ccagagtact
      961 tcgacggcta ctgggggtac tcggtggccg tgggcgagtt cgacggggat ctcaacacta
     1021 cagaatatgt cgtcggtgcc cccacttgga gctggaccct gggagcggtg gaaattttgg
     1081 attcctacta ccagaggctg catcggctgc gcggagagca gatggcgtcg tattttgggc
     1141 attcagtggc tgtcactgac gtcaacgggg atgggaggca tgatctgctg gtgggcgctc
     1201 cactgtatat ggagagccgg gcagaccgaa aactggccga agtggggcgt gtgtatttgt
     1261 tcctgcagcc gcgaggcccc cacgcgctgg gtgcccccag cctcctgctg actggcacac
     1321 agctctatgg gcgattcggc tctgccatcg cacccctggg cgacctcgac cgggatggct
     1381 acaatgacat tgcagtggct gccccctacg ggggtcccag tggccggggc caagtgctgg
     1441 tgttcctggg tcagagtgag gggctgaggt cacgtccctc ccaggtcctg gacagcccct
     1501 tccccacagg ctctgccttt ggcttctccc ttcgaggtgc cgtagacatc gatgacaacg
     1561 gatacccaga cctgatcgtg ggagcttacg gggccaacca ggtggctgtg tacagagctc
     1621 agccagtggt gaaggcctct gtccagctac tggtgcaaga ttcactgaat cctgctgtga
     1681 agagctgtgt cctacctcag accaagacac ccgtgagctg cttcaacatc cagatgtgtg
     1741 ttggagccac tgggcacaac attcctcaga agctatccct aaatgccgag ctgcagctgg
     1801 accggcagaa gccccgccag ggccggcggg tgctgctgct gggctctcaa caggcaggca
     1861 ccaccctgaa cctggatctg ggcggaaagc acagccccat ctgccacacc accatggcct
     1921 tccttcgaga tgaggcagac ttccgggaca agctgagccc cattgtgctc agcctcaatg
     1981 tgtccctacc gcccacggag gctggaatgg cccctgctgt cgtgctgcat ggagacaccc
     2041 atgtgcagga gcagacacga atcgtcctgg actgtgggga agatgacgta tgtgtgcccc
     2101 agcttcagct cactgccagc gtgacgggct ccccgctcct agttggggca gataatgtcc
     2161 tggagctgca gatggacgca gccaacgagg gcgagggggc ctatgaagca gagctggccg
     2221 tgcacctgcc ccagggcgcc cactacatgc gggccctaag caatgtcgag ggctttgaga
     2281 gactcatctg taatcagaag aaggagaatg agaccagggt ggtgctgtgt gagctgggca
     2341 accccatgaa gaagaacgcc cagataggaa tcgcgatgtt ggtgagcgtg gggaatctgg
     2401 aagaggctgg ggagtctgtg tccttccagc tgcagatacg gagcaagaac agccagaatc
     2461 caaacagcaa gattgtgctg ctggacgtgc cggtccgggc agaggcccaa gtggagctgc
     2521 gagggaactc ctttccagcc tccctggtgg tggcagcaga agaaggtgag agggagcaga
     2581 acagcttgga cagctgggga cccaaagtgg agcacaccta tgagctccac aacaatggcc
     2641 ctgggactgt gaatggtctt cacctcagca tccaccttcc gggacagtcc cagccctccg
     2701 acctgctcta catcctggat atacagcccc aggggggcct tcagtgcttc ccacagcctc
     2761 ctgtcaaccc tctcaaggtg gactgggggc tgcccatccc cagcccctcc cccattcacc
     2821 cggcccatca caagcgggat cgcagacaga tcttcctgcc agagcccgag cagccctcga
     2881 ggcttcagga tccagttctc gtaagctgcg actcggcgcc ctgtactgtg gtgcagtgtg
     2941 acctgcagga gatggcgcgc gggcagcggg ccatggtcac ggtgctggcc ttcctgtggc
     3001 tgcccagcct ctaccagagg cctctggatc agtttgtgct gcagtcgcac gcatggttca
     3061 acgtgtcctc cctcccctat gcggtgcccc cgctcagcct gccccgaggg gaagctcagg
     3121 tgtggacaca gctgctccgg gccttggagg agagggccat tccaatctgg tgggtgctgg
     3181 tgggtgtgct gggtggcctg ctgctgctca ccatcctggt cctggccatg tggaaggtcg
     3241 gcttcttcaa gcggaaccgg ccacccctgg aagaagatga tgaagagggg gagtgatggt
     3301 gcagcctaca ctattctagc aggagggttg ggcgtgctac ctgcaccgcc ccttctccaa
     3361 caagttgcct ccaagctttg ggttggagct gttccattgg gtcctcttgg tgtcgtttcc
     3421 ctcccaacag agctgggcta ccccccctcc tgctgcctaa taaagagact gagccctga
//
