LOCUS       NM_002203               7843 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens integrin subunit alpha 2 (ITGA2), transcript variant
            1, mRNA.
ACCESSION   NM_002203
VERSION     NM_002203.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7843)
  AUTHORS   Zhang,X., Wang,S., Li,W., Wang,J., Gong,Y., Chen,Q., Cao,S.,
            Pang,D. and Gao,S.
  TITLE     PSAT1 Promotes Metastasis via p-AKT/SP1/ITGA2 Axis in Estrogen
            Receptor-Negative Breast Cancer Cell
  JOURNAL   Biomolecules 14 (8), 990 (2024)
   PUBMED   39199378
  REMARK    GeneRIF: PSAT1 Promotes Metastasis via p-AKT/SP1/ITGA2 Axis in
            Estrogen Receptor-Negative Breast Cancer Cell.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7843)
  AUTHORS   Zhang,J., Li,R., Zhang,H., Wang,S. and Zhao,Y.
  TITLE     ITGA2 as a prognostic factor of glioma promotes GSCs invasion and
            EMT by activating STAT3 phosphorylation
  JOURNAL   Carcinogenesis 45 (4), 235-246 (2024)
   PUBMED   38142122
  REMARK    GeneRIF: ITGA2 as a prognostic factor of glioma promotes GSCs
            invasion and EMT by activating STAT3 phosphorylation.
REFERENCE   3  (bases 1 to 7843)
  AUTHORS   Zhang,C.L., Shen,Q., Liu,F.D., Yang,F., Gao,M.Q., Jiang,X.C.,
            Li,Y., Zhang,X.Y., En,G.E., Pan,X. and Pang,B.
  TITLE     SDC1 and ITGA2 as novel prognostic biomarkers for PDAC related to
            IPMN
  JOURNAL   Sci Rep 13 (1), 18727 (2023)
   PUBMED   37907515
  REMARK    GeneRIF: SDC1 and ITGA2 as novel prognostic biomarkers for PDAC
            related to IPMN.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7843)
  AUTHORS   White,D.J., Puranen,S., Johnson,M.S. and Heino,J.
  TITLE     The collagen receptor subfamily of the integrins
  JOURNAL   Int J Biochem Cell Biol 36 (8), 1405-1410 (2004)
   PUBMED   15147720
  REMARK    Review article
REFERENCE   5  (bases 1 to 7843)
  AUTHORS   Emsley,J., King,S.L., Bergelson,J.M. and Liddington,R.C.
  TITLE     Crystal structure of the I domain from integrin alpha2beta1
  JOURNAL   J Biol Chem 272 (45), 28512-28517 (1997)
   PUBMED   9353312
REFERENCE   6  (bases 1 to 7843)
  AUTHORS   Zutter,M.M., Santoro,S.A., Painter,A.S., Tsung,Y.L. and Gafford,A.
  TITLE     The human alpha 2 integrin gene promoter. Identification of
            positive and negative regulatory elements important for cell-type
            and developmentally restricted gene expression
  JOURNAL   J Biol Chem 269 (1), 463-469 (1994)
   PUBMED   8276836
REFERENCE   7  (bases 1 to 7843)
  AUTHORS   Jaspers,M., Marynen,P., Aly,M.S., Cuppens,H., Hilliker,C. and
            Cassiman,J.J.
  TITLE     Localization of the gene encoding the alpha 2 subunit of the human
            VLA-2 receptor to chromosome 5q23-31
  JOURNAL   Somat Cell Mol Genet 17 (5), 505-511 (1991)
   PUBMED   1763388
REFERENCE   8  (bases 1 to 7843)
  AUTHORS   Staatz,W.D., Walsh,J.J., Pexton,T. and Santoro,S.A.
  TITLE     The alpha 2 beta 1 integrin cell surface collagen receptor binds to
            the alpha 1 (I)-CB3 peptide of collagen
  JOURNAL   J Biol Chem 265 (9), 4778-4781 (1990)
   PUBMED   2156854
REFERENCE   9  (bases 1 to 7843)
  AUTHORS   Takada,Y. and Hemler,M.E.
  TITLE     The primary structure of the VLA-2/collagen receptor alpha 2
            subunit (platelet GPIa): homology to other integrins and the
            presence of a possible collagen-binding domain
  JOURNAL   J Cell Biol 109 (1), 397-407 (1989)
   PUBMED   2545729
REFERENCE   10 (bases 1 to 7843)
  AUTHORS   Nieuwenhuis,H.K., Akkerman,J.W., Houdijk,W.P. and Sixma,J.J.
  TITLE     Human blood platelets showing no response to collagen fail to
            express surface glycoprotein Ia
  JOURNAL   Nature 318 (6045), 470-472 (1985)
   PUBMED   2933589
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP280760.1, X17033.1,
            BE048389.1, BM828183.1, AU126174.1, AC008966.9, BF355124.1,
            DA545055.1, BP381403.1, DA343078.1, BM979113.1, CN272390.1,
            BG288116.1, BG494837.1, BG771368.1, CA442768.1 and CK904145.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002203.3.
            
            Summary: This gene encodes the alpha subunit of a transmembrane
            receptor for collagens and related proteins. The encoded protein
            forms a heterodimer with a beta subunit and mediates the adhesion
            of platelets and other cell types to the extracellular matrix. Loss
            of the encoded protein is associated with bleeding disorder
            platelet-type 9. Antibodies against this protein are found in
            several immune disorders, including neonatal alloimmune
            thrombocytopenia. This gene is located adjacent to a related alpha
            subunit gene. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Aug 2012].
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X17033.1, AK307952.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296585.10/ ENSP00000296585.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               BP280760.1         29-292
            265-722             X17033.1           196-653
            723-1093            BE048389.1         4-374               c
            1094-1424           BM828183.1         275-605
            1425-1716           X17033.1           1356-1647
            1717-1719           AU126174.1         423-425
            1720-2492           X17033.1           1651-2423
            2493-2494           AC008966.9         70323-70324         c
            2495-2600           X17033.1           2426-2531
            2601-2608           BF355124.1         75-82
            2609-2684           X17033.1           2540-2615
            2685-2688           BF355124.1         159-162
            2689-3725           X17033.1           2620-3656
            3726-4249           DA545055.1         3-526
            4250-4683           BP381403.1         192-625
            4684-5049           DA343078.1         128-493
            5050-5704           BM979113.1         3-657               c
            5705-6046           CN272390.1         418-759
            6047-6232           BG288116.1         301-486
            6233-6761           BG494837.1         61-589
            6762-7349           BG771368.1         51-638
            7350-7652           CA442768.1         12-314              c
            7653-7843           CK904145.1         10-200              c
FEATURES             Location/Qualifiers
     source          1..7843
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q11.2"
     gene            1..7843
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /note="integrin subunit alpha 2"
                     /db_xref="GeneID:3673"
                     /db_xref="HGNC:HGNC:6137"
                     /db_xref="MIM:192974"
     exon            1..181
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..3663
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /note="very late activation protein 2 receptor, alpha-2
                     subunit; platelet antigen Br; platelet glycoprotein GPIa;
                     collagen receptor; CD49 antigen-like family member B;
                     platelet membrane glycoprotein Ia; human platelet
                     alloantigen system 5; integrin, alpha 2 (CD49B, alpha 2
                     subunit of VLA-2 receptor); alpha 2 integrin; very late
                     activation receptor alpha-2 subunit; human platelet
                     alloantigen 5; very late activation receptor subunit
                     alpha-2"
                     /codon_start=1
                     /product="integrin alpha-2 precursor"
                     /protein_id="NP_002194.2"
                     /db_xref="CCDS:CCDS3957.1"
                     /db_xref="GeneID:3673"
                     /db_xref="HGNC:HGNC:6137"
                     /db_xref="MIM:192974"
                     /translation="MGPERTGAAPLPLLLVLALSQGILNCCLAYNVGLPEAKIFSGPS
                     SEQFGYAVQQFINPKGNWLLVGSPWSGFPENRMGDVYKCPVDLSTATCEKLNLQTSTS
                     IPNVTEMKTNMSLGLILTRNMGTGGFLTCGPLWAQQCGNQYYTTGVCSDISPDFQLSA
                     SFSPATQPCPSLIDVVVVCDESNSIYPWDAVKNFLEKFVQGLDIGPTKTQVGLIQYAN
                     NPRVVFNLNTYKTKEEMIVATSQTSQYGGDLTNTFGAIQYARKYAYSAASGGRRSATK
                     VMVVVTDGESHDGSMLKAVIDQCNHDNILRFGIAVLGYLNRNALDTKNLIKEIKAIAS
                     IPTERYFFNVSDEAALLEKAGTLGEQIFSIEGTVQGGDNFQMEMSQVGFSADYSSQND
                     ILMLGAVGAFGWSGTIVQKTSHGHLIFPKQAFDQILQDRNHSSYLGYSVAAISTGEST
                     HFVAGAPRANYTGQIVLYSVNENGNITVIQAHRGDQIGSYFGSVLCSVDVDKDTITDV
                     LLVGAPMYMSDLKKEEGRVYLFTIKEGILGQHQFLEGPEGIENTRFGSAIAALSDINM
                     DGFNDVIVGSPLENQNSGAVYIYNGHQGTIRTKYSQKILGSDGAFRSHLQYFGRSLDG
                     YGDLNGDSITDVSIGAFGQVVQLWSQSIADVAIEASFTPEKITLVNKNAQIILKLCFS
                     AKFRPTKQNNQVAIVYNITLDADGFSSRVTSRGLFKENNERCLQKNMVVNQAQSCPEH
                     IIYIQEPSDVVNSLDLRVDISLENPGTSPALEAYSETAKVFSIPFHKDCGEDGLCISD
                     LVLDVRQIPAAQEQPFIVSNQNKRLTFSVTLKNKRESAYNTGIVVDFSENLFFASFSL
                     PVDGTEVTCQVAASQKSVACDVGYPALKREQQVTFTINFDFNLQNLQNQASLSFQALS
                     ESQEENKADNLVNLKIPLLYDAEIHLTRSTNINFYEISSDGNVPSIVHSFEDVGPKFI
                     FSLKVTTGSVPVSMATVIIHIPQYTKEKNPLMYLTGVQTDKAGDISCNADINPLKIGQ
                     TSSSVSFKSENFRHTKELNCRTASCSNVTCWLKDVHMKGEYFVNVTTRIWNGTFASST
                     FQTVQLTAAAEINTYNPEIYVIEDNTVTIPLMIMKPDEKAEVPTGVIIGSIIAGILLL
                     LALVAILWKLGFFKRKYEKMTKNPDEIDETTELSS"
     exon            182..302
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     exon            303..412
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     exon            413..504
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     exon            505..619
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     exon            620..747
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     exon            748..896
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1047
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1213
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1290
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1429
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1575
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1719
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1923
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2060
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2200
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2352
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2463
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2546
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2688
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2781
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2782..2858
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..2942
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3045
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3046..3156
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..3261
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3262..3375
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3376..3465
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3466..3582
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3583..7843
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5680
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /note="major polyA site"
     regulatory      7629..7634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /note="hexamer: AATAAA"
     polyA_site      7652
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /note="major polyA site"
     regulatory      7810..7815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
                     /note="hexamer: AATAAA"
     polyA_site      7843
                     /gene="ITGA2"
                     /gene_synonym="BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2"
ORIGIN      
        1 agagaagccc tctggacagc ttctagagtg tgcaggttct cgtatccctc ggccaagggt
       61 atcctctgca aacctctgca aacccagcgc aactacggtc ccccggtcag acccaggatg
      121 gggccagaac ggacaggggc cgcgccgctg ccgctgctgc tggtgttagc gctcagtcaa
      181 ggcattttaa attgttgttt ggcctacaat gttggtctcc cagaagcaaa aatattttcc
      241 ggtccttcaa gtgaacagtt tggctatgca gtgcagcagt ttataaatcc aaaaggcaac
      301 tggttactgg ttggttcacc ctggagtggc tttcctgaga accgaatggg agatgtgtat
      361 aaatgtcctg ttgacctatc cactgccaca tgtgaaaaac taaatttgca aacttcaaca
      421 agcattccaa atgttactga gatgaaaacc aacatgagcc tcggcttgat cctcaccagg
      481 aacatgggaa ctggaggttt tctcacatgt ggtcctctgt gggcacagca atgtgggaat
      541 cagtattaca caacgggtgt gtgttctgac atcagtcctg attttcagct ctcagccagc
      601 ttctcacctg caactcagcc ctgcccttcc ctcatagatg ttgtggttgt gtgtgatgaa
      661 tcaaatagta tttatccttg ggatgcagta aagaattttt tggaaaaatt tgtacaaggc
      721 ctggatatag gccccacaaa gacacaggtg gggttaattc agtatgccaa taatccaaga
      781 gttgtgttta acttgaacac atataaaacc aaagaagaaa tgattgtagc aacatcccag
      841 acatcccaat atggtgggga cctcacaaac acattcggag caattcaata tgcaagaaaa
      901 tatgcttatt cagcagcttc tggtgggcga cgaagtgcta cgaaagtaat ggtagttgta
      961 actgacggtg aatcacatga tggttcaatg ttgaaagctg tgattgatca atgcaaccat
     1021 gacaatatac tgaggtttgg catagcagtt cttgggtact taaacagaaa cgcccttgat
     1081 actaaaaatt taataaaaga aataaaagca atcgctagta ttccaacaga aagatacttt
     1141 ttcaatgtgt ctgatgaagc agctctacta gaaaaggctg ggacattagg agaacaaatt
     1201 ttcagcattg aaggtactgt tcaaggagga gacaactttc agatggaaat gtcacaagtg
     1261 ggattcagtg cagattactc ttctcaaaat gatattctga tgctgggtgc agtgggagct
     1321 tttggctgga gtgggaccat tgtccagaag acatctcatg gccatttgat ctttcctaaa
     1381 caagcctttg accaaattct gcaggacaga aatcacagtt catatttagg ttactctgtg
     1441 gctgcaattt ctactggaga aagcactcac tttgttgctg gtgctcctcg ggcaaattat
     1501 accggccaga tagtgctata tagtgtgaat gagaatggca atatcacggt tattcaggct
     1561 caccgaggtg accagattgg ctcctatttt ggtagtgtgc tgtgttcagt tgatgtggat
     1621 aaagacacca ttacagacgt gctcttggta ggtgcaccaa tgtacatgag tgacctaaag
     1681 aaagaggaag gaagagtcta cctgtttact atcaaagagg gcattttggg tcagcaccaa
     1741 tttcttgaag gccccgaggg cattgaaaac actcgatttg gttcagcaat tgcagctctt
     1801 tcagacatca acatggatgg ctttaatgat gtgattgttg gttcaccact agaaaatcag
     1861 aattctggag ctgtatacat ttacaatggt catcagggca ctatccgcac aaagtattcc
     1921 cagaaaatct tgggatccga tggagccttt aggagccatc tccagtactt tgggaggtcc
     1981 ttggatggct atggagattt aaatggggat tccatcaccg atgtgtctat tggtgccttt
     2041 ggacaagtgg ttcaactctg gtcacaaagt attgctgatg tagctataga agcttcattc
     2101 acaccagaaa aaatcacttt ggtcaacaag aatgctcaga taattctcaa actctgcttc
     2161 agtgcaaagt tcagacctac taagcaaaac aatcaagtgg ccattgtata taacatcaca
     2221 cttgatgcag atggattttc atccagagta acctccaggg ggttatttaa agaaaacaat
     2281 gaaaggtgcc tgcagaagaa tatggtagta aatcaagcac agagttgccc cgagcacatc
     2341 atttatatac aggagccctc tgatgttgtc aactctttgg atttgcgtgt ggacatcagt
     2401 ctggaaaacc ctggcactag ccctgccctt gaagcctatt ctgagactgc caaggtcttc
     2461 agtattcctt tccacaaaga ctgtggtgag gacggacttt gcatttctga tctagtccta
     2521 gatgtccgac aaataccagc tgctcaagaa caacccttta ttgtcagcaa ccaaaacaaa
     2581 aggttaacat tttcagtaac gctgaaaaat aaaagggaaa gtgcatacaa cactggaatt
     2641 gttgttgatt tttcagaaaa cttgtttttt gcatcattct ccctgccggt tgatgggaca
     2701 gaagtaacat gccaggtggc tgcatctcag aagtctgttg cctgcgatgt aggctaccct
     2761 gctttaaaga gagaacaaca ggtgactttt actattaact ttgacttcaa tcttcaaaac
     2821 cttcagaatc aggcgtctct cagtttccaa gccttaagtg aaagccaaga agaaaacaag
     2881 gctgataatt tggtcaacct caaaattcct ctcctgtatg atgctgaaat tcacttaaca
     2941 agatctacca acataaattt ttatgaaatc tcttcggatg ggaatgttcc ttcaatcgtg
     3001 cacagttttg aagatgttgg tccaaaattc atcttctccc tgaaggtaac aacaggaagt
     3061 gttccagtaa gcatggcaac tgtaatcatc cacatccctc agtataccaa agaaaagaac
     3121 ccactgatgt acctaactgg ggtgcaaaca gacaaggctg gtgacatcag ttgtaatgca
     3181 gatatcaatc cactgaaaat aggacaaaca tcttcttctg tatctttcaa aagtgaaaat
     3241 ttcaggcaca ccaaagaatt gaactgcaga actgcttcct gtagtaatgt tacctgctgg
     3301 ttgaaagacg ttcacatgaa aggagaatac tttgttaatg tgactaccag aatttggaac
     3361 gggactttcg catcatcaac gttccagaca gtacagctaa cggcagctgc agaaatcaac
     3421 acctataacc ctgagatata tgtgattgaa gataacactg ttacgattcc cctgatgata
     3481 atgaaacctg atgagaaagc cgaagtacca acaggagtta taataggaag tataattgct
     3541 ggaatccttt tgctgttagc tctggttgca attttatgga agctcggctt cttcaaaaga
     3601 aaatatgaaa agatgaccaa aaatccagat gagattgatg agaccacaga gctcagtagc
     3661 tgaaccagca gacctacctg cagtgggaac cggcagcatc ccagccaggg tttgctgttt
     3721 gcgtgaatgg atttcttttt aaatcccata ttttttttat catgtcgtag gtaaactaac
     3781 ctggtatttt aagagaaaac tgcaggtcag tttggaatga agaaattgtg gggggtgggg
     3841 gaggtgcggg gggcaggtag ggaaataata gggaaaatac ctattttata tgatggggga
     3901 aaaaaagtaa tctttaaact ggctggccca gagtttacat tctaatttgc attgtgtcag
     3961 aaacatgaaa tgcttccaag catgacaact tttaaagaaa aatatgatac tctcagattt
     4021 taagggggaa aactgttctc tttaaaatat ttgtctttaa acagcaacta cagaagtgga
     4081 agtgcttgat atgtaagtac ttccacttgt gtatatttta atgaatattg atgttaacaa
     4141 gaggggaaaa caaaacacag gttttttcaa tttatgctgc tcatccaaag ttgccacaga
     4201 tgatacttcc aagtgataat tttatttata aactaggtaa aatttgttgt tggttccttt
     4261 tagaccacgg ctgccccttc cacaccccat cttgctctaa tgatcaaaac atgcttgaat
     4321 aactgagctt agagtatacc tcctatatgt ccatttaagt taggagaggg ggcgatatag
     4381 agaataaggc acaaaatttt gtttaaaact cagaatataa catgtaaaat cccatctgct
     4441 agaagcccat cctgtgccag aggaaggaaa aggaggaaat ttcctttctc ttttaggagg
     4501 cacaacagtt ctcttctagg atttgtttgg ctgactggca gtaacctagt gaatttctga
     4561 aagatgagta atttctttgg caaccttcct cctcccttac tgaaccactc tcccacctcc
     4621 tggtggtacc attattatag aagccctcta cagcctgact ttctctccag cggtccaaag
     4681 ttatcccctc ctttacccct catccaaagt tcccactcct tcaggacagc tgctgtgcat
     4741 tagatattag gggggaaagt catctgttta atttacacac ttgcatgaat tactgtatat
     4801 aaactcctta acttcaggga gctattttca tttagtgcta aacaagtaag aaaaataagc
     4861 tcgagtgaat ttctaaatgt tggaatgtta tgggatgtaa acaatgtaaa gtaagacatc
     4921 tcaggatttc accagaagtt acagatgagg cactggaagc caccaaatta gcaggtgcac
     4981 cttctgtggc tgtcttgttt ctgaagtact taaacttcca caagagtgaa tttgacctag
     5041 gcaagtttgt tcaaaaggta gatcctgaga tgatttggtc agattgggat aaggcccagc
     5101 aatctgcatt ttaacaagca ccccagtcac taggatgcag atggaccaca ctttgagaaa
     5161 caccacccat ttctactttt tgcaccttat tttctctgtt cctgagcccc cacattctct
     5221 aggagaaact tagaggaaaa gggcacagac actacatatc taaagctttg gacaagtcct
     5281 tgacctctat aaacttcaga gtcctcatta taaaatggga agactgagct ggagttcagc
     5341 agtgatgctt ttagttttaa aagtctatga tctggacttc ctataataca aatacacaat
     5401 cctccaagaa tttgacttgg aaaaaaatgt caaaggaaaa caggttatct gcccatgtgc
     5461 atatggacaa ccttgactac cctggcctgg cccgtggtgg cagtccaggg ctatctgtac
     5521 tgtttacaga attactttgt agttgacaac acaaaacaaa caaaaaaggc ataaaatgcc
     5581 agcggtttat agaaaaaaca gcatggtatt ctccagttag gtatgccaga gtccaattct
     5641 tttaacagct gtgagaattt gctgcttcat tccaacaaaa ttttatttaa aaaaaaaaaa
     5701 aaaagactgg agaaactagt cattagcttg ataaagaata tttaacagct agtggtgctg
     5761 gtgtgtacct gaagctccag ctacttgaga gactgagaca ggaagatcgc ttgagcccag
     5821 gagttcaagt ccagcctaag caacatagca agaccctgtc tcaaaaaaat gactatttaa
     5881 aaagacaatg tggccaggca cggtggctca cacctgtaat cccaacactt tgggaggctg
     5941 aggccggtgg atcacgaggt caggagtttg agactagcct ggccaacatg gtgaaacccc
     6001 atctctaata atataaaaat tagctgggcg tagtagcagg tgcctgtaat cccagttact
     6061 cgggaagctg aggcaggaga atcacttgaa cccgggaggc agaggtttca gtgagccgag
     6121 atcgcgccac tgcactccag cctgggtgac agggcaagac tctgtctcaa acaaacaaac
     6181 aaaaaaaaag ttagtactgt atatgtaaat actagctttt caatgtgcta tacaaacaat
     6241 tatagcacat ccttcctttt actctgtctc acctccttta ggtgagtact tccttaaata
     6301 agtgctaaac atacatatac ggaacttgaa agctttggtt agccttgcct taggtaatca
     6361 gcctagttta cactgtttcc agggagtagt tgaattacta taaaccatta gccacttgtc
     6421 tctgcaccat ttatcacacc aggacagggt ctctcaacct gggcgctact gtcatttggg
     6481 gccaggtgat tcttccttgc aggggctgtc ctgtaccttg taggacagca gccctgtcct
     6541 agaaggtatg tttagcagca ttcctggcct ctagctaccc gatgccagag catgctcccc
     6601 ccgcagtcat gacaatcaaa aaatgtctcc agacattgtc aaatgcctcc tggggggcag
     6661 tatttctcaa gcacttttaa gcaaaggtaa gtattcatac aagaaattta gggggaaaaa
     6721 acattgttta aataaaagct atgtgttcct attcaacaat atttttgctt taaaagtaag
     6781 tagagggcat aaaagatgtc atattcaaat ttccatttca taaatggtgt acagacaagg
     6841 tctatagaat gtggtaaaaa cttgactgca acacaaggct tataaaatag taagatagta
     6901 aaatagctta tgaagaaact acagagattt aaaattgtgc atgactcatt tcagcagcaa
     6961 aataagaact cctaactgaa cagaaatttt tctacctagc aatgttattc ttgtaaaata
     7021 gttacctatt aaaactgtga agagtaaaac taaagccaat ttattatagt cacacaagtg
     7081 attatactaa aaattattat aaaggttata attttataat gtatttacct gtcctgatat
     7141 atagctataa cccaatatat gaaaatctca aaaattaaga catcatcata cagaaggcag
     7201 gattccttaa actgagatcc ctgatccatc tttaatattt caatttgcac acataaaaca
     7261 atgccctttt gtgtacattc aggcataccc attttaatca atttgaaagg ttaatttaaa
     7321 cctctagagg tgaatgagaa acatggggga aaagtatgaa ataggtgaaa atcttaacta
     7381 tttctttgaa ctctaaagac tgaaactgta gccattatgt aaataaagtt tcatatgtac
     7441 ctgtttattt tggcagatta agtcaaaata tgaatgtata tattgcataa ctatgttaga
     7501 attgtatata ttttaaagaa attgtcttgg atattttcct ttatacataa tagataagtc
     7561 ttttttcaaa tgtggtgttt gatgtttttg attaaatgtg ttttgcctct ttccacaaaa
     7621 actgtaaaaa taaatgcatg tttgtacaaa aagttgcaga attcatttga tttatgagaa
     7681 acaaaaatta aattgtagtc aacagttagt agtttttctc atatccaagt ataacaaaca
     7741 gaaaagtttc attattgtaa cccacttttt tcataccaca ttattgaata ttgttacaat
     7801 tgttttgaaa ataaagccat tttctttggg cttttataag tta
//
