LOCUS       NM_001004439           10191 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens integrin subunit alpha 11 (ITGA11), mRNA.
ACCESSION   NM_001004439
VERSION     NM_001004439.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10191)
  AUTHORS   Zheng,H., An,M., Luo,Y., Diao,X., Zhong,W., Pang,M., Lin,Y.,
            Chen,J., Li,Y., Kong,Y., Zhao,Y., Yin,Y., Ai,L., Huang,J., Chen,C.
            and Lin,T.
  TITLE     PDGFRalpha+ITGA11+ fibroblasts foster early-stage cancer
            lymphovascular invasion and lymphatic metastasis via ITGA11-SELE
            interplay
  JOURNAL   Cancer Cell 42 (4), 682-700 (2024)
   PUBMED   38428409
  REMARK    GeneRIF: PDGFRalpha[+]ITGA11[+] fibroblasts foster early-stage
            cancer lymphovascular invasion and lymphatic metastasis via
            ITGA11-SELE interplay.
REFERENCE   2  (bases 1 to 10191)
  AUTHORS   Xu,Y., Deng,C., Chen,H., Song,Y., Xu,H., Song,G., Wang,X., Luo,T.,
            Chen,W., Ma,J., Zeng,A., Huang,S., Chen,Z., Fu,J., Gong,M., Tai,Y.,
            Huang,A., Feng,H., Hu,J., Zhu,X., Tang,Q., Lu,J. and Wang,J.
  TITLE     Osteosarcoma Cells Secrete CXCL14 That Activates Integrin
            alpha11beta1 on Fibroblasts to Form a Lung Metastatic Niche
  JOURNAL   Cancer Res 84 (7), 994-1012 (2024)
   PUBMED   38295227
  REMARK    GeneRIF: Osteosarcoma Cells Secrete CXCL14 That Activates Integrin
            alpha11beta1 on Fibroblasts to Form a Lung Metastatic Niche.
REFERENCE   3  (bases 1 to 10191)
  AUTHORS   Zhang,H., Zhang,L. and Lu,M.
  TITLE     Inhibition of integrin subunit alpha 11 restrains gastric cancer
            progression through phosphatidylinositol 3-kinase/Akt pathway
  JOURNAL   Bioengineered 12 (2), 11909-11921 (2021)
   PUBMED   34802381
  REMARK    GeneRIF: Inhibition of integrin subunit alpha 11 restrains gastric
            cancer progression through phosphatidylinositol 3-kinase/Akt
            pathway.
REFERENCE   4  (bases 1 to 10191)
  AUTHORS   Iwai,M., Tulafu,M., Togo,S., Kawaji,H., Kadoya,K., Namba,Y.,
            Jin,J., Watanabe,J., Okabe,T., Hidayat,M., Sumiyoshi,I., Itoh,M.,
            Koyama,Y., Ito,Y., Orimo,A., Takamochi,K., Oh,S., Suzuki,K.,
            Hayashizaki,Y., Yoshida,K. and Takahashi,K.
  TITLE     Cancer-associated fibroblast migration in non-small cell lung
            cancers is modulated by increased integrin alpha11 expression
  JOURNAL   Mol Oncol 15 (5), 1507-1527 (2021)
   PUBMED   33682233
  REMARK    GeneRIF: Cancer-associated fibroblast migration in non-small cell
            lung cancers is modulated by increased integrin alpha11 expression.
REFERENCE   5  (bases 1 to 10191)
  AUTHORS   Song,H., Li,H., Ding,X., Li,M., Shen,H., Li,Y., Zhang,X. and
            Xing,L.
  TITLE     Long non-coding RNA FEZF1-AS1 facilitates non-small cell lung
            cancer progression via the ITGA11/miR-516b-5p axis
  JOURNAL   Int J Oncol 57 (6), 1333-1347 (2020)
   PUBMED   33174014
  REMARK    GeneRIF: Long noncoding RNA FEZF1AS1 facilitates nonsmall cell lung
            cancer progression via the ITGA11/miR516b5p axis.
REFERENCE   6  (bases 1 to 10191)
  AUTHORS   Zhang,W.M., Popova,S.N., Bergman,C., Velling,T., Gullberg,M.K. and
            Gullberg,D.
  TITLE     Analysis of the human integrin alpha11 gene (ITGA11) and its
            promoter
  JOURNAL   Matrix Biol 21 (6), 513-523 (2002)
   PUBMED   12392762
  REMARK    GeneRIF: Major transcription start site mapped. A core promoter [nt
            (-)127-(+)25], a potential silencer region [nt (-)400-(-)127] and a
            potential enhancer region [nt (-)1519-(-)400] identified as
            important for alpha11 transcription in mesenchymal cells.
REFERENCE   7  (bases 1 to 10191)
  AUTHORS   Tiger,C.F., Fougerousse,F., Grundstrom,G., Velling,T. and
            Gullberg,D.
  TITLE     alpha11beta1 integrin is a receptor for interstitial collagens
            involved in cell migration and collagen reorganization on
            mesenchymal nonmuscle cells
  JOURNAL   Dev Biol 237 (1), 116-129 (2001)
   PUBMED   11518510
REFERENCE   8  (bases 1 to 10191)
  AUTHORS   Velling,T., Kusche-Gullberg,M., Sejersen,T. and Gullberg,D.
  TITLE     cDNA cloning and chromosomal localization of human alpha(11)
            integrin. A collagen-binding, I domain-containing,
            beta(1)-associated integrin alpha-chain present in muscle tissues
  JOURNAL   J Biol Chem 274 (36), 25735-25742 (1999)
   PUBMED   10464311
REFERENCE   9  (bases 1 to 10191)
  AUTHORS   Lehnert,K., Ni,J., Leung,E., Gough,S.M., Weaver,A., Yao,W.P.,
            Liu,D., Wang,S.X., Morris,C.M. and Krissansen,G.W.
  TITLE     Cloning, sequence analysis, and chromosomal localization of the
            novel human integrin alpha11 subunit (ITGA11)
  JOURNAL   Genomics 60 (2), 179-187 (1999)
   PUBMED   10486209
REFERENCE   10 (bases 1 to 10191)
  AUTHORS   Genini,M., Schwalbe,P., Scholl,F.A. and Schafer,B.W.
  TITLE     Isolation of genes differentially expressed in human primary
            myoblasts and embryonal rhabdomyosarcoma
  JOURNAL   Int J Cancer 66 (4), 571-577 (1996)
   PUBMED   8635876
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC100825.2, AF137378.2,
            AK095863.1, AF109681.1, BX496541.1, CN358985.1, AL359064.1 and
            AC021553.14.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001004439.1.
            
            Summary: This gene encodes an alpha integrin. Integrins are
            heterodimeric integral membrane proteins composed of an alpha chain
            and a beta chain. This protein contains an I domain, is expressed
            in muscle tissue, dimerizes with beta 1 integrin in vitro, and
            appears to bind collagen in this form. Therefore, the protein may
            be involved in attaching muscle tissue to the extracellular matrix.
            Alternative transcriptional splice variants have been found for
            this gene, but their biological validity is not determined.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.2578651.1, AK292445.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315757.9/ ENSP00000327290.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC100825.2         31019-31028         c
            11-13               AF137378.2         2-4
            14-273              AK095863.1         16-275
            274-747             AF109681.1         249-722
            748-1356            AK095863.1         750-1358
            1357-1413           AF109681.1         1332-1388
            1414-1615           BX496541.1         393-594
            1616-1667           AF109681.1         1591-1642
            1668-1807           CN358985.1         438-577
            1808-2655           AF137378.2         1801-2648
            2656-3011           AF109681.1         2631-2986
            3012-4667           AL359064.1         58-1713
            4668-5017           AL359064.1         1718-2067
            5018-5019           AL359064.1         2070-2071
            5020-10191          AC021553.14        54387-59558         c
FEATURES             Location/Qualifiers
     source          1..10191
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q23"
     gene            1..10191
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /note="integrin subunit alpha 11"
                     /db_xref="GeneID:22801"
                     /db_xref="HGNC:HGNC:6136"
                     /db_xref="MIM:604789"
     exon            1..149
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..3664
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /note="integrin alpha-11"
                     /codon_start=1
                     /product="integrin alpha-11 precursor"
                     /protein_id="NP_001004439.1"
                     /db_xref="CCDS:CCDS45291.1"
                     /db_xref="GeneID:22801"
                     /db_xref="HGNC:HGNC:6136"
                     /db_xref="MIM:604789"
                     /translation="MDLPRGLVVAWALSLWPGFTDTFNMDTRKPRVIPGSRTAFFGYT
                     VQQHDISGNKWLVVGAPLETNGYQKTGDVYKCPVIHGNCTKLNLGRVTLSNVSERKDN
                     MRLGLSLATNPKDNSFLACSPLWSHECGSSYYTTGMCSRVNSNFRFSKTVAPALQRCQ
                     TYMDIVIVLDGSNSIYPWVEVQHFLINILKKFYIGPGQIQVGVVQYGEDVVHEFHLND
                     YRSVKDVVEAASHIEQRGGTETRTAFGIEFARSEAFQKGGRKGAKKVMIVITDGESHD
                     SPDLEKVIQQSERDNVTRYAVAVLGYYNRRGINPETFLNEIKYIASDPDDKHFFNVTD
                     EAALKDIVDALGDRIFSLEGTNKNETSFGLEMSQTGFSSHVVEDGVLLGAVGAYDWNG
                     AVLKETSAGKVIPLRESYLKEFPEELKNHGAYLGYTVTSVVSSRQGRVYVAGAPRFNH
                     TGKVILFTMHNNRSLTIHQAMRGQQIGSYFGSEITSVDIDGDGVTDVLLVGAPMYFNE
                     GRERGKVYVYELRQNLFVYNGTLKDSHSYQNARFGSSIASVRDLNQDSYNDVVVGAPL
                     EDNHAGAIYIFHGFRGSILKTPKQRITASELATGLQYFGCSIHGQLDLNEDGLIDLAV
                     GALGNAVILWSRPVVQINASLHFEPSKINIFHRDCKRSGRDATCLAAFLCFTPIFLAP
                     HFQTTTVGIRYNATMDERRYTPRAHLDEGGDRFTNRAVLLSSGQELCERINFHVLDTA
                     DYVKPVTFSVEYSLEDPDHGPMLDDGWPTTLRVSVPFWNGCNEDEHCVPDLVLDARSD
                     LPTAMEYCQRVLRKPAQDCSAYTLSFDTTVFIIESTRQRVAVEATLENRGENAYSTVL
                     NISQSANLQFASLIQKEDSDGSIECVNEERRLQKQVCNVSYPFFRAKAKVAFRLDFEF
                     SKSIFLHHLEIELAAGSDSNERDSTKEDNVAPLRFHLKYEADVLFTRSSSLSHYEVKP
                     NSSLERYDGIGPPFSCIFRIQNLGLFPIHGMMMKITIPIATRSGNRLLKLRDFLTDEA
                     NTSCNIWGNSTEYRPTPVEEDLRRAPQLNHSNSDVVSINCNIRLVPNQEINFHLLGNL
                     WLRSLKALKYKSMKIMVNAALQRQFHSPFIFREEDPSRQIVFEISKQEDWQVPIWIIV
                     GSTLGGLLLLALLVLALWKLGFFRSARRRREPGLDPTPKVLE"
     exon            150..261
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     exon            262..362
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     exon            363..454
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     exon            455..569
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     exon            570..697
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     exon            698..846
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     exon            847..991
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1157
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1228
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1373
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1522
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1663
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1867
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1998
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2165
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2308
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2419
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2505
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..2713
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     exon            2714..2812
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     exon            2813..2889
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..2979
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3070
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     exon            3071..3184
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     exon            3185..3271
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     exon            3272..3382
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     exon            3383..3478
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     exon            3479..3592
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     exon            3593..10191
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4753..4758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /note="hexamer: AATAAA"
     polyA_site      4779
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /note="major polyA site"
     regulatory      5000..5005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /note="hexamer: AATACA"
     polyA_site      5019
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /note="major polyA site"
     polyA_site      5458
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /note="major polyA site"
     regulatory      5627..5632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /note="hexamer: ACTAAA"
     polyA_site      5647
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
     regulatory      6580..6585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /note="hexamer: ATTAAA"
     polyA_site      6600
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
     regulatory      7909..7914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /note="hexamer: ATTAAA"
     polyA_site      7929
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
     regulatory      10168..10173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /note="hexamer: AATAAA"
     polyA_site      10191
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
ORIGIN      
        1 agtgcaggct gcaggcgccg cgccgaggag gctgccgctc tggcttgccg ccccccgccg
       61 ccgctgcaca ccggacccag ccgccgtgcc gcgggccatg gacctgccca ggggcctggt
      121 ggtggcctgg gcgctcagcc tgtggccagg gttcacggac accttcaaca tggacaccag
      181 gaagccccgg gtcatccctg gctccaggac cgccttcttt ggctacacag tgcagcagca
      241 cgacatcagt ggcaataagt ggctggtcgt gggcgcccca ctggaaacca atggctacca
      301 gaagacggga gacgtgtaca agtgtccagt gatccacggg aactgcacca aactcaacct
      361 gggaagggtc accctgtcca acgtgtccga gcggaaagac aacatgcgcc tcggccttag
      421 tctcgccacc aaccccaagg acaacagctt cctggcctgc agccccctct ggtctcatga
      481 gtgtgggagc tcctactaca ccacagggat gtgttcaaga gtcaactcca acttcaggtt
      541 ctccaagacc gtggccccag ctctccaaag gtgccagacc tacatggaca tcgtcattgt
      601 cctggatggc tccaacagca tctacccctg ggtggaggtt cagcacttcc tcatcaacat
      661 cctgaaaaag ttttacattg gcccagggca gatccaggtt ggagttgtgc agtatggcga
      721 agatgtggtg catgagtttc acctcaacga ctacaggtct gtaaaagatg tggtggaagc
      781 tgccagccac attgagcaga gaggaggaac agagacccgg acggcatttg gcattgaatt
      841 tgcacgctca gaggctttcc agaagggtgg aaggaaagga gccaagaagg tgatgattgt
      901 catcacagat ggggagtccc acgacagccc agacctggag aaggtgatcc agcaaagcga
      961 aagagacaac gtaacaagat atgcggtggc cgtcctgggc tactacaacc gcagggggat
     1021 caatccagaa acttttctaa atgaaatcaa atacatcgcc agtgaccctg atgacaagca
     1081 cttcttcaat gtcactgatg aggctgcctt gaaggacatt gtcgatgccc tgggggacag
     1141 aatcttcagc ctggaaggca ccaacaagaa cgagacctcc tttgggctgg agatgtcaca
     1201 gacgggcttt tcctcgcacg tggtggagga tggggttctg ctgggagccg tcggtgccta
     1261 tgactggaat ggagctgtgc taaaggagac gagtgccggg aaggtcattc ctctccgcga
     1321 gtcctacctg aaagagttcc ccgaggagct caagaaccat ggtgcatacc tggggtacac
     1381 agtcacatcg gtcgtgtcct ccaggcaggg gcgggtgtac gtggccggag ccccccggtt
     1441 caaccacacg ggcaaggtca tcctgttcac catgcacaac aaccggagcc tcaccatcca
     1501 ccaggctatg cggggccagc agataggctc ttactttggg agtgaaatca cctcggtgga
     1561 catcgacggc gacggcgtga ctgatgtcct gctggtgggc gcacccatgt acttcaacga
     1621 gggccgtgag cgaggcaagg tgtacgtcta tgagctgaga cagaacctgt ttgtttataa
     1681 cggaacgcta aaggattcac acagttacca gaatgcccga tttgggtcct ccattgcctc
     1741 agttcgagac ctcaaccagg attcctacaa tgacgtggtg gtgggagccc ccctggagga
     1801 caaccacgca ggagccatct acatcttcca cggcttccga ggcagcatcc tgaagacacc
     1861 taagcagaga atcacagcct cagagctggc taccggcctc cagtattttg gctgcagcat
     1921 ccacgggcaa ttggacctca atgaggatgg gctcatcgac ctggcagtgg gagcccttgg
     1981 caacgctgtg attctgtggt cccgcccagt ggttcagatc aatgccagcc tccactttga
     2041 gccatccaag atcaacatct tccacagaga ctgcaagcgc agtggcaggg atgccacctg
     2101 cctggccgcc ttcctctgct tcacgcccat cttcctggca ccccatttcc aaacaacaac
     2161 tgttggcatc agatacaacg ccaccatgga tgagaggcgg tatacaccga gggcccacct
     2221 ggacgagggc ggggaccgat tcaccaacag agccgtactg ctctcctccg gccaggagct
     2281 ctgtgagcgg atcaacttcc atgtcctgga cactgctgac tacgtgaagc cagtgacctt
     2341 ctcagtcgag tattccctgg aggaccctga ccatggcccc atgctggacg acggctggcc
     2401 caccactctc agagtctcgg tgcccttctg gaacggctgc aatgaggatg agcactgtgt
     2461 ccctgacctt gtgttggatg cccggagtga cctgcccacg gccatggagt actgccagag
     2521 ggtgctgagg aagcctgcgc aggactgctc cgcatacacg ctgtccttcg acaccacagt
     2581 cttcatcata gagagcacac gccagcgagt ggcggtggag gccacactgg agaacagggg
     2641 cgagaacgcc tacagcacgg tcctaaatat ctcgcagtca gcaaacctgc agtttgccag
     2701 cttgatccag aaggaggact cagacggtag cattgagtgt gtgaacgagg agaggaggct
     2761 ccagaagcaa gtctgcaacg tcagctatcc cttcttccgg gccaaggcca aggtggcttt
     2821 ccgtcttgat tttgagttca gcaaatccat cttcctacac cacctggaga tcgagctcgc
     2881 tgcaggcagt gacagtaatg agcgggacag caccaaggaa gacaacgtgg cccccttacg
     2941 cttccacctc aaatacgagg ctgacgtcct cttcaccagg agcagcagcc tgagccacta
     3001 cgaggtcaag cccaacagct cgctggagag atacgatggt atcgggcctc ccttcagctg
     3061 catcttcagg atccagaact tgggcttgtt ccccatccac gggatgatga tgaagatcac
     3121 cattcccatc gccaccagga gcggcaaccg cctactgaag ctgagggact tcctcacgga
     3181 cgaggcgaac acgtcctgta acatctgggg caatagcact gagtaccggc ccaccccagt
     3241 ggaggaagac ttgcgtcgtg ctccacagct gaatcacagc aactctgatg tcgtctccat
     3301 caactgcaat atacggctgg tccccaacca ggaaatcaat ttccatctac tggggaacct
     3361 gtggttgagg tccctaaaag cactcaagta caaatccatg aaaatcatgg tcaacgcagc
     3421 cttgcagagg cagttccaca gccccttcat cttccgtgag gaggatccca gccgccagat
     3481 cgtgtttgag atctccaagc aagaggactg gcaggtcccc atctggatca ttgtaggcag
     3541 caccctgggg ggcctcctac tgctggccct gctggtcctg gcactgtgga agctcggctt
     3601 ctttagaagt gccaggcgca ggagggagcc tggtctggac cccaccccca aagtgctgga
     3661 gtgaggctcc agaggagact ttgagttgat gggggccagg acaccagtcc aggtagtgtt
     3721 gagacccagg cctgtggccc caccgagctg gagcggagag gaagccagct ggctttgcac
     3781 ttgacctcat ctcccgagca atggcgcctg ctccctccag aatggaactc aagctggttt
     3841 taagtggaac tgccctactg ggagactggg acacctttaa cacagacccc tagggattta
     3901 aagggacacc cctacacaca cccaggccca tgccaaggcc tccctcaggc tctgtggagg
     3961 gcatttgctg ccccagctac taaggtgcta ggaattcgta atcatcccca tcctccagag
     4021 aaacccaggg aggaagactg taaatacgaa cccaatctgc acactccagg cctctagttc
     4081 cagaaggatc caagacaaaa cagatctgaa ttctgccctt ttctctcacc catcccaccc
     4141 ctccattggc tcccaagtca cacccactcc cttccccata gataggcccc tggggctccc
     4201 gaagaatgaa cccaagagca agggcttgat ggtgacagct gcaagccagg gatgaagaaa
     4261 gactctgaga tgtggagact gatggccagg caagtgggac caggatactg gacgctgtcc
     4321 tgagatgaga ggtagccggg ctctgcaccc acgtgcattc acattgaccg caactcacac
     4381 attcccccac cagctgcagc cccttgctct cagctgccaa ccctcccggg tcacttttgt
     4441 tcccaggtac ctcatgggaa gcatgtggat gacacaatcc ctggggctgt gcattcccac
     4501 gtcttcttgc tgcagcctgc ccctagacat ggacgcaccg gcctggctgc agctgggcag
     4561 caggggtagg ggtagggagc ctcccctccc tgtatcaccc cctccctaca cacacacaca
     4621 cacacacaca cacacacaca cacacacaca cacacacaca cacacactgc ctcccatcct
     4681 tccctcatgc ccgccagtgc acagggaagg gcttggccag cgctgttgag gggtcccctc
     4741 tggaatgcac tgaataaagc acgtgcaagg actcccggag cctgtgcagc cttggtggca
     4801 aatatctcat ctgccggccc ccaggacaag tggtatgacc agtgataatg ccccaaggac
     4861 aaggggcgtg cctggcgccc agtggagtaa tttatgcctt agtcttgttt tgaggtagaa
     4921 atgcaagggg gacacatgaa aggcatcagt ccccctgtgc atagtacgac ctttactgtc
     4981 gtatttttga aaaattaaaa atacagtgtt taaaaacaac caagcactga catcccattc
     5041 tgtgggcaga gcatatcaca gtgagccata ctcccctttg aaggagagga agtagaatga
     5101 gggagttcct tgcttcctcc cccctacctc tacatgtcag aagggactca tccaccattt
     5161 gctgcccaca acatgccctc ctagtggctg cctggcctcc gtgtgacgtc tccagtggtg
     5221 gagcgctccc tctcccaaga tcacccttcc atctatggcc agtgtggacg gttaggacct
     5281 aaatgtttca ctgtagcttc tgcccttggt tccagctctt ccctctcacg cctcccagac
     5341 ttctccaggc cggtttcatt gttaaccgtc ttacactctg acatcagcca aggcgtctcc
     5401 attctgttct tgtgccattc atgtcttgga ttcccagtaa gtagaacctt ggaaataatt
     5461 tgatcttgtt tttgcataaa tgaggacact cagaaccagg aagagcccta ggctcccaca
     5521 gcaaaaccaa aactaaaccc aggactgcta tttcccaagc cagattctgt tattcgagcc
     5581 cagccttaga agggcttgat gtggagcaaa aggtgaaaat ggtgaaacta aaatttgagt
     5641 atcaaaaccc attgccttct aatagaatca gaaggaaatg ttgctaaatc atattccatt
     5701 tccgtcatca ctcttatgaa tggggtaacc tggctaaatg agaattaatg aacccacact
     5761 cataagtttt cattgactta gcaccaagtc gtccatcaaa tatcatcaga tctgagaatg
     5821 ctcttatgga tatctgattt ttagaggctg gcattcatat ttttaaaaac tgccacctgt
     5881 gaccacactg caggccaaac agaatgtacc tgctggtcag atgcagccca gaggtcactg
     5941 aattgcaacc tctggactct cggtcagagg caagcagccc ttattccaga actccacagt
     6001 ccttcacacc cttccccaga cctacaccaa gaccaactaa gtggtcaaaa ggtggacaaa
     6061 ctgagagttg tatcaaggcc cttagcctct caatttgtta tcaagtttcc ctttctgaat
     6121 ctatttaccc tgaagtataa atacccaaga tgagccttaa gagtgcctgg tagagcaaac
     6181 aaagatgcat cttataggga gcaaagtcta tgctaacgca gtgtttctca atcctggctg
     6241 cacctttgaa ccacgggagc tttaaaagtg accactgcaa gggccctacc cactatggat
     6301 cccaatttca ttggttggga gaggggccaa gtttgtttcc aacttcccca gatgactcta
     6361 atggctgaga gttgcaatca acaggtaagt gaatatccag gctgtaagat gaagaaagag
     6421 ggggttgtgc ccaagcccac tgtgcctcat aaagcagatg atctctgcag cgctgcgctt
     6481 ctcaaagagt ggtcccagga ctgcctcagt cagaccacag actcctaagt tcctcctcag
     6541 acttcatgga tccaagctct gtgaggtaat tctaagcaca ttaaacttgt agaacagcca
     6601 tctggattta atattacata atagctataa tattctgcta ttctctaatc ttcaatgtca
     6661 gtttcttaaa ctgtcaggcc tgtctttaga tgcccttcaa ctgtgctggg gactatcttg
     6721 atggcagcca gcaaagaaaa tcagcaaaaa ccccagtgga gtttctgggt tttacttttg
     6781 ttaaggaagg tgatggtttc ttgacatgac aggtatctag gtggaaaggg caaagtgcta
     6841 atgcaaacac aatggagaca ctatggaata gctctgccta gggacatgtg gaagagcttc
     6901 taggagacag tgtggacctt tccatcccta gaggtcttca caagataaat tcctacctcc
     6961 gtcagtattc aaaaggtttt agcatcaata ctgtctgaga ataagacatt agacttgagt
     7021 cagtcccctg gcttcaatcc caggatgcca agcagcctct aatggagacc gctggcttaa
     7081 tcgtgctcct ttcctggcat aacaactcac tgcacccatg cctcaccacc acgaagcagt
     7141 ctcctcacca cccaaatgtg ccttgggtga cttaaataca gccattagta tgaatggtcc
     7201 cctgttttta ttcaacacca caccagtctt tgcttttacc ttcggctaat gtggttccag
     7261 ccttttatcc tgcactcctt cttataattt aaaaaaaaaa aaaactcccc tactatcttt
     7321 atgttaatat taacatcaac taggttcttc tcaaaggaca gccaggccta actggccacg
     7381 ttaaaatctg cacagtgctt ttgtgtcact gtctattcta ttagtttcaa catcatgcta
     7441 aaataggaca gcatgttcca aaactgaaac tgaaacagga acggagcctt gctgatttag
     7501 catgaggagg gaattgtaag ccttgcacct ggacactaaa acttttcaat aagatgtatg
     7561 ctaagccgta cctagcaaac ttaccaggtc caaagtagag tacaagcaga aagttatttt
     7621 taaaggatgg gcactatcct tgagggactt accctttcta atcagctttg catggtttgt
     7681 tttgagacag tgtctcactc tgttgcccag gctagagtgc agcggcacca tcacagctca
     7741 cggcagcctc tgcctcccgg gctcaagcaa tcccacctca gtttcccaag tagctgggac
     7801 tacaggcaca caccacactc agctaatttt agtatttttt gtagagacag ggtctcgcca
     7861 tgttgcccag gctggtctca aactcctgga ttatctccct ggccctgcat taaaaaagat
     7921 gtgcaacaac ttagtgatgt gtctgaaatg ttttcagaag gtggcccaag tcagagtcaa
     7981 aaaatttttt tatttggaaa attagaggaa atacagaaaa tcaaatttca aatagatgca
     8041 tctaaatgga gaacaagctt atcaaggaca gagtccatct ttcttatttt tatttttgag
     8101 acagggtctt gctctgtcac ccaggctaga gtgcagcggc acaatcacag ctccctgcag
     8161 cctcgacctc ctggacttca gtgatcctcc cacctcagcc tcttgagtag ctgggactac
     8221 agacatgcac caccatgccc agctaatttt ttttttaatt ttgtgcagag agggggtctc
     8281 actttgttgc ccacactggt ctctcttatt tttgtatgca tatctgtggt gcagtgcctg
     8341 aaatacagta ggtgttcaat aagcgccaac atgcaagagt atcttgccat tgattaaggc
     8401 aaaagcaaaa ccccagtccg cccctctgat ggactgagca caccaaattt ctaaagcaca
     8461 ggcaaattag aaaatataat tttgtctaaa cttgccaaca agctaaggtt ttgtgaacca
     8521 cctaaaattt gcctctctca tactgaaatt ttctaggtca agtatctgaa ggaatacact
     8581 actgccagta ttttctttgg tgatctgtca tatacagcag acattacttg aaacaaagaa
     8641 aaaaatgttt taaaacctgt ctggatgatt tccgcagtct cactaggtta ttgcagccag
     8701 ggagtgacct agcagagatc tgaaggtgag cttccctagt actggcatct cacagtgaaa
     8761 gagcactgtt cagtgggtca agagacccag agcctactct cagttacgac acacatagtc
     8821 cttgtgtggc ctttctgggc ttgtgtcctg aactataaaa tgagagggtg gcactaaatg
     8881 tttttttcag atctctatag aggctggaat ggccacagag aatctaaatt tgaaaacaaa
     8941 catgtcctga gggtgtgctc caataccacc ctttaatact ctcctgagat gtgaaggctg
     9001 gaaatgagaa tgccatatta ttgttacttg caaacgatta gtgtatctgg gacatccaaa
     9061 agaagtaact gaaaatttat ttctttaaaa acaaaaaaaa ccattacagt gcttttgtaa
     9121 aaacattaat atttagaagt acgtagtggt aataaaagga aaatagttgt aagaccttca
     9181 ttaaaaagaa aaacctaaaa aaaaaaacaa aacaaaactc tggatacagg tgtatgattt
     9241 acctaaccag acatagcttt cttttggata aaaaaaaaaa aaaaaaaaaa gctcagaagt
     9301 gcagaactgt acagatgtcc ctaaatctat taattcaatg ctaaacgaaa taatctctta
     9361 acatgataaa attacaccaa acttcatctg gaaaaataaa cacgtaataa tgaaaaaagt
     9421 tagccactcc cacctcccca cttaaaaaag acaaatgaag aaatactagt ccaaggccag
     9481 gtgtggtggc tcacatctgt aatcccaaca ctttgagagg ctgaggtggg aggactgctt
     9541 gaacccagga gttcaagacc agcctaggca tcatggcaaa accccatctc tacaaaaaat
     9601 accaaaataa aaagaattag ctgggcatgg tggcacatac ctgtagtccc agctacttgg
     9661 gaggctgagg tgagaggatc acttgagccc ggaagatcaa ggcgacagta agccatgatg
     9721 gcaccactgc actccagcct gggtgacaga atgaaaccct gtctcaaaaa acaaacaaac
     9781 aaaaaccaaa caaattatag gaaaatcaac attttaaacc aaagaagaga aggagaaaga
     9841 agggaaggga agccataaaa gtgtcttttt caaatagatc atgggggaaa aaaaaaaaaa
     9901 gtatgacttg gaatagagac agccttacaa gcaggatcta aaactcagaa tccatttttt
     9961 taaattgtga taaatttgac tatagaaaaa tgtaaacttt ggatacaaaa gtaccatatt
    10021 taaagtaaat aagctacaac tattacatga cagagaaaat gtcctcaaac ttctaaggaa
    10081 cttctaacaa gtagaaaaaa aacacacaca accccaaagc aaacaccaat agtcaataaa
    10141 tatatgaaag tgttcaatgt tactcataat aaaggcatac aaatcaaacc a
//
