LOCUS       NM_003637               5130 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens integrin subunit alpha 10 (ITGA10), transcript variant
            1, mRNA.
ACCESSION   NM_003637
VERSION     NM_003637.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5130)
  AUTHORS   Li,H., Shen,X., Ma,M., Liu,W., Yang,W., Wang,P., Cai,Z., Mi,R.,
            Lu,Y., Zhuang,J., Jiang,Y., Song,Y., Wu,Y. and Shen,H.
  TITLE     ZIP10 drives osteosarcoma proliferation and chemoresistance through
            ITGA10-mediated activation of the PI3K/AKT pathway
  JOURNAL   J Exp Clin Cancer Res 40 (1), 340 (2021)
   PUBMED   34706747
  REMARK    GeneRIF: ZIP10 drives osteosarcoma proliferation and
            chemoresistance through ITGA10-mediated activation of the PI3K/AKT
            pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5130)
  AUTHORS   Hu,Q., Zhou,S., Hu,X., Zhang,H., Huang,S. and Wang,Y.
  TITLE     Systematic screening identifies a 2-gene signature as a
            high-potential prognostic marker of undifferentiated pleomorphic
            sarcoma/myxofibrosarcoma
  JOURNAL   J Cell Mol Med 24 (1), 1010-1021 (2020)
   PUBMED   31742892
  REMARK    GeneRIF: Systematic screening identifies a 2-gene signature as a
            high-potential prognostic marker of undifferentiated pleomorphic
            sarcoma/myxofibrosarcoma.
REFERENCE   3  (bases 1 to 5130)
  AUTHORS   Nakamura,K., Ikeuchi,T., Nara,K., Rhodes,C.S., Zhang,P., Chiba,Y.,
            Kazuno,S., Miura,Y., Ago,T., Arikawa-Hirasawa,E., Mukouyama,Y.S.
            and Yamada,Y.
  TITLE     Perlecan regulates pericyte dynamics in the maintenance and repair
            of the blood-brain barrier
  JOURNAL   J Cell Biol 218 (10), 3506-3525 (2019)
   PUBMED   31541017
REFERENCE   4  (bases 1 to 5130)
  AUTHORS   Wenke,A.K., Rothhammer,T., Moser,M. and Bosserhoff,A.K.
  TITLE     Regulation of integrin alpha10 expression in chondrocytes by the
            transcription factors AP-2epsilon and Ets-1
  JOURNAL   Biochem Biophys Res Commun 345 (1), 495-501 (2006)
   PUBMED   16684505
  REMARK    GeneRIF: Analyses of the functional regulatory domains of the
            integrin alpha 10 promoter suggest that AP-2epsilon and Ets-1 are
            involved in the transcriptional regulation of this gene in
            chondrocytes.
REFERENCE   5  (bases 1 to 5130)
  AUTHORS   Kapyla,J., Jaalinoja,J., Tulla,M., Ylostalo,J., Nissinen,L.,
            Viitasalo,T., Vehvilainen,P., Marjomaki,V., Nykvist,P.,
            Saamanen,A.M., Farndale,R.W., Birk,D.E., Ala-Kokko,L. and Heino,J.
  TITLE     The fibril-associated collagen IX provides a novel mechanism for
            cell adhesion to cartilaginous matrix
  JOURNAL   J Biol Chem 279 (49), 51677-51687 (2004)
   PUBMED   15383545
REFERENCE   6  (bases 1 to 5130)
  AUTHORS   Gullberg,D.E. and Lundgren-Akerlund,E.
  TITLE     Collagen-binding I domain integrins--what do they do?
  JOURNAL   Prog Histochem Cytochem 37 (1), 3-54 (2002)
   PUBMED   11876085
  REMARK    Review article
REFERENCE   7  (bases 1 to 5130)
  AUTHORS   Tulla,M., Pentikainen,O.T., Viitasalo,T., Kapyla,J., Impola,U.,
            Nykvist,P., Nissinen,L., Johnson,M.S. and Heino,J.
  TITLE     Selective binding of collagen subtypes by integrin alpha 1I, alpha
            2I, and alpha 10I domains
  JOURNAL   J Biol Chem 276 (51), 48206-48212 (2001)
   PUBMED   11572855
REFERENCE   8  (bases 1 to 5130)
  AUTHORS   Bengtsson,T., Camper,L., Schneller,M. and Lundgren-Akerlund,E.
  TITLE     Characterization of the mouse integrin subunit alpha10 gene and
            comparison with its human homologue. Genomic structure, chromosomal
            localization and identification of splice variants
  JOURNAL   Matrix Biol 20 (8), 565-576 (2001)
   PUBMED   11731273
  REMARK    GeneRIF: Mouse and human articular chondrocytes express
            extracellular splice variants of the alpha10 subunit
REFERENCE   9  (bases 1 to 5130)
  AUTHORS   Lehnert,K., Ni,J., Leung,E., Gough,S., Morris,C.M., Liu,D.,
            Wang,S.X., Langley,R. and Krissansen,G.W.
  TITLE     The integrin alpha10 subunit: expression pattern, partial gene
            structure, and chromosomal localization
  JOURNAL   Cytogenet Cell Genet 87 (3-4), 238-244 (1999)
   PUBMED   10702680
REFERENCE   10 (bases 1 to 5130)
  AUTHORS   Camper,L., Hellman,U. and Lundgren-Akerlund,E.
  TITLE     Isolation, cloning, and sequence analysis of the integrin subunit
            alpha10, a beta1-associated collagen binding integrin expressed on
            chondrocytes
  JOURNAL   J Biol Chem 273 (32), 20383-20389 (1998)
   PUBMED   9685391
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF112345.1, AF074015.1 and
            AC243547.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003637.4.
            
            Summary: Integrins are integral transmembrane glycoproteins
            composed of noncovalently linked alpha and beta chains. They
            participate in cell adhesion as well as cell-surface mediated
            signalling. This gene encodes an integrin alpha chain and is
            expressed at high levels in chondrocytes, where it is
            transcriptionally regulated by AP-2epsilon and Ets-1. The protein
            encoded by this gene binds to collagen. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Dec
            2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF112345.1, AF074015.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369304.8/ ENSP00000358310.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1037              AF112345.1         41-1077
            1038-1305           AF074015.1         1023-1290
            1306-1306           AC243547.1         133319-133319
            1307-1307           AF074015.1         1292-1292
            1308-5130           AF112345.1         1348-5170
FEATURES             Location/Qualifiers
     source          1..5130
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.1"
     gene            1..5130
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /note="integrin subunit alpha 10"
                     /db_xref="GeneID:8515"
                     /db_xref="HGNC:HGNC:6135"
                     /db_xref="MIM:604042"
     exon            1..88
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..3540
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; integrin alpha-10"
                     /codon_start=1
                     /product="integrin alpha-10 isoform 1 precursor"
                     /protein_id="NP_003628.2"
                     /db_xref="CCDS:CCDS72869.1"
                     /db_xref="GeneID:8515"
                     /db_xref="HGNC:HGNC:6135"
                     /db_xref="MIM:604042"
                     /translation="MELPFVTHLFLPLVFLTGLCSPFNLDEHHPRLFPGPPEAEFGYS
                     VLQHVGGGQRWMLVGAPWDGPSGDRRGDVYRCPVGGAHNAPCAKGHLGDYQLGNSSHP
                     AVNMHLGMSLLETDGDGGFMACAPLWSRACGSSVFSSGICARVDASFQPQGSLAPTAQ
                     RCPTYMDVVIVLDGSNSIYPWSEVQTFLRRLVGKLFIDPEQIQVGLVQYGESPVHEWS
                     LGDFRTKEEVVRAAKNLSRREGRETKTAQAIMVACTEGFSQSHGGRPEAARLLVVVTD
                     GESHDGEELPAALKACEAGRVTRYGIAVLGHYLRRQRDPSSFLREIRTIASDPDERFF
                     FNVTDEAALTDIVDALGDRIFGLEGSHAENESSFGLEMSQIGFSTHRLKDGILFGMVG
                     AYDWGGSVLWLEGGHRLFPPRMALEDEFPPALQNHAAYLGYSVSSMLLRGGRRLFLSG
                     APRFRHRGKVIAFQLKKDGAVRVAQSLQGEQIGSYFGSELCPLDTDRDGTTDVLLVAA
                     PMFLGPQNKETGRVYVYLVGQQSLLTLQGTLQPEPPQDARFGFAMGALPDLNQDGFAD
                     VAVGAPLEDGHQGALYLYHGTQSGVRPHPAQRIAAASMPHALSYFGRSVDGRLDLDGD
                     DLVDVAVGAQGAAILLSSRPIVHLTPSLEVTPQAISVVQRDCRRRGQEAVCLTAALCF
                     QVTSRTPGRWDHQFYMRFTASLDEWTAGARAAFDGSGQRLSPRRLRLSVGNVTCEQLH
                     FHVLDTSDYLRPVALTVTFALDNTTKPGPVLNEGSPTSIQKLVPFSKDCGPDNECVTD
                     LVLQVNMDIRGSRKAPFVVRGGRRKVLVSTTLENRKENAYNTSLSLIFSRNLHLASLT
                     PQRESPIKVECAAPSAHARLCSVGHPVFQTGAKVTFLLEFEFSCSSLLSQVFVKLTAS
                     SDSLERNGTLQDNTAQTSAYIQYEPHLLFSSESTLHRYEVHPYGTLPVGPGPEFKTTL
                     RVQNLGCYVVSGLIISALLPAVAHGGNYFLSLSQVITNNASCIVQNLTEPPGPPVHPE
                     ELQHTNRLNGSNTQCQVVRCHLGQLAKGTEVSVGLLRLVHNEFFRRAKFKSLTVVSTF
                     ELGTEEGSVLQLTEASRWSESLLEVVQTRPILISLWILIGSVLGGLLLLALLVFCLWK
                     LGFFAHKKIPEEEKREEKLEQ"
     exon            89..200
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     exon            201..310
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     exon            311..402
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     exon            403..517
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     exon            518..645
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     exon            646..794
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     exon            795..945
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1111
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1185
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1330
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1479
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1623
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1827
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1958
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2125
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2268
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2382
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2468
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2610
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..2703
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2780
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     exon            2781..2870
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     exon            2871..2955
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     exon            2956..3069
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     exon            3070..3150
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     exon            3151..3264
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     exon            3265..3360
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     exon            3361..3474
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..5130
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5109..5114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /note="hexamer: AATAAA"
     polyA_site      5130
                     /gene="ITGA10"
                     /gene_synonym="PRO827"
                     /note="major polyA site"
ORIGIN      
        1 agaggacttc tcatactgga cagaaaccga tcaggcatgg aactcccctt cgtcactcac
       61 ctgttcttgc ccctggtgtt cctgacaggt ctctgctccc cctttaacct ggatgaacat
      121 cacccacgcc tattcccagg gccaccagaa gctgaatttg gatacagtgt cttacaacat
      181 gttgggggtg gacagcgatg gatgctggtg ggcgccccct gggatgggcc ttcaggcgac
      241 cggagggggg acgtttatcg ctgccctgta gggggggccc acaatgcccc atgtgccaag
      301 ggccacttag gtgactacca actgggaaat tcatctcatc ctgctgtgaa tatgcacctg
      361 gggatgtctc tgttagagac agatggtgat gggggattca tggcctgtgc ccctctctgg
      421 tctcgtgctt gtggcagctc tgtcttcagt tctgggatat gtgcccgtgt ggatgcttca
      481 ttccagcctc agggaagcct ggcacccact gcccaacgct gcccaacata catggatgtt
      541 gtcattgtct tggatggctc caacagcatc tacccctggt ctgaagttca gaccttccta
      601 cgaagactgg tagggaaact gtttattgac ccagaacaga tacaggtggg actggtacag
      661 tatggggaga gccctgtaca tgagtggtcc ctgggagatt tccgaacgaa ggaagaagtg
      721 gtgagagcag caaagaacct cagtcggcgg gagggacgag aaacaaagac tgcccaagca
      781 ataatggtgg cctgcacaga agggttcagt cagtcccatg ggggccgacc cgaggctgcc
      841 aggctactgg tggttgtcac tgatggagag tcccatgatg gagaggagct tcctgcagca
      901 ctaaaggcct gtgaggctgg aagagtgaca cgctatggga ttgcagtcct tggtcactac
      961 ctccggcggc agcgagatcc cagctctttc ctgagagaaa ttagaactat tgccagtgat
     1021 ccagatgagc gattcttctt caatgtcaca gatgaggctg ctctgactga cattgtggat
     1081 gcactaggag atcggatttt tggccttgaa gggtcccatg cagaaaacga aagctccttt
     1141 gggctggaaa tgtctcagat tggtttctcc actcatcggc taaaggatgg gattcttttt
     1201 gggatggtgg gggcctatga ctggggaggc tctgtgctat ggcttgaagg aggccaccgc
     1261 cttttccccc cacgaatggc actggaagac gagttccccc ctgcattgca gaaccatgca
     1321 gcctacctgg gttactctgt ttcttccatg cttttgcggg gtggacgccg cctgtttctc
     1381 tctggggctc ctcgatttag acatcgagga aaagtcatcg ccttccagct taagaaagat
     1441 ggggctgtga gggttgccca gagcctccag ggggagcaga ttggttcata ctttggcagt
     1501 gagctctgcc cattggatac agatagggat ggaacaactg atgtcttact tgtggctgcc
     1561 cccatgttcc tgggacccca gaacaaggaa acaggacgtg tttatgtgta tctggtaggc
     1621 cagcagtcct tgctgaccct ccaaggaaca cttcagccag aaccccccca ggatgctcgg
     1681 tttggctttg ccatgggagc tcttcctgat ctgaaccaag atggttttgc tgatgtggct
     1741 gtgggggcgc ctctggaaga tgggcaccag ggagcactgt acctgtacca tggaacccag
     1801 agtggagtca ggccccatcc tgcccagagg attgctgctg cctccatgcc acatgccctc
     1861 agctactttg gccgaagtgt ggatggtcgg ctagatctgg atggagatga tctggtcgat
     1921 gtggctgtgg gtgcccaggg ggcagccatc ctgctcagct cccggcccat tgtccatctg
     1981 accccatcac tggaggtgac cccacaggcc atcagtgtgg ttcagaggga ctgtaggcgg
     2041 cgaggccaag aggcagtctg tctgactgca gccctttgct tccaagtgac ctcccgtact
     2101 cctggtcgct gggatcacca attctacatg aggttcaccg catcactgga tgaatggact
     2161 gctggggcac gtgcagcatt tgatggctct ggccagaggt tgtcccctcg gaggctccgg
     2221 ctcagtgtgg ggaatgtcac ttgtgagcag ctacacttcc atgtgctgga tacatcagat
     2281 tacctccggc cagtggcctt gactgtgacc tttgccttgg acaatactac aaagccaggg
     2341 cctgtgctga atgagggctc acccacctct atacaaaagc tggtcccctt ctcaaaggat
     2401 tgtggccctg acaatgaatg tgtcacagac ctggtgcttc aagtgaatat ggacatcaga
     2461 ggctccagga aggccccatt tgtggttcga ggtggccggc ggaaagtgct ggtatctaca
     2521 actctggaga acagaaagga aaatgcttac aatacgagcc tgagtctcat cttctctaga
     2581 aacctccacc tggccagtct cactcctcag agagagagcc caataaaggt ggaatgtgcc
     2641 gccccttctg ctcatgcccg gctctgcagt gtggggcatc ctgtcttcca gactggagcc
     2701 aaggtgacct ttctgctaga gtttgagttt agctgctcct ctctcctgag ccaggtcttc
     2761 gtgaagctga ctgccagcag tgacagcctg gagagaaatg ggacccttca agataacaca
     2821 gcccagacct cagcctacat ccaatatgag ccccacctcc tgttctctag tgagtctacc
     2881 ctgcaccgct atgaggttca cccatatggg accctcccag tgggtcctgg cccagaattc
     2941 aaaaccactc tcagggttca gaacctaggc tgctatgtgg tcagtggcct catcatctca
     3001 gccctccttc cagctgtggc ccatgggggc aattacttcc tatcactgtc tcaagtcatc
     3061 actaacaatg caagctgcat agtgcagaac ctgactgaac ccccaggccc acctgtgcat
     3121 ccagaggagc ttcaacacac aaacagactg aatgggagca atactcagtg tcaggtggtg
     3181 aggtgccacc ttgggcagct ggcaaagggg actgaggtct ctgttggact attgaggctg
     3241 gttcacaatg aatttttccg aagagccaag ttcaagtccc tgacggtggt cagcaccttt
     3301 gagctgggaa ccgaagaggg cagtgtccta cagctgactg aagcctcccg ttggagtgag
     3361 agcctcttgg aggtggttca gacccggcct atcctcatct ccctgtggat cctcataggc
     3421 agtgtcctgg gagggttgct cctgcttgct ctccttgtct tctgcctgtg gaagcttggc
     3481 ttctttgccc ataagaaaat ccctgaggaa gaaaaaagag aagagaagtt ggagcaatga
     3541 atgtagaata agggtctaga aagtcctccc tggcagcttc ttcaagagac ttgcataaaa
     3601 gcagaggttt gggggctcag atgggacaag aagccgcctc tggactatct ccccagacca
     3661 gcagcctgac ttgacttttg agtcctaggg atgctgctgg ctagagatga ggctttacct
     3721 cagacaagaa gagctggcac caaaactagc catgctccca ccctctgctt ccctcctcct
     3781 cgtgatcctg gttccatagc caacactggg gcttttgttt ggggtccttt tatccccagg
     3841 aatcaataat ttttttgcct aggtgcctga ctcctttcag attccctctt tatcttccct
     3901 cacagtttgg aaaggatgag ggttatcttc ctcgattctt ccaccctctc actttcctgc
     3961 ctgttcccca ctccacagga gggagctgac gttggcttga aaggagtaaa gtcaacatct
     4021 gctgctttcc tgtggactct ggtgattcat agagccggat ggggagagtc aacaggaaaa
     4081 aaggagggag gaggaaaagc cacaagagac attctgtaca attccaagga acagagaagc
     4141 ctttagacag gcaactgcca tcccccctga aacctgagac ctgtagtgca ctcgaccgcc
     4201 ctcaggtgtt ggtgaaacag agctgccccc aggctcgctg ggcataggct tcctgattcc
     4261 aagccttttc tgggagcaaa gccagggcct ggtgcctgat tttctgaagc caggagccct
     4321 caggtggctg gagctggaat agcagggagg actgggtgta cctaggcagt attttctcta
     4381 cttctctcaa gtcttatact cactcttgag ccctccttgg ggcctgctta gaaagcagac
     4441 aggagagaga gtactgctac ttgatgatgg gaaatgcttt cactttacca gctttgggaa
     4501 gcagcagccc catgggatct aaaagtgtgg agtctgcatt aagaaaccta catgggtggc
     4561 atggggctct ggggagcaag cccttacttg ctcagcactg gttatgtagc acaaatagct
     4621 cctaggaaaa tgtttctggg gcaaccctag aaccctggtc atattttgca gggtttctct
     4681 ggtggaatca gtttgccagc ccttgcttga tgcttactgg aaatctccag gttaatttct
     4741 atctctgatc cctccccaac ccactccata tttgggtcat ggacagtaaa ggcagttgga
     4801 ttctcataga caactgggta acttatattt ctttgtaatc aagacttgag atatcgaagt
     4861 cagttattgg tctccagagt gcagctctgg gagccttttg aagaatcagc actcattaag
     4921 agctgagaag agagaagacc tgattgggtg gttgactagc agtcacagaa cctgtcctcc
     4981 caggctgttc ctgaggcctg accacagtat ttattttggc atgtctctgg ccttctgcag
     5041 aggcccaccc tcatgggcat tgtctctgtt tcccagtggg gtggacagta tatcagatgg
     5101 tcagaacaaa taaagttcag tgtcaaatga
//
