LOCUS       NM_181501              10736 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens integrin subunit alpha 1 (ITGA1), mRNA.
ACCESSION   NM_181501
VERSION     NM_181501.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10736)
  AUTHORS   Hunter,E.J., Hamaia,S.W., Kim,P.S., Malcor,J.M. and Farndale,R.W.
  TITLE     The effects of inhibition and siRNA knockdown of collagen-binding
            integrins on human umbilical vein endothelial cell migration and
            tube formation
  JOURNAL   Sci Rep 12 (1), 21601 (2022)
   PUBMED   36517525
  REMARK    GeneRIF: The effects of inhibition and siRNA knockdown of
            collagen-binding integrins on human umbilical vein endothelial cell
            migration and tube formation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10736)
  AUTHORS   Li,X., Wang,N., Leng,H., Yuan,H. and Xu,L.
  TITLE     Hsa_circ_0043949 reinforces temozolomide resistance via
            upregulating oncogene ITGA1 axis in glioblastoma
  JOURNAL   Metab Brain Dis 37 (8), 2979-2993 (2022)
   PUBMED   36301458
  REMARK    GeneRIF: Hsa_circ_0043949 reinforces temozolomide resistance via
            upregulating oncogene ITGA1 axis in glioblastoma.
REFERENCE   3  (bases 1 to 10736)
  AUTHORS   Singh,J.P., Li,Y., Chen,Y.Y., Hsu,S.D., Page,R., Peti,W. and
            Meng,T.C.
  TITLE     The catalytic activity of TCPTP is auto-regulated by its
            intrinsically disordered tail and activated by Integrin alpha-1
  JOURNAL   Nat Commun 13 (1), 94 (2022)
   PUBMED   35013194
  REMARK    GeneRIF: The catalytic activity of TCPTP is auto-regulated by its
            intrinsically disordered tail and activated by Integrin alpha-1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10736)
  AUTHORS   Li,X., Liu,X., Xing,Y., Zeng,L., Liu,X., Shen,H. and Ma,J.
  TITLE     Erianin Controls Collagen-Mediated Retinal Angiogenesis via the
            RhoA/ROCK1 Signaling Pathway Induced by the alpha2/beta1
            Integrin-Collagen Interaction
  JOURNAL   Invest Ophthalmol Vis Sci 63 (1), 27 (2022)
   PUBMED   35060996
  REMARK    GeneRIF: Erianin Controls Collagen-Mediated Retinal Angiogenesis
            via the RhoA/ROCK1 Signaling Pathway Induced by the alpha2/beta1
            Integrin-Collagen Interaction.
REFERENCE   5  (bases 1 to 10736)
  AUTHORS   Gao,Y., Zhang,H., Zhao,S., He,D. and Gu,C.
  TITLE     Nanofluorescence Probes to Detect miR-192/Integrin Alpha 1 and
            Their Correlations with Retinoblastoma
  JOURNAL   J Biomed Nanotechnol 17 (11), 2176-2185 (2021)
   PUBMED   34906278
  REMARK    GeneRIF: Nanofluorescence Probes to Detect miR-192/Integrin Alpha 1
            and Their Correlations with Retinoblastoma.
REFERENCE   6  (bases 1 to 10736)
  AUTHORS   Clover,J., Dodds,R.A. and Gowen,M.
  TITLE     Integrin subunit expression by human osteoblasts and osteoclasts in
            situ and in culture
  JOURNAL   J Cell Sci 103 (Pt 1), 267-271 (1992)
   PUBMED   1429908
REFERENCE   7  (bases 1 to 10736)
  AUTHORS   Belkin,V.M., Belkin,A.M., Dol'nikova,A.E., Tarasova,E.A. and
            Kotelianskii,V.E.
  TITLE     [Isolation and characteristics of ligand specificity of VLA-1
            integrin from human smooth muscles]
  JOURNAL   Biokhimiia 56 (12), 2198-2206 (1991)
   PUBMED   1807406
REFERENCE   8  (bases 1 to 10736)
  AUTHORS   Bank,I., Roth,D., Book,M., Guterman,A., Shnirrer,I., Block,R.,
            Ehrenfeld,M., Langevitz,P., Brenner,H. and Pras,M.
  TITLE     Expression and functions of very late antigen 1 in inflammatory
            joint diseases
  JOURNAL   J Clin Immunol 11 (1), 29-38 (1991)
   PUBMED   1827128
REFERENCE   9  (bases 1 to 10736)
  AUTHORS   Virtanen,I., Korhonen,M., Kariniemi,A.L., Gould,V.E., Laitinen,L.
            and Ylanne,J.
  TITLE     Integrins in human cells and tumors
  JOURNAL   Cell Differ Dev 32 (3), 215-227 (1990)
   PUBMED   2099238
  REMARK    Review article
REFERENCE   10 (bases 1 to 10736)
  AUTHORS   Tabibzadeh,S.
  TITLE     Evidence of T-cell activation and potential cytokine action in
            human endometrium
  JOURNAL   J Clin Endocrinol Metab 71 (3), 645-649 (1990)
   PUBMED   2144294
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC026230.5, AC027326.6,
            AC022133.7, KF510907.1, AC025180.6 and KF457900.1.
            
            On May 17, 2019 this sequence version replaced NM_181501.1.
            
            Summary: This gene encodes the alpha 1 subunit of integrin
            receptors. This protein heterodimerizes with the beta 1 subunit to
            form a cell-surface receptor for collagen and laminin. The
            heterodimeric receptor is involved in cell-cell adhesion and may
            play a role in inflammation and fibrosis. The alpha 1 subunit
            contains an inserted (I) von Willebrand factor type I domain which
            is thought to be involved in collagen binding. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.21043.1,
                                           SRR1803617.256505.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282588.7/ ENSP00000282588.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-499               AC026230.5         58150-58648
            500-620             AC027326.6         20810-20930
            621-733             AC027326.6         32892-33004
            734-822             AC022133.7         6596-6684
            823-934             AC022133.7         6804-6915
            935-1062            AC022133.7         7523-7650
            1063-1211           AC022133.7         23704-23852
            1212-1362           AC022133.7         29646-29796
            1363-1528           AC022133.7         35505-35670
            1529-1602           KF510907.1         66-139
            1603-1747           AC022133.7         40068-40212
            1748-1893           AC022133.7         47592-47737
            1894-2037           AC022133.7         50727-50870
            2038-2295           AC022133.7         51991-52248
            2296-2426           AC025180.6         72716-72846         c
            2427-2593           AC025180.6         69412-69578         c
            2594-2730           AC025180.6         67842-67978         c
            2731-2841           AC025180.6         65423-65533         c
            2842-3022           AC025180.6         62852-63032         c
            3023-3051           KF457900.1         358-386             c
            3052-3132           AC025180.6         60646-60726         c
            3133-3209           AC025180.6         58609-58685         c
            3210-3299           AC025180.6         56174-56263         c
            3300-3402           AC025180.6         54314-54416         c
            3403-3516           AC025180.6         50796-50909         c
            3517-3618           AC025180.6         48619-48720         c
            3619-3723           AC025180.6         48366-48470         c
            3724-3816           AC025180.6         43275-43367         c
            3817-3933           AC025180.6         40849-40965         c
            3934-10736          AC025180.6         29101-35903         c
FEATURES             Location/Qualifiers
     source          1..10736
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q11.2"
     gene            1..10736
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /note="integrin subunit alpha 1"
                     /db_xref="GeneID:3672"
                     /db_xref="HGNC:HGNC:6134"
                     /db_xref="MIM:192968"
     exon            1..499
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             439..3978
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /note="very late activation protein 1; laminin and
                     collagen receptor; VLA-1; CD49 antigen-like family member
                     A; integrin alpha-1; very late antigen-1"
                     /codon_start=1
                     /product="integrin alpha-1 precursor"
                     /protein_id="NP_852478.1"
                     /db_xref="CCDS:CCDS3955.1"
                     /db_xref="GeneID:3672"
                     /db_xref="HGNC:HGNC:6134"
                     /db_xref="MIM:192968"
                     /translation="MAPRPRARPGVAVACCWLLTVVLRCCVSFNVDVKNSMTFSGPVE
                     DMFGYTVQQYENEEGKWVLIGSPLVGQPKNRTGDVYKCPVGRGESLPCVKLDLPVNTS
                     IPNVTEVKENMTFGSTLVTNPNGGFLACGPLYAYRCGHLHYTTGICSDVSPTFQVVNS
                     IAPVQECSTQLDIVIVLDGSNSIYPWDSVTAFLNDLLERMDIGPKQTQVGIVQYGENV
                     THEFNLNKYSSTEEVLVAAKKIVQRGGRQTMTALGIDTARKEAFTEARGARRGVKKVM
                     VIVTDGESHDNHRLKKVIQDCEDENIQRFSIAILGSYNRGNLSTEKFVEEIKSIASEP
                     TEKHFFNVSDELALVTIVKTLGERIFALEATADQSAASFEMEMSQTGFSAHYSQDWVM
                     LGAVGAYDWNGTVVMQKASQIIIPRNTTFNVESTKKNEPLASYLGYTVNSATASSGDV
                     LYIAGQPRYNHTGQVIIYRMEDGNIKILQTLSGEQIGSYFGSILTTTDIDKDSNTDIL
                     LVGAPMYMGTEKEEQGKVYVYALNQTRFEYQMSLEPIKQTCCSSRQHNSCTTENKNEP
                     CGARFGTAIAAVKDLNLDGFNDIVIGAPLEDDHGGAVYIYHGSGKTIRKEYAQRIPSG
                     GDGKTLKFFGQSIHGEMDLNGDGLTDVTIGGLGGAALFWSRDVAVVKVTMNFEPNKVN
                     IQKKNCHMEGKETVCINATVCFDVKLKSKEDTIYEADLQYRVTLDSLRQISRSFFSGT
                     QERKVQRNITVRKSECTKHSFYMLDKHDFQDSVRITLDFNLTDPENGPVLDDSLPNSV
                     HEYIPFAKDCGNKEKCISDLSLHVATTEKDLLIVRSQNDKFNVSLTVKNTKDSAYNTR
                     TIVHYSPNLVFSGIEAIQKDSCESNHNITCKVGYPFLRRGEMVTFKILFQFNTSYLME
                     NVTIYLSATSDSEEPPETLSDNVVNISIPVKYEVGLQFYSSASEYHISIAANETVPEV
                     INSTEDIGNEINIFYLIRKSGSFPMPELKLSISFPNMTSNGYPVLYPTGLSSSENANC
                     RPHIFEDPFSINSGKKMTTSTDHLKRGTILDCNTCKFATITCNLTSSDISQVNVSLIL
                     WKPTFIKSYFSSLNLTIRGELRSENASLVLSSSNQKRELAIQISKDGLPGRVPLWVIL
                     LSAFAGLLLLMLLILALWKIGFFKRPLKKKMEK"
     exon            500..620
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            621..733
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            734..822
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            823..934
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1062
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1211
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1362
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1528
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1602
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1747
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1893
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2037
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2295
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2426
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2593
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2730
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..2841
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..3051
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3052..3132
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3133..3209
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3210..3299
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3300..3402
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3403..3516
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3517..3618
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3619..3723
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3724..3816
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3817..3933
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3934..10736
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8000..8005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /note="hexamer: AATAAA"
     polyA_site      8018
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
                     /note="major polyA site"
     polyA_site      10736
                     /gene="ITGA1"
                     /gene_synonym="CD49a; VLA1"
ORIGIN      
        1 acccgccttc ctaccacctt aggggatttg gcccggagaa cgagatcacc ctctcaatga
       61 aaggcagatg tccctttaag gtttgcttct acagcccgtg gactttagcc taaacacgga
      121 cccgcgaagc tggctttatt tgtccatgtc tcggacagag cctgggaagc tgccagtgag
      181 atttcagaga ccaagagcgc gaaggggcgg gcgatgtggc aatccgtctg ggatgtgaaa
      241 agcgtggagc gcatttagag gaattcgacg aaaacacagg aaatcactcc tctcccgctc
      301 ctgggcgccg ctgccactgg ggcagaggac tgggaaccgc ggcagcggga taagtggccc
      361 agccagagag cgcagctccc gcgcccggtc ctgccctgcg aaccagcgcg gccccctggc
      421 gctgaggctg ctccggccat ggcccctcgg ccccgcgccc gcccaggggt cgctgtcgcc
      481 tgctgctggc tcctcactgt tgttctacgc tgctgcgtat cattcaatgt tgatgtgaaa
      541 aattcaatga ctttcagcgg cccggtggaa gacatgtttg gatatactgt tcaacaatat
      601 gaaaatgaag aaggaaaatg ggtgcttatt ggttctccgt tagttggcca acccaaaaac
      661 agaactggag atgtctataa gtgtccagtt gggagaggtg aatcattacc ttgtgtaaag
      721 ttggatctac cagttaatac atcaattccc aatgtcacag aagtaaagga gaacatgaca
      781 tttggatcaa ctttagtcac caacccaaat ggaggatttc tggcttgtgg gcccttatat
      841 gcctatagat gtggacattt gcattacaca actggaatct gttctgacgt cagccccaca
      901 tttcaagtcg tgaattccat tgcccctgta caagaatgca gcactcaact ggacatagtc
      961 atagtgctgg atggttccaa cagtatttac ccatgggaca gtgttacagc ttttttaaat
     1021 gaccttcttg aaagaatgga tattggtcct aaacagacac aggttggaat tgtacagtat
     1081 ggagaaaacg tgacccatga gttcaacctc aataagtatt cttccaccga agaggtactt
     1141 gttgcagcaa agaaaatagt ccagagaggt ggccgccaga ctatgacagc tcttggaata
     1201 gacacagcaa gaaaggaggc attcacggaa gcccggggtg cccgaagagg agttaaaaaa
     1261 gtcatggtta ttgtgacaga tggagagtct catgacaatc atcgactgaa gaaggtcatc
     1321 caagactgtg aagatgaaaa cattcaacgg ttttccatag ctattcttgg cagctataac
     1381 cgaggaaatt taagcactga aaaatttgtg gaggaaataa aatcaattgc aagtgaaccc
     1441 actgaaaagc atttcttcaa tgtctctgat gaattggctc tagtcaccat tgttaaaact
     1501 ctgggagaaa gaatatttgc cctggaagcc acagctgacc agtcagcagc ttcatttgaa
     1561 atggaaatgt ctcagactgg cttcagtgct cattattcac aggactgggt catgcttgga
     1621 gcagtaggag cctatgattg gaatggaaca gttgtcatgc agaaggctag tcaaatcata
     1681 atccctcgaa acacaacctt taatgttgag tctaccaaaa agaatgaacc gcttgcttct
     1741 tatttaggtt acactgtaaa ctctgctact gcttcttctg gagatgtgct ctatattgct
     1801 ggacagcctc ggtacaatca tacaggccag gtcattatct acaggatgga agatggaaac
     1861 atcaaaattc tccagacgct cagtggagaa cagattggtt cctactttgg cagtatttta
     1921 acaacaactg acattgacaa ggattctaat actgacattc ttctagtcgg agcccctatg
     1981 tacatgggaa cagagaagga ggagcaagga aaagtgtatg tgtatgctct caatcagaca
     2041 aggtttgaat atcaaatgag cctggaacct attaagcaga cgtgctgttc atctcggcag
     2101 cacaattcat gcacaacaga aaacaaaaat gagccatgcg gggctcgttt tggaactgca
     2161 attgctgctg taaaagacct caatcttgat ggatttaatg acatcgtgat aggagctccg
     2221 ctggaagatg atcacggggg agctgtgtac atttatcatg gaagtggcaa gactataagg
     2281 aaagagtatg cacaacgtat tccatcaggt ggggatggta agacactgaa attttttggc
     2341 cagtctatcc acggagaaat ggatttaaat ggtgacggtc tgacagatgt gactattggg
     2401 ggccttggtg gtgctgccct cttctggtcc cgagatgtgg ccgtagttaa agtgaccatg
     2461 aattttgagc caaataaagt gaatattcaa aagaaaaact gccatatgga gggaaaggaa
     2521 acagtatgca taaatgctac agtgtgtttt gatgtgaaat taaagtctaa agaagacacg
     2581 atttatgaag ctgatttgca gtaccgtgtc accctagatt cactaagaca aatatcacga
     2641 agttttttct ctggaactca agagagaaag gttcaaagga acatcacagt tcgaaaatca
     2701 gaatgcacta agcactcctt ctacatgttg gacaagcatg actttcagga ctctgtgaga
     2761 ataacgttgg actttaatct taccgatcca gaaaatgggc ctgttcttga tgattctcta
     2821 ccaaactcag tacatgaata tattcccttt gccaaagatt gtggaaataa ggaaaaatgt
     2881 atctcagacc tcagcctgca tgtcgccacc actgaaaagg acctgctgat tgtccgatcc
     2941 cagaatgata agttcaacgt tagcctcaca gtcaaaaata caaaggacag tgcctataac
     3001 accaggacaa tagtgcatta ttctccaaat ctagtttttt caggaattga ggctatccaa
     3061 aaagacagtt gtgaatctaa tcataatatc acatgtaaag ttggatatcc cttcctgaga
     3121 agaggagaga tggtaacttt caaaatattg tttcagttta acacatccta tctcatggaa
     3181 aatgtgacca tttatttaag tgcaacaagt gacagcgaag aacctcctga aaccctttct
     3241 gataatgtag taaacatttc tatcccggta aaatatgaag ttggactaca gttttacagc
     3301 tctgcaagtg aataccacat ttcaattgct gccaatgaga cagtccctga agttattaat
     3361 tctactgagg acattggaaa tgaaattaat atcttctact tgattagaaa aagtggatct
     3421 tttccaatgc cagagcttaa gctgtcaatt tcattcccca atatgacatc aaatggttac
     3481 cctgtgctgt acccaactgg attgtcatct tctgagaatg caaactgcag accccatatc
     3541 tttgaggatc ctttcagtat caactctgga aagaaaatga ctacatcaac tgaccatctc
     3601 aaacgaggca caattctgga ctgcaataca tgtaaatttg ctaccatcac atgtaatctc
     3661 acttcttctg acatcagcca agtcaatgtt tcgcttatct tgtggaaacc aacttttata
     3721 aaatcatatt tttccagctt aaatcttact ataaggggag aacttcggag tgaaaatgca
     3781 tctctggttt taagtagcag caatcaaaaa agagagcttg ctattcaaat atccaaagat
     3841 gggctaccgg gcagagtgcc attatgggtc atcctgctga gtgcttttgc cggattgttg
     3901 ctgttaatgc tgctcatttt agcactgtgg aagattggat tcttcaaaag accactgaaa
     3961 aagaaaatgg agaaatgaaa tattttatga aagaaaataa taacaattat tcaataatct
     4021 atcctcaggt ttgcctcaaa tatgtgacaa gaaatgtata attcatgaca tagtcatgta
     4081 actatgtaat ccatcaggga ttcattactt ggaaaatgac aggtcatgca ttatccaaaa
     4141 acaataccaa aaagacatat tttataaaat gacaaaaaat attttacata attactcatt
     4201 tttgttgagt aagcaaaatt acaaagtgtt tttaaaaaaa cctgtacaaa tatgtttatg
     4261 tattaaatca ccatccaaaa tatttaagga atatataaaa agatttttat gatcatagaa
     4321 acatctattt tcaaaacaat ataaattaag cttttcccct tgattcctgt tggatatcca
     4381 tgttcagcat gacagtcagc actcgtaaat gccaagaaaa gaattacctg aaaaagatca
     4441 tttctcccta ttcaaatgag aatattttcc cttggtagaa tccatataca atatggattg
     4501 aaaattaagt caccaagaat acatttagca tctttgtgtt gggttctata cctaaaaatt
     4561 ttccctccct gcccaaggtg attggaaagt actgcaattg agctaaaatt ttatctagga
     4621 tggaaaatca ggatagactc gtttaaaaac aagtatatta aatgggttaa attaagcttt
     4681 tacagaacat gcttaatttt gatattgagc tctaaatgca aaactctttt atactgaaaa
     4741 aacacttaaa gtagttttgt gtggcatcac agtgatttgt catgaaaagc catatatggg
     4801 ggacatgcta aaatggcttc tgaatgaaat acgacagcag agaaagatgc cactgaaatg
     4861 ctgaaattat ctttgctgag cagcttttga atgctaaggg ttccagtatg tgacccaaag
     4921 aaagagttgt ctcaactcct tggtacaggg ttcattcaaa cccccaagct gtgagagtgt
     4981 gtttattttt aattttttaa aaggtattta atttccaacc acacttctta tttttttgaa
     5041 aagacaattt tccatttcag tattacattt taccaagaag tcactgcttt ttaggtgtgt
     5101 tgcatcaata tttaaataaa atcccagaaa tgtattttaa agaatttcag gtttgaaaac
     5161 tcaaaccaac aggaagatat cacacctttg tatgtgcttc tttgttcttg aagtagtcat
     5221 tatggttcat tggaatctac tgtagcataa gctcctaggt tgctccattt cttaggaaaa
     5281 tagcaatgaa tgaatgtata gtagctgcat gtgtgaacta ctgctgtaaa gtttgctgac
     5341 atttctgcaa caacatttct ccatctgatt taccagaacc tgtaacaaga ccagaacatg
     5401 tattcatcca gaaactcctg ggctctgctt tgttcaaaga ggagcaaatc cacatagaaa
     5461 ttaaatgtta taaatttatt tttttaaact aatttccaaa gaatttagct gaagactcag
     5521 agtcagccta cctcttgact ctccacatcc gcatctaaga tcctgaaggc caaaggaatg
     5581 cgcctgtggg atgccaaagc catcagtagc tggaagaaag aatacctctt tctagaggtt
     5641 tggtgtcctc ttgctggcct gtcattattt ggaaatacgc gcttttggaa tttccttcat
     5701 tttcgctatt tccaggttca gaaatcatac ctaccacttg ttctttcttt gcccagtaaa
     5761 actcagggtt tctcttattc agagttacca tgttgcacac ccccagtgct cagcctgccc
     5821 agaagccctt ctctgatctc agcaagatct tagtagtaaa gctaacggat ccattgaaat
     5881 tcatactcag catctgtgac tactagacaa agcccattta ctgaaccata agtgtgcact
     5941 tttaaactaa attgttaact gaaagggaaa aaatagaaat gagggcattt tgaagttttt
     6001 agaaaagaga ggaagagctg ttggccagat caaagagata cttataagcc cggcacaatt
     6061 tttaacataa gtcattcctg gctattaagt aaaatatttc atgaaccaga agtcctgttt
     6121 ctctaatatt ataatttgtt gaggtttgtg tgtgtgtgtg tgtgcatgtg cagacacatg
     6181 tacacatata aattgaatac aaaaatagct ctataacacc aaaaaacaga gtttacagaa
     6241 aataaacaca aaagctatat ctgcaagaca agtttgattc atctagtttc atatagtttc
     6301 atatagtttc atttttatta atatttaggt ttaacttata gttctgcaat tatttaaaaa
     6361 acaagtacag agcgtttgat taaaaaaagt caacaaatgt ttcaaaacag ctttgtacaa
     6421 atgttataaa acatatttaa tgattaagaa atgtactaga ctctatcatt tacttttaaa
     6481 acatttaatt agaaaaacag gtgatattta agactattta taaacttatt ggccaaattg
     6541 ccaaaaagtt tctttttctc taactttggt attctaaata attgattatt gctcccattg
     6601 taaactgaac catgtatgca ctctcttttc tgaccaaact acaatggtat attggtaaat
     6661 tatttaacaa cacactgtcc aggagggaaa aaaaaaacag tctctgattt gtatcatttg
     6721 ccaatttcca tggtccaaat attctctctc cattttcaaa ctaccaaagt gaccctaatc
     6781 agcttacaaa attcctggaa atgtatctgc cacctcttac caaccagtgt gagctgactt
     6841 cagcacacca ctgagacaga ttacacgata gacagataga tagatagata gatagataga
     6901 tagatagata gatagataga tattgataga gaacatgttg tgtctatata catatccaat
     6961 gacacacagt ataatcatgt tttaaattat gccaaaagta ctgattatat caagcccagt
     7021 aaacataatg ctacacagca cccattcttt aattttgatt tctaaaatta taaccttcct
     7081 ttgatattaa taaaatgtta tgaacttgca ggagaaggaa ggagttgaaa gaaggaaaat
     7141 ataaagggtg atccacagtg aaaatcagac ctacacaagc cacaaaaaaa ttgtctcatt
     7201 ttcccaagga attcaaagtc ctgtgataca cattacaaaa gatgacactt tgtaaatatt
     7261 ttgaacttct atgatccaat ttcaacttca ttggtccaat ttgtcaaact attttcctct
     7321 gagcactaga ttcatgggca atttaatctc tgaatatttt ctgtgtcata agtgtgcttg
     7381 aaaagaggct tgtagtaaac agatattttt acaaaatttg atgcttctgc aaccataata
     7441 attttatcta taaatgcgta tatacatata tatatatata tatatacaca tacactcaca
     7501 tgcagatatt tacatatata gatattctct tttcctttta taaaatcaaa gtctaggctc
     7561 aattggaaaa tggaaatatt tgcaccaaaa gaaaaaagtg ccattgttgt gatcaatgga
     7621 gtaaagctgg ggtatagtag aggctgggga atccctgccc atgttctctc caaggccaca
     7681 gcttgcacac cgtgaatggt ggccccactg gctccatgga gtgtgccttc acgcggggga
     7741 atgtccttgt ccaacacgct gtaatctact ccatgggaac tgactgtcct gcttttcaca
     7801 acattgagaa acaggcccag agcctgtctc atgtgccagg tgcagtcaca ttattgttaa
     7861 aataaagtgg cttctgacaa atcagttttt caaaatagca tcctatgtac ttttcatttc
     7921 ttccaacaac cctcaggccc ccttttgcca gttttctccc ccaggggaga ttttcaagac
     7981 tactggagaa aaatctgtta ataaaacatt tgctctgagt accagcttca gtgactcaat
     8041 catttataca ggatttcagt gttttgttct gcagcggtgt tctaaagggt tcacatagta
     8101 taatggagga gggacaaagc agaatatact tccaagctgg aacatcttta agacatttac
     8161 aaactgttat gggacactat cagcaactac gcctggggaa gctagcagga tttagctctt
     8221 caatggccct ccaaatgcac ccaacaatcg ccaacctcac ccatggaaat catctaaaaa
     8281 atgaaaagaa gggccttaaa gtcctcacat ggatgctgta tttataacta aaatgtacag
     8341 tttaattcta aatagcaggc ttttaaatgc aaacagcttc caggtgagtc ctctggctgc
     8401 caatcagact gctgattcta aaccattctc acacagaatt tctgaaacca acaccaggta
     8461 ttaattgtta actgcagtga aaggaaacca aggcacatta caaaaggcta aatgctgctg
     8521 tttctaagtg gaagcactgt tgaacaacac tcttaggtgg aataagaaaa ttagggttaa
     8581 actgtaacat tgtaatcgga cgaacaaatc agcatctttg atcctcaggt taaaatttaa
     8641 tcttaaattt agaaattcaa agtaacagcc tttaaccatt aaccttgagg aaaatgtgaa
     8701 gtagcatctg gagtctctta agccccagcc ctgttgtccc ctacagcatc tccacccagg
     8761 aagtccagtt cctaactaat gggaatggat ccttttccca ttataaaggg ccgatgctta
     8821 acccttgaac ccactactgt tcttatgccc caagatctgc accttacatc aggcacccgg
     8881 gaatgcttct cattgaaatt ttaccatacc aaaaaatatg taagggtgac tcatcactcc
     8941 taactttgga ctccttgctt tgagatcggt atttttttct ctctctttac atatagcaaa
     9001 agctttcccc agtagctgat gaatttagaa ctttatacaa gactccctag cattttcctc
     9061 ctcccacagg ctggagaatt tcagtgctat gagactgggc agtaggagcc agagccaatt
     9121 tgcaggatct cttttccttc tgccttccag ttggcttctc ttctcagctg cgtggtgggg
     9181 atgatttggg gtttcctcag caaggccatt ctctgccttg tgcccatagc agggccttgg
     9241 gtggtgacat gttatctttg ttggtgagca gacactcaga gatcctttaa ttatctgaca
     9301 caccagggaa atcttggcaa tcaactaagg acctgtgaca ctcataacta tgtttacatt
     9361 tggctttagc atatttcagg taatatcttt atgaaaaaaa gatgaagtat ggaattgtag
     9421 gaactctttt gcaatagact gagatccaat gtttaaatct ttttatttca gtttgatctg
     9481 tgcctttaga ttggggacaa aattttaaaa acaaatcttc caaatgacac cacaatgaaa
     9541 gccagttgtg gtcttgaaaa atctctctat tgcattactt atcctcaccc ttgtttttta
     9601 agaggtagag agagattact gggaagcagt gagccaacat aattgtcctt tcctctacag
     9661 aatagctgtg cagaagggga ccaccacact taggaccagt gccaggtgac aatctttccg
     9721 tcatgctgct gcagcatttt gcaccttgag agacaggaaa aaaaatgggg gtgagggagt
     9781 ggaagatgat gaaactattt ctcttttatg tctacatcct tactcctcaa aatactttaa
     9841 gctcactcag accccatata ccctgcccac aatactaaca catgtacttt gcataagtaa
     9901 attgttgatt aaataagagc aaaactatat tcttatgtgt agattaacca aggctaattt
     9961 cctggagttt aatacacttt ggattcaagt aaaaacaatc acttaatgca gcaacatctc
    10021 agaccctctt cactctagaa ccgttttata caagagaact caacatttac tgttttattt
    10081 ctgatattgc ctgccattac tcaggatgca agagatgctc tgcattcctt attaggaaaa
    10141 attggcctgt aaggagaatg gtatactgcg tattactact gtgagactgt aaaattgtta
    10201 atggacagtg taaagaattg tattcatttt attagcaaga aaaatattgc atacaagaac
    10261 tactgccctg aaatatccat cactccaatg aactgttctg cctgatctaa cataaagtta
    10321 tatttcattg ctcatttttt tttgcctcac taaaatgact aacttaaggg aatgtgcatt
    10381 tctacaagac tttaattgga taaactcatt agaagaaaat gtttcgattg cattcaggaa
    10441 caaagaagca taacctttgt tgactcttgt aatttattat atgcttcatt taaacccatt
    10501 ttgtaaagaa atcaggtaac agtcatttaa tctgatataa ttagaaatag ctgagagagt
    10561 aaaaaagcat tttgaatgtc ctatgtatgg catatcctgt acaccaattg aaggtcagag
    10621 ctttggtatt tttgtataat tctgtcttat ctggtgcatc agctgtgtat tttacgtcaa
    10681 ggtaaatgag catcctgttt tatatgttaa attttaaaaa tgactttttc aaagaa
//
