LOCUS       NM_018463               2320 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens integrin alpha FG-GAP repeat containing 2 (ITFG2),
            transcript variant 1, mRNA.
ACCESSION   NM_018463
VERSION     NM_018463.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2320)
  AUTHORS   Li,J., Yang,D., Lin,Y., Xu,W., Zhao,S.M. and Wang,C.
  TITLE     OTUD3 suppresses the mTORC1 signaling by deubiquitinating KPTN
  JOURNAL   Front Pharmacol 14, 1337732 (2024)
   PUBMED   38288086
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2320)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2320)
  AUTHORS   Wolfson,R.L., Chantranupong,L., Wyant,G.A., Gu,X., Orozco,J.M.,
            Shen,K., Condon,K.J., Petri,S., Kedir,J., Scaria,S.M.,
            Abu-Remaileh,M., Frankel,W.N. and Sabatini,D.M.
  TITLE     KICSTOR recruits GATOR1 to the lysosome and is necessary for
            nutrients to regulate mTORC1
  JOURNAL   Nature 543 (7645), 438-442 (2017)
   PUBMED   28199306
  REMARK    GeneRIF: identification of a protein complex (KICSTOR) that is
            composed of four proteins, KPTN, ITFG2, C12orf66 and SZT2, and that
            is required for amino acid or glucose deprivation to inhibit mTORC1
            in cultured human cells
REFERENCE   4  (bases 1 to 2320)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ058412.1, BC013399.2, BQ003916.1 and AC005841.3.
            
            On Nov 22, 2018 this sequence version replaced NM_018463.3.
            
            Transcript Variant: This variant (1) encodes a functional protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.170156.1,
                                           SRR1803617.232727.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000228799.7/ ENSP00000228799.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                BQ058412.1         47-114
            69-1913             BC013399.2         1-1845
            1914-2315           BQ003916.1         18-419              c
            2316-2320           AC005841.3         50928-50932         c
FEATURES             Location/Qualifiers
     source          1..2320
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.33"
     gene            1..2320
                     /gene="ITFG2"
                     /gene_synonym="FGGAP1; KICS3; MDS028"
                     /note="integrin alpha FG-GAP repeat containing 2"
                     /db_xref="GeneID:55846"
                     /db_xref="HGNC:HGNC:30879"
                     /db_xref="MIM:617421"
     exon            1..189
                     /gene="ITFG2"
                     /gene_synonym="FGGAP1; KICS3; MDS028"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1437
                     /gene="ITFG2"
                     /gene_synonym="FGGAP1; KICS3; MDS028"
                     /note="integrin-alpha FG-GAP repeat-containing protein 2;
                     FG-GAP repeat containing 1"
                     /codon_start=1
                     /product="KICSTOR complex protein ITFG2"
                     /protein_id="NP_060933.3"
                     /db_xref="CCDS:CCDS8513.1"
                     /db_xref="GeneID:55846"
                     /db_xref="HGNC:HGNC:30879"
                     /db_xref="MIM:617421"
                     /translation="MRSVSYVQRVALEFSGSLFPHAICLGDVDNDTLNELVVGDTSGK
                     VSVYKNDDSRPWLTCSCQGMLTCVGVGDVCNKGKNLLVAVSAEGWFHLFDLTPAKVLD
                     ASGHHETLIGEEQRPVFKQHIPANTKVMLISDIDGDGCRELVVGYTDRVVRAFRWEEL
                     GEGPEHLTGQLVSLKKWMLEGQVDSLSVTLGPLGLPELMVSQPGCAYAILLCTWKKDT
                     GSPPASEGPTDGSRETPAARDVVLHQTSGRIHNKNVSTHLIGNIKQGHGTESSGSGLF
                     ALCTLDGTLKLMEEMEEADKLLWSVQVDHQLFALEKLDVTGNGHEEVVACAWDGQTYI
                     IDHNRTVVRFQVDENIRAFCAGLYACKEGRNSPCLVYVTFNQKIYVYWEVQLERMEST
                     NLVKLLETKPEYHSLLQELGVDPDDLPVTRALLHQTLYHPDQPPQCAPSSLQDPT"
     exon            190..285
                     /gene="ITFG2"
                     /gene_synonym="FGGAP1; KICS3; MDS028"
                     /inference="alignment:Splign:2.1.0"
     exon            286..327
                     /gene="ITFG2"
                     /gene_synonym="FGGAP1; KICS3; MDS028"
                     /inference="alignment:Splign:2.1.0"
     exon            328..499
                     /gene="ITFG2"
                     /gene_synonym="FGGAP1; KICS3; MDS028"
                     /inference="alignment:Splign:2.1.0"
     exon            500..639
                     /gene="ITFG2"
                     /gene_synonym="FGGAP1; KICS3; MDS028"
                     /inference="alignment:Splign:2.1.0"
     exon            640..788
                     /gene="ITFG2"
                     /gene_synonym="FGGAP1; KICS3; MDS028"
                     /inference="alignment:Splign:2.1.0"
     exon            789..886
                     /gene="ITFG2"
                     /gene_synonym="FGGAP1; KICS3; MDS028"
                     /inference="alignment:Splign:2.1.0"
     exon            887..940
                     /gene="ITFG2"
                     /gene_synonym="FGGAP1; KICS3; MDS028"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1041
                     /gene="ITFG2"
                     /gene_synonym="FGGAP1; KICS3; MDS028"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1159
                     /gene="ITFG2"
                     /gene_synonym="FGGAP1; KICS3; MDS028"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1333
                     /gene="ITFG2"
                     /gene_synonym="FGGAP1; KICS3; MDS028"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..2320
                     /gene="ITFG2"
                     /gene_synonym="FGGAP1; KICS3; MDS028"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2166..2171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITFG2"
                     /gene_synonym="FGGAP1; KICS3; MDS028"
                     /note="hexamer: ATTATA"
     polyA_site      2185
                     /gene="ITFG2"
                     /gene_synonym="FGGAP1; KICS3; MDS028"
                     /note="major polyA site"
     polyA_site      2234
                     /gene="ITFG2"
                     /gene_synonym="FGGAP1; KICS3; MDS028"
     regulatory      2287..2292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITFG2"
                     /gene_synonym="FGGAP1; KICS3; MDS028"
                     /note="hexamer: AATAGA"
     regulatory      2292..2297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITFG2"
                     /gene_synonym="FGGAP1; KICS3; MDS028"
                     /note="hexamer: AATAAA"
     polyA_site      2303
                     /gene="ITFG2"
                     /gene_synonym="FGGAP1; KICS3; MDS028"
     polyA_site      2320
                     /gene="ITFG2"
                     /gene_synonym="FGGAP1; KICS3; MDS028"
ORIGIN      
        1 gccttaggtg gccttccgct ctggcggctg tcgcgacggg ggttcaggga atatttactg
       61 ggcctctccg ctccctctgc tcttggaggt gccatgaggt cagttagcta cgtgcagcgc
      121 gtggcgctgg agttcagcgg gagcctcttc ccgcacgcaa tctgcctcgg agacgttgat
      181 aacgatacgt taaatgaact ggtggtggga gacaccagcg ggaaggtgtc tgtgtataaa
      241 aatgatgaca gtcggccatg gctcacctgt tcctgccagg gaatgctgac ttgcgttggg
      301 gttggagacg tgtgtaataa aggaaagaac ctgttggtgg cagtgagtgc tgaaggctgg
      361 tttcatttgt ttgacctgac acctgccaag gtgttggatg cttctgggca ccacgagaca
      421 ctaatcggag aggagcagcg tccagtcttc aagcagcaca tccctgccaa caccaaggtc
      481 atgctgatca gcgacatcga tggagatggg tgtcgtgagc tggtggtggg ctacacagac
      541 cgtgtggtgc gagctttccg ctgggaggag ctaggtgagg gtcctgaaca tctgacaggg
      601 cagctggtgt ccctcaagaa atggatgctg gagggtcagg tggacagcct ctcagtgact
      661 ctggggccac tgggtcttcc tgaactgatg gtgtctcagc caggttgtgc gtatgcaatt
      721 ctactgtgta cctggaaaaa ggacactggg tcccctcctg cctctgaagg gcccacggat
      781 ggtagtaggg agaccccagc tgcccgagac gtggtgctgc accagacatc tggccgtatc
      841 cacaacaaga atgtctccac tcacctaatt ggcaacatca aacaaggcca cggcactgag
      901 agtagtggct ctggcctctt tgccctgtgc accctggatg ggacactgaa gctcatggaa
      961 gaaatggaag aagcagacaa gctgctgtgg tcagtgcagg tggatcacca gctctttgcc
     1021 ctggagaaac tggatgtcac cggcaacggg catgaggagg tagttgcatg cgcctgggat
     1081 ggacagacat atatcattga tcacaaccgc accgtcgtcc gcttccaagt ggatgaaaat
     1141 atccgtgcct tctgtgcagg cctgtacgcc tgcaaagagg gccgcaacag cccctgcctc
     1201 gtatatgtca ctttcaacca gaagatctat gtgtactggg aggtgcagct ggagcggatg
     1261 gagtctacca atctggtgaa actgctggag accaagccgg agtaccacag cctgctgcag
     1321 gagctgggcg tggatcctga cgacctccct gtgactcgtg ccctgcttca ccaaacgctc
     1381 taccatccag accagccacc acagtgtgct ccctcaagcc tccaggatcc cacctagctg
     1441 tacttgcctc atagctggtg aaggattctt ctgaaccccc accctacccc ctaaaggtat
     1501 ctgtggtatt ggcaggatag ggaatatgca ttacagaaat gcaggatttg actctgggca
     1561 tgaaagatgg cagcagccct agggtgaccg tgaactatag acctcgcagt cttttcggtg
     1621 aaagaagaga caagttgacc ctctgcccat ttccttatgg acctcaccca tcatgccagc
     1681 agggtcatag gaccctggcc ttgttccaaa tcatctggga catgacccac tccccactgt
     1741 cactgtgttg aaaacagaga cttgtttgtg tggccccaac acccataagg aaaccaggct
     1801 ttaggcccag gggagcagtg gaggtaaggg ctccacccca tcttaagctc tgtcttccgt
     1861 ggcacaattc caagttcttg acgttagtaa ttgttaaagg aatggcaaac tgttttgttt
     1921 tgaaggatct ttctacagtc tggtcttacc catgttccta gcaaccctga gatgattttc
     1981 ttccatttac caaagcagcc gggtcagtgc tttctcacgt tgccgtattc ttcaggtatt
     2041 agtcagcttc agaagccctg ctcccatttt tccacccacc cattccccca taaaacagct
     2101 tattgtctcc aagacaatag acatttaaaa tgtgatgcgg gtttatgatc cagaccacaa
     2161 tcagaattat atcttgggtc atttatgtgc cgtctgttct tgattctcta tgctctaaat
     2221 cggtgttttt caaactgtgg ttgcagtcct ttggtggatt atggccagca ttttttaaat
     2281 aggtagaata gaataaagta aaatagaaaa tagcagagta
//
