LOCUS       NM_030790               3185 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens integrin alpha FG-GAP repeat containing 1 (ITFG1),
            transcript variant 1, mRNA.
ACCESSION   NM_030790
VERSION     NM_030790.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3185)
  AUTHORS   Fan,W., Xie,J., Xia,J., Zhang,Y., Yang,M., Wang,H., Pan,Y.,
            Zhang,M., Han,B., Wu,B., Hou,Z., Liang,D., Wang,C., Xu,J., Song,L.
            and Liu,Q.
  TITLE     RUVBL1-ITFG1 interaction is required for collective invasion in
            breast cancer
  JOURNAL   Biochim Biophys Acta Gen Subj 1861 (7), 1788-1800 (2017)
   PUBMED   28341484
  REMARK    GeneRIF: The interaction between RUVBL1 and ITFG1 is required for
            breast cancer cell collective invasion and progression.
REFERENCE   2  (bases 1 to 3185)
  AUTHORS   Kato,M., Chou,T.F., Yu,C.Z., DeModena,J. and Sternberg,P.W.
  TITLE     LINKIN, a new transmembrane protein necessary for cell adhesion
  JOURNAL   Elife 3, e04449 (2014)
   PUBMED   25437307
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3185)
  AUTHORS   Fiscella,M., Perry,J.W., Teng,B., Bloom,M., Zhang,C., Leung,K.,
            Pukac,L., Florence,K., Concepcion,A., Liu,B., Meng,Y., Chen,C.,
            Elgin,E.C., Kanakaraj,P., Kaufmann,T.E., Porter,J., Cibotti,R.,
            Mei,Y., Zhou,J., Chen,G., Roschke,V., Komatsoulis,G., Mansfield,B.,
            Ruben,S., Sanyal,I. and Migone,T.S.
  TITLE     TIP, a T-cell factor identified using high-throughput screening
            increases survival in a graft-versus-host disease model
  JOURNAL   Nat Biotechnol 21 (3), 302-307 (2003)
   PUBMED   12598909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC024162.1, EL948664.1 and BM680211.1.
            
            On May 17, 2019 this sequence version replaced NM_030790.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.145378.1,
                                           SRR1660809.203626.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320640.11/ ENSP00000319918.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2190              BC024162.1         46-2235
            2191-2752           EL948664.1         114-675
            2753-3185           BM680211.1         16-448              c
FEATURES             Location/Qualifiers
     source          1..3185
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q12.1"
     gene            1..3185
                     /gene="ITFG1"
                     /gene_synonym="2310047C21Rik; CDA08; LINKIN; LNKN-1; TIP"
                     /note="integrin alpha FG-GAP repeat containing 1"
                     /db_xref="GeneID:81533"
                     /db_xref="HGNC:HGNC:30697"
                     /db_xref="MIM:611803"
     exon            1..226
                     /gene="ITFG1"
                     /gene_synonym="2310047C21Rik; CDA08; LINKIN; LNKN-1; TIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1857
                     /gene="ITFG1"
                     /gene_synonym="2310047C21Rik; CDA08; LINKIN; LNKN-1; TIP"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; T-cell immunomodulatory protein; integrin-alpha
                     FG-GAP repeat-containing protein 1"
                     /codon_start=1
                     /product="T-cell immunomodulatory protein isoform 1
                     precursor"
                     /protein_id="NP_110417.2"
                     /db_xref="CCDS:CCDS10728.1"
                     /db_xref="GeneID:81533"
                     /db_xref="HGNC:HGNC:30697"
                     /db_xref="MIM:611803"
                     /translation="MAAAGRLPSSWALFSPLLAGLALLGVGPVPARALHNVTAELFGA
                     EAWGTLAAFGDLNSDKQTDLFVLRERNDLIVFLADQNAPYFKPKVKVSFKNHSALITS
                     VVPGDYDGDSQMDVLLTYLPKNYAKSELGAVIFWGQNQTLDPNNMTILNRTFQDEPLI
                     MDFNGDLIPDIFGITNESNQPQILLGGNLSWHPALTTTSKMRIPHSHAFIDLTEDFTA
                     DLFLTTLNATTSTFQFEIWENLDGNFSVSTILEKPQNMMVVGQSAFADFDGDGHMDHL
                     LPGCEDKNCQKSTIYLVRSGMKQWVPVLQDFSNKGTLWGFVPFVDEQQPTEIPIPITL
                     HIGDYNMDGYPDALVILKNTSGSNQQAFLLENVPCNNASCEEARRMFKVYWELTDLNQ
                     IKDAMVATFFDIYEDGILDIVVLSKGYTKNDFAIHTLKNNFEADAYFVKVIVLSGLCS
                     NDCPRKITPFGVNQPGPYIMYTTVDANGYLKNGSAGQLSQSAHLALQLPYNVLGLGRS
                     ANFLDHLYVGIPRPSGEKSIRKQEWTAIIPNSQLIVIPYPHNVPRSWSAKLYLTPSNI
                     VLLTAIALIGVCVFILAIIGILHWQEKKADDREKRQEAHRFHFDAM"
     exon            227..299
                     /gene="ITFG1"
                     /gene_synonym="2310047C21Rik; CDA08; LINKIN; LNKN-1; TIP"
                     /inference="alignment:Splign:2.1.0"
     exon            300..445
                     /gene="ITFG1"
                     /gene_synonym="2310047C21Rik; CDA08; LINKIN; LNKN-1; TIP"
                     /inference="alignment:Splign:2.1.0"
     exon            446..503
                     /gene="ITFG1"
                     /gene_synonym="2310047C21Rik; CDA08; LINKIN; LNKN-1; TIP"
                     /inference="alignment:Splign:2.1.0"
     exon            504..578
                     /gene="ITFG1"
                     /gene_synonym="2310047C21Rik; CDA08; LINKIN; LNKN-1; TIP"
                     /inference="alignment:Splign:2.1.0"
     exon            579..673
                     /gene="ITFG1"
                     /gene_synonym="2310047C21Rik; CDA08; LINKIN; LNKN-1; TIP"
                     /inference="alignment:Splign:2.1.0"
     exon            674..738
                     /gene="ITFG1"
                     /gene_synonym="2310047C21Rik; CDA08; LINKIN; LNKN-1; TIP"
                     /inference="alignment:Splign:2.1.0"
     exon            739..820
                     /gene="ITFG1"
                     /gene_synonym="2310047C21Rik; CDA08; LINKIN; LNKN-1; TIP"
                     /inference="alignment:Splign:2.1.0"
     exon            821..915
                     /gene="ITFG1"
                     /gene_synonym="2310047C21Rik; CDA08; LINKIN; LNKN-1; TIP"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1088
                     /gene="ITFG1"
                     /gene_synonym="2310047C21Rik; CDA08; LINKIN; LNKN-1; TIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1239
                     /gene="ITFG1"
                     /gene_synonym="2310047C21Rik; CDA08; LINKIN; LNKN-1; TIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1348
                     /gene="ITFG1"
                     /gene_synonym="2310047C21Rik; CDA08; LINKIN; LNKN-1; TIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1392
                     /gene="ITFG1"
                     /gene_synonym="2310047C21Rik; CDA08; LINKIN; LNKN-1; TIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1471
                     /gene="ITFG1"
                     /gene_synonym="2310047C21Rik; CDA08; LINKIN; LNKN-1; TIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1596
                     /gene="ITFG1"
                     /gene_synonym="2310047C21Rik; CDA08; LINKIN; LNKN-1; TIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1679
                     /gene="ITFG1"
                     /gene_synonym="2310047C21Rik; CDA08; LINKIN; LNKN-1; TIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1797
                     /gene="ITFG1"
                     /gene_synonym="2310047C21Rik; CDA08; LINKIN; LNKN-1; TIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..3185
                     /gene="ITFG1"
                     /gene_synonym="2310047C21Rik; CDA08; LINKIN; LNKN-1; TIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2185..2190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITFG1"
                     /gene_synonym="2310047C21Rik; CDA08; LINKIN; LNKN-1; TIP"
                     /note="hexamer: ATTAAA"
     polyA_site      2200
                     /gene="ITFG1"
                     /gene_synonym="2310047C21Rik; CDA08; LINKIN; LNKN-1; TIP"
                     /note="major polyA site"
     regulatory      3165..3170
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ITFG1"
                     /gene_synonym="2310047C21Rik; CDA08; LINKIN; LNKN-1; TIP"
                     /note="hexamer: AATAAA"
     polyA_site      3185
                     /gene="ITFG1"
                     /gene_synonym="2310047C21Rik; CDA08; LINKIN; LNKN-1; TIP"
                     /note="major polyA site"
ORIGIN      
        1 gggggctgag gggctgccat ggcggcggcg ggccggctcc cgagctcctg ggccctcttc
       61 tcgccgctcc tcgcagggct tgcactactg ggagtcgggc cggtcccagc gcgggcgctg
      121 cacaacgtca cggccgagct ctttggggcc gaggcctggg gcacccttgc ggctttcggg
      181 gacctcaact ccgacaagca gacggatctc ttcgtgctgc gggaaagaaa tgacttaatc
      241 gtctttttgg cagaccagaa tgcaccctat tttaaaccca aagtaaaggt atctttcaag
      301 aatcacagtg cattgataac aagtgtagtc cctggggatt atgatggaga ttctcaaatg
      361 gatgtccttc tgacatatct tcccaaaaat tatgccaaga gtgaattagg agctgttatc
      421 ttctggggac aaaatcaaac attagatcct aacaatatga ccatactcaa taggactttt
      481 caagatgagc cactaattat ggatttcaat ggtgatctaa ttcctgatat ttttggtatc
      541 acaaatgaat ccaaccagcc acagatacta ttaggaggga atttatcatg gcatccagca
      601 ttgaccacta caagtaaaat gcgaattcca cattctcatg catttattga tctgactgaa
      661 gattttacag cagatttatt cctgacgaca ttgaatgcca ccactagtac cttccagttt
      721 gaaatatggg aaaatttgga tggaaacttc tctgtcagta ctatattgga aaaacctcaa
      781 aatatgatgg tggttggaca gtcagcattt gcagactttg atggagatgg acacatggat
      841 catttactgc caggctgtga agataaaaat tgccaaaaga gtaccatcta cttagtgaga
      901 tctgggatga agcagtgggt tccagtccta caagatttca gcaataaggg cacactctgg
      961 ggctttgtgc catttgtgga tgaacagcaa ccaactgaaa taccaattcc aattaccctt
     1021 catattggag actacaatat ggatggctat ccagacgctc tggtcatact aaagaacaca
     1081 tctggaagca accagcaggc ctttttactg gagaacgtcc cttgtaataa tgcaagctgt
     1141 gaagaggcgc gtcgaatgtt taaagtctac tgggagctga cagacctaaa tcaaattaag
     1201 gatgccatgg ttgccacctt ctttgacatt tacgaagatg gaatcttgga cattgtagtg
     1261 ctaagtaaag gatatacaaa gaatgatttt gccattcata cactaaaaaa taactttgaa
     1321 gcagatgctt attttgttaa agttattgtt cttagtggtc tgtgttctaa tgactgtcct
     1381 cgtaagataa caccctttgg agtgaatcaa cctggacctt atatcatgta tacaactgta
     1441 gatgcaaatg ggtatctgaa aaatggatca gctggccaac tcagccaatc cgcacattta
     1501 gctctccaac taccatacaa cgtgcttggt ttaggtcgga gcgcaaattt tcttgaccat
     1561 ctctacgttg gtattccccg tccatctgga gaaaaatcta tacgaaaaca agagtggact
     1621 gcaatcattc caaattccca gctaattgtc attccatacc ctcacaatgt ccctcgaagt
     1681 tggagtgcca aactgtatct tacaccaagt aatattgttc tgcttactgc tatagctctc
     1741 atcggtgtct gtgttttcat cttggcaata attggcattt tacattggca ggaaaagaaa
     1801 gcagatgata gagaaaaacg acaagaagcc caccggtttc attttgatgc tatgtgactt
     1861 gcctttaata ttacataatg gaatggctgt tcacttgatt agttgaaaca caaattctgg
     1921 cttgaaaaaa taggggagat taaatattat ttataaatga tgtatcccat ggtaattatt
     1981 ggaaagtatt caaataaata tggtttgaat atgtcacaag gtcttttttt ttaaagcact
     2041 ttgtatataa aaatttgggt tctctattct gtagtgctgt acatttttgt tcctttgtgg
     2101 aatgtgttgc atgtactcca gtgtttgtgt atttataatc ttatttgcat catgatgatg
     2161 gaaaaagttg tgtaaataaa aataattaaa tgagcaggaa tttttgtgtc cacttgactt
     2221 ggtcttgctt cttattctaa tgatgcaaat tatacttttg tgaatatatc acggagtcat
     2281 taggcattca gcttcatcac agcaggtcag gggtctcact gatggcatac aatatagtga
     2341 tcgggtactc tgacttggta gcacagtaag acagacttgc cttaaactcc taattcaacc
     2401 acttacaaag tcattgtttg aacttggctc ttgtttaacc tctgtaaacc tcagttttct
     2461 tgtttattca gtggggctaa tacttgagtt actgtaaaca ttaaatggga tgatgtatgt
     2521 gaagtgctta gcttggtgcc tagcacagag taagtggtca atatgtggta gttgtcatta
     2581 ttaatatttt agatgatctt attagactta tacatctaat tatagaaata catagacttg
     2641 atagaatttt attttcaggc atgaagaaat attctttgga aaagctaaat ttttggtgat
     2701 tgacataaag atttacttgc tcatattaac taaaaattat agtactctcc aagaattaat
     2761 gtgccctaaa aattttcctc caaaaactta tccttatcat gtgataatga agaacatttg
     2821 atttcttgaa aggaaactgc tgtaggcagc atctgggaat gcaaatcttc aatcacattt
     2881 ctattctcaa acacttggag aagtctataa tttacattca gacttcaatg caaattttgt
     2941 attgtgaact tcacatttcc aaaaagttac tttaaaaaga ctttaagact gaaaaaaaaa
     3001 agtttatcaa tgctaataat tttctagtat gcaaatggac atgtgatgcc tataaaacac
     3061 aaaaatttct ctgaaaacaa ttttgttctt atttttttct ttatagttca ctgagattgg
     3121 catgtgtttt tactttgtat ctaagcatgt taacatgtct tcttaataaa tattccttat
     3181 tgaaa
//
