LOCUS       NM_016368               2252 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens inositol-3-phosphate synthase 1 (ISYNA1), transcript
            variant 1, mRNA.
ACCESSION   NM_016368
VERSION     NM_016368.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2252)
  AUTHORS   Yang,L., Yang,M., Cui,C., Long,X., Li,Y., Dai,W., Lang,T. and
            Zhou,Q.
  TITLE     The myo-inositol biosynthesis rate-limiting enzyme ISYNA1
            suppresses the stemness of ovarian cancer via Notch1 pathway
  JOURNAL   Cell Signal 107, 110688 (2023)
   PUBMED   37105506
  REMARK    GeneRIF: The myo-inositol biosynthesis rate-limiting enzyme ISYNA1
            suppresses the stemness of ovarian cancer via Notch1 pathway.
REFERENCE   2  (bases 1 to 2252)
  AUTHORS   Zi,Y., Wang,X., Zi,Y., Yu,H., Lan,Y., Fan,Y., Ren,C., Liao,K. and
            Chen,H.
  TITLE     Cigarette smoke induces the ROS accumulation and iNOS activation
            through deactivation of Nrf-2/SIRT3 axis to mediate the human
            bronchial epithelium ferroptosis
  JOURNAL   Free Radic Biol Med 200, 73-86 (2023)
   PUBMED   36871899
  REMARK    GeneRIF: Cigarette smoke induces the ROS accumulation and iNOS
            activation through deactivation of Nrf-2/SIRT3 axis to mediate the
            human bronchial epithelium ferroptosis.
REFERENCE   3  (bases 1 to 2252)
  AUTHORS   Zhou,L., Sheng,W., Jia,C., Shi,X., Cao,R., Wang,G., Lin,Y., Zhu,F.,
            Dong,Q. and Dong,M.
  TITLE     Musashi2 promotes the progression of pancreatic cancer through a
            novel ISYNA1-p21/ZEB-1 pathway
  JOURNAL   J Cell Mol Med 24 (18), 10560-10572 (2020)
   PUBMED   32779876
  REMARK    GeneRIF: Musashi2 promotes the progression of pancreatic cancer
            through a novel ISYNA1-p21/ZEB-1 pathway.
REFERENCE   4  (bases 1 to 2252)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2252)
  AUTHORS   Guo,X., Li,H.H., Hu,J., Duan,Y.X., Ren,W.G., Guo,Q., Liu,P.H.,
            Cui,Y., Liu,L.F., Chen,M.F., Chen,J.B. and Zu,X.B.
  TITLE     ISYNA1 is overexpressed in bladder carcinoma and regulates cell
            proliferation and apoptosis
  JOURNAL   Biochem Biophys Res Commun 519 (2), 246-252 (2019)
   PUBMED   31495492
  REMARK    GeneRIF: The ISYNA1 was an important regulatory factors and related
            networks were involved in multiple functional processes.
REFERENCE   6  (bases 1 to 2252)
  AUTHORS   Chhetri,D.R., Gupta,S., Mukherjee,A.K. and Adhikari,J.
  TITLE     L-myo-inositol-1-phosphate synthase expressed in developing organ:
            isolation and characterisation of the enzyme from human fetal liver
  JOURNAL   Appl Biochem Biotechnol 167 (8), 2269-2282 (2012)
   PUBMED   22707096
  REMARK    GeneRIF: MIP synthase expressed in developing fetal liver and shows
            optima pH between 7.0 and 7.5.
REFERENCE   7  (bases 1 to 2252)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   8  (bases 1 to 2252)
  AUTHORS   Seelan,R.S., Parthasarathy,L.K. and Parthasarathy,R.N.
  TITLE     E2F1 regulation of the human myo-inositol 1-phosphate synthase
            (ISYNA1) gene promoter
  JOURNAL   Arch Biochem Biophys 431 (1), 95-106 (2004)
   PUBMED   15464731
  REMARK    GeneRIF: Upregulation occurs through the interaction of several
            low-affinity E2F binding motifs present in the minimal promoter.
REFERENCE   9  (bases 1 to 2252)
  AUTHORS   Ju,S., Shaltiel,G., Shamir,A., Agam,G. and Greenberg,M.L.
  TITLE     Human 1-D-myo-inositol-3-phosphate synthase is functional in yeast
  JOURNAL   J Biol Chem 279 (21), 21759-21765 (2004)
   PUBMED   15024000
REFERENCE   10 (bases 1 to 2252)
  AUTHORS   Guan,G., Dai,P. and Shechter,I.
  TITLE     cDNA cloning and gene expression analysis of human myo-inositol
            1-phosphate synthase
  JOURNAL   Arch Biochem Biophys 417 (2), 251-259 (2003)
   PUBMED   12941308
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK021526.1, BP392170.1 and
            AI983065.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_016368.4.
            
            Summary: This gene encodes an inositol-3-phosphate synthase enzyme.
            The encoded protein plays a critical role in the myo-inositol
            biosynthesis pathway by catalyzing the rate-limiting conversion of
            glucose 6-phosphate to myoinositol 1-phosphate. Alternatively
            spliced transcript variants encoding multiple isoforms have been
            observed for this gene, and a pseudogene of this gene is located on
            the short arm of chromosome 4. [provided by RefSeq, Nov 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005613.1, AF220530.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2151119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338128.13/ ENSP00000337746.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1818              AK021526.1         1-1818
            1819-2208           BP392170.1         111-500
            2209-2252           AI983065.1         8-51                c
FEATURES             Location/Qualifiers
     source          1..2252
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..2252
                     /gene="ISYNA1"
                     /gene_synonym="INO1; INOS; IPS; IPS 1; IPS-1"
                     /note="inositol-3-phosphate synthase 1"
                     /db_xref="GeneID:51477"
                     /db_xref="HGNC:HGNC:29821"
                     /db_xref="MIM:611670"
     exon            1..41
                     /gene="ISYNA1"
                     /gene_synonym="INO1; INOS; IPS; IPS 1; IPS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            42..170
                     /gene="ISYNA1"
                     /gene_synonym="INO1; INOS; IPS; IPS 1; IPS-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1727
                     /gene="ISYNA1"
                     /gene_synonym="INO1; INOS; IPS; IPS 1; IPS-1"
                     /EC_number="5.5.1.4"
                     /note="isoform 1 is encoded by transcript variant 1; MIP
                     synthase; myo-inositol 1-phosphate synthase A1; MI-1-P
                     synthase; testis secretory sperm-binding protein Li 200a"
                     /codon_start=1
                     /product="inositol-3-phosphate synthase 1 isoform 1"
                     /protein_id="NP_057452.1"
                     /db_xref="CCDS:CCDS12379.1"
                     /db_xref="GeneID:51477"
                     /db_xref="HGNC:HGNC:29821"
                     /db_xref="MIM:611670"
                     /translation="MEAAAQFFVESPDVVYGPEAIEAQYEYRTTRVSREGGVLKVHPT
                     STRFTFRTARQVPRLGVMLVGWGGNNGSTLTAAVLANRLRLSWPTRSGRKEANYYGSL
                     TQAGTVSLGLDAEGQEVFVPFSAVLPMVAPNDLVFDGWDISSLNLAEAMRRAKVLDWG
                     LQEQLWPHMEALRPRPSVYIPEFIAANQSARADNLIPGSRAQQLEQIRRDIRDFRSSA
                     GLDKVIVLWTANTERFCEVIPGLNDTAENLLRTIELGLEVSPSTLFAVASILEGCAFL
                     NGSPQNTLVPGALELAWQHRVFVGGDDFKSGQTKVKSVLVDFLIGSGLKTMSIVSYNH
                     LGNNDGENLSAPLQFRSKEVSKSNVVDDMVQSNPVLYTPGEEPDHCVVIKYVPYVGDS
                     KRALDEYTSELMLGGTNTLVLHNTCEDSLLAAPIMLDLALLTELCQRVSFCTDMDPEP
                     QTFHPVLSLLSFLFKAPLVPPGSPVVNALFRQRSCIENILRACVGLPPQNHMLLEHKM
                     ERPGPSLKRVGPVAATYPMLNKKGPVPAATNGCTGDANGHLQEEPPMPTT"
     exon            171..332
                     /gene="ISYNA1"
                     /gene_synonym="INO1; INOS; IPS; IPS 1; IPS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            333..465
                     /gene="ISYNA1"
                     /gene_synonym="INO1; INOS; IPS; IPS 1; IPS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            466..659
                     /gene="ISYNA1"
                     /gene_synonym="INO1; INOS; IPS; IPS 1; IPS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            660..809
                     /gene="ISYNA1"
                     /gene_synonym="INO1; INOS; IPS; IPS 1; IPS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            810..1025
                     /gene="ISYNA1"
                     /gene_synonym="INO1; INOS; IPS; IPS 1; IPS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1190
                     /gene="ISYNA1"
                     /gene_synonym="INO1; INOS; IPS; IPS 1; IPS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1304
                     /gene="ISYNA1"
                     /gene_synonym="INO1; INOS; IPS; IPS 1; IPS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1522
                     /gene="ISYNA1"
                     /gene_synonym="INO1; INOS; IPS; IPS 1; IPS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..2252
                     /gene="ISYNA1"
                     /gene_synonym="INO1; INOS; IPS; IPS 1; IPS-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1800..1805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ISYNA1"
                     /gene_synonym="INO1; INOS; IPS; IPS 1; IPS-1"
                     /note="hexamer: AATAAA"
     polyA_site      1819
                     /gene="ISYNA1"
                     /gene_synonym="INO1; INOS; IPS; IPS 1; IPS-1"
                     /note="major polyA site"
     regulatory      2175..2180
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ISYNA1"
                     /gene_synonym="INO1; INOS; IPS; IPS 1; IPS-1"
                     /note="hexamer: AATACA"
     polyA_site      2210
                     /gene="ISYNA1"
                     /gene_synonym="INO1; INOS; IPS; IPS 1; IPS-1"
     regulatory      2235..2240
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ISYNA1"
                     /gene_synonym="INO1; INOS; IPS; IPS 1; IPS-1"
                     /note="hexamer: AATAAA"
     polyA_site      2252
                     /gene="ISYNA1"
                     /gene_synonym="INO1; INOS; IPS; IPS 1; IPS-1"
ORIGIN      
        1 ccgcgctgtc cgccgccgct gcctgagtcg actctgcgcc gcccgccgcg atggaggccg
       61 ccgcccagtt cttcgtcgag agcccggacg tggtctacgg ccccgaggcc atcgaggcgc
      121 aatacgagta ccggacgacg cgcgtcagcc gcgagggtgg cgttctcaag gtgcacccca
      181 cgtccacgcg cttcaccttc cggaccgccc ggcaggtgcc ccggctcggg gtcatgcttg
      241 tcggctgggg cgggaacaac ggctccacac tcaccgccgc ggtgctggcc aatcgactgc
      301 gtttgtcctg gcccacgcgc agcggccgca aggaggccaa ctactacggc tcgctgactc
      361 aggcgggcac cgtgagcctg ggcctggacg ccgagggcca ggaggtgttc gtacccttca
      421 gcgcggtgct gcccatggtg gcgcccaacg acctcgtgtt cgatggctgg gacatctcgt
      481 cgctgaacct ggccgaggcg atgcggcgcg cgaaggtgct ggactggggg ctgcaggagc
      541 aactgtggcc gcacatggag gccctgcggc cccggccttc tgtttacatc cccgaattca
      601 tcgcggccaa ccagagcgcg cgcgcggaca acctcatccc aggctcgcgt gcgcagcagc
      661 tggagcagat ccgcagggac atccgagact tccggtctag cgcggggctg gacaaagtca
      721 tagtgctgtg gacggcgaac acggagcgct tctgtgaggt gattccaggc ctcaacgaca
      781 cagccgagaa cctgctgcgc accattgagc tcggtctgga ggtgtcgccc tccacgctct
      841 tcgccgtggc cagcatcctg gagggctgtg ccttcctcaa tgggtctccg cagaacaccc
      901 tggtgcccgg agctcttgag ctcgcgtggc agcaccgggt ttttgtgggc ggagatgact
      961 tcaagtcagg ccagaccaaa gtcaagtccg tgcttgtgga cttcctcatt ggctccggcc
     1021 tcaagaccat gtccatcgtg agttacaacc acctgggcaa caacgatggg gagaacctat
     1081 cggcgccatt gcagttccgc tctaaggagg tgtccaagag caacgtggtg gacgacatgg
     1141 tgcagagcaa cccagtgctc tatacgcccg gcgaagagcc tgaccactgc gtggtcatca
     1201 agtatgtgcc gtacgtgggt gacagcaagc gcgcgctgga tgagtatacc tcggagctga
     1261 tgctgggcgg aaccaacaca ctggtgctgc acaacacgtg tgaggactcg ctgctggccg
     1321 cacccatcat gctggaccta gcgctgctga ccgagctgtg ccagcgcgtg agcttctgca
     1381 ctgacatgga ccccgagccg cagaccttcc accccgtgct gtccctgctc agcttcctct
     1441 tcaaggcgcc actagtgccg cccggcagcc cggtggtcaa tgcgcttttc cgccagcgca
     1501 gctgcatcga gaacatcctc agggcctgcg tggggctccc gccacagaac cacatgctcc
     1561 tggaacacaa aatggagcgc ccagggccca gcctcaagcg agttggaccc gtggctgcca
     1621 cctaccctat gttgaacaag aaaggaccgg tacccgctgc caccaatggc tgcaccggtg
     1681 atgccaatgg gcatctgcaa gaggagcccc caatgcccac cacctgaggc cccggtcaca
     1741 cagtttctcg gctcttcctc cccgctgccc cccacgaccc taccttgaag gcccccacaa
     1801 ataaaggcgc tgccactcag ccctccttcc acctggggtt cttggggcct gtgacctgac
     1861 tctgcctccc tctacttccc cgactcttga gcgcccagct tcagtcccat cccctctgcc
     1921 catggtcatc accccaactc ccagggagag cccagaacct ggagcctcgc tctgccccca
     1981 gttctcaaag gtggggctag atgggggcgg ggacggaaca agaccacagg gtggagagtg
     2041 tggtggcaga aggccaaaga gggaatctga gacaagctac caaaaaccaa aaccagcttc
     2101 catttattta tgggccccac cccctgacgt cctggggaga ggggcccccc aaagagcctt
     2161 tctctctggg acaaaataca aatggcagga agggtccata cagaaaagaa cgtctctgag
     2221 gtccttgcgt ttttaataaa atggtaagag tc
//
