LOCUS       NM_001136201            1075 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens isochorismatase domain containing 2 (ISOC2),
            transcript variant 1, mRNA.
ACCESSION   NM_001136201
VERSION     NM_001136201.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1075)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1075)
  AUTHORS   Huang,X., Shi,Z., Wang,W., Bai,J., Chen,Z., Xu,J., Zhang,D. and
            Fu,S.
  TITLE     Identification and characterization of a novel protein ISOC2 that
            interacts with p16INK4a
  JOURNAL   Biochem Biophys Res Commun 361 (2), 287-293 (2007)
   PUBMED   17658461
  REMARK    GeneRIF: ISOC2 is a novel functional protein, which is able to bind
            and co-localize with a tumor suppressor gene p16(INK4a).
REFERENCE   3  (bases 1 to 1075)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
REFERENCE   4  (bases 1 to 1075)
  AUTHORS   Leem,S.H., Kouprina,N., Grimwood,J., Kim,J.H., Mullokandov,M.,
            Yoon,Y.H., Chae,J.Y., Morgan,J., Lucas,S., Richardson,P.,
            Detter,C., Glavina,T., Rubin,E., Barrett,J.C. and Larionov,V.
  TITLE     Closing the gaps on human chromosome 19 revealed genes with a high
            density of repetitive tandemly arrayed elements
  JOURNAL   Genome Res 14 (2), 239-246 (2004)
   PUBMED   14718380
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP226043.1, AC008735.9, BC017344.2 and AC135592.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001136201.1.
            
            Transcript Variant: This variant (1) uses an alternate in-frame
            splice site, compared to variant 2, that results in a shorter
            protein (isoform 1) compared to isoform 2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.177995.1,
                                           SRR1163657.216425.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000425675.7/
                                                  ENSP00000401726.1
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                BP226043.1         42-100
            60-73               AC008735.9         214763-214776
            74-880              BC017344.2         1-807
            881-1075            AC135592.2         45200-45394         c
FEATURES             Location/Qualifiers
     source          1..1075
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..1075
                     /gene="ISOC2"
                     /note="isochorismatase domain containing 2"
                     /db_xref="GeneID:79763"
                     /db_xref="HGNC:HGNC:26278"
                     /db_xref="MIM:612928"
     exon            1..131
                     /gene="ISOC2"
                     /inference="alignment:Splign:2.1.0"
     exon            132..272
                     /gene="ISOC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..752
                     /gene="ISOC2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     isochorismatase domain-containing protein 2,
                     mitochondrial"
                     /codon_start=1
                     /product="isochorismatase domain-containing protein 2
                     isoform 1"
                     /protein_id="NP_001129673.1"
                     /db_xref="CCDS:CCDS46195.1"
                     /db_xref="GeneID:79763"
                     /db_xref="HGNC:HGNC:26278"
                     /db_xref="MIM:612928"
                     /translation="MAAARPSLGRVLPGSSVLFLCDMQEKFRHNIAYFPQIVSVAARM
                     LKVARLLEVPVMLTEQYPQGLGPTVPELGTEGLRPLAKTCFSMVPALQQELDSRPQLR
                     SVLLCGIEAQACILNTTLDLLDRGLQVHVVVDACSSRSQVDRLVALARMRQSGAFLST
                     SEGLILQLVGDAVHPQFKEIQKLIKEPAPDSGLLGLFQGQNSLLH"
     exon            273..482
                     /gene="ISOC2"
                     /inference="alignment:Splign:2.1.0"
     exon            483..553
                     /gene="ISOC2"
                     /inference="alignment:Splign:2.1.0"
     exon            554..671
                     /gene="ISOC2"
                     /inference="alignment:Splign:2.1.0"
     exon            672..1075
                     /gene="ISOC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1054..1059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ISOC2"
                     /note="hexamer: AATAAA"
     polyA_site      1075
                     /gene="ISOC2"
                     /note="major polyA site"
ORIGIN      
        1 aacgaaacgg taaccagccc tgggaagccc gcaagaggcc tcagcggtgg ccgtccgaga
       61 gccgagaggt gagggtgccc ccgcctcacc tgcagagggg ccgttccggg ctcgaacccg
      121 gcaccttccg gaaaatggcg gctgccaggc ccagcctggg ccgagtcctc ccaggatcct
      181 ctgtcctgtt cctgtgtgac atgcaggaga agttccgcca caacatcgcc tacttcccac
      241 agatcgtctc agtggctgcc cgcatgctca aggtggcccg gctgcttgag gtgccagtca
      301 tgctgacgga gcagtaccca caaggcctgg gccccacggt gcccgagctg gggactgagg
      361 gccttcggcc gctggccaag acctgcttca gcatggtgcc tgccctgcag caggagctgg
      421 acagtcggcc ccagctgcgc tctgtgctgc tctgtggcat tgaggcacag gcctgcatct
      481 tgaacacgac cctggacctc ctagaccggg ggctgcaggt ccatgtggtg gtggacgcct
      541 gctcctcacg cagccaggtg gaccggctgg tggctctggc ccgcatgaga cagagtggtg
      601 ccttcctctc caccagcgaa gggctcattc tgcagcttgt gggcgatgcc gtccaccccc
      661 agttcaagga gatccagaaa ctcatcaagg agcccgcccc agacagcgga ctgctgggcc
      721 tcttccaagg ccagaactcc ctcctccact gaactccaac cctgccttga gggaagacca
      781 ccctcctgtc acccggacct cagtggaagc ccgttccccc catccctgga tcccaagagt
      841 ggtgcgatcc accaggagtg ccgccccctt gtgggggggg cagggtgctg ccttcccatt
      901 ggacagctgc tcccggaaat gcaaatgaga ctcctggaaa ctgggtggga attggctgag
      961 ccaagatgga ggcggggctc ggccccgggc cacttcacgg ggcgggaagg ggaggggaag
     1021 aagagtctca gactgtggga cacggactcg cagaataaac atatatgtgg ctgtg
//
