LOCUS       NM_016048               1942 bp    mRNA    linear   PRI 29-APR-2024
DEFINITION  Homo sapiens isochorismatase domain containing 1 (ISOC1), mRNA.
ACCESSION   NM_016048
VERSION     NM_016048.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1942)
  AUTHORS   Kushnareva,Y., Mathews,I.T., Andreyev,A.Y., Altay,G., Lindestam
            Arlehamn,C.S., Pandurangan,V., Nilsson,R., Jain,M., Sette,A.,
            Peters,B. and Sharma,S.
  TITLE     Functional Analysis of Immune Signature Genes in Th1* Memory Cells
            Links ISOC1 and Pyrimidine Metabolism to IFN-gamma and IL-17
            Production
  JOURNAL   J Immunol 206 (6), 1181-1193 (2021)
   PUBMED   33547171
  REMARK    GeneRIF: Functional Analysis of Immune Signature Genes in Th1*
            Memory Cells Links ISOC1 and Pyrimidine Metabolism to IFN-gamma and
            IL-17 Production.
REFERENCE   2  (bases 1 to 1942)
  AUTHORS   Zhao,J.Q., Li,X.N., Fu,L.P., Zhang,N. and Cai,J.H.
  TITLE     ISOC1 promotes the proliferation of gastric cancer cells by
            positively regulating CDK19
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (22), 11602-11609 (2020)
   PUBMED   33275227
  REMARK    GeneRIF: ISOC1 promotes the proliferation of gastric cancer cells
            by positively regulating CDK19.
REFERENCE   3  (bases 1 to 1942)
  AUTHORS   Gao,B., Zhao,L., Wang,F., Bai,H., Li,J., Li,M., Hu,X., Cao,J. and
            Wang,G.
  TITLE     Knockdown of ISOC1 inhibits the proliferation and migration and
            induces the apoptosis of colon cancer cells through the
            AKT/GSK-3beta pathway
  JOURNAL   Carcinogenesis 41 (8), 1123-1133 (2020)
   PUBMED   31740942
  REMARK    GeneRIF: Knockdown of ISOC1 inhibits the proliferation and
            migration and induces the apoptosis of colon cancer cells through
            the AKT/GSK-3beta pathway.
REFERENCE   4  (bases 1 to 1942)
  AUTHORS   Litovkin,K.V., Ivanova,O.V., Bauer,A., Hoheisel,J.D., Bubnov,V.V.
            and Zaporozhan,V.N.
  TITLE     Microarray study of gene expression in uterine leiomyoma
  JOURNAL   Exp Oncol 30 (2), 106-111 (2008)
   PUBMED   18566572
REFERENCE   5  (bases 1 to 1942)
  AUTHORS   Kikuchi,M., Hatano,N., Yokota,S., Shimozawa,N., Imanaka,T. and
            Taniguchi,H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG715081.1 and BC014105.2.
            
            On May 27, 2006 this sequence version replaced NM_016048.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.132948.1,
                                           SRR1660809.257720.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000173527.6/ ENSP00000173527.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BG715081.1         6-17
            13-1942             BC014105.2         1-1930
FEATURES             Location/Qualifiers
     source          1..1942
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23.3"
     gene            1..1942
                     /gene="ISOC1"
                     /gene_synonym="CGI-111"
                     /note="isochorismatase domain containing 1"
                     /db_xref="GeneID:51015"
                     /db_xref="HGNC:HGNC:24254"
                     /db_xref="MIM:620805"
     exon            1..327
                     /gene="ISOC1"
                     /gene_synonym="CGI-111"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..915
                     /gene="ISOC1"
                     /gene_synonym="CGI-111"
                     /codon_start=1
                     /product="isochorismatase domain-containing protein 1"
                     /protein_id="NP_057132.2"
                     /db_xref="CCDS:CCDS43357.1"
                     /db_xref="GeneID:51015"
                     /db_xref="HGNC:HGNC:24254"
                     /db_xref="MIM:620805"
                     /translation="MAAAEPAVLALPNSGAGGAGAPSGTVPVLFCFSVFARPSSVPHG
                     AGYELLIQKFLSLYGDQIDMHRKFVVQLFAEEWGQYVDLPKGFAVSERCKVRLVPLQI
                     QLTTLGNLTPSSTVFFCCDMQERFRPAIKYFGDIISVGQRLLQGARILGIPVIVTEQY
                     PKGLGSTVQEIDLTGVKLVLPKTKFSMVLPEVEAALAEIPGVRSVVLFGVETHVCIQQ
                     TALELVGRGVEVHIVADATSSRSMMDRMFALERLARTGIIVTTSEAVLLQLVADKDHP
                     KFKEIQNLIKASAPESGLLSKV"
     exon            328..447
                     /gene="ISOC1"
                     /gene_synonym="CGI-111"
                     /inference="alignment:Splign:2.1.0"
     exon            448..651
                     /gene="ISOC1"
                     /gene_synonym="CGI-111"
                     /inference="alignment:Splign:2.1.0"
     exon            652..768
                     /gene="ISOC1"
                     /gene_synonym="CGI-111"
                     /inference="alignment:Splign:2.1.0"
     exon            769..1942
                     /gene="ISOC1"
                     /gene_synonym="CGI-111"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1923..1928
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ISOC1"
                     /gene_synonym="CGI-111"
                     /note="hexamer: ATTAAA"
     polyA_site      1942
                     /gene="ISOC1"
                     /gene_synonym="CGI-111"
                     /note="major polyA site"
ORIGIN      
        1 gcagacgctc gggggaacat ggcggctgcg gagccggcgg tccttgcgct ccccaacagc
       61 ggcgccgggg gcgcgggggc gccgtcgggc acagtcccgg tgctcttctg tttctcagtc
      121 ttcgcgcgac cctcgtcggt gccacacggg gcgggctacg agctgctcat ccagaagttc
      181 ctcagcctgt acggcgacca gatcgacatg caccgcaaat tcgtggtgca gctgttcgcc
      241 gaggagtggg gccagtacgt ggacttgccc aagggcttcg cggtgagcga gcgctgcaag
      301 gtgcgcctcg tgccgttgca gatccagctc actaccctgg gaaatcttac accttcaagc
      361 actgtgtttt tctgctgtga tatgcaggaa aggttcagac cagccatcaa gtattttggg
      421 gatattatta gcgtgggaca gagattgttg caaggggccc ggattttagg aattcctgtt
      481 attgtaacag aacaataccc taaaggtctt gggagcacgg ttcaagaaat tgatttaaca
      541 ggtgtaaaac tggtacttcc aaagaccaag ttttcaatgg tattaccaga agtagaagcg
      601 gcattagcag agattcccgg agtcaggagt gttgtattat ttggagtaga aactcatgtg
      661 tgcatccaac aaactgccct ggagctagtt ggccgaggag tcgaggttca cattgttgct
      721 gatgccacct catcaagaag catgatggac aggatgtttg ccctcgagcg tctcgctcga
      781 accgggatca tagtgaccac gagtgaggct gttctgcttc agctggtagc tgataaggac
      841 catccaaaat tcaaggaaat tcagaatcta attaaggcga gtgctccaga gtcgggtctg
      901 ctttccaaag tataggacat ttgaagaact ggtatgctac tcactggtga aggacagtca
      961 ggtgaaggac tgtaagccca cacaagctct tcttatctct actagaatta aaatgttaag
     1021 tcaaaaacgg ctcctttttt gcgcctccta gtgaaactta accagctaga ccatttgagt
     1081 accagcattt agttacaaac gtcaaaggct tccggtgctg cttaccttcc ttttttgtta
     1141 atgtgctttt atttattaaa aaaaattaca atgaagatgc ctgttttgtc tctactgtgt
     1201 actctgatcg tatctttcca aagtgcagac tcttgtgaag ttttcttaaa ttgttcactt
     1261 taaagaaaat gacgtaccaa caatgatttg gcttttatat tactgtaaga tgttataatg
     1321 ttaatgtgga tgtagtgctt ttactttaca gattgattgg aataagatta ttgcatatga
     1381 atttacccac aggactctga atcatgttac ccactcccct cacaatgttg tccacttagt
     1441 gagttgcatt gatctatccg taccaaatga tgttgaataa ttacatatct ttcttgacta
     1501 tactgatttc ttattttggt cactattact aaatctctgt taatattctc tcttttaact
     1561 gaaaagggat gggatagaag ggtttgcaat gccatattat tggtggaggg ctgttttaac
     1621 atctttgaag tatggcttgc tgaatatctt taccaacatc ttgaatatat attctagtgt
     1681 ccacaagatt tagcaaaaag ataaagcttg ggtggaatat cattttaaaa tgttcatgtt
     1741 ctgttctata ttttcttcac ctactctcca aatattgtaa tgcaaaaagt ctcagtaatg
     1801 atttggtagt attaattttg tggtcattgt ttctcttcga taaatttatt ttcattaaat
     1861 acttgttaga gggttttgaa atgtttttca aatatgtgaa atgtgaaact gctgtctttt
     1921 atattaaagt aattaaagaa aa
//
