LOCUS       NM_199296               2940 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens isthmin 2 (ISM2), transcript variant 1, mRNA.
ACCESSION   NM_199296
VERSION     NM_199296.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2940)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2940)
  AUTHORS   Rossi,V., Beffagna,G., Rampazzo,A., Bauce,B. and Danieli,G.A.
  TITLE     TAIL1: an isthmin-like gene, containing type 1
            thrombospondin-repeat and AMOP domain, mapped to ARVD1 critical
            region
  JOURNAL   Gene 335, 101-108 (2004)
   PUBMED   15194193
  REMARK    GeneRIF: TAIL1 gene is located on chromosome 14q24.3 within ARVD1
            (arrhythmogenic right ventricular dysplasia/cardiomyopathy, type 1)
            critical region; preliminary evidence suggests that it is expressed
            in several tissues, showing multiple alternative splicing.
REFERENCE   3  (bases 1 to 2940)
  AUTHORS   Bork,P.
  TITLE     The modular architecture of a new family of growth regulators
            related to connective tissue growth factor
  JOURNAL   FEBS Lett 327 (2), 125-130 (1993)
   PUBMED   7687569
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB025298.1, BX248277.1,
            AJ583024.1 and BC033140.1.
            
            On Nov 23, 2018 this sequence version replaced NM_199296.2.
            
            Summary: The protein encoded by this gene contains a type 1
            thrombospondin domain, which is present in thrombospondin, a number
            of proteins involved in the complement pathway, as well as in
            extracellular matrix proteins. Two alternatively spliced transcript
            variants encoding distinct isoforms have been observed. [provided
            by RefSeq, Mar 2009].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR749863.1, AK075445.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342219.9/ ENSP00000341490.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DB025298.1         53-68
            17-649              BX248277.1         1-633
            650-2453            AJ583024.1         662-2465
            2454-2816           BC033140.1         2282-2644
            2817-2817           AJ583024.1         2763-2763
            2818-2940           BC033140.1         2646-2768
FEATURES             Location/Qualifiers
     source          1..2940
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..2940
                     /gene="ISM2"
                     /gene_synonym="TAIL1; THSD3"
                     /note="isthmin 2"
                     /db_xref="GeneID:145501"
                     /db_xref="HGNC:HGNC:23176"
                     /db_xref="MIM:612684"
     exon            1..164
                     /gene="ISM2"
                     /gene_synonym="TAIL1; THSD3"
                     /inference="alignment:Splign:2.1.0"
     exon            165..407
                     /gene="ISM2"
                     /gene_synonym="TAIL1; THSD3"
                     /inference="alignment:Splign:2.1.0"
     exon            408..650
                     /gene="ISM2"
                     /gene_synonym="TAIL1; THSD3"
                     /inference="alignment:Splign:2.1.0"
     exon            651..996
                     /gene="ISM2"
                     /gene_synonym="TAIL1; THSD3"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1137
                     /gene="ISM2"
                     /gene_synonym="TAIL1; THSD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1221
                     /gene="ISM2"
                     /gene_synonym="TAIL1; THSD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..2940
                     /gene="ISM2"
                     /gene_synonym="TAIL1; THSD3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2919..2924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ISM2"
                     /gene_synonym="TAIL1; THSD3"
                     /note="hexamer: AATAAA"
     polyA_site      2940
                     /gene="ISM2"
                     /gene_synonym="TAIL1; THSD3"
                     /note="major polyA site"
ORIGIN      
        1 agagcagcct cggaaccgag acgatgcgtg cgctccgcga ccgagccggg ctcctcctct
       61 gcgtgctgct gctggcggcg ctgctggagg cggcgctagg gctccccgtg aagaagccgc
      121 ggctccgcgg accacggcct gggagcctca cgaggctcgc agaggtctca gcctccccag
      181 atcctaggcc tctgaaggaa gaggaggagg caccactgct ccccagaacc cacctgcagg
      241 cagagccaca ccaacatgga tgctggactg tcactgagcc agcagccatg accccaggca
      301 acgccacccc tcccaggacc ccagaggtta ctccgttgcg gctggagctg cagaagctgc
      361 cgggattggc caacacaacc ttgagtaccc ctaaccctga tacccaggct tcagcctccc
      421 cagatcctag gcctctgagg gaagaggagg aggcacgact gctccccaga acccacctgc
      481 aggcagagct acaccaacat ggatgttgga ctgtcactga gccagcagcc ctgaccccag
      541 ggaatgccac gcctcccagg acccaggagg ttactccctt gctgctggag ctgcagaagc
      601 tgccagaatt ggtccacgca accttgagta cccctaaccc tgataaccag gtgaccatca
      661 aggtggtgga ggacccccag gccgaggtgt cgatagacct gttggctgag cccagcaatc
      721 ccccgcccca ggataccctt agctggctgc ccgccctctg gtccttcctc tggggagact
      781 acaaaggaga ggaaaaagac agggccccag gggagaaggg ggaggaaaag gaggaagacg
      841 aggactatcc ttcagaggat atcgagggtg aggatcaaga ggacaaagag gaagatgagg
      901 aagagcaggc gctctggttc aatggaacta cagacaactg ggaccagggc tggctggccc
      961 ccggggattg ggtcttcaag gattctgtca gctacgacta tgagcctcag aaggagtgga
     1021 gtccctggtc tccctgcagt gggaactgca gcactggcaa gcagcagagg actcggccct
     1081 gtggctatgg ctgcactgcc accgagaccc gtacctgtga cctgccctcc tgtcctggca
     1141 ctgaggacaa ggacaccttg ggcctcccca gtgaggagtg gaagctcctg gcccgcaatg
     1201 ctacggacat gcatgatcaa gatgtggaca gctgtgagaa gtggctgaac tgcaagagcg
     1261 acttcctaat caagtatctg agccagatgc tgcgggacct gcccagctgc ccgtgtgcct
     1321 acccactgga ggccatggac agccctgtga gcctacagga cgagcaccag ggccgcagct
     1381 tccggtggag ggatgccagt ggccctcgcg agcgcctgga catctaccag cccacggcgc
     1441 gcttctgcct gcgttccatg ctgtctgggg agagcagcac actggccgcc cagcactgct
     1501 gctatgacga ggacagccgg ctgctgaccc gtggcaaggg cgccggcatg cccaacctca
     1561 tcagcaccga cttctcacct aagctgcact tcaagttcga cacgacgccc tggatcctgt
     1621 gcaaggggga ctggagccgc ctccacgctg tgctccctcc caacaacggc cgagcctgca
     1681 ccgacaaccc cctggaggag gagtacctag cacagttgca ggaggccaag gagtactagt
     1741 gacggggttg ctgaacagac actgcaggga gagggcaggc ggctgctgct gttgcacggg
     1801 agaactttcc tcacccgccc ctgcccagac agggtgagga aagggctccc ccagtgaggt
     1861 tggtccgagg ctgtgtgccc tctgccagcg accccgaagc agatatctca gtggggttag
     1921 tgagaaggtt gaagggtatg tagggcccag ggtgggtgtc cctgggagcc ctggaaatgt
     1981 gcatatgtgc atgtgtctgc cggggcctcc ctctgctgcc tgctgggacc ctggccactc
     2041 atttttctcc tccttgggag ctgggctctt ctgccctggc tctgcacata agtgttagcc
     2101 agcagctcca gaaaaatccc gattcccggg atctgccacg agtcactcct actccaccct
     2161 gatggccagc agaggaaggg ccactcttct catgggcaca gccatccttt gccggggggg
     2221 gcatccagcc tgggtggcca cccctcctta tctctgggtg gtgcacatgc ccttctttcc
     2281 ccactccctg ccacgagcca ctgcacagga ggctatctgt agccccaagc tgcctttctg
     2341 ttggacacca actttagtct tgggctgcaa gccagcccag ctgaggcgaa gtggactcca
     2401 ggcagggaat gggttgccca attctggtcc ctttcctttg ctcagccccc tctgttctgc
     2461 tgattgtagg gatgtgcagg gctgggagtt ggcactcccc ccgagtgggg aggtgacagc
     2521 ttgtcacagt agccaggctt gggtgggttc agcactagct cgggacggtg tgtcacacgt
     2581 ctatagtaaa ccagttctct gggaggggaa aaaagccctg atttattgca tttgggcagc
     2641 ttctgtggtg taaattctcc cagcagtgtc ccatgtcatg ctgccagcat cactgaatgc
     2701 actgaactca gagttgggaa gagatgcaca taatcgctct cccggcacac ctcatgcctc
     2761 ttccctgcct ccccattccc ctggctgcac ttccttgcct tctatggggt tgaaatattg
     2821 aagtctcaac tgtctctgtt cacaagagcc accaaaagtt aggggacttc agtcctagcc
     2881 cccagatggc cgccctgaag ctctctgggc tcctcagcaa taaagcactt tattttcaaa
//
