LOCUS       NM_020851               4202 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens immunoglobulin superfamily containing leucine rich
            repeat 2 (ISLR2), transcript variant 2, mRNA.
ACCESSION   NM_020851 XM_027396
VERSION     NM_020851.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4202)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4202)
  AUTHORS   Alazami,A.M., Maddirevula,S., Seidahmed,M.Z., Albhlal,L.A. and
            Alkuraya,F.S.
  TITLE     A novel ISLR2-linked autosomal recessive syndrome of congenital
            hydrocephalus, arthrogryposis and abdominal distension
  JOURNAL   Hum Genet 138 (1), 105-107 (2019)
   PUBMED   30483960
  REMARK    GeneRIF: Deletion in ISLR2 gene is associated with autosomal
            recessive syndrome of congenital hydrocephalus, arthrogryposis and
            abdominal distension.
REFERENCE   3  (bases 1 to 4202)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA911394.1 and BC152429.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020851.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All four transcripts encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358316.1, AK092297.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000453268.3/ ENSP00000411834.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               DA911394.1         185-388
            205-4202            BC152429.1         820-4817
FEATURES             Location/Qualifiers
     source          1..4202
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.1"
     gene            1..4202
                     /gene="ISLR2"
                     /gene_synonym="LINX"
                     /note="immunoglobulin superfamily containing leucine rich
                     repeat 2"
                     /db_xref="GeneID:57611"
                     /db_xref="HGNC:HGNC:29286"
                     /db_xref="MIM:614179"
     exon            1..36
                     /gene="ISLR2"
                     /gene_synonym="LINX"
                     /inference="alignment:Splign:2.1.0"
     exon            37..146
                     /gene="ISLR2"
                     /gene_synonym="LINX"
                     /inference="alignment:Splign:2.1.0"
     exon            147..4202
                     /gene="ISLR2"
                     /gene_synonym="LINX"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..2392
                     /gene="ISLR2"
                     /gene_synonym="LINX"
                     /note="immunoglobulin superfamily containing leucine-rich
                     repeat protein 2; leucine-rich repeat domain and
                     immunoglobulin domain-containing axon extension protein"
                     /codon_start=1
                     /product="immunoglobulin superfamily containing
                     leucine-rich repeat protein 2 precursor"
                     /protein_id="NP_065902.1"
                     /db_xref="CCDS:CCDS10259.1"
                     /db_xref="GeneID:57611"
                     /db_xref="HGNC:HGNC:29286"
                     /db_xref="MIM:614179"
                     /translation="MFPLRALWLVWALLGVAGSCPEPCACVDKYAHQFADCAYKELRE
                     VPEGLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLK
                     NLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLR
                     TLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQ
                     GVPVYRLPALPCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQI
                     PGGTVVLEPPVLSGEDDGVGAEEGEGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLA
                     LANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAVAATGPPKHAPGAGGEPDGQA
                     PTSERKSTAKGRGNSVLPSKPEGKIKGQGLAKVSILGETETEPEEDTSEGEEAEDQIL
                     ADPAEEQRCGNGDPSRYVSNHAFNQSAELKPHVFELGVIALDVAEREARVQLTPLAAR
                     WGPGPGGAGGAPRPGRRPLRLLYLCPAGGGAAVQWSRVEEGVNAYWFRGLRPGTNYSV
                     CLALAGEACHVQVVFSTKKELPSLLVIVAVSVFLLVLATVPLLGAACCHLLAKHPGKP
                     YRLILRPQAPDPMEKRIAADFDPRASYLESEKSYPAGGEAGGEEPEDVQGEGLDEDAE
                     QGDPSGDLQREESLAACSLVESQSKANQEEFEAGSEYSDRLPLGAEAVNIAQEINGNY
                     RQTAG"
     regulatory      4183..4188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ISLR2"
                     /gene_synonym="LINX"
                     /note="hexamer: AATAAA"
     polyA_site      4202
                     /gene="ISLR2"
                     /gene_synonym="LINX"
                     /note="major polyA site"
ORIGIN      
        1 gaagctcgcg ggcgctggcg ggacaggcgc gtgaggccac aacacatgcg tgtatcttgc
       61 ttgggctatc ttccctgctc tgccacgccg ggtctggaga aggggtttca gccccaggac
      121 atttactgag agtcggcgaa tattgggagc cgcgatgttc ccccttcggg ccctgtggtt
      181 ggtctgggcg cttctaggag tggccggatc atgcccggag ccgtgcgcct gcgtggacaa
      241 gtacgctcac cagttcgcgg actgcgctta caaagagttg cgtgaggtgc cggaaggact
      301 gcctgccaac gtgacgacgc ttagtctgtc cgcgaacaag atcactgtgc tgcggcgcgg
      361 ggccttcgcc gacgtcacac aggtcacgtc gctgtggctg gcgcacaatg aggtgcgcac
      421 cgtggagcca ggcgcactgg ccgtgctgag tcagctcaag aacctcgatc tgagccacaa
      481 cttcatatcc agctttccgt ggagcgacct gcgcaacctg agcgcgctgc agctgctcaa
      541 aatgaaccac aaccgcctgg gctctctgcc ccgggacgca ctcggtgcgc tacccgacct
      601 gcgttccctg cgcatcaaca acaaccggct gcgtacgctg gcgcctggca ccttcgacgc
      661 gcttagcgcg ctgtcacact tgcaactcta tcacaatccc ttccactgcg gctgcggcct
      721 tgtgtggctg caggcctggg ccgcgagcac ccgggtgtcc ttacccgagc ccgactccat
      781 tgcttgtgcc tcgcctcccg cgctgcaggg ggtgccggtg taccgcctgc ccgccctgcc
      841 ctgtgcaccg cccagcgtgc atctgagtgc cgagccaccg cttgaagcac ccggcacccc
      901 actgcgcgca ggactggcgt tcgtgttaca ctgcatcgcc gacggccacc ctacgcctcg
      961 cctgcaatgg caacttcaga tccccggtgg caccgtagtc ttagagccac cggttctgag
     1021 cggggaggac gacggggttg gggcggagga aggagaggga gaaggagatg gggatttgct
     1081 gacgcagacc caagcccaaa cgccgactcc agcacccgct tggccggcgc ccccagccac
     1141 accgcgcttc ctggccctcg caaatggctc cctgttggtg cccctcctga gtgccaagga
     1201 ggcgggcgtc tacacttgcc gtgcacacaa tgagctgggc gccaactcta cgtcaatacg
     1261 cgtggcggtg gcagcaaccg ggcccccaaa acacgcgcct ggcgccgggg gagaacccga
     1321 cggacaggcc ccgacctctg agcgcaagtc cacagccaag ggccggggca acagcgtcct
     1381 gccttccaaa cccgagggca aaatcaaagg ccaaggcctg gccaaggtca gcattctcgg
     1441 ggagaccgag acggagccgg aggaggacac aagtgaggga gaggaggccg aagaccagat
     1501 cctcgcggac ccggcggagg agcagcgctg tggcaacggg gacccctctc ggtacgtttc
     1561 taaccacgcg ttcaaccaga gcgcagagct caagccgcac gtcttcgagc tgggcgtcat
     1621 cgcgctggat gtggcggagc gcgaggcgcg ggtgcagctg actccgctgg ctgcgcgctg
     1681 gggccctggg cccggcgggg ctggcggagc cccgcgaccc gggcggcgac ccctgcgcct
     1741 actctatctg tgtccagcgg ggggcggcgc ggcagtgcag tggtcccgcg tagaggaagg
     1801 cgtcaacgcc tactggttcc gcggcctgcg gccgggtacc aactactccg tgtgcctggc
     1861 gctggcgggc gaagcctgcc acgtgcaagt ggtgttttcc accaagaagg agctcccatc
     1921 gctgctggtc atagtggcag tgagcgtatt cctcctggtg ctggccacag tgccccttct
     1981 gggcgccgcc tgctgccatc tgctggctaa acacccgggc aagccctacc gtctgatcct
     2041 gcggcctcag gcccctgacc ctatggagaa gcgcatcgcc gcagacttcg acccgcgtgc
     2101 ttcgtacctc gagtccgaga aaagctaccc ggcaggcggc gaggcgggcg gcgaggagcc
     2161 agaggacgtg cagggggagg gccttgatga agacgcggag cagggagacc caagtgggga
     2221 cctgcagaga gaggagagcc tggcggcctg ctcactggtg gagtcccagt ccaaggccaa
     2281 ccaagaggag ttcgaggcgg gctctgagta cagcgatcgg ctgcccctgg gcgccgaggc
     2341 ggtcaacatc gcccaggaga ttaatggcaa ctacaggcag acggcaggct gaacctccgc
     2401 ccgtccggcc cgcccattcc cgacctccac ctagggtgcc tgggagcagc agtctagggc
     2461 tggcaggact tatgtccccc gtccccaacc ttcacctact cctccccctt actactcccc
     2521 aaccttgact accagggact tctattaggg agtgggccga tttcaccagt ccctgctacc
     2581 cacggctgcc attctccctg cgggctgaat ccccttcccc gccaagcaca gtgtttatct
     2641 taccccatgc aagactccac ccgcagacgg tgggcgatat ctatgtccct ccattcccgt
     2701 cgcgattatc tgcgaaatcc accccgcagc ccgccccacc gtgggctctg gagccagagg
     2761 aaacgagcga agactttgga aacctcgcgg taacgcggtg gtttcggggg ccagccaagg
     2821 ccagtggagt gctgtggggt cccacctcga cccctcctcc tccctttctt tctttccttt
     2881 ttttttattt tttaatttta tttatttatt tatttatttt ttgacggagt cttggtctgt
     2941 cgccaggctg gagtgcagtg gcgcgatctc ggctcactgc atcttccgcc tcccgggttc
     3001 aagcgattct cctgcctcag cctgcctagt agctgggact acaggcgcgc gccaccacga
     3061 ccagctaatt tcttctattt ttagtagaga cggggtttca ccatgttggc caggatggtc
     3121 tggatctctt gacctcaggt gatccatctg cctcggcctc tcaaagtgct gggattacag
     3181 gcgtgaggca ccgcgcccgg cccctcctcc ctttcaatcc ctactcccag aagccgggat
     3241 tcgtggcaac ccctagtttt tagttccaaa gcctcctgcc ggcagggaac caaatccttc
     3301 tgtcctccca cccccacccc acttctggcc agttggagtc cagcccggtg cctggggcgc
     3361 ctttcagctc cgcgctcaga ttttcctgtt ttcgttgttt tcaaagacag cgacatttcg
     3421 ggtctggtgc taacaccccc ttcccagcct ctgggaaaat cgagtgtgtg tgtcgggggg
     3481 tagggaggga atgcgttttc tgtcgtctct ctcctaactt aaagcgccgc aggaccgcgc
     3541 gccccttggc ggctgagcct gtggacttgg tcgcgggcca atttcgttgt ccgtgtgttg
     3601 ggctttccgg aggtctgtgc gcccaacagc gccgctcccg cggctccacc cgacccagac
     3661 cctagctgga aagcgccgga ggcggaggaa gctgactgtg gcctcccggg ccgcggctct
     3721 ctggagggct cgcgccctag ttcgcacaaa gcctgctcgt gactgtgcga ctgtgcgacg
     3781 ggatccggat ggagccgagc ccctccgtcc tcgcgtctcg gtcctcgcgt cgccccgccc
     3841 cacccgcccc tgcttcggcg ggaatcgtgt ttgcccggcg tgtagtccct gacaagcgtg
     3901 ccctgtagga gaaaagtctg tgtcctgtga agtgtgaccg tgtagtgtag gggggcgggc
     3961 gggggggcgg atgggcgggg agggagggaa ggggaggggc gcggcgcggc gactcggggc
     4021 ggggttcttt tttccatttt gaaagaaagc gtcggggttg gggtgggggg agtttcagtc
     4081 ctcgggatca gccctctccg cgaagcgcag cacaagcgcg ggcctgggac ggagtagccc
     4141 cccggagccc gtgccctttt ctaaacgcgt ctgtatgcag tcaataaaac aatcgatttg
     4201 aa
//
