LOCUS       NM_005545               2331 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens immunoglobulin superfamily containing leucine rich
            repeat (ISLR), transcript variant 1, mRNA.
ACCESSION   NM_005545
VERSION     NM_005545.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2331)
  AUTHORS   Wang,T., Chen,M., Su,Y., Zhang,Y., Liu,C., Lan,M., Li,L., Liu,F.,
            Li,N., Yu,Y., Xiong,L., Wang,K., Liu,J., Xu,Q., Hu,Y., Jia,Y.,
            Cao,Y., Pan,J. and Meng,Q.
  TITLE     Immunoglobulin Superfamily Containing Leucine-Rich Repeat (ISLR)
            Serves as a Redox Sensor That Modulates Antioxidant Capacity by
            Suppressing Pyruvate Kinase Isozyme M2 Activity
  JOURNAL   Cells 13 (10), 838 (2024)
   PUBMED   38786060
  REMARK    GeneRIF: Immunoglobulin Superfamily Containing Leucine-Rich Repeat
            (ISLR) Serves as a Redox Sensor That Modulates Antioxidant Capacity
            by Suppressing Pyruvate Kinase Isozyme M2 Activity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2331)
  AUTHORS   Ando,R., Shiraki,Y., Miyai,Y., Shimizu,H., Furuhashi,K.,
            Minatoguchi,S., Kato,K., Kato,A., Iida,T., Mizutani,Y., Ito,K.,
            Asai,N., Mii,S., Esaki,N., Takahashi,M. and Enomoto,A.
  TITLE     Meflin is a marker of pancreatic stellate cells involved in
            fibrosis and epithelial regeneration in the pancreas
  JOURNAL   J Pathol 262 (1), 61-75 (2024)
   PUBMED   37796386
  REMARK    GeneRIF: Meflin is a marker of pancreatic stellate cells involved
            in fibrosis and epithelial regeneration in the pancreas.
REFERENCE   3  (bases 1 to 2331)
  AUTHORS   Zhang,P., Li,Z. and Yang,G.
  TITLE     Silencing of ISLR inhibits tumour progression and glycolysis by
            inactivating the IL-6/JAK/STAT3 pathway in non-small cell lung
            cancer
  JOURNAL   Int J Mol Med 48 (6) (2021)
   PUBMED   34713300
  REMARK    GeneRIF: Silencing of ISLR inhibits tumour progression and
            glycolysis by inactivating the IL6/JAK/STAT3 pathway in nonsmall
            cell lung cancer.
REFERENCE   4  (bases 1 to 2331)
  AUTHORS   Kobayashi,H., Gieniec,K.A., Wright,J.A., Wang,T., Asai,N.,
            Mizutani,Y., Lida,T., Ando,R., Suzuki,N., Lannagan,T.R.M., Ng,J.Q.,
            Hara,A., Shiraki,Y., Mii,S., Ichinose,M., Vrbanac,L.,
            Lawrence,M.J., Sammour,T., Uehara,K., Davies,G., Lisowski,L.,
            Alexander,I.E., Hayakawa,Y., Butler,L.M., Zannettino,A.C.W.,
            Din,M.O., Hasty,J., Burt,A.D., Leedham,S.J., Rustgi,A.K.,
            Mukherjee,S., Wang,T.C., Enomoto,A., Takahashi,M., Worthley,D.L.
            and Woods,S.L.
  TITLE     The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR
            Drives Colorectal Carcinogenesis
  JOURNAL   Gastroenterology 160 (4), 1224-1239 (2021)
   PUBMED   33197448
  REMARK    GeneRIF: The Balance of Stromal BMP Signaling Mediated by GREM1 and
            ISLR Drives Colorectal Carcinogenesis.
            Erratum:[Gastroenterology. 2021 Nov;161(5):1728. doi:
            10.1053/j.gastro.2021.09.038.. PMID: 34562358]
REFERENCE   5  (bases 1 to 2331)
  AUTHORS   Xu,J., Tang,Y., Sheng,X., Tian,Y., Deng,M., Du,S., Lv,C., Li,G.,
            Pan,Y., Song,Y., Lou,P., Luo,Y., Li,Y., Zhang,B., Chen,Y., Liu,Z.,
            Cong,Y., Plikus,M.V., Meng,Q., Zhou,Z. and Yu,Z.
  TITLE     Secreted stromal protein ISLR promotes intestinal regeneration by
            suppressing epithelial Hippo signaling
  JOURNAL   EMBO J 39 (7), e103255 (2020)
   PUBMED   32128839
  REMARK    GeneRIF: Secreted stromal protein ISLR promotes intestinal
            regeneration by suppressing epithelial Hippo signaling.
REFERENCE   6  (bases 1 to 2331)
  AUTHORS   Hara,A., Kobayashi,H., Asai,N., Saito,S., Higuchi,T., Kato,K.,
            Okumura,T., Bando,Y.K., Takefuji,M., Mizutani,Y., Miyai,Y.,
            Saito,S., Maruyama,S., Maeda,K., Ouchi,N., Nagasaka,A., Miyata,T.,
            Mii,S., Kioka,N., Worthley,D.L., Murohara,T., Takahashi,M. and
            Enomoto,A.
  TITLE     Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac
            Tissue Repair and the Development of Diastolic Dysfunction
  JOURNAL   Circ Res 125 (4), 414-430 (2019)
   PUBMED   31221024
REFERENCE   7  (bases 1 to 2331)
  AUTHORS   Maeda,K., Enomoto,A., Hara,A., Asai,N., Kobayashi,T.,
            Horinouchi,A., Maruyama,S., Ishikawa,Y., Nishiyama,T., Kiyoi,H.,
            Kato,T., Ando,K., Weng,L., Mii,S., Asai,M., Mizutani,Y.,
            Watanabe,O., Hirooka,Y., Goto,H. and Takahashi,M.
  TITLE     Identification of Meflin as a Potential Marker for Mesenchymal
            Stromal Cells
  JOURNAL   Sci Rep 6, 22288 (2016)
   PUBMED   26924503
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2331)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 2331)
  AUTHORS   Nagasawa,A., Kudoh,J., Noda,S., Mashima,Y., Wright,A., Oguchi,Y.
            and Shimizu,N.
  TITLE     Human and mouse ISLR (immunoglobulin superfamily containing
            leucine-rich repeat) genes: genomic structure and tissue expression
  JOURNAL   Genomics 61 (1), 37-43 (1999)
   PUBMED   10512678
REFERENCE   10 (bases 1 to 2331)
  AUTHORS   Nagasawa,A., Kubota,R., Imamura,Y., Nagamine,K., Wang,Y.,
            Asakawa,S., Kudoh,J., Minoshima,S., Mashima,Y., Oguchi,Y. and
            Shimizu,N.
  TITLE     Cloning of the cDNA for a new member of the immunoglobulin
            superfamily (ISLR) containing leucine-rich repeat (LRR)
  JOURNAL   Genomics 44 (3), 273-279 (1997)
   PUBMED   9325048
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC023545.16, AB024536.1 and BR001380.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005545.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358871.2, AK000817.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000249842.8/ ENSP00000249842.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AC023545.16        65333-65368
            37-2179             AB024536.1         1-2143
            2180-2331           BR001380.1         2144-2295
FEATURES             Location/Qualifiers
     source          1..2331
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.1"
     gene            1..2331
                     /gene="ISLR"
                     /gene_synonym="HsT17563; Meflin"
                     /note="immunoglobulin superfamily containing leucine rich
                     repeat"
                     /db_xref="GeneID:3671"
                     /db_xref="HGNC:HGNC:6133"
                     /db_xref="MIM:602059"
     exon            1..310
                     /gene="ISLR"
                     /gene_synonym="HsT17563; Meflin"
                     /inference="alignment:Splign:2.1.0"
     exon            311..2331
                     /gene="ISLR"
                     /gene_synonym="HsT17563; Meflin"
                     /inference="alignment:Splign:2.1.0"
     CDS             319..1605
                     /gene="ISLR"
                     /gene_synonym="HsT17563; Meflin"
                     /note="immunoglobulin superfamily containing leucine-rich
                     repeat protein; mesenchymal stromal cell- and
                     fibroblast-expressing Linx paralogue"
                     /codon_start=1
                     /product="immunoglobulin superfamily containing
                     leucine-rich repeat protein precursor"
                     /protein_id="NP_005536.1"
                     /db_xref="CCDS:CCDS10260.1"
                     /db_xref="GeneID:3671"
                     /db_xref="HGNC:HGNC:6133"
                     /db_xref="MIM:602059"
                     /translation="MQELHLLWWALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESV
                     PPGFPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKS
                     LDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHT
                     LAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKG
                     TPLSRLPPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSG
                     IVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELG
                     SAESSVDVALATPGEGGEDTLGRRFHGKAVEGKGCYTVDNEVQPSGPEDNVVIIYLSR
                     AGNPEAAVAEGVPGQLPPGLLLLGQSLLLFFFLTSF"
     regulatory      2310..2315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ISLR"
                     /gene_synonym="HsT17563; Meflin"
                     /note="hexamer: AATAAA"
     polyA_site      2331
                     /gene="ISLR"
                     /gene_synonym="HsT17563; Meflin"
                     /note="major polyA site"
ORIGIN      
        1 gtcacttatg aaacacaggt ccttgttgct gcagagaagc agttgttttg ctggaaggag
       61 ggagtgcgcg ggctgccccg ggctcctccc tgccgcctcc tctcagtgga tggttccagg
      121 caccctgtct ggggcaggga gggcacaggc ctgcacatcg aaggtggggt gggaccaggc
      181 tgcccctcgc cccagcatcc aagtcctccc ttgggcgccc gtggccctgc agactctcag
      241 ggctaaggtc ctctgttgct ttttggttcc accttagaag aggctccgct tgactaagag
      301 tagcttgaag gaggcaccat gcaggagctg catctgctct ggtgggcgct tctcctgggc
      361 ctggctcagg cctgccctga gccctgcgac tgtggggaaa agtatggctt ccagatcgcc
      421 gactgtgcct accgcgacct agaatccgtg ccgcctggct tcccggccaa tgtgactaca
      481 ctgagcctgt cagccaaccg gctgccaggc ttgccggagg gtgccttcag ggaggtgccc
      541 ctgctgcagt cgctgtggct ggcacacaat gagatccgca cggtggccgc cggagccctg
      601 gcctctctga gccatctcaa gagcctggac ctcagccaca atctcatctc tgactttgcc
      661 tggagcgacc tgcacaacct cagtgccctc caattgctca agatggacag caacgagctg
      721 accttcatcc cccgcgacgc cttccgcagc ctccgtgctc tgcgctcgct gcaactcaac
      781 cacaaccgct tgcacacatt ggccgagggc accttcaccc cgctcaccgc gctgtcccac
      841 ctgcagatca acgagaaccc cttcgactgc acctgcggca tcgtgtggct caagacatgg
      901 gccctgacca cggccgtgtc catcccggag caggacaaca tcgcctgcac ctcaccccat
      961 gtgctcaagg gtacgccgct gagccgcctg ccgccactgc catgctcggc gccctcagtg
     1021 cagctcagct accaacccag ccaggatggt gccgagctgc ggcctggttt tgtgctggca
     1081 ctgcactgtg atgtggacgg gcagccggcc cctcagcttc actggcacat ccagataccc
     1141 agtggcattg tggagatcac cagccccaac gtgggcactg atgggcgtgc cctgcctggc
     1201 acccctgtgg ccagctccca gccgcgcttc caggcctttg ccaatggcag cctgcttatc
     1261 cccgactttg gcaagctgga ggaaggcacc tacagctgcc tggccaccaa tgagctgggc
     1321 agtgctgaga gctcagtgga cgtggcactg gccacgcccg gtgagggtgg tgaggacaca
     1381 ctggggcgca ggttccatgg caaagcggtt gagggaaagg gctgctatac ggttgacaac
     1441 gaggtgcagc catcagggcc ggaggacaat gtggtcatca tctacctcag ccgtgctggg
     1501 aaccctgagg ctgcagtcgc agaaggggtc cctgggcagc tgcccccagg cctgctcctg
     1561 ctgggccaaa gcctcctcct cttcttcttc ctcacctcct tctagcccca cccagggctt
     1621 ccctaactcc tccccttgcc cctaccaatg cccctttaag tgctgcaggg gtctggggtt
     1681 ggcaactcct gaggcctgca tgggtgactt cacattttcc tacctctcct tctaatctct
     1741 tctagagcac ctgctatccc caacttctag acctgctcca aactagtgac taggatagaa
     1801 tttgatcccc taactcactg tctgcggtgc tcattgctgc taacagcatt gcctgtgctc
     1861 tcctctcagg ggcagcatgc taacggggcg acgtcctaat ccaactggga gaagcctcag
     1921 tggtggaatt ccaggcactg tgactgtcaa gctggcaagg gccaggattg ggggaatgga
     1981 gctggggctt agctgggagg tggtctgaag cagacaggga atgggagagg aggatgggaa
     2041 gtagacagtg gctggtatgg ctctgaggct ccctggggcc tgctcaagct cctcctgctc
     2101 cttgctgttt tctgatgatt tgggggcttg ggagtccctt tgtcctcatc tgagactgaa
     2161 atgtggggat ccaggatggc cttccttcct cttacccttc ctccctcagc ctgcaacctc
     2221 tatcctggaa cctgtcctcc ctttctcccc aactatgcat ctgttgtctg ctcctctgca
     2281 aaggccagcc agcttgggag cagcagagaa ataaacagca tttctgatgc c
//
