LOCUS       NM_145805               1831 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ISL LIM homeobox 2 (ISL2), mRNA.
ACCESSION   NM_145805
VERSION     NM_145805.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1831)
  AUTHORS   Ozturk,H., Cingoz,H., Tufan,T., Yang,J., Adair,S.J., Tummala,K.S.,
            Kuscu,C., Kinali,M., Comertpay,G., Nagdas,S., Goudreau,B.J.,
            Luleyap,H.U., Bingul,Y., Ware,T.B., Hwang,W.L., Hsu,K.L.,
            Kashatus,D.F., Ting,D.T., Chandel,N.S., Bardeesy,N., Bauer,T.W. and
            Adli,M.
  TITLE     ISL2 is a putative tumor suppressor whose epigenetic silencing
            reprograms the metabolism of pancreatic cancer
  JOURNAL   Dev Cell 57 (11), 1331-1346 (2022)
   PUBMED   35508175
  REMARK    GeneRIF: ISL2 is a putative tumor suppressor whose epigenetic
            silencing reprograms the metabolism of pancreatic cancer.
REFERENCE   2  (bases 1 to 1831)
  AUTHORS   Goos,H., Kinnunen,M., Salokas,K., Tan,Z., Liu,X., Yadav,L.,
            Zhang,Q., Wei,G.H. and Varjosalo,M.
  TITLE     Human transcription factor protein interaction networks
  JOURNAL   Nat Commun 13 (1), 766 (2022)
   PUBMED   35140242
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1831)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1831)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1831)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 1831)
  AUTHORS   Dykes,I.M., Lanier,J., Eng,S.R. and Turner,E.E.
  TITLE     Brn3a regulates neuronal subtype specification in the trigeminal
            ganglion by promoting Runx expression during sensory
            differentiation
  JOURNAL   Neural Dev 5, 3 (2010)
   PUBMED   20096094
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1831)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   8  (bases 1 to 1831)
  AUTHORS   Li,Y., Zhang,Y., He,B., Wang,Y., Yuan,Z., Yuan,W., Liao,P.,
            Deng,Y., Xiao,J., Zhu,C., Wang,Y., Wu,X. and Liu,M.
  TITLE     Cloning and expression of a novel human gene, Isl-2, encoded a
            LIM-homeodomain protein
  JOURNAL   Mol Biol Rep 34 (1), 19-26 (2007)
   PUBMED   17091338
  REMARK    GeneRIF: The broad expression of Isl-2 gene in tissues during
            embryogenesis and adult development suggests that it may be
            involved in both differentiation and maintenance of these tissues
            and might play an important role.
REFERENCE   9  (bases 1 to 1831)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   10 (bases 1 to 1831)
  AUTHORS   Jurata,L.W., Pfaff,S.L. and Gill,G.N.
  TITLE     The nuclear LIM domain interactor NLI mediates homo- and
            heterodimerization of LIM domain transcription factors
  JOURNAL   J Biol Chem 273 (6), 3152-3157 (1998)
   PUBMED   9452425
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB055557.1, BC012136.1 and AC027243.20.
            
            On Nov 22, 2018 this sequence version replaced NM_145805.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012136.1, SRR1163657.507285.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000290759.9/ ENSP00000290759.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                DB055557.1         50-82
            34-353              BC012136.1         1-320
            354-354             AC027243.20        33371-33371         c
            355-1831            BC012136.1         322-1798
FEATURES             Location/Qualifiers
     source          1..1831
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.3"
     gene            1..1831
                     /gene="ISL2"
                     /note="ISL LIM homeobox 2"
                     /db_xref="GeneID:64843"
                     /db_xref="HGNC:HGNC:18524"
                     /db_xref="MIM:609481"
     exon            1..169
                     /gene="ISL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1191
                     /gene="ISL2"
                     /note="ISL2 transcription factor, LIM/homeodomain,
                     (islet-2)"
                     /codon_start=1
                     /product="insulin gene enhancer protein ISL-2"
                     /protein_id="NP_665804.1"
                     /db_xref="CCDS:CCDS10290.1"
                     /db_xref="GeneID:64843"
                     /db_xref="HGNC:HGNC:18524"
                     /db_xref="MIM:609481"
                     /translation="MVDIIFHYPFLGAMGDHSKKKPGTAMCVGCGSQIHDQFILRVSP
                     DLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRLFGIKCAKCQVGFSSSDLV
                     MRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCRADHGLLLERAAAGSPRSPGP
                     LPGARGLHLPDAGSGRQPALRPHVHKQTEKTTRVRTVLNEKQLHTLRTCYAANPRPDA
                     LMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHSDKTSLQGLTGTPLV
                     AGSPIRHENAVQGSAVEVQTYQPPWKALSEFALQSDLDQPAFQQLVSFSESGSLGNSS
                     GSDVTSLSSQLPDTPNSMVPSPVET"
     exon            170..359
                     /gene="ISL2"
                     /inference="alignment:Splign:2.1.0"
     exon            360..622
                     /gene="ISL2"
                     /inference="alignment:Splign:2.1.0"
     exon            623..906
                     /gene="ISL2"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1074
                     /gene="ISL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1831
                     /gene="ISL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1811..1816
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ISL2"
                     /note="hexamer: AATAAA"
     polyA_site      1831
                     /gene="ISL2"
                     /note="major polyA site"
ORIGIN      
        1 ccttcaactc cgcggggcag taggagttag ttagcaaaga gccgaggccg ggcgcgcgac
       61 cctcgtcctt ctgcccctgg ccgcacactt tgcgcacatc tctttttctg catggtggat
      121 attatttttc attatccttt tctgggtgct atgggtgatc attccaagaa gaagcccggg
      181 acggccatgt gcgtgggctg cgggagtcag atccacgacc agtttatcct gcgggtgtcg
      241 cccgacctcg agtggcacgc ggcctgcctc aagtgtgccg agtgcagcca gtacctggac
      301 gagacgtgca cgtgcttcgt gagagacggg aagacctact gcaagcggga ctatgtcagg
      361 ctgttcggca tcaagtgcgc caagtgccag gtgggcttca gcagcagcga cctggtgatg
      421 agggcgcggg acagcgtgta ccacatcgag tgcttccgct gctccgtgtg cagccgccag
      481 ctgctgcctg gggacgagtt ctcgctgcgg gagcacgagc tgctctgccg cgccgaccac
      541 ggcctcctgc tcgagcgcgc cgcggccggc agcccgcgca gccccggccc gcttcccggc
      601 gcccgcggcc tgcatctgcc cgacgctggg tcgggccggc agcccgcgtt gcgcccgcac
      661 gtgcacaagc agacggagaa gacgacccgc gtgcggactg tgctgaacga gaagcagctg
      721 cacactctgc ggacctgcta cgccgccaac ccgcggcccg acgctctcat gaaggagcag
      781 ctggtggaga tgaccggcct gagcccgcgg gtcatccgcg tctggttcca gaacaagcgc
      841 tgcaaggaca agaagaaatc cattctcatg aagcagctgc agcagcagca gcacagcgac
      901 aagacgagcc ttcagggact gactgggacg cccctggtgg cgggcagtcc catccgccat
      961 gagaacgccg tgcagggcag cgcagtggag gtgcagacgt accagccgcc gtggaaggcg
     1021 ctcagcgagt ttgccctcca gagcgacctg gaccaacccg ccttccaaca gctggtctcc
     1081 ttctccgagt ccggctccct aggcaactcc tccggcagcg acgtgacctc cctgtcctcg
     1141 cagctcccgg acacccccaa cagtatggtg ccgagtcccg tggagacgtg agggggaccc
     1201 ctccctgcca gcccgcggac ctcgcatgct ccctgcatga gactcaccca tgctcaggcc
     1261 attccagttc cgaaagctct ctcgccttcg taattattct attgttattt atgagagagt
     1321 accgagagac acggtctgga cagcccaagg cgccaggatg caacctgctt tcaccagact
     1381 gcagacccct gctccgagga ctcttagttt ttcaaaacca gaatctggga cttaccaggg
     1441 ttagctctgc cctctcctct cctctctacg tggccgccgc tctgtctctc cacgccccac
     1501 ctgtgtcccc atctcggccg gcccggagct cgcccacgcg gacccccgcc ctgccccagc
     1561 tcagcgctcc ctggcggctt cgcccgggct cctagcgggg aaaaggaagg ggataactca
     1621 gaggaacaga cactcaaact cccaaagcgc atgattgctg ggaaacagta gaaaccagac
     1681 ttgccttgaa agtgtttaag ttattcgacg gaggacagag tatgtgagcc tttgccgaac
     1741 aaacaaacgt aagttattgt tatttattgt gagaacagcc agttcatagt gggacttgta
     1801 ttttgatctt aataaaaaat aataacccgg g
//
