LOCUS       NM_001370150            2985 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens interferon stimulated exonuclease gene 20 like 2
            (ISG20L2), transcript variant 2, mRNA.
ACCESSION   NM_001370150 XM_005245516
VERSION     NM_001370150.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2985)
  AUTHORS   Ma,Y., Wang,J., He,X., Liu,Y., Zhen,S., An,L., Yang,Q., Niu,F.,
            Wang,H., An,B., Tai,X., Yan,Z., Wu,C., Yang,X. and Liu,X.
  TITLE     Molecular mechanism of human ISG20L2 for the ITS1 cleavage in the
            processing of 18S precursor ribosomal RNA
  JOURNAL   Nucleic Acids Res 52 (4), 1878-1895 (2024)
   PUBMED   38153123
  REMARK    GeneRIF: Molecular mechanism of human ISG20L2 for the ITS1 cleavage
            in the processing of 18S precursor ribosomal RNA.
REFERENCE   2  (bases 1 to 2985)
  AUTHORS   Rodriguez-Galan,A., Dosil,S.G., Hrckova,A., Fernandez-Messina,L.,
            Feketova,Z., Pokorna,J., Fernandez-Delgado,I., Camafeita,E.,
            Gomez,M.J., Ramirez-Huesca,M., Gutierrez-Vazquez,C.,
            Sanchez-Cabo,F., Vazquez,J., Vanacova,S. and Sanchez-Madrid,F.
  TITLE     ISG20L2: an RNA nuclease regulating T cell activation
  JOURNAL   Cell Mol Life Sci 80 (9), 273 (2023)
   PUBMED   37646974
  REMARK    GeneRIF: ISG20L2: an RNA nuclease regulating T cell activation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2985)
  AUTHORS   Zhu,Y., Zhou,C. and He,Q.
  TITLE     High miR-139-3p expression predicts a better prognosis for
            hepatocellular carcinoma: a pooled analysis
  JOURNAL   J Int Med Res 47 (1), 383-390 (2019)
   PUBMED   30394818
  REMARK    GeneRIF: miR-139-3p target genes ISG20L2, RAD54B, KIAA0101, and
            PIGS were significantly negatively correlated with miR-139-3p
            expression in patients with hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 2985)
  AUTHORS   Simabuco,F.M., Morello,L.G., Aragao,A.Z., Paes Leme,A.F. and
            Zanchin,N.I.
  TITLE     Proteomic characterization of the human FTSJ3 preribosomal
            complexes
  JOURNAL   J Proteome Res 11 (6), 3112-3126 (2012)
   PUBMED   22540864
REFERENCE   5  (bases 1 to 2985)
  AUTHORS   Zhou,Z., Wang,N., Woodson,S.E., Dong,Q., Wang,J., Liang,Y.,
            Rijnbrand,R., Wei,L., Nichols,J.E., Guo,J.T., Holbrook,M.R.,
            Lemon,S.M. and Li,K.
  TITLE     Antiviral activities of ISG20 in positive-strand RNA virus
            infections
  JOURNAL   Virology 409 (2), 175-188 (2011)
   PUBMED   21036379
REFERENCE   6  (bases 1 to 2985)
  AUTHORS   Coute,Y., Kindbeiter,K., Belin,S., Dieckmann,R., Duret,L.,
            Bezin,L., Sanchez,J.C. and Diaz,J.J.
  TITLE     ISG20L2, a novel vertebrate nucleolar exoribonuclease involved in
            ribosome biogenesis
  JOURNAL   Mol Cell Proteomics 7 (3), 546-559 (2008)
   PUBMED   18065403
  REMARK    GeneRIF: ISG20L2 is a 3' to 5' exoribonuclease involved in ribosome
            biogenesis at the level of 5.8 S rRNA maturation, more specifically
            in the processing of the 12 S precursor rRNA.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590666.8.
            
            On Aug 27, 2019 this sequence version replaced NM_001370150.1.
            
            Summary: This gene encodes a 3'-5' exoribonuclease that may be
            involved in the processing of the 12S pre-rRNA. Pseudogenes have
            been identified on chromosomes 6 and 11. [provided by RefSeq, Dec
            2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1299108.1,
                                           SRR1660803.22730.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368219.2/ ENSP00000357202.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-352               AL590666.8         77040-77391         c
            353-1216            AL590666.8         75531-76394         c
            1217-1417           AL590666.8         72773-72973         c
            1418-2985           AL590666.8         70520-72087         c
FEATURES             Location/Qualifiers
     source          1..2985
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.1"
     gene            1..2985
                     /gene="ISG20L2"
                     /gene_synonym="HSD38"
                     /note="interferon stimulated exonuclease gene 20 like 2"
                     /db_xref="GeneID:81875"
                     /db_xref="HGNC:HGNC:25745"
                     /db_xref="MIM:611930"
     exon            1..352
                     /gene="ISG20L2"
                     /gene_synonym="HSD38"
                     /inference="alignment:Splign:2.1.0"
     exon            353..1216
                     /gene="ISG20L2"
                     /gene_synonym="HSD38"
                     /inference="alignment:Splign:2.1.0"
     CDS             470..1531
                     /gene="ISG20L2"
                     /gene_synonym="HSD38"
                     /note="interferon stimulated exonuclease gene 20kDa like
                     2"
                     /codon_start=1
                     /product="interferon-stimulated 20 kDa exonuclease-like 2"
                     /protein_id="NP_001357079.1"
                     /db_xref="CCDS:CCDS1153.1"
                     /db_xref="GeneID:81875"
                     /db_xref="HGNC:HGNC:25745"
                     /db_xref="MIM:611930"
                     /translation="MSTLLLNLDFGEPPPKKALEGNAKHRNFVKKRRLLERRGFLSKK
                     NQPPSKAPKLHSEPSKKGETPTVDGTWKTPSFPKKKTAASSNGSGQPLDKKAAVSWLT
                     PAPSKKADSVAAKVDLLGEFQSALPKINSHPTRSQKKSSQKKSSKKNHPQKNAPQNST
                     QAHSENKCSGASQKLPRKMVAIDCEMVGTGPKGHVSSLARCSIVNYNGDVLYDEYILP
                     PCHIVDYRTRWSGIRKQHMVNATPFKIARGQILKILTGKIVVGHAIHNDFKALQYFHP
                     KSLTRDTSHIPPLNRKADCPENATMSLKHLTKKLLNRDIQVGKSGHSSVEDAQATMEL
                     YKLVEVEWEEHLARNPPTD"
     exon            1217..1417
                     /gene="ISG20L2"
                     /gene_synonym="HSD38"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..2985
                     /gene="ISG20L2"
                     /gene_synonym="HSD38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2964..2969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ISG20L2"
                     /gene_synonym="HSD38"
                     /note="hexamer: GATAAA"
     polyA_site      2985
                     /gene="ISG20L2"
                     /gene_synonym="HSD38"
                     /note="major polyA site"
ORIGIN      
        1 acactcctct cctcttacgg aagtgaagcc ggaggtgtcc ggcgggctgc agttccggtt
       61 tatcgcggcc ttcccacacc ttcgcgttgt accaccacgg ggctagaggg gccggggagc
      121 gcatcccgcc cccgccccca cccacgccgc cccctcctcc gccgccactg ccgctcctca
      181 cacactcgga atcactggcc tcactacctg gggtcggggc ggtgcgggtg tgcgcgcgcc
      241 gacctctggc gcgttctaac ccgcgcgcct gccttcccgg gcttcgtcgg cgcgcaccga
      301 tttccgcatc cggctccgga cgcttccggt cttagctgga cccgtctggg agggtgtact
      361 acagacctcc acatgttgga cagtaggatt cagcagagaa tgagtcccac atcctctttt
      421 catccataag ccactcttcc caactactct tccgccttcc attgtcccta tgtctacttt
      481 actgctcaat ctggattttg gggaacctcc tcccaaaaag gcattagaag gaaatgccaa
      541 gcaccgaaat tttgtcaaga agcggaggct cttagaacgg agaggctttc tgagtaaaaa
      601 gaaccaaccc cctagcaagg cgcctaagtt gcactctgaa ccttcaaaga aaggggaaac
      661 tcctacggtc gatggcactt ggaagacccc ttccttccca aaaaagaaga cagctgcttc
      721 cagcaatggg tcaggacagc ccctggacaa gaaagctgca gtgtcttggt tgacccctgc
      781 cccttcaaaa aaggctgatt ctgttgctgc taaagtagat ttgctggggg agttccagag
      841 tgcccttcca aagatcaata gccacccaac ccgctctcag aagaagagct cccagaagaa
      901 atcctctaaa aagaaccatc ctcagaagaa tgccccacag aactccaccc aagctcattc
      961 agagaataaa tgctccggag catcccagaa gttgccacgg aagatggtgg caattgactg
     1021 tgagatggtg ggcacaggac caaaggggca tgttagttcc ttggctcgat gtagcattgt
     1081 caactacaac ggagatgtgc tttatgacga gtacattctt cccccctgcc acattgtgga
     1141 ctaccgaacc aggtggagtg gtatccggaa gcagcacatg gtgaatgcca cacccttcaa
     1201 gattgctcga ggccagatct tgaagatact cacagggaag atagtggtgg ggcatgccat
     1261 ccacaacgac ttcaaagccc ttcagtactt tcaccccaag tccctcaccc gtgacacctc
     1321 ccatatcccc cccctcaacc ggaaggctga ctgcccggag aatgccacca tgtctctgaa
     1381 gcatctcacc aagaagctgc taaaccggga tatccaggtt gggaagagcg gacattcctc
     1441 tgtggaagat gcccaggcca ccatggagct atataagttg gttgaagtcg agtgggaaga
     1501 gcacctagcc cggaatcccc ctacagacta gtggcagtgg ggacgctggt gatatgagga
     1561 ggcagaggca gcacccagga gaaacagggc agtggaccaa tggacagctc caccagctcc
     1621 acatctttgg aagctagatt tggggagaga gaagctctac cccagactta atacccattg
     1681 aaatttcacc tcaggtgttg tgtcctgtgt ctggttaagt gtcccatgga aggggaaagc
     1741 cttcacgtca gaacccaacc ctataccttt tacttcttaa atggtgctaa ccacaggtgt
     1801 cccagggtgc tctgtgccag ttaagatttt taactttcaa ggggcagggc atactgggaa
     1861 atgtagtttc ccaaactgcc ttatcacttg ggtggacata tgtctccttt tatgcctttt
     1921 ggtcttgagt aattaacagc atcctcttcc acgctcagaa gtgttctggt tggggccagg
     1981 catggtggct cacacctgta gtcccaacac ttagggaggc cgaggcgggc ggatcacctg
     2041 agatcaggag ttcaagacca gcctggccaa catggcgaat tcccgttctc tactaaaaat
     2101 acaaaaaatg tgtggggtgt ggtggcagga gcctgtaatc ctagctactc aggaggctga
     2161 ggcaggagaa tcgcttgagc ccaggaggcg gagattgcag tgagccgaga tcgtgtcact
     2221 gcactccagc ctgggtgaca agagtgagac tccgtctcca aaaaaaaaaa aaaagaattt
     2281 attaacctgg ttggttaata aattgtgtgg tccctgccgg gcgtggtggc tcacgcctgt
     2341 aatcccagca ctttgggagg ccgagacggg cagatcacga ggtcaggaga tcgagaccat
     2401 cctggctaac acggtgaaac cccgtctcta ctaaaaatac aaaaaattag ccaggcgtgg
     2461 tggcgggcac ctgtagttcc agctacttgg gaggctgagg caggagaatg gcgtgaaccc
     2521 aggaggcgga gcttgcagtg agccgagatt gtgccactgc actccagcct gggccacggc
     2581 cacagagcga gactctgtct caaaaaaaaa aaaaaattaa aattgtgtgg tccctttcca
     2641 tgtcacagag tctgcttttg gctcagagtc tgtatctagc ctgtgtcagg atattgcctg
     2701 ttcttcccac cttgacttcc agagcagcca tcgctggtga gctttagttc tccttagggt
     2761 tccaaggcat tagaagtaag agtgtagctt ggaaaccaac ttctgtgatt taggaaagct
     2821 gtctctttcc taaggtaata gggggtttat ttcatttagg ccccagttgg taggttttaa
     2881 aataatttat aaagtgtttt aataatttgg ttgtcttttt taccttgcta aaccaagcct
     2941 ctaaaaactc aaattattcc cttgataaat ttttataatg gaaaa
//
