LOCUS       NM_002201               1583 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens interferon stimulated exonuclease gene 20 (ISG20),
            transcript variant 1, mRNA.
ACCESSION   NM_002201
VERSION     NM_002201.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1583)
  AUTHORS   Du,H., Sun,J., Wang,X., Zhao,L., Liu,X., Zhang,C., Wang,F. and
            Wu,J.
  TITLE     FOSL2-mediated transcription of ISG20 induces M2 polarization of
            macrophages and enhances tumorigenic ability of glioblastoma cells
  JOURNAL   J Neurooncol 169 (3), 659-670 (2024)
   PUBMED   39073688
  REMARK    GeneRIF: FOSL2-mediated transcription of ISG20 induces M2
            polarization of macrophages and enhances tumorigenic ability of
            glioblastoma cells.
REFERENCE   2  (bases 1 to 1583)
  AUTHORS   Wang,Y., Suo,J., Wang,Z., Ran,K., Tian,Y., Han,W., Liu,Y. and
            Peng,X.
  TITLE     The PTPRZ1-MET/STAT3/ISG20 axis in glioma stem-like cells modulates
            tumor-associated macrophage polarization
  JOURNAL   Cell Signal 120, 111191 (2024)
   PUBMED   38685521
  REMARK    GeneRIF: The PTPRZ1-MET/STAT3/ISG20 axis in glioma stem-like cells
            modulates tumor-associated macrophage polarization.
REFERENCE   3  (bases 1 to 1583)
  AUTHORS   Karasawa,T., Sato,R., Imaizumi,T., Fujita,M., Aizawa,T.,
            Tsugawa,K., Mattinzoli,D., Kawaguchi,S., Seya,K., Terui,K., Joh,K.
            and Tanaka,H.
  TITLE     Expression of interferon-stimulated gene 20 (ISG20), an antiviral
            effector protein, in glomerular endothelial cells: possible
            involvement of ISG20 in lupus nephritis
  JOURNAL   Ren Fail 45 (1), 2224890 (2023)
   PUBMED   37340981
  REMARK    GeneRIF: Expression of interferon-stimulated gene 20 (ISG20), an
            antiviral effector protein, in glomerular endothelial cells:
            possible involvement of ISG20 in lupus nephritis.
REFERENCE   4  (bases 1 to 1583)
  AUTHORS   Luo,H., Zhu,Y., Guo,B., Ruan,Z., Liu,Z., Fan,Z. and Zhao,S.
  TITLE     Causal relationships between CD25 on immune cells and hip
            osteoarthritis
  JOURNAL   Front Immunol 14, 1247710 (2023)
   PUBMED   37731506
  REMARK    GeneRIF: Causal relationships between CD25 on immune cells and hip
            osteoarthritis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1583)
  AUTHORS   Chen,Z., Yin,M., Jia,H., Chen,Q. and Zhang,H.
  TITLE     ISG20 stimulates anti-tumor immunity via a double-stranded
            RNA-induced interferon response in ovarian cancer
  JOURNAL   Front Immunol 14, 1176103 (2023)
   PUBMED   37342328
  REMARK    GeneRIF: ISG20 stimulates anti-tumor immunity via a double-stranded
            RNA-induced interferon response in ovarian cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1583)
  AUTHORS   Izmailova,E., Bertley,F.M., Huang,Q., Makori,N., Miller,C.J.,
            Young,R.A. and Aldovini,A.
  TITLE     HIV-1 Tat reprograms immature dendritic cells to express
            chemoattractants for activated T cells and macrophages
  JOURNAL   Nat Med 9 (2), 191-197 (2003)
   PUBMED   12539042
REFERENCE   7  (bases 1 to 1583)
  AUTHORS   Nguyen,L.H., Espert,L., Mechti,N. and Wilson,D.M. 3rd.
  TITLE     The human interferon- and estrogen-regulated ISG20/HEM45 gene
            product degrades single-stranded RNA and DNA in vitro
  JOURNAL   Biochemistry 40 (24), 7174-7179 (2001)
   PUBMED   11401564
REFERENCE   8  (bases 1 to 1583)
  AUTHORS   Pentecost,B.T.
  TITLE     Expression and estrogen regulation of the HEM45 MRNA in human tumor
            lines and in the rat uterus
  JOURNAL   J Steroid Biochem Mol Biol 64 (1-2), 25-33 (1998)
   PUBMED   9569007
REFERENCE   9  (bases 1 to 1583)
  AUTHORS   Gongora,C., David,G., Pintard,L., Tissot,C., Hua,T.D., Dejean,A.
            and Mechti,N.
  TITLE     Molecular cloning of a new interferon-induced PML nuclear
            body-associated protein
  JOURNAL   J Biol Chem 272 (31), 19457-19463 (1997)
   PUBMED   9235947
REFERENCE   10 (bases 1 to 1583)
  AUTHORS   Mattei,M.G., Tissot,C., Gongora,C. and Mechti,N.
  TITLE     Assignment of ISG20 encoding a new interferon-induced PML nuclear
            body-associated protein, to chromosome 15q26 by in situ
            hybridization
  JOURNAL   Cytogenet Cell Genet 79 (3-4), 286-287 (1997)
   PUBMED   9605874
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG759382.1, BC007922.2, BX339191.2, AK307769.1 and AC104259.14.
            
            On Nov 22, 2018 this sequence version replaced NM_002201.5.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Variants 1, 2, and 3 all encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.154782.1,
                                           SRR1660809.129679.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306072.10/ ENSP00000306565.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                BG759382.1         275-358
            85-498              BC007922.2         293-706
            499-663             BX339191.2         710-874
            664-1303            AK307769.1         735-1374
            1304-1304           AC104259.14        52960-52960         c
            1305-1398           AK307769.1         1376-1469
            1399-1399           AC104259.14        52865-52865         c
            1400-1444           AK307769.1         1471-1515
            1445-1583           AC104259.14        52681-52819         c
FEATURES             Location/Qualifiers
     source          1..1583
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..1583
                     /gene="ISG20"
                     /gene_synonym="CD25; HEM45"
                     /note="interferon stimulated exonuclease gene 20"
                     /db_xref="GeneID:3669"
                     /db_xref="HGNC:HGNC:6130"
                     /db_xref="MIM:604533"
     exon            1..61
                     /gene="ISG20"
                     /gene_synonym="CD25; HEM45"
                     /inference="alignment:Splign:2.1.0"
     exon            62..313
                     /gene="ISG20"
                     /gene_synonym="CD25; HEM45"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..631
                     /gene="ISG20"
                     /gene_synonym="CD25; HEM45"
                     /EC_number="3.1.13.1"
                     /note="isoform a is encoded by transcript variant 1;
                     interferon-stimulated gene 20 kDa protein;
                     estrogen-regulated transcript 45 protein; promyelocytic
                     leukemia nuclear body-associated protein ISG20; interferon
                     stimulated exonuclease gene 20kDa"
                     /codon_start=1
                     /product="interferon-stimulated gene 20 kDa protein
                     isoform a"
                     /protein_id="NP_002192.2"
                     /db_xref="CCDS:CCDS10345.1"
                     /db_xref="GeneID:3669"
                     /db_xref="HGNC:HGNC:6130"
                     /db_xref="MIM:604533"
                     /translation="MAGSREVVAMDCEMVGLGPHRESGLARCSLVNVHGAVLYDKFIR
                     PEGEITDYRTRVSGVTPQHMVGATPFAVARLEILQLLKGKLVVGHDLKHDFQALKEDM
                     SGYTIYDTSTDRLLWREAKLDHCRRVSLRVLSERLLHKSIQNSLLGHSSVEDARATME
                     LYQISQRIRARRGLPRLAVSD"
     exon            314..514
                     /gene="ISG20"
                     /gene_synonym="CD25; HEM45"
                     /inference="alignment:Splign:2.1.0"
     exon            515..1583
                     /gene="ISG20"
                     /gene_synonym="CD25; HEM45"
                     /inference="alignment:Splign:2.1.0"
     regulatory      706..711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ISG20"
                     /gene_synonym="CD25; HEM45"
                     /note="hexamer: AATACA"
     regulatory      720..725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ISG20"
                     /gene_synonym="CD25; HEM45"
                     /note="hexamer: AGTAAA"
     polyA_site      725
                     /gene="ISG20"
                     /gene_synonym="CD25; HEM45"
     polyA_site      750
                     /gene="ISG20"
                     /gene_synonym="CD25; HEM45"
                     /note="major polyA site"
     regulatory      1562..1567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ISG20"
                     /gene_synonym="CD25; HEM45"
                     /note="hexamer: AATAAA"
     polyA_site      1583
                     /gene="ISG20"
                     /gene_synonym="CD25; HEM45"
ORIGIN      
        1 gcagtagctg agcagtggca gcagagaggc agacgtgagc tgagggcgca gaggcaggca
       61 gcatctctga gggtccccaa ggaacatggc tgggagccgt gaggtggtgg ccatggactg
      121 cgagatggtg gggctggggc cccaccggga gagtggcctg gctcgttgca gcctcgtgaa
      181 cgtccacggt gctgtgctgt acgacaagtt catccggcct gagggagaga tcaccgatta
      241 cagaacccgg gtcagcgggg tcacccctca gcacatggtg ggggccacac catttgccgt
      301 ggccaggcta gagatcctgc agctcctgaa aggcaagctg gtggtgggtc atgacctgaa
      361 gcacgacttc caggcactga aagaggacat gagcggctac acaatctacg acacgtccac
      421 tgacaggctg ttgtggcgtg aggccaagct ggaccactgc aggcgtgtct ccctgcgggt
      481 gctgagtgag cgcctcctac acaagagcat ccagaacagc ctgcttggac acagctcggt
      541 ggaagatgcg agggcaacga tggagctcta tcaaatctcc cagagaatcc gagcccgccg
      601 agggctgccc cgcctggctg tgtcagactg aagccccatc cagcccgttc cgcagggact
      661 agaggctttc ggctttttgg gacagcaact accttgcttt tggaaaatac atttttaata
      721 gtaaagtggc tctatatttt ctctacgcca tcactgggtc ctcttcttat tcttctctcc
      781 aagctgggtt aacagtagac aggacccatt tctgtgtgat gttaggaggg aatgaagtct
      841 tatgctgggg aggtgggcaa gtatcaattt ccttaatatc ttgaatcctg tgggtccaaa
      901 atgtggcttg gaaatctaag tagcatgtgg cttaattact aatcccaccc tttgctgttg
      961 catcccagcc ctattcctgg tgcatttatg cccagagagg tggcattatt tcctggggtg
     1021 gcattcagct cctcttgagt tggtgccaca gcatttgtgg gctttgaagc aaaggtacag
     1081 gaaatgtcaa gggtgccacc ccggcaacct tgagcaagtc acccctccta tttgtaaaat
     1141 gaggaaggaa aggtaacaaa ctgtggagtc agagagaagt aggttggaat cctctttgtc
     1201 atttagtagc tgtttgacct aaggtggttt actgaacttc tcagtttctc catctgtaaa
     1261 atgagaattc tagcaactcg tagggtattt gtgagatgtt gcaggcaaag cccccagcac
     1321 catgcctgtc ctagcttaag cacccaccag gtgtcgataa gtaattgttc ttccctggac
     1381 tgcctgcaca tctagggcac cccaggaaga gtcaccgcac tctgtttcgg ggctcggctc
     1441 tctgagggga gggcatcctg tatggggagg agggtctgga ccagagctgt ccctgatcgc
     1501 tagaatcaac ggcagaattc ttgttatttt aataataatt aataatttag tgcttccact
     1561 aaataaaaat cattggaatg gtg
//
