LOCUS       NM_005101                637 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens ISG15 ubiquitin like modifier (ISG15), mRNA.
ACCESSION   NM_005101
VERSION     NM_005101.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 637)
  AUTHORS   Cui,N., Liu,C., Tang,X., Song,L., Xiao,Z., Wang,C., Wu,Y., Zhou,Y.,
            Peng,C., Liu,Y., Zheng,L., Liu,X., Huang,K. and Chen,H.
  TITLE     ISG15 accelerates acute kidney injury and the subsequent AKI-to-CKD
            transition by promoting TGFbetaR1 ISGylation
  JOURNAL   Theranostics 14 (11), 4536-4553 (2024)
   PUBMED   39113797
  REMARK    GeneRIF: ISG15 accelerates acute kidney injury and the subsequent
            AKI-to-CKD transition by promoting TGFbetaR1 ISGylation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 637)
  AUTHORS   Homma,H., Yoshioka,Y., Fujita,K., Shirai,S., Hama,Y., Komano,H.,
            Saito,Y., Yabe,I., Okano,H., Sasaki,H., Tanaka,H. and Okazawa,H.
  TITLE     Dynamic molecular network analysis of iPSC-Purkinje cells
            differentiation delineates roles of ISG15 in SCA1 at the earliest
            stage
  JOURNAL   Commun Biol 7 (1), 413 (2024)
   PUBMED   38594382
  REMARK    GeneRIF: Dynamic molecular network analysis of iPSC-Purkinje cells
            differentiation delineates roles of ISG15 in SCA1 at the earliest
            stage.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 637)
  AUTHORS   Sefatjoo,Z., Mohebbi,S.R., Hosseini,S.M., Shoraka,S., Saeedi
            Niasar,M., Baghaei,K., Meyfour,A., Sadeghi,A., Malekpour,H.,
            Asadzadeh Aghdaei,H. and Zali,M.R.
  TITLE     Evaluation of long non-coding RNAs EGOT, NRAV, NRIR and mRNAs ISG15
            and IFITM3 expressions in COVID-19 patients
  JOURNAL   Cytokine 175, 156495 (2024)
   PUBMED   38184893
  REMARK    GeneRIF: Evaluation of long non-coding RNAs EGOT, NRAV, NRIR and
            mRNAs ISG15 and IFITM3 expressions in COVID-19 patients.
REFERENCE   4  (bases 1 to 637)
  AUTHORS   Meng,Y., Bian,L., Zhang,M., Zhou,P., Zhang,S., Ying,Y., Yang,S.,
            Liu,Y., Yao,Y. and Li,D.
  TITLE     ISG15 Promotes Progression and Gemcitabine Resistance of Pancreatic
            Cancer Cells Through ATG7
  JOURNAL   Int J Biol Sci 20 (4), 1180-1193 (2024)
   PUBMED   38385083
  REMARK    GeneRIF: ISG15 Promotes Progression and Gemcitabine Resistance of
            Pancreatic Cancer Cells Through ATG7.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 637)
  AUTHORS   Burleigh,A., Moraitis,E., Al Masroori,E., Al-Abadi,E., Hong,Y.,
            Omoyinmi,E., Titheradge,H., Stals,K., Jones,W.D., Gait,A.,
            Jayarajan,V., Di,W.L., Sebire,N., Solman,L., Ogboli,M., Welch,S.B.,
            Sudarsanam,A., Wacogne,I., Price-Kuehne,F., Jensen,B., Brogan,P.A.
            and Eleftheriou,D.
  TITLE     Case Report: ISG15 deficiency caused by novel variants in two
            families and effective treatment with Janus kinase inhibition
  JOURNAL   Front Immunol 14, 1287258 (2023)
   PUBMED   38115997
  REMARK    GeneRIF: Case Report: ISG15 deficiency caused by novel variants in
            two families and effective treatment with Janus kinase inhibition.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 637)
  AUTHORS   Loeb,K.R. and Haas,A.L.
  TITLE     The interferon-inducible 15-kDa ubiquitin homolog conjugates to
            intracellular proteins
  JOURNAL   J Biol Chem 267 (11), 7806-7813 (1992)
   PUBMED   1373138
REFERENCE   7  (bases 1 to 637)
  AUTHORS   Knight,E. Jr. and Cordova,B.
  TITLE     IFN-induced 15-kDa protein is released from human lymphocytes and
            monocytes
  JOURNAL   J Immunol 146 (7), 2280-2284 (1991)
   PUBMED   2005397
REFERENCE   8  (bases 1 to 637)
  AUTHORS   Clauss,I.M., Wathelet,M.G., Szpirer,J., Content,J., Islam,M.Q.,
            Levan,G., Szpirer,C. and Huez,G.A.
  TITLE     Chromosomal localization of two human genes inducible by
            interferons, double-stranded RNA, and viruses
  JOURNAL   Cytogenet Cell Genet 53 (2-3), 166-168 (1990)
   PUBMED   1695131
REFERENCE   9  (bases 1 to 637)
  AUTHORS   Feltham,N., Hillman,M. Jr., Cordova,B., Fahey,D., Larsen,B.,
            Blomstrom,D. and Knight,E. Jr.
  TITLE     A 15-kD interferon-induced protein and its 17-kD precursor:
            expression in Escherichia coli, purification, and characterization
  JOURNAL   J Interferon Res 9 (5), 493-507 (1989)
   PUBMED   2477469
REFERENCE   10 (bases 1 to 637)
  AUTHORS   Haas,A.L., Ahrens,P., Bright,P.M. and Ankel,H.
  TITLE     Interferon induces a 15-kilodalton protein exhibiting marked
            homology to ubiquitin
  JOURNAL   J Biol Chem 262 (23), 11315-11323 (1987)
   PUBMED   2440890
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL645608.30, M13755.1,
            BC009507.2 and BU161226.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 1, 2018 this sequence version replaced NM_005101.3.
            
            Summary: The protein encoded by this gene is a ubiquitin-like
            protein that is conjugated to intracellular target proteins upon
            activation by interferon-alpha and interferon-beta. Several
            functions have been ascribed to the encoded protein, including
            chemotactic activity towards neutrophils, direction of ligated
            target proteins to intermediate filaments, cell-to-cell signaling,
            and antiviral activity during viral infections. While conjugates of
            this protein have been found to be noncovalently attached to
            intermediate filaments, this protein is sometimes secreted.
            [provided by RefSeq, Dec 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU625929.1, CD174495.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000649529.1/ ENSP00000496832.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL645608.30        137347-137348
            3-184               M13755.1           1-182
            185-324             BC009507.2         149-288
            325-628             BU161226.1         312-615
            629-637             BC009507.2         593-601
FEATURES             Location/Qualifiers
     source          1..637
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.33"
     gene            1..637
                     /gene="ISG15"
                     /gene_synonym="G1P2; hUCRP; IFI15; IMD38; IP17; UCRP"
                     /note="ISG15 ubiquitin like modifier"
                     /db_xref="GeneID:9636"
                     /db_xref="HGNC:HGNC:4053"
                     /db_xref="MIM:147571"
     exon            1..80
                     /gene="ISG15"
                     /gene_synonym="G1P2; hUCRP; IFI15; IMD38; IP17; UCRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..575
                     /gene="ISG15"
                     /gene_synonym="G1P2; hUCRP; IFI15; IMD38; IP17; UCRP"
                     /note="interferon-stimulated protein, 15 kDa; interferon,
                     alpha-inducible protein (clone IFI-15K);
                     interferon-induced 17-kDa/15-kDa protein; ubiquitin
                     cross-reactive protein"
                     /codon_start=1
                     /product="ubiquitin-like protein ISG15"
                     /protein_id="NP_005092.1"
                     /db_xref="CCDS:CCDS6.1"
                     /db_xref="GeneID:9636"
                     /db_xref="HGNC:HGNC:4053"
                     /db_xref="MIM:147571"
                     /translation="MGWDLTVKMLAGNEFQVSLSSSMSVSELKAQITQKIGVHAFQQR
                     LAVHPSGVALQDRVPLASQGLGPGSTVLLVVDKCDEPLSILVRNNKGRSSTYEVRLTQ
                     TVAHLKQQVSGLEGVQDDLFWLTFEGKPLEDQLPLGEYGLKPLSTVFMNLRLRGGGTE
                     PGGRS"
     exon            81..637
                     /gene="ISG15"
                     /gene_synonym="G1P2; hUCRP; IFI15; IMD38; IP17; UCRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      614..619
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ISG15"
                     /gene_synonym="G1P2; hUCRP; IFI15; IMD38; IP17; UCRP"
                     /note="hexamer: AATAAA"
     polyA_site      637
                     /gene="ISG15"
                     /gene_synonym="G1P2; hUCRP; IFI15; IMD38; IP17; UCRP"
                     /note="major polyA site"
ORIGIN      
        1 ggcggctgag aggcagcgaa ctcatctttg ccagtacagg agcttgtgcc gtggcccaca
       61 gcccacagcc cacagccatg ggctgggacc tgacggtgaa gatgctggcg ggcaacgaat
      121 tccaggtgtc cctgagcagc tccatgtcgg tgtcagagct gaaggcgcag atcacccaga
      181 agatcggcgt gcacgccttc cagcagcgtc tggctgtcca cccgagcggt gtggcgctgc
      241 aggacagggt cccccttgcc agccagggcc tgggccccgg cagcacggtc ctgctggtgg
      301 tggacaaatg cgacgaacct ctgagcatcc tggtgaggaa taacaagggc cgcagcagca
      361 cctacgaggt acggctgacg cagaccgtgg cccacctgaa gcagcaagtg agcgggctgg
      421 agggtgtgca ggacgacctg ttctggctga ccttcgaggg gaagcccctg gaggaccagc
      481 tcccgctggg ggagtacggc ctcaagcccc tgagcaccgt gttcatgaat ctgcgcctgc
      541 ggggaggcgg cacagagcct ggcgggcgga gctaagggcc tccaccagca tccgagcagg
      601 atcaagggcc ggaaataaag gctgttgtaa agagaaa
//
