LOCUS       NP_112202                129 aa            linear   PRI 27-APR-2025
DEFINITION  iron-sulfur cluster assembly 1 homolog, mitochondrial precursor
            [Homo sapiens].
ACCESSION   NP_112202
VERSION     NP_112202.2
DBSOURCE    REFSEQ: accession NM_030940.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 129)
  AUTHORS   Du,J., Huang,Z., Li,Y., Ren,X., Zhou,C., Liu,R., Zhang,P., Lei,G.,
            Lyu,J., Li,J. and Tan,G.
  TITLE     Copper exerts cytotoxicity through inhibition of iron-sulfur
            cluster biogenesis on ISCA1/ISCA2/ISCU assembly proteins
  JOURNAL   Free Radic Biol Med 204, 359-373 (2023)
   PUBMED   37225108
  REMARK    GeneRIF: Copper exerts cytotoxicity through inhibition of
            iron-sulfur cluster biogenesis on ISCA1/ISCA2/ISCU assembly
            proteins.
REFERENCE   2  (residues 1 to 129)
  AUTHORS   Zhou,R., Peng,N. and Li,W.
  TITLE     Identification of ISCA1 as novel immunological and prognostic
            biomarker for bladder cancer
  JOURNAL   Front Immunol 13, 975503 (2022)
   PUBMED   36072584
  REMARK    GeneRIF: Identification of ISCA1 as novel immunological and
            prognostic biomarker for bladder cancer.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 129)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (residues 1 to 129)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (residues 1 to 129)
  AUTHORS   Suraci,D., Saudino,G., Nasta,V., Ciofi-Baffoni,S. and Banci,L.
  TITLE     ISCA1 Orchestrates ISCA2 and NFU1 in the Maturation of Human
            Mitochondrial [4Fe-4S] Proteins
  JOURNAL   J Mol Biol 433 (10), 166924 (2021)
   PUBMED   33711344
  REMARK    GeneRIF: ISCA1 Orchestrates ISCA2 and NFU1 in the Maturation of
            Human Mitochondrial [4Fe-4S] Proteins.
REFERENCE   6  (residues 1 to 129)
  AUTHORS   Song,D., Tu,Z. and Lee,F.S.
  TITLE     Human ISCA1 interacts with IOP1/NARFL and functions in both
            cytosolic and mitochondrial iron-sulfur protein biogenesis
  JOURNAL   J Biol Chem 284 (51), 35297-35307 (2009)
   PUBMED   19864422
  REMARK    GeneRIF: human IscA1 plays an important role in both mitochondrial
            and cytosolic iron-sulfur cluster biogenesis, and a notable
            component of the latter is the interaction between IscA1 and IOP1.
REFERENCE   7  (residues 1 to 129)
  AUTHORS   Nilsson,R., Schultz,I.J., Pierce,E.L., Soltis,K.A.,
            Naranuntarat,A., Ward,D.M., Baughman,J.M., Paradkar,P.N.,
            Kingsley,P.D., Culotta,V.C., Kaplan,J., Palis,J., Paw,B.H. and
            Mootha,V.K.
  TITLE     Discovery of genes essential for heme biosynthesis through
            large-scale gene expression analysis
  JOURNAL   Cell Metab 10 (2), 119-130 (2009)
   PUBMED   19656490
  REMARK    GeneRIF: Required for functional heme biosynthesis in erythroid
            cells.
REFERENCE   8  (residues 1 to 129)
  AUTHORS   Cozar-Castellano,I., del Valle Machargo,M., Trujillo,E.,
            Arteaga,M.F., Gonzalez,T., Martin-Vasallo,P. and Avila,J.
  TITLE     hIscA: a protein implicated in the biogenesis of iron-sulfur
            clusters
  JOURNAL   Biochim Biophys Acta 1700 (2), 179-188 (2004)
   PUBMED   15262227
  REMARK    GeneRIF: screening a human brain cDNA expression library with serum
            from a patient suffering from the autoimmune Sjogren's syndrome
            yielded a gene product called hIscA implicated in iron-sulfur
            cluster biogenesis
REFERENCE   9  (residues 1 to 129)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   10 (residues 1 to 129)
  AUTHORS   Shukla,A., Narayanan,D.L., Kaur,P. and Girisha,K.M.
  TITLE     ISCA1-Related Multiple Mitochondrial Dysfunctions Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   31580634
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG772866.1, BC002675.2, BC071621.1, AI436792.1 and AA745613.1.
            
            On Sep 22, 2004 this sequence version replaced NP_112202.1.
            
            Summary: ISCA1 is a mitochondrial protein involved in the
            biogenesis and assembly of iron-sulfur clusters, which play a role
            in electron-transfer reactions (Cozar-Castellano et al., 2004
            [PubMed 15262227]).[supplied by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225937.1, SRR3476690.915749.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000375991.9/
                                                  ENSP00000365159.4
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..129
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.33"
     Protein         1..129
                     /product="iron-sulfur cluster assembly 1 homolog,
                     mitochondrial precursor"
                     /EC_number="2.7.7.52"
                     /note="HESB like domain containing 2; iron-sulfur cluster
                     assembly 1 homolog, mitochondrial; HESB-like
                     domain-containing protein 2; iron-sulfur assembly protein
                     IscA"
                     /calculated_mol_wt=12936
     transit_peptide 1..12
                     /note="Mitochondrion. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (Q9BUE6.1)"
                     /calculated_mol_wt=1262
     mat_peptide     13..129
                     /product="Iron-sulfur cluster assembly 1 homolog,
                     mitochondrial. /id=PRO_0000042734"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BUE6.1)"
                     /calculated_mol_wt=12936
     Region          24..129
                     /region_name="IscA"
                     /note="Fe-S cluster assembly iron-binding protein IscA
                     [Posttranslational modification, protein turnover,
                     chaperones]; COG0316"
                     /db_xref="CDD:440085"
     CDS             1..129
                     /gene="ISCA1"
                     /gene_synonym="HBLD2; hIscA; hIscA1; ISA1; MMDS5"
                     /coded_by="NM_030940.4:81..470"
                     /db_xref="CCDS:CCDS35056.1"
                     /db_xref="GeneID:81689"
                     /db_xref="HGNC:HGNC:28660"
                     /db_xref="MIM:611006"
ORIGIN      
        1 msaslvratv ravskrklqp traaltltps avnkikqllk dkpehvgvkv gvrtrgcngl
       61 sytleytktk gdsdeeviqd gvrvfiekka qltllgtemd yvedklssef vfnnpnikgt
      121 cgcgesfni
//
