LOCUS       NM_005853               2398 bp    mRNA    linear   PRI 24-JUN-2024
DEFINITION  Homo sapiens iroquois homeobox 5 (IRX5), transcript variant 1,
            mRNA.
ACCESSION   NM_005853 XM_001129953
VERSION     NM_005853.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2398)
  AUTHORS   Jiang,B., Zheng,J., Yao,H., Wang,Y., Song,F. and Huang,C.
  TITLE     IRX5 suppresses osteogenic differentiation of hBMSCs by inhibiting
            protein synthesis
  JOURNAL   J Cell Physiol 239 (6), e31286 (2024)
   PUBMED   38666481
  REMARK    GeneRIF: IRX5 suppresses osteogenic differentiation of hBMSCs by
            inhibiting protein synthesis.
REFERENCE   2  (bases 1 to 2398)
  AUTHORS   Nagel,S., Pommerenke,C., Meyer,C. and MacLeod,R.A.F.
  TITLE     The Hematopoietic TALE-Code Shows Normal Activity of IRX1 in
            Myeloid Progenitors and Reveals Ectopic Expression of IRX3 and IRX5
            in Acute Myeloid Leukemia
  JOURNAL   Int J Mol Sci 23 (6), 3192 (2022)
   PUBMED   35328612
  REMARK    GeneRIF: The Hematopoietic TALE-Code Shows Normal Activity of IRX1
            in Myeloid Progenitors and Reveals Ectopic Expression of IRX3 and
            IRX5 in Acute Myeloid Leukemia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2398)
  AUTHORS   Kohl,S., Llavona,P., Sauer,A., Reuter,P., Weisschuh,N., Kempf,M.,
            Dehmelt,F.A., Arrenberg,A.B., Sliesoraityte,I., Zrenner,E., van
            Schooneveld,M.J., Rudolph,G., Kuhlewein,L. and Wissinger,B.
  TITLE     A duplication on chromosome 16q12 affecting the IRXB gene cluster
            is associated with autosomal dominant cone dystrophy with early
            tritanopic color vision defect
  JOURNAL   Hum Mol Genet 30 (13), 1218-1229 (2021)
   PUBMED   33891002
  REMARK    GeneRIF: A duplication on chromosome 16q12 affecting the IRXB gene
            cluster is associated with autosomal dominant cone dystrophy with
            early tritanopic color vision defect.
REFERENCE   4  (bases 1 to 2398)
  AUTHORS   Sobreira,D.R., Joslin,A.C., Zhang,Q., Williamson,I., Hansen,G.T.,
            Farris,K.M., Sakabe,N.J., Sinnott-Armstrong,N., Bozek,G.,
            Jensen-Cody,S.O., Flippo,K.H., Ober,C., Bickmore,W.A., Potthoff,M.,
            Chen,M., Claussnitzer,M., Aneas,I. and Nobrega,M.A.
  TITLE     Extensive pleiotropism and allelic heterogeneity mediate metabolic
            effects of IRX3 and IRX5
  JOURNAL   Science 372 (6546), 1085-1091 (2021)
   PUBMED   34083488
  REMARK    GeneRIF: Extensive pleiotropism and allelic heterogeneity mediate
            metabolic effects of IRX3 and IRX5.
REFERENCE   5  (bases 1 to 2398)
  AUTHORS   Zhu,Z., Gong,J., Kong,J., Qian,Y., Lu,K., Wang,H. and Yu,M.
  TITLE     Iroquois Homeobox 5 Negatively Regulated by miRNA-147 Promotes the
            Proliferation, Metastasis, and Invasion by Oral Squamous Cell
            Carcinoma
  JOURNAL   J Biomed Nanotechnol 17 (6), 1098-1108 (2021)
   PUBMED   34167624
  REMARK    GeneRIF: Iroquois Homeobox 5 Negatively Regulated by miRNA-147
            Promotes the Proliferation, Metastasis, and Invasion by Oral
            Squamous Cell Carcinoma.
REFERENCE   6  (bases 1 to 2398)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 2398)
  AUTHORS   Myrthue,A., Rademacher,B.L., Pittsenbarger,J., Kutyba-Brooks,B.,
            Gantner,M., Qian,D.Z. and Beer,T.M.
  TITLE     The iroquois homeobox gene 5 is regulated by 1,25-dihydroxyvitamin
            D3 in human prostate cancer and regulates apoptosis and the cell
            cycle in LNCaP prostate cancer cells
  JOURNAL   Clin Cancer Res 14 (11), 3562-3570 (2008)
   PUBMED   18519790
  REMARK    GeneRIF: Irx5 is involved in the regulation of both the cell cycle
            and apoptosis in human prostate cancer cells
REFERENCE   8  (bases 1 to 2398)
  AUTHORS   Bruneau,B.G.
  TITLE     [Irx5: a transcription factor that regulates the cardiac
            repolarization gradient]
  JOURNAL   Med Sci (Paris) 22 (3), 231-232 (2006)
   PUBMED   16527195
  REMARK    GeneRIF: involved in transcriptional regulation of heart
            morphogenesis
REFERENCE   9  (bases 1 to 2398)
  AUTHORS   Ogura,K., Matsumoto,K., Kuroiwa,A., Isobe,T., Otoguro,T.,
            Jurecic,V., Baldini,A., Matsuda,Y. and Ogura,T.
  TITLE     Cloning and chromosome mapping of human and chicken Iroquois (IRX)
            genes
  JOURNAL   Cytogenet Cell Genet 92 (3-4), 320-325 (2001)
   PUBMED   11435706
REFERENCE   10 (bases 1 to 2398)
  AUTHORS   Lewis,M.T., Ross,S., Strickland,P.A., Snyder,C.J. and Daniel,C.W.
  TITLE     Regulated expression patterns of IRX-2, an Iroquois-class homeobox
            gene, in the human breast
  JOURNAL   Cell Tissue Res 296 (3), 549-554 (1999)
   PUBMED   10370142
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC106738.3, AY335945.1 and
            BC074850.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_005853.5.
            
            Summary: This gene encodes a member of the iroquois homeobox gene
            family, which are involved in several embryonic developmental
            processes. Knockout mice lacking this gene show that it is required
            for retinal cone bipolar cell differentiation, and that it
            negatively regulates potassium channel gene expression in the heart
            to ensure coordinated cardiac repolarization. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Nov 2011].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AI814659.1, AI338253.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394636.9/ ENSP00000378132.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-334               AC106738.3         139477-139810       c
            335-989             AY335945.1         1-655
            990-1816            BC074850.2         485-1311
            1817-2398           AY335945.1         1480-2061
FEATURES             Location/Qualifiers
     source          1..2398
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q12.2"
     gene            1..2398
                     /gene="IRX5"
                     /gene_synonym="HMMS; IRX-2a; IRXB2"
                     /note="iroquois homeobox 5"
                     /db_xref="GeneID:10265"
                     /db_xref="HGNC:HGNC:14361"
                     /db_xref="MIM:606195"
     exon            1..583
                     /gene="IRX5"
                     /gene_synonym="HMMS; IRX-2a; IRXB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             335..1786
                     /gene="IRX5"
                     /gene_synonym="HMMS; IRX-2a; IRXB2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     iroquois-class homeodomain protein IRX-5; homeodomain
                     protein IRXB2; homeodomain protein IRX-2A"
                     /codon_start=1
                     /product="iroquois-class homeodomain protein IRX-5 isoform
                     1"
                     /protein_id="NP_005844.4"
                     /db_xref="CCDS:CCDS10751.1"
                     /db_xref="GeneID:10265"
                     /db_xref="HGNC:HGNC:14361"
                     /db_xref="MIM:606195"
                     /translation="MSYPQGYLYQPSASLALYSCPAYSTSVISGPRTDELGRSSSGSA
                     FSPYAGSTAFTAPSPGYNSHLQYGADPAAAAAAAFSSYVGSPYDHTPGMAGSLGYHPY
                     AAPLGSYPYGDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV
                     STWFANARRRLKKENKMTWTPRNRSEDEEEEENIDLEKNDEDEPQKPEDKGDPEGPEA
                     GGAEQKAASGCERLQGPPTPAGKETEGSLSDSDFKEPPSEGRLDALQGPPRTGGPSPA
                     GPAAARLAEDPAPHYPAGAPAPGPHPAAGEVPPGPGGPSVIHSPPPPPPPAVLAKPKL
                     WSLAEIATSSDKVKDGGGGNEGSPCPPCPGPIAGQALGGSRASPAPAPSRSPSAQCPF
                     PGGTVLSRPLYYTAPFYPGYTNYGSFGHLHGHPGPGPGPTTGPGSHFNGLNQTVLNRA
                     DALAKDPKMLRSQSQLDLCKDSPYELKKGMSDI"
     exon            584..989
                     /gene="IRX5"
                     /gene_synonym="HMMS; IRX-2a; IRXB2"
                     /inference="alignment:Splign:2.1.0"
     exon            990..2398
                     /gene="IRX5"
                     /gene_synonym="HMMS; IRX-2a; IRXB2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2318..2323
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRX5"
                     /gene_synonym="HMMS; IRX-2a; IRXB2"
                     /note="hexamer: ATTAAA"
     polyA_site      2339
                     /gene="IRX5"
                     /gene_synonym="HMMS; IRX-2a; IRXB2"
                     /note="major polyA site"
     regulatory      2371..2376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRX5"
                     /gene_synonym="HMMS; IRX-2a; IRXB2"
                     /note="hexamer: AATAAA"
     polyA_site      2398
                     /gene="IRX5"
                     /gene_synonym="HMMS; IRX-2a; IRXB2"
ORIGIN      
        1 agcatcttgg caggaccttt gcaaaggcaa aagcagagcc ccccggtgca aagagcgagg
       61 ggaaaaaaga gaaagcagca agggagggga ggggagggga aaaaaagccc agctggggcg
      121 agcgaggcgc gcagaggagc gggcgcggcg gtcgcagccg gaggcgcgcg ggaagccagc
      181 gaggaggcgc cgcgggccgg agccccggag ccggggccag aggagcggcg gcccagggca
      241 gccagaggcc aggtgcccgc ccgctcgccc tcgcagggcg ccgcccggct cgttggcggc
      301 cgcggcgcgg cgcgccccat gcccgtgtgt ggccatgtcc tatccgcagg gctacttgta
      361 ccagccgtcc gcctcgctgg cgctctactc gtgcccggcg tacagcacca gcgtcatttc
      421 ggggccccgc acggatgagc tcggccgctc ttcttcgggc tccgcgttct cgccctacgc
      481 tggctcgact gccttcacgg cgccctcgcc gggctacaac tcgcacctcc agtacggcgc
      541 cgaccccgcg gccgccgccg ccgccgcctt ctcctcgtac gtgggctctc cctacgacca
      601 cacacccggc atggcgggct ccttggggta ccatccttac gcggcgcccc tgggatcgta
      661 cccttacggg gacccagcgt accggaagaa cgccacaagg gacgccacgg ctaccctcaa
      721 ggcctggctc aacgagcacc gcaagaaccc ctaccccacc aagggcgaga agatcatgct
      781 ggccatcatc accaagatga ccctcaccca ggtgtccacc tggttcgcca acgcgcgccg
      841 gcgcctcaag aaagagaata aaatgacgtg gacgccgcgg aaccgcagcg aggacgagga
      901 agaggaggag aacattgacc tggagaagaa cgacgaggac gagccccaga agcccgagga
      961 caagggcgac cccgagggcc ccgaagcagg aggagctgag cagaaggcgg cttcgggctg
     1021 cgaacggctt cagggaccac ccacccctgc aggcaaggag acggagggca gcctcagcga
     1081 ctcggatttt aaggagccgc cctcggaggg ccgcctcgac gcgctgcagg gccccccccg
     1141 caccggcggg ccctccccgg ctgggccagc ggcggcgcgg ctggcggagg acccggcccc
     1201 tcactacccc gccggagcgc cggcgcccgg cccgcatcca gccgcgggcg aggtgcctcc
     1261 gggtcccggc gggccctcgg ttatccattc gccgcctccg ccgccgcctc ctgcggtgct
     1321 cgccaagccc aaactgtggt ctttggcaga gatcgccaca tcgtcggaca aggtcaagga
     1381 cgggggcggc gggaacgagg gctctccatg cccaccgtgt cccgggccca tagccgggca
     1441 agccctagga ggcagccggg cgtcgccggc cccggcgccg tcacgctcgc cctcggcgca
     1501 gtgtcctttt ccaggcggga cggtgctgtc ccggcctctc tactacaccg cgcccttcta
     1561 tcccggctac acgaactatg gctccttcgg acaccttcat ggccacccgg ggcccgggcc
     1621 aggccccaca accggtccgg ggtctcattt caatggatta aaccagaccg tgttgaaccg
     1681 agcggacgct ttggctaaag acccgaaaat gttgcggagc cagtctcagc tagacctgtg
     1741 caaagactct ccctatgaat tgaagaaagg tatgtccgac atttaacgcg ggctgcgtcg
     1801 gtcccggact tttctaattt attaaaaaca tggccttggc agttattttt ccatcaccga
     1861 gagagagaga cagagagaga aaataaacta cccctcctat tcagaagttt atagtttatg
     1921 gagatggatg acataaaaat gtaaacatct ccacacaaaa aaaaaaatgt cttaaccaac
     1981 cgaaaagaaa aattaaaaaa ggatttgtat taaatcttat tctgtatatt taatgtagca
     2041 tttttgtatt taaattgata attcaatatc tttgaagtaa attatgaaat caagacacct
     2101 gtacaggcat ttaatgtttt tttgtaatat aaatatatac atttgtgttt cccccaaaac
     2161 tgtttcatag ttaaaaaata caagtttaat ttaatttttt acacctattg attctgctgg
     2221 gtatgagcta aagtattaca gaaaggaaac aggttatact cttagattta aaaagtgaaa
     2281 gaaactgcag gcgcctttgt aaaatgcaaa atatttaatt aaaagagatt ttaacataat
     2341 gagagccact cattactttt tagaagcctc aataaactgt ccattgcctt ggtcaaaa
//
