LOCUS       NM_024336               2625 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens iroquois homeobox 3 (IRX3), mRNA.
ACCESSION   NM_024336 XM_113857
VERSION     NM_024336.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2625)
  AUTHORS   Ma,Y., Chen,G., Yi,J., Li,Q., Tan,Z., Fan,W., Luo,X., He,Z., Si,Z.
            and Li,J.
  TITLE     IRX3 plays an important role in the pathogenesis of
            metabolic-associated fatty liver disease by regulating hepatic
            lipid metabolism
  JOURNAL   Front Endocrinol (Lausanne) 13, 895593 (2022)
   PUBMED   35957832
  REMARK    GeneRIF: IRX3 plays an important role in the pathogenesis of
            metabolic-associated fatty liver disease by regulating hepatic
            lipid metabolism.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2625)
  AUTHORS   Ruiz-Diaz,M.S., Mena-Yi,D., Gomez-Camargo,D. and Mora-Garcia,G.
  TITLE     Interaction analysis of FTO and IRX3 genes with obesity and related
            metabolic disorders in an admixed Latin American population: a
            possible risk increases of body weight excess
  JOURNAL   Colomb Med (Cali) 53 (2), e2044874 (2022)
   PUBMED   36415696
  REMARK    GeneRIF: Interaction analysis of FTO and IRX3 genes with obesity
            and related metabolic disorders in an admixed Latin American
            population: a possible risk increases of body weight excess.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2625)
  AUTHORS   Nagel,S., Pommerenke,C., Meyer,C. and MacLeod,R.A.F.
  TITLE     The Hematopoietic TALE-Code Shows Normal Activity of IRX1 in
            Myeloid Progenitors and Reveals Ectopic Expression of IRX3 and IRX5
            in Acute Myeloid Leukemia
  JOURNAL   Int J Mol Sci 23 (6), 3192 (2022)
   PUBMED   35328612
  REMARK    GeneRIF: The Hematopoietic TALE-Code Shows Normal Activity of IRX1
            in Myeloid Progenitors and Reveals Ectopic Expression of IRX3 and
            IRX5 in Acute Myeloid Leukemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2625)
  AUTHORS   Sobreira,D.R., Joslin,A.C., Zhang,Q., Williamson,I., Hansen,G.T.,
            Farris,K.M., Sakabe,N.J., Sinnott-Armstrong,N., Bozek,G.,
            Jensen-Cody,S.O., Flippo,K.H., Ober,C., Bickmore,W.A., Potthoff,M.,
            Chen,M., Claussnitzer,M., Aneas,I. and Nobrega,M.A.
  TITLE     Extensive pleiotropism and allelic heterogeneity mediate metabolic
            effects of IRX3 and IRX5
  JOURNAL   Science 372 (6546), 1085-1091 (2021)
   PUBMED   34083488
  REMARK    GeneRIF: Extensive pleiotropism and allelic heterogeneity mediate
            metabolic effects of IRX3 and IRX5.
REFERENCE   5  (bases 1 to 2625)
  AUTHORS   Zhang,Z., Wu,Q., He,Y., Lu,P., Li,D., Yang,M., Gu,W., Liu,R.,
            Hong,J. and Wang,J.
  TITLE     IRX3 Overexpression Enhances Ucp1 Expression In Vivo
  JOURNAL   Front Endocrinol (Lausanne) 12, 634191 (2021)
   PUBMED   33776928
  REMARK    GeneRIF: IRX3 Overexpression Enhances Ucp1 Expression In Vivo.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2625)
  AUTHORS   Ragvin,A., Moro,E., Fredman,D., Navratilova,P., Drivenes,O.,
            Engstrom,P.G., Alonso,M.E., de la Calle Mustienes,E., Gomez
            Skarmeta,J.L., Tavares,M.J., Casares,F., Manzanares,M., van
            Heyningen,V., Molven,A., Njolstad,P.R., Argenton,F., Lenhard,B. and
            Becker,T.S.
  TITLE     Long-range gene regulation links genomic type 2 diabetes and
            obesity risk regions to HHEX, SOX4, and IRX3
  JOURNAL   Proc Natl Acad Sci U S A 107 (2), 775-780 (2010)
   PUBMED   20080751
  REMARK    GeneRIF: IRX3 function may have a direct functional relationship to
            both obesity and type 2 diabetes.
            Erratum:[Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4264]
REFERENCE   7  (bases 1 to 2625)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2625)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   9  (bases 1 to 2625)
  AUTHORS   Lewis,M.T., Ross,S., Strickland,P.A., Snyder,C.J. and Daniel,C.W.
  TITLE     Regulated expression patterns of IRX-2, an Iroquois-class homeobox
            gene, in the human breast
  JOURNAL   Cell Tissue Res 296 (3), 549-554 (1999)
   PUBMED   10370142
REFERENCE   10 (bases 1 to 2625)
  AUTHORS   Bellefroid,E.J., Kobbe,A., Gruss,P., Pieler,T., Gurdon,J.B. and
            Papalopulu,N.
  TITLE     Xiro3 encodes a Xenopus homolog of the Drosophila Iroquois genes
            and functions in neural specification
  JOURNAL   EMBO J 17 (1), 191-203 (1998)
   PUBMED   9427753
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC018553.6, AY335943.1 and BC023667.2.
            
            On Nov 23, 2018 this sequence version replaced NM_024336.2.
            
            Summary: IRX3 is a member of the Iroquois homeobox gene family (see
            IRX1; MIM 606197) and plays a role in an early step of neural
            development (Bellefroid et al., 1998 [PubMed 9427753]). Members of
            this family appear to play multiple roles during pattern formation
            of vertebrate embryos (Lewis et al., 1999 [PubMed
            10370142]).[supplied by OMIM, Aug 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY335943.1, BC023667.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2150585 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329734.4/ ENSP00000331608.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-321               AC018553.6         10088-10408         c
            322-1400            AY335943.1         1-1079
            1401-2001           BC023667.2         1047-1647
            2002-2625           AY335943.1         1681-2304
FEATURES             Location/Qualifiers
     source          1..2625
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q12.2"
     gene            1..2625
                     /gene="IRX3"
                     /gene_synonym="IRX-1; IRXB1"
                     /note="iroquois homeobox 3"
                     /db_xref="GeneID:79191"
                     /db_xref="HGNC:HGNC:14360"
                     /db_xref="MIM:612985"
     exon            1..1004
                     /gene="IRX3"
                     /gene_synonym="IRX-1; IRXB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             738..2243
                     /gene="IRX3"
                     /gene_synonym="IRX-1; IRXB1"
                     /note="iroquois homeobox protein 3; iroquois-class
                     homeodomain protein IRX-1; homeodomain protein IRXB1"
                     /codon_start=1
                     /product="iroquois-class homeodomain protein IRX-3"
                     /protein_id="NP_077312.2"
                     /db_xref="CCDS:CCDS10750.1"
                     /db_xref="GeneID:79191"
                     /db_xref="HGNC:HGNC:14360"
                     /db_xref="MIM:612985"
                     /translation="MSFPQLGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELN
                     ASGSLSNVLSSVYGAPYAAAAAAAAAQGYGAFLPYAAELPIFPQLGAQYELKDSPGVQ
                     HPAAAAAFPHPHPAFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEK
                     IMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEED
                     EEDGKRELELEEEELGGEEEDTGGEGLADDDEDEEIDLENLDGAATEPELSLAGAARR
                     DGDLGLGPISDSKNSDSEDSSEGLEDRPLPVLSLAPAPPPVAVASPSLPSPPVSLDPC
                     APAPAPASALQKPKIWSLAETATSPDNPRRSPPGAGGSPPGAAVAPSALQLSPAAAAA
                     AAHRLVSAPLGKFPAWTNRPFPGPPPGPRLHPLSLLGSAPPHLLGLPGAAGHPAAAAA
                     FARPAEPEGGTDRCSALEVEKKLLKTAFQPVPRRPQNHLDAALVLSALSSS"
     exon            1005..2121
                     /gene="IRX3"
                     /gene_synonym="IRX-1; IRXB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2188
                     /gene="IRX3"
                     /gene_synonym="IRX-1; IRXB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2625
                     /gene="IRX3"
                     /gene_synonym="IRX-1; IRXB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2595..2600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRX3"
                     /gene_synonym="IRX-1; IRXB1"
                     /note="hexamer: AATAAA"
     polyA_site      2625
                     /gene="IRX3"
                     /gene_synonym="IRX-1; IRXB1"
                     /note="major polyA site"
ORIGIN      
        1 agacagacac cgacacacac cccccgcgcg gcaccctaag tgtccacaac ttttggctgc
       61 cttacttagc ccagggcgca gaggctggaa aggtcgcggg gagtatcgtg tgagtaaaga
      121 gagagattta caaaatagaa gtagtgagaa aggaagaagt gaagggaacg gaccggagag
      181 caaaagccct cgtgagaaag ggaaagagaa ggggagagga gaaaggagag tttcatagcg
      241 tccagggcag tgcaggagcc cgaagcagcg gaagcgatcc tggggggaag aggagtgcgg
      301 agaggggagg ggagaggaag ggcgaggagg gggagtgaaa actagaggag ggcgaaggaa
      361 gcgaggcgcg acactgctgg ggagaggagg gcagtgagga gcgaggagcg ggcagaggca
      421 gctccggcgg ccgagaggag ggagcgcggc gcagagagga ggggcttgcg ccccgtagaa
      481 atgtcaatca gagcccggag ccccgggaat ctccgccaat ctgttcggac ctgacctggc
      541 tcctcgccgc cgccctcgcc gccgccgtcg ccgccgcgga gcagatcaat aggcgaacgc
      601 ggagcacagc gcagcgcggg cggcagcgcg gccccaagcc cggcccagcc cccgatgcgc
      661 gccggagccc gcgggcggcg ctgagctggg cggcccgggg gtcggccccc ctctccgtcc
      721 gtgccccgcg ggccaccatg tccttccccc agctgggata ccaatacatc cgcccgcttt
      781 acccgtccga gcgcccgggg gccgctggcg gcagcggcgg cagcgcgggg gcccggggcg
      841 gcctgggtgc cggagcctcg gagctgaacg cctcggggtc cctgtccaac gtgctctcgt
      901 ccgtgtacgg ggcgccctac gccgcggccg ctgcggccgc cgccgcccaa ggctacggcg
      961 ccttcctgcc ctacgccgcg gagctgccca tcttcccgca gctgggcgcg cagtatgagc
     1021 tgaaggacag ccccggggtg cagcatccgg ccgcggctgc cgcgtttccg cacccgcacc
     1081 ccgccttcta cccgtatggc cagtaccagt tcggggaccc gtcccgtccc aagaacgcca
     1141 ccagggagag caccagcacg ctgaaggcct ggctcaacga gcaccgcaag aacccctacc
     1201 ccaccaaggg cgagaagatc atgctggcca tcatcaccaa gatgaccctc acccaggtgt
     1261 ccacctggtt cgccaacgcg cgccggcgcc tcaagaagga gaataagatg acttgggcgc
     1321 ctcgcagccg cactgacgag gagggaaacg cttatgggag cgagcgcgag gaggaagacg
     1381 aagaggagga cgaggaggac ggcaaacgcg agctagagct ggaggaggag gagctcgggg
     1441 gggaggagga ggacacgggg ggcgagggcc tggctgacga cgacgaggac gaggagatcg
     1501 atttggagaa cttagacggc gcggccaccg agcctgagct gtccctggct ggggcggcgc
     1561 gcagggatgg cgacctaggc ctgggaccca tttcggactc caaaaatagc gactcggaag
     1621 atagctctga gggcttagag gaccggccac taccggtcct gagtctggct ccagcgccac
     1681 caccagtggc cgtggcctcg ccgtctctgc cgtcgccccc cgtgagcctg gacccctgcg
     1741 ctcccgcacc agcccccgcc tccgccctgc agaagcccaa gatctggtcc ctcgcggaga
     1801 ctgccacaag cccggacaac ccgcgccgct cgcctcccgg cgcggggggg tctccaccgg
     1861 gggcagcggt cgcgccttcc gccctgcagc tctctccggc cgccgccgcc gccgccgctc
     1921 acagactggt ctcagcgccg ctgggcaagt tcccggcttg gaccaaccgg ccgtttccag
     1981 gcccaccgcc cggcccccgc ctgcacccgc tctccctgct gggctctgcc cctccgcacc
     2041 tgctgggact tcccggagcc gcgggccacc cggctgccgc cgccgccttc gctcggccag
     2101 cggagcccga aggcggaaca gatcgctgta gtgccttgga agtggagaaa aagttactca
     2161 agacagcttt ccagcccgtg cccaggcggc cccagaacca tctggacgcc gccctggtct
     2221 tatcggctct ctcctcatcc tagttcttta aaaaaaacaa aaaaacaaaa aaaacttttt
     2281 ttaatcgttg taataattgt ataaaaaaaa tcgctctgta tagttacaac ttgtaagcat
     2341 gtccgtgtat aaatacctaa aagcaaaact aaacaaagaa agtaagaaaa agaaataaaa
     2401 ccagtcctcc tcagccctcc ccaagtcgct tctgtggcac cccgcattcg ctgtgaggtt
     2461 tgtttgtccg gttgattttg gggggtggag tttcagtgag aataaacgtg tctgcctttg
     2521 tgtgtgtgta tatatacaga gaaatgtaca tatgtgtgaa ccaaattgta cgagaaagta
     2581 tctatttttg gctaaataaa tgagctgctg ccactttgac tataa
//
