LOCUS       NM_033267               3079 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens iroquois homeobox 2 (IRX2), transcript variant 1,
            mRNA.
ACCESSION   NM_033267 XM_098392
VERSION     NM_033267.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3079)
  AUTHORS   Sim,H., Lee,J.E., Yoo,H.M., Cho,S., Lee,H., Baek,A., Kim,J.,
            Seo,H., Kweon,M.N., Kim,H.G., Jeon,Y.J., Son,M.Y. and Kim,J.
  TITLE     Iroquois Homeobox Protein 2 Identified as a Potential Biomarker for
            Parkinson's Disease
  JOURNAL   Int J Mol Sci 21 (10), 3455 (2020)
   PUBMED   32422864
  REMARK    GeneRIF: Iroquois Homeobox Protein 2 Identified as a Potential
            Biomarker for Parkinson's Disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3079)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3079)
  AUTHORS   Werner,S., Stamm,H., Pandjaitan,M., Kemming,D., Brors,B., Pantel,K.
            and Wikman,H.
  TITLE     Iroquois homeobox 2 suppresses cellular motility and chemokine
            expression in breast cancer cells
  JOURNAL   BMC Cancer 15, 896 (2015)
   PUBMED   26560478
  REMARK    GeneRIF: IRX2 transcription factor might represent a novel
            metastasis associated protein that acts as a negative regulator of
            cellular motility and as a repressor of chemokine expression and
            loss of IRX2 expression could therefore contribute to early
            hematogenous dissemination of breast cancer by sustaining chemokine
            secretion and enabling mobilization of tumor cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3079)
  AUTHORS   Liu,T., Zhou,W., Cai,B., Chu,J., Shi,G., Teng,H., Xu,J., Xiao,J.
            and Wang,Y.
  TITLE     IRX2-mediated upregulation of MMP-9 and VEGF in a
            PI3K/AKT-dependent manner
  JOURNAL   Mol Med Rep 12 (3), 4346-4351 (2015)
   PUBMED   26062523
  REMARK    GeneRIF: IRX2 modulates the expression levels of MMP2 and VEGF in
            an AKTdependent manner.
REFERENCE   5  (bases 1 to 3079)
  AUTHORS   Cornelis,M.C., Fornage,M., Foy,M., Xun,P., Gladyshev,V.N.,
            Morris,S., Chasman,D.I., Hu,F.B., Rimm,E.B., Kraft,P., Jordan,J.M.,
            Mozaffarian,D. and He,K.
  TITLE     Genome-wide association study of selenium concentrations
  JOURNAL   Hum Mol Genet 24 (5), 1469-1477 (2015)
   PUBMED   25343990
REFERENCE   6  (bases 1 to 3079)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 3079)
  AUTHORS   Lam,C.Y., Tam,P.O., Fan,D.S., Fan,B.J., Wang,D.Y., Lee,C.W.,
            Pang,C.P. and Lam,D.S.
  TITLE     A genome-wide scan maps a novel high myopia locus to 5p15
  JOURNAL   Invest Ophthalmol Vis Sci 49 (9), 3768-3778 (2008)
   PUBMED   18421076
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 3079)
  AUTHORS   Adamowicz,M., Radlwimmer,B., Rieker,R.J., Mertens,D.,
            Schwarzbach,M., Schraml,P., Benner,A., Lichter,P.,
            Mechtersheimer,G. and Joos,S.
  TITLE     Frequent amplifications and abundant expression of TRIO, NKD2, and
            IRX2 in soft tissue sarcomas
  JOURNAL   Genes Chromosomes Cancer 45 (9), 829-838 (2006)
   PUBMED   16752383
  REMARK    GeneRIF: IRX2 represents a candidate target of 5p amplifications in
            soft tissue sarcomas and might play a crucial role during the
            progression of this disease.
REFERENCE   9  (bases 1 to 3079)
  AUTHORS   Ogura,K., Matsumoto,K., Kuroiwa,A., Isobe,T., Otoguro,T.,
            Jurecic,V., Baldini,A., Matsuda,Y. and Ogura,T.
  TITLE     Cloning and chromosome mapping of human and chicken Iroquois (IRX)
            genes
  JOURNAL   Cytogenet Cell Genet 92 (3-4), 320-325 (2001)
   PUBMED   11435706
REFERENCE   10 (bases 1 to 3079)
  AUTHORS   Lewis,M.T., Ross,S., Strickland,P.A., Snyder,C.J. and Daniel,C.W.
  TITLE     Regulated expression patterns of IRX-2, an Iroquois-class homeobox
            gene, in the human breast
  JOURNAL   Cell Tissue Res 296 (3), 549-554 (1999)
   PUBMED   10370142
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091891.3, BC065189.1, AB188492.1, AI928035.1, AI131378.1,
            AY335940.1 and BM969863.1.
            
            On Nov 22, 2018 this sequence version replaced NM_033267.4.
            
            Summary: IRX2 is a member of the Iroquois homeobox gene family.
            Members of this family appear to play multiple roles during pattern
            formation of vertebrate embryos.[supplied by OMIM, Apr 2004].
            
            Transcript Variant: This variant (1) represents the longer
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB188492.1, ERR279849.7347.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302057.6/ ENSP00000307006.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC091891.3         133652-133673       c
            23-1703             BC065189.1         8-1688
            1704-1921           AB188492.1         1685-1902
            1922-2061           AI928035.1         402-541
            2062-2480           AI131378.1         1-419               c
            2481-3072           AY335940.1         1473-2064
            3073-3079           BM969863.1         14-20               c
FEATURES             Location/Qualifiers
     source          1..3079
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.33"
     gene            1..3079
                     /gene="IRX2"
                     /gene_synonym="IRXA2"
                     /note="iroquois homeobox 2"
                     /db_xref="GeneID:153572"
                     /db_xref="HGNC:HGNC:14359"
                     /db_xref="MIM:606198"
     exon            1..513
                     /gene="IRX2"
                     /gene_synonym="IRXA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..1680
                     /gene="IRX2"
                     /gene_synonym="IRXA2"
                     /note="iroquois homeobox protein 2; homeodomain protein
                     IRXA2"
                     /codon_start=1
                     /product="iroquois-class homeodomain protein IRX-2"
                     /protein_id="NP_150366.1"
                     /db_xref="CCDS:CCDS3868.1"
                     /db_xref="GeneID:153572"
                     /db_xref="HGNC:HGNC:14359"
                     /db_xref="MIM:606198"
                     /translation="MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSA
                     FSPYPGSAAFTAQAATGFGSPLQYSADAAAAAAGFPSYMGAPYDAHTTGMTGAISYHP
                     YGSAAYPYQLNDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQ
                     VSTWFANARRRLKKENKMTWAPRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDE
                     GISLHVDSLTDHSCSAESDGEKLPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERG
                     LAPPKPVTSSPLTGLEAPLLSPPPEAAPRGGRKTPQGSRTSPGAPPPASKPKLWSLAE
                     IATSDLKQPSLGPGCGPPGLPAAAAPASTGAPPGGSPYPASPLLGRPLYYTSPFYGNY
                     TNYGNLNAALQGQGLLRYNSAAAAPGEALHTAPKAASDAGKAGAHPLESHYRSPGGGY
                     EPKKDASEGCTVVGGGVQPYL"
     exon            514..919
                     /gene="IRX2"
                     /gene_synonym="IRXA2"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1627
                     /gene="IRX2"
                     /gene_synonym="IRXA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..3079
                     /gene="IRX2"
                     /gene_synonym="IRXA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2956..2961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRX2"
                     /gene_synonym="IRXA2"
                     /note="hexamer: AATAAA"
     polyA_site      2983
                     /gene="IRX2"
                     /gene_synonym="IRXA2"
     regulatory      3054..3059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRX2"
                     /gene_synonym="IRXA2"
                     /note="hexamer: AATAAA"
     polyA_site      3079
                     /gene="IRX2"
                     /gene_synonym="IRXA2"
                     /note="major polyA site"
ORIGIN      
        1 actcccgact ccagactccc ccaaaccccg accgccggcc tggcgcgcgg ctgcgcccac
       61 cggctccgcg ctgctgccgc cgccaccgcc accccgccgc cgccccggcc cgcgggccgc
      121 ccaggctagt acccgggccg gcctgcctcc gccggccgtc cgggtgcccg ccgccgcgcc
      181 gcgccccggc cgggcgtgga tggagggcgc cgcgcgccct gcccgctgct cggcgtgacg
      241 cgggccccgc gccccgcgcc caccatgtcc tacccgcagg gctacctgta ccaggcgccc
      301 ggctcgctgg cgctctactc gtgcccggcc tacggcgcgt cggctttggc ggctccgcgc
      361 agcgaggagc tggcgcgctc ggcgtcgggc tcggcgttca gcccctaccc gggctcggcg
      421 gccttcacgg cgcaggcggc caccggcttc gggagcccgc tgcagtactc ggccgacgcc
      481 gccgccgccg ccgccggctt cccgtcctac atgggcgcac cctacgacgc gcacaccacc
      541 ggcatgaccg gcgccatcag ctaccacccg tacggcagcg cggcctaccc gtaccagctc
      601 aacgaccccg cgtaccgcaa gaacgccacg cgggacgcca cggccactct caaggcctgg
      661 ctcaacgagc accgcaagaa cccctacccc accaagggcg agaagatcat gctagccatc
      721 atcaccaaga tgaccctcac ccaggtctcc acctggttcg ccaacgcgcg ccggcgcctc
      781 aagaaggaga acaagatgac ctgggccccg agaaacaaaa gcgaagatga ggacgaggac
      841 gagggcgacg ctaccagaag caaggacgag agtcccgaca aggcgcagga gggcacggag
      901 acctcggcag aggacgaagg gatcagcctg cacgtggact cgctcacgga tcactcgtgc
      961 tcggccgagt cggacgggga gaagcttccg tgccgcgccg gggaccccct gtgcgaatcg
     1021 ggctcggagt gcaaggacaa gtatgacgac ctggaggacg acgaggacga cgacgaggag
     1081 ggcgagcggg gcctggcgcc gcccaagccc gtgacctcgt cgccgcttac cggcttggag
     1141 gcgccgctgc tgagcccccc gcccgaggcc gcgccccgcg gtggccgcaa gacgccccag
     1201 ggcagccgga cgtctccggg cgcgccgccc cccgccagca agcccaagct gtggtcgctg
     1261 gccgagatcg ccacgtcgga cctcaagcag ccgagcctgg gcccgggctg cgggccaccg
     1321 gggctgcccg cggccgccgc gccggcctca accggggcac cgccaggagg ctcgccctac
     1381 cctgcctcgc cgctgctggg ccgccccctc tactacacgt cgcccttcta cggcaactac
     1441 acaaactacg ggaacttgaa cgcggcgctg cagggccagg gtctcctgcg gtacaactct
     1501 gcggccgcgg cccccggcga ggccctgcac accgcgccaa aggcggccag cgacgcgggc
     1561 aaggcgggcg cgcacccgct cgagtcccac taccggtccc cgggcggcgg ctacgagccc
     1621 aagaaagatg ccagcgaggg ctgcaccgtg gttggcgggg gcgtccagcc ctacctatag
     1681 aagggccgag cacagcaatg caagtaagtg ggcaccctgg tgcttcccag accctgtgga
     1741 gcctcccagc accaacttgc ttaatgtgtt tttcttgctt ctggtcatgg ggttagaaga
     1801 cagagcattt caatcttgtc cagcttttct ttccttaagg gggaaactat attttctgtt
     1861 ttatagattc cctctttttg gcacaagttc tatcactcct ttacctaggg aaggaaaaaa
     1921 aaaatatata tatatatgtg tgtgtgtgtg tgtgtaatat atatatgtat atatatagta
     1981 catgtatata tatagtacat gtgtatatat atattacaca ctactgttgt tttcttttga
     2041 aacaatagat tattaaaatc tgggcattta tatgcaattt agagccattt ttactatgct
     2101 agacacataa tagacacatg ctttgatgag cttgggctac caaaacttgg agtagcaaaa
     2161 acctttatag atgatgtttg caaaataaga ctgaagagac acgaggcgta ctagtctttt
     2221 atcagccctg tccaacctcc cctccaccca tgtccaagtg gacaggactc tgacattctc
     2281 ccggggctca caacagtatc tcaaaaaata tgttgctttg caacgagtca gaattactaa
     2341 tcatagatct tgaagataag aaagatttgg aaccacttca gatcaactcg tttttataat
     2401 ggtgttgttg tggaactgaa agattgggga tgatttggtt ttttccttgg tccacaggta
     2461 ggtgtcacaa ttgctttgaa aaaaaaaaaa aaaaaaaagt cagcaggcca ttctctcttc
     2521 ccaagctcat aaatttacag atacaacaaa cagatgtcta aatccagacc acatcttgtg
     2581 ccactgtaaa agagaaggat ccacacagca ctgtcagccc acagactcta acaattggaa
     2641 cagactattg ttggacatat gtgaatttgt tggcatagta tagtttcccc gatgtatgtg
     2701 tgacttttga aaacaatctg tttttctcag gatatcttga attgatcact tcattgccac
     2761 ggtatatatt ctataggtgt gataggattt actgtaaagt ttatttgtaa aagatgtaca
     2821 cagtagaaat aaaacgtgat ggaagaactt gagtacttca gaagtggaaa caaatttgat
     2881 atttattttt ataatgatat aaagcttcta gtaatttatg caagttgtat tgcaatggaa
     2941 tctaaacttt ttgtaaataa attctgcctg gtttttattt gaacattgct ggttatacaa
     3001 tctttgttgg ttgtttaaca cgaattcttt actaatttat atcttaaatt gtaaataaaa
     3061 acagactagt ctacaataa
//
